黄花败酱皂甙的分离鉴定

从黄花败酱根茎中用柱层析方法分离出一单体化合物，经化学反应和光谱分析鉴定为齐墩果酸－3－β－0－α－L－鼠李吡喃糖基（1→2）－α－L－阿拉伯吡喃糖甙，即β-常春藤素（β-hederin）．     

黄花败酱中三糖皂甙的分离鉴定

从黄花败酱根和根茎的丙酮提取物中用柱层相和高效液相层析法分离出１个化合物,经化学反应和光谱分析鉴定为：３－０－（２′－０－乙酰基）－α－Ｌ阿拉伯吡喃糖基常春藤皂甙元２８－β－Ｄ－葡萄吡喃糖基（１→９）β－Ｄ葡萄吡喃糖酯甙。     

黄花败酱中甙元与单糖链皂甙的分离鉴定

从黄花败酱根茎和根的丙酮提取物中用柱层析方法分离出3个单体化合物,经化学反应和光谱分析鉴定为:齐墩果酸、常春藤皂甙元和常春藤皂甙元-3-0(2'-0-乙酰基)-α-L-阿位伯吡喃糖甙.     

黄花败酱的化学成分及药理作用研究进展

依据文献报道,对黄花败酱中的化学成分、药理作用进行了综述,为对其进一步的开发利用提供依据。     

黄花败酱提取物抗肿瘤作用的实验观察

目的：通过实验观察黄花败酱提取物的抗肿瘤作用。方法：采用小鼠肉瘤180(S180)实验模型和艾氏癌腹水型(EAC)细胞体外筛选法。结果：黄花败酱根提取物及其甲醇洗脱物硅胶柱层析所得H部分体内对S180有抑制作用;而根提取物的30％甲醇洗脱物、60％甲醇洗脱物及H部分体外对EAC无抑制作用。结论：黄花败酱根提取物及其H部分体内有抗肿瘤作用。     

牛膝中酸性三萜皂苷成分的分离与鉴定

目的研究中药牛膝中的三萜皂苷类成分.方法采用大孔树脂、硅胶、ODS柱色谱分离纯化,经理化常数、光谱学方法鉴定结构.结果分离得到了6个化合物,鉴定了其中的两个,结构分别为3-O-[2′-O-β-D-吡喃葡萄糖基-3′-O-(2″-羟基-1″-羧乙氧基羧丙基)]-β-D-葡萄糖醛酸基齐墩果酸-28-O-β-D-吡喃葡萄糖苷(牛膝皂苷Ⅰ)和齐墩果酸3-O-[3′-O-(2″-羟基-1″-羧乙氧基羧丙基)]-β-D-葡萄糖醛酸苷(牛膝皂苷Ⅱ).结论牛膝皂苷Ⅰ和Ⅱ均为首次从牛膝中得到.     

败酱属植物化学成分与药理作用

败酱属药用植物中含有皂苷类、环烯醚萜类、黄酮类、香豆素类、挥发油和有机酸类等主要化学成分.该属植物及其提取物具有镇静、抗肿瘤、抗菌、抗病毒、保肝利胆及调节免疫系统、调节循环系统等方面的药理作用.综述了9种、3亚种败酱属药用植物的生药资源、化学成分与药理作用,并总结了目前研究中存在的问题与发展前景.     

黄花败酱皂甙表面张力的研究

目的:对黄花败酱皂甙的表面张力进行研究。方法:用滴体积法对天然表面活性剂黄花败酱皂甙水溶液、黄花败酱皂甙复配水溶液的表面张力及离子添加剂和非离子添加剂的影响进行研究。结果:花败酱皂甙大大降低水的表面张力(cmc约1.0%),具有较高的表面活性。结论:黄花败酱皂甙具有表面活性,可作为天然表面活性物质加以开发利用。     

黄花败酱根与茎化学成份对比分析

采用双波长薄层扫描法绘制了黄花败酱根与茎化学成分的指纹图谱，表明二者化学成分存在很大差异，临床应用时不可用茎代替根。     

黄花败酱总皂苷提取物抗肿瘤作用的实验研究

目的:观察黄花败酱总皂苷提取物体内抗肿瘤活性.方法:用MTT法观察黄花败酱总皂苷对荷艾腹水癌小鼠的生命延长率.结果:黄花败酱总皂苷对荷艾腹水癌的小鼠存活时间有一定的延长作用.结论:黄花败酱总皂苷有效成分有一定的体内抗肿瘤活性,其作用机制还有待进一步研究.     

Coumarins and triterpenoid glycosides from the roots ofPatrinia scabiosaefolia

From the roots ofPatrinia scabiosaefolia (Valerianaceae), scopoletin (1), esculetin (2), oleanonic acid (3), 3-O-α-l-rhamnopyranosyl(1→2)-α-l-arabinopyranosyl oleanolic acid (4) and 3-O-α-l-rhamnopyranosyl (1→2)-α-l-arabinopyranosyl hederagenin (5) were isolated and characterized by spectral data.     

Two new triterpenoid saponins from Symplocos Chinensis

Two new triterpenoid saponins, symplocososides X (1) and Y (2) have been isolated from the roots of Symplocos chinensis, and their structures elucidated as 21β-O- cinnamoyl-22α-O-(2-methylbutanoyl)-15α, 16α, 28-trihydroxyolean-12-ene-3β-O-[β-d-glucopyranosyl (1 → 2)]-α-l-arabinofuranosyl (1 → 4)-β-d-glucuronopyranoside (1) and 21β-O-cinnamoyl-22α-O-(2-methylbutanoyl)-15α, 16α, 28-trihydroxyolean-12-ene-3β-O-(3-O-acetyl)-[β-d-glucopyranosyl (1 → 2)]-α-l-arabinofuranosyl (1 → 4)-β-d-glucuronopyranoside (2) by spectral and chemical methods. Their antitumor activities have also been tested.     

Three new triterpenoid saponins from the rhizomes of Impatiens pritzellii var. hupehensis

Three new triterpenoid saponins, impatiprins A-C (1-3), together with a known triterpenoid (4) and two known triterpenoid saponins (5, 6), were isolated from the rhizomes of Impatiens pritzellii Hook. f. var. hupehensis Hook. f. The structures of 1-3 were determined by 1D and 2D NMR, FAB-MS techniques and chemical methods. Compounds 1 and 2 showed weak cytotoxicities against S-180, HeLa and HepG2 cell lines.     

Rapid profiling and identification of triterpenoid saponins in crude extracts from Albizia julibrissin Durazz. by ultra high-performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry

Ultra high-performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry (UHPLC/ESI-Q-TOF-MS/MS) was applied to separate and identify triterpenoid saponins in crude extract from the stem bark of Albizia julibrissin Durazz. The molecular weights were determined by comparing quasi-molecular ions [M+NH(4)](+) in positive mode and [M-H](-) and [M-2H](2-) ions in negative mode. The MS/MS spectra of the [M-H](-) ions for saponins provided a wealth of structural information related to aglycone skeletons, sugar types and linked sequence. On the basis of the fragmentation behavior of known saponins isolated before, saponins from this plant were identified, even though references were not available. As a result, a total of twenty-eight saponins in the crude extract were identified, which all had a common basic skeleton of the triterpene oleanolic acid and eight of them were new compounds.     

GC-MS分析糙叶败酱不同部位的挥发油成分

目的研究糙叶败酱植物的根及根茎、茎、叶中的挥发油成分,比较其在化学成分及含量上的差异。方法采用水蒸气蒸馏法分别提取糙叶败酱的植物三个不同部位的挥发油,采用GC-MS技术分析、鉴定其化学成分。结果糙叶败酱根及根茎中挥发油得率约为1.5%,从中鉴定出59种化学成分,占总挥发油的99.9%;茎中挥发油得率约为0.3%,从中鉴定出60个化学成分,占总挥发油的100%;叶中挥发油得率约为0.5%,从中鉴定出60个化学成分,占总挥发油的100%;3个部位的挥发性共有成分11个,主要为1-石竹烯、α-古芸烯和苯并环庚烯类化合物。结论糙叶败酱的根及根茎、茎、叶中的挥发性成分在化合物组成及含量上均有一定差别;根及根茎部位和茎中的挥发性成分基本相同,主要为萜类和芳香族化合物;叶中除含上述萜类和芳香族化合物外,脂肪族化合物的种类更为丰富,含量也较高。     

Four new triterpenoid saponins from Ilex Godajam

Four new triterpenoid saponins, godosides A - D ( 1 - 4 ), along with eight known saponins, have been isolated from the fresh aerial parts of Ilex godajam . Structure elucidation of 1 - 4 was based on NMR, MS, IR and chemical analyses.