Studies on Nutritional Effects of Traditional Chinese Tonics with Nutrients Fortification on Pregnantrats

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Study on effect of Baoyuan Qiangshen Capsule No. II on tubular interstitial injury in chronic renal failure patientsCapsule No. II on tubular interstitial injury in chronic renal failure patients

Objective: To explore the protective effect of Baoyuan Qiangshen Capsule No. II (BYQS) and its mechanism in treating chronic renal failure (CRF).Methods: Sixty CRF patients were divided into 2 groups randomly, the treated group used BYQS combined with Lotensin and the control group administered with essential amino acid combined with Lotensin. Changes of renal functions and tubular labelled proteins were observed.Results: The markedly effective rate and total effective rate of the treated group were 63.3% and 93.3% respectively, and those of the control group were 30.0% and 56.7% respectively, the effect of the treated group was obviously better than that of the control group (P < 0.01). In the treated group after medication, blood urea nitrogen, serum creatinine and clearance rate of creatinine were improved significantly (P < 0.01), while Tamm-Horfau protein increased significantly (P < 0.01).Conclusion: BYQS could alleviate tubular interstitial injury significantly so as to improve the renal function and enhance the effective rate in treating CRF.     

Clinical observation on effect of Xiaoyu Zhixue Tablet on 104 patients with idiopathic multifocal bleeding and pletelet aggregation defect

Objective: To explore the effect and pharmacological mechanism of Xiaoyu Zhixue Tablet (XZT).Methods: XZT mainly composed of Chinese medical herbs to replenish Qi and remove stasis was used to treat patients with idiopathic multifocal bleeding and platelet aggregation defect. Patients were divided into 2 groups, the TCM group (104 cases) treated with XZT, and the control group (84 cases) with vitamin C, K and P, adrenosin and/or artificial menstruation, for at least 4 months.Results: The hemostatic effective rate was 92.3% in the TCM group and 27.4% in the control group (P< 0.005), the recovery rate of platelet aggregation after 6 months’ therapy was 69.2% and only 1.8% respectively. The difference between the two groups was very significant (P < 0.005).Conclusion: XZT could regulate the hemostatic action and platelet aggregation     

胃食管反流合并难治性咳嗽患者食管动力特点分析

目的 应用食管高分辨率测压,探讨胃食管反流病（GER）合并难治性咳嗽患者食管动力特点。方法 选取2016年1月—2018年3月郑州大学第一附属医院确诊为GER并行食管高分辨率测压（HRM）的患者71例,根据其是否合并难治性咳嗽分为GER合并难治性咳嗽组（22例）和GER组（49例）。采用HRM测量食管上括约肌静息压（UESP）、食管下括约肌静息压（LESP）、远端收缩积分（DCI）、远端潜伏期（DL）及4 s综合松弛压（4?s IRP）,分析两组患者食管动力特点的差异。结果 两组患者在性别、年龄、体重指数、吸烟史、饮酒史等方面差异无统计学意义（P?>0.05）;GER合并难治性咳嗽组存在无效食管动力（IEM）的患者比例高于GER组（P?<0.05）;GER合并难治性咳嗽组DCI更低（P?<0.05）;两组患者UESP、LESP、DL、4?s IRP比较,差异均无统计学意义（P?>0.05）。结论 GER合并难治性咳嗽患者IEM比例高,DCI低于单纯GER患者,HRM可客观评价食管动力,为临床诊治提供指导。     

Study on treatment of uloerative colitis with Liver-Qi stagnation by nourishing the Liver

Objective: To study the links between stagnation of the Liver-Qi and the pathogenesis of ulcerative colitis (UC) were studied clinically and experimentally.Methods: Using the principle of nourishing the Liver in the treated group and invigorating the Spleen in the control group.Results: The effective rate was 96% in the treated group and 82% in the control group, and the difference was significant (P<0.05); the formation rate of E rosettes and the transformation rate of lymphocytes were significantly raised in the two groups compared with the pre-treatment period, and the rate of adjusting dysfunction of vegetative nerve system in the treated group was evidently higher than that in the control group (P < 0.01). The level of intestinal styrenated phenol (SP) and vasoactive intestinal polypeptide (VIP) of UC model were determined in rats, and results showed that the level of SP and VIP significantly increased in the UC model group. They were markedly lowered in the treated group compared with model group (P < 0. 01) and there was significant difference from the control group (P<0.01).Conclusion: Wei Chang Ning , a drug to nourish the Liver, had the action of regulating neurological-endocrinological (gastrointestinal hormone)-immunological system.     

Bidirectional regulatory effect of listen injection on sex hormones in senile female patients with coronary heart disease of kidney Deficiency typeon sex hormones in senile female patients with coronary heart disease of kidney Deficiency type

Objective: To assess the efficacy of Lishen injection (LSI) in treating coronary heart disease (CHD).Methods: The effect of LSI on serum estradiol (E₂) testosterone (T) and E₂/T ratio in 30 postmenopausal patients with CHD of Kidney Deficiency (KD) were observed.Results: (l) Serum E₂ and the E₂/T ratio were lower (P < 0.01) in the group of Kidney Yang Deficiency type (KYaDT) and higher (P < 0.01) in the group of Kidney Yin Deficiency type (KYiDT) as compared with normal control. (2) After treatment with LSI the levels of serum E₂ and the E₂/T ratio were elevated in the KYaDT group (P < 0.01) and lowered in the KYiDT group (P < 0.01). Both approached the normal level (P >0.05). (3) The levels of T in both groups were unaffected (P >0.05) before and after treatment.Conclusion: The imbalance of Kidney-Yin and Kidney-Yang is correlated to the disturbance of sex hormones and LSI could not only regulate the Kidney-Yin and Kidney-Yang, improve the symptoms of KD, but also reverse the disturbance of sex hormone. With a good bidirectional regulatory effect on E₂, it is beneficial on balance of sex hormones of both sexes in the inner environment of human body.     

Effect of Zhuchun Pill on immunity and endocrine function of senile Kidney-Yang Deficiency) on immunity and endocrine function of senile Kidney-Yang Deficiency

Objective: To evaluate the effect of Zhuchun pill (ZCP) on senile Kidney-Yang Deficiency (KYD).Methods: By single blind method, 45 elderly males with KYD were divided randomly into the ZCP group (treated by ZCP) and the control group (treated by placebo, starch capsule) and treated for 3 months.Results: ZCP could greatly improve the main symptoms of KYD,P < 0. 01 in comparison with the control group. After treatment, in the ZCP group, the³H-TdR lymphocyte transformation rate, levels of serum C₃, IgA, IgD, IgG and IgM, superoxide dismutase, plasma adrenocortical hormone, testosterone and cyclic adenosine monophosphate all increased,P < 0.01, and plasma lipid peroxide decreased,P < 0.01. While in the control group, no remarkable change was found in these parameters.Conclusion: ZCP could improve the KYD through regulating the immunity, endocrine function and scavenging the free radicals in organism.     

Effect of Shashen Maidong Decoction on gastric motility in vivo) on gastric motility in vivo

Objective: To evaluate the effect of Shashen Maidong Decoction (SSMDD) on gastric motility.Method: Effect of SSMDD on the gastric motility of mice and rats was observed in vivo by administration of SSMDD in various dosages and observation on gastric phenol red excretion rate, gastric emptying rate, frequency and amplitude of contraction of fundic longitudinal muscles, etc.Results: SSMDD could reduce markedly the gastric phenol red excretion rate of mice, antagonize the acceleration of gastric emptying induced by neostigmine, inhibit the frequency and amplitude of contraction of fundic longitudinal muscle, slow down the frequency and decrease the amplitude of gastric peristalsis, and reduce the gastric hypermotility induced by indomethacin significantly.Conclusion: SSMDD has evident inhibition action on motility of experimental animals in vivo, its mechanism might be related with adrenergic nerve and metabolism of prostaglandin E.     

Bailong tablet and chemotherapy in the treatment of moderate and advanced cancersand chemotherapy in the treatment of moderate and advanced cancers

Objective: To determine the effectiveness of Bailong Tablet and chemotherapy on treatment of moderate and advanced cancers.Methods: The patients were divided randomly into two groups. The treated group (n= 41) was treated with chemotherapy plus Bailong Tablet; and the control group (n= 22) treated with chemotherapy alone. Treatment effectiveness was measured with Karnofsky scores.Results: Karnofsky performance status in the treated group before and after treatment was 66.0 ± 8.7 and 68.0 ± 5.9 respectively, that in the control group was 67. 0 ± 6.8 and 53. 0 ± 7.3 respectively. The completion rate of chemotherapy in the treated group (92.6%, 38/41) was higher than that in control (77.2%, 17/22,P < 0.05). The side-effects caused by chemotherapy in the treated group were lower than that in the control group (P < 0.05). CD₃ ⁺, CD₄ ⁺ and CD₄ ⁺ /CD₈ ⁺ ratio were higher in the treated group.Conclusion: Bailong Tablet can enhance the therapeutic effect and reduce the side-effects of chemotherapy. One possible mechanism is the modulation of cellular immune function.     

Comparative study of Tiaoxue Yisui recipe with SSL regimen in treating infantile chronic aplastic anemia) with SSL regimen in treating infantile chronic aplastic anemia

Objective: To find the effective method in treating infantile chronic aplastic anemia (ICAA) by using traditional Chinese medicine (TCM).Methods: Seventy-eight cases of ICAA were observed, 48 in the treated group were treated with Tiaoxue Yisui recipe, and 30 cases in the control group with SSL regimen.Results: The remission rate and total effective rate in the treated group were 52.08% and 81.25% respectively, which were higher than those in the control group (P < 0.05). After one year’s treatment the ratio of hemopoietic and non-hemopoietic cells in the treated group was higher than that in the control group (P < 0.05).Conclusion: Tiaoxue Yisui recipe could improve the living quality of ICAA patients. The therapeutical mechanism of the recipe might be related to its promoting the proliferation of hemopoietic stem cells and regulating the immune function.     

Effect of Xueguantong on plasma endothelin and calcitonin gene-related peptide in quail atherosis modelon plasma endothelin and calcitonin gene-related peptide in quail atherosis model

Objective: To explore the antiatherogenic mechanism of the action of Xueguantong at molecular level.Methods: After being established by feeding with high fat diet for 12 weeks, the quail atherosis models were given Xueguantong for 30 days. Then, their plasma endothelin and calcitonin gene-related peptide (CGRP) were determined with radioimmunoassay (RIA) and the effects of Xueguantong on plasma endothelin and CGRP in the models were observed.Results: The plasma endothelin increased and CGRP decreased during quail atherosis formation. The plasma endothelin was decreased (P < 0.05) and CGRP increased (P < 0.05) by Xueguantong.Conclusion: One of antiatherogenic mechanisms of Xueguantong was decreasing endothelin and increasing CGRP.     

Clinical and experimental study on treatment of mid-late stage rheumatoid arthritis with Shuguan Granules ())

Objective: To explore the therapeutic mechanism of Shuguan Granule ( , SGG) in treating mid-late stage rheumatoid arthritis (RA).Methods: Based on the principle of reinforcing Kidney to treat arthritis, removing phlegm to relieve stasis, two SGG, Shuguan Wenjing (SW) and Shuguan Qingluo (SQ) were prepared and used to treat 44 and 43 mid-late stage patients of RA respectively. The clinical results were compared with those of Wangbi Granule. Animal experiments on the effect of these two SGG were conducted.Results: The total effective rate of the SW, SQ and control group was 88.64%, 93.02% and 73.17% respectively. Results of experimental studies in rats with adjuvant-induced arthritis showed that the two SGG obviously raise the level of serum superoxide dismutase, and lowered the levels of serum interleukin-1, plasma prostaglandin E₂ and thromboxane B₂, as compared with the model group, the difference was significant (P < 0.05,P < 0.01).Conclusion: The two SGG have a comprehensive function of anti-inflammatory, analgesic, antioxidatory, antihypercoagulatory and immunoregulatory effect.     

胃食管反流病患者食管、胃运动功能的研究

目的 观察胃食管反流病(gastroesophageal reflux disease,GERD)患者食管下括约肌功能及胃底容受性舒张、胃窦排空功能,为临床治疗GERD提供理论依据.方法 31例GERD患者和10例志愿者通过灌注式测压导管监测GERD患者食管括约肌压(LESP)和一过性食管下括约肌松弛(TLESR),并实时B型超声监测胃近端容积和胃窦截面面积来反映胃底容受性舒张及胃排空情况,来观察GERD患者的食管、胃运动功能.结果 GERD患者LESP降低,TLESR频次增加(P<0.05);试餐时胃近端容积减小(P<0.05);胃排空时间延长、速率降低(P<0.05).结论 胃食管反流病患者可能存在着食管下括约肌运动障碍和胃运动障碍.     

Effect of Sanhuang Jiangtang recipe on insulin peripheral resistance in Type II diabetes mellitus) recipe on insulin peripheral resistance in Type II diabetes mellitus

Objective: To observe the effect of Sanhuang Jiangtang recipe ( , SHJT) on insulin peripheral resistance in Type II diabetes mellitus (DM).Methods: Ninety-five patients with type II DM were randomly divided into two groups. Fifty-three cases of SHJT group were given decoction and tablets of SHJT orally for 4–6 months. The efficacy was compared with that of 42 cases treated with Glipizide as the control. Before and after treatment standard steamed bread meal test was performed to measure the insulin peripheral sensitivity, insulin release to glucose and insulin sensitivity index.Results: (1) The total effective rates of improving insulin peripheral resistance and reducing blood sugar in SHJT group were 79. 2% and 80.1 %, which was equivalent to levels in the control group, but SHJT recipe was more effective in relieving symptoms of Qi deficiency and signs of blood stasis. (2) In SHJT group, the insulin peripheral sensitivity and insulin sensitivity index were significantly increased (P < 0.05 and 0.01), meanwhile the fasting blood sugar and blood sugar area were reduced (P < 0.05), but the change of insulin release to glucose was blunted. (3)The lowering of blood sugar in SHJT group was significantly negative correlated with the changing of degree of insulin peripheral sensitivity and index of insulin sensitivity (P < 0.01 and 0.05), but not with that of insulin area.Conclusion: It suggested that the treatment of SHJT recipe might decrease insulin peripheral resistance (partial reversal) by means of reducing hyperinsulinemia and improving insulin sensitivity.     

Clinical studies on Liangxue Piyan Granule No. 2 2 in treatment of psoriasisin treatment of psoriasis

Objective: To evaluate the therapeutic mechanism of Liangxue Piyan Granule No. 2 (LPG, 2 ) on psoriasis.Methods: Ninety six patients with psoriasis were treated with LPG, another 32 patients treated with Fufang Qingdai Capsule (FQC, ) were taken as control; clinical comparison was done with experimental studies.Results: The total effective rate of LPG group was 84.7 %, that of the control 71.9%, there was no significant difference (P<0.05). However, the recurrence rate of LPG group (3.6%) was significantly lower than that of the control (21.7%),P<0.01. Conclusions: LPG could modulate the immune function of the body, by inhibiting directly the proliferation of epidermal cells and the production of interleukin-6.     

Clinical study on Shuxuening combined with antipsychotics in treating chronic schizophreniacombined with antipsychotics in treating chronic schizophrenia

Objective: To make a preliminary evaluation of the clinical efficacy of Shuxuening (SXN).Methods: One hundred and forty-nine chronic schizophrenic patients were divided randomly into the SXN group and the control group in a double-blind research. SXN was given to the SXN group and placebo to the control group, and patients of both groups went on receiving the previous antipsychotic treatment. Brief Psychiatric Rating Scale (BPRS), Scale for Assessment of Negative Symptoms (SANS) and Treatment Emergent Symptoms Scale (TESS) were used to assess the effects of treatment and side effects of the drug. The evaluation was done before and during the 2nd, 4th, 6th, 10th and 12 th weeks in the course of treatment.Results: SXN was effective by BPRS evaluation (P < 0.05), and even the more effective to negative symptoms than positive symptoms by SANS evaluation (P < 0.05). It was safe and with little side effect. In addition, it was found that the incipience of SXN’ s efficacy was somehow related with the course of disease and the daily dosage used.Conclusion: SXN is worthy of further study n the treatment of chronic schizophrenia.     

Clinical study on treatment of large metastatic cervical lymphnodes of nasopharyngeal carcinoma by Shenlong Liquid in combination with thermotherapy and radiotherapy) in combination with thermotherapy and radiotherapy

Objective: To observe the clinical treatment of 105 patients of nasopharyngeal carcinoma with large metastatic cervical lymphnodes.Methods: The patients were divided randomly into three groups, 35 for each group. Group A was treated by combined therapy of Shenlong Liquid (SLL) with thermo- and radio-therapy, group B with combined therapy of thermo- and radio-therapy and group C with radiotherapy alone. The clinical conditions of the three groups were similar before treatment.Results: At the end of the treatment, the immediate regression rates of cervical lymphnodes of A, B and C group were 68.57%, 60.00% and 42.86% respectively, and the effect of group A was the best. In comparison of group A and C, the difference was significant (P < 0.05), but the comparison of group B with A, or B with C was insignificant (P >0.05).Conclusions: The combination therapy of SLL with thermo- and radio-therapy was preferable in treating large metastatic lymphnodes, as SLL was beneficial in increasing the sensitivity of tumor to thermotherapy, reducing their side-effect and preventing the hematogenous metastasis.     

Clinical study on influence of Buyang Huanwu Decoction on the metabolic imbalance of endothelin and calcitonin gene related peptide in patients with early cerebral infarctionon the metabolic imbalance of endothelin and calcitonin gene related peptide in patients with early cerebral infarction

Objective: To explore the mechanism of Buyang Huanwu Decoction (BHD) in treating early cerebral infarction.Methods: Seventy cases with early cerebral infarction were randomly divided into two groups. Chinese medicine group (CMG, n = 35) was treated with BHD; western medicine group (WMG, n = 35) was treated with hydroxyethyl starch injection and enteric coated aspirin tablets. The levels of endothelin (ET) and calcitonin gene related peptide (CGRP) in plasma before and after treatment and the results of clinical treatment were observed. Also healthy subjects were used as the normal control.Results: The levels of ET before treatment in the two treated groups were significantly higher than that of the healthy subjects (P<0. 001), and the levels of CGRP were significantly lower (P < 0.001). After treatment the metabolic imbalance of ET and CGRP improved significantly in the two treated groups (P<0. 001), but the ET and CGRP in CMG improved more obviously than those in WMG (P<0.01, P<0.05). The markedly effective and curative rate of CMG was higher than that of WMG (68. 6 % vs 31.4 %; ?² = 9. 65, P < 0. 01).Conclusion: BHD could improve the metabolic imbalance of ET and CGRP in patients with early cerebral infarction and on the virtue of this mechanism it could be used to treat cerebral infarction.     

Clinical Study of Weishu capsule () in treating precancerous lesions of chronic atrophic gastritis) in treating precancerous lesions of chronic atrophic gastritis

Objective: To explore the therapeutic effect and mechanism of Weishu capsule (WSC), in treating precancerous lesions of chronic atrophic gastritis (CAG).Methods: Seventy-five cases of precancerous lesions of CAG were distributed to two groups randomly, the WSC group (45 patients) treated with WSC taken orally and the Weining granule (WNG) group (30 patients) treated with Weining granule orally. The treatment course of both groups were 6 months. The clinical and pathological effects and the changes in scores of atrophy, intestinal metaplasia (IM) and its subgroups, dysplasia, carcinoembryonic antigen and proliferating cell nuclear antigen expression were observed before and after treatment.Results: The total effective rate was 91% and the effective rate of atrophy, IM, dysplasia in the WSC group were 64%, 67% and 65% respectively, and the respective scores were lowered significantly after treatment. Compared with the WNG group, the difference between the two groups was statistically significant (P < 0.01,P < 0.05). Immunohistochemical test showed that WSC could inhibit the subgroups of IM, circinoembryonic antigen and proliferating cell nuclear antigen expression significantly (P < 0.01).Conclusions: WSC could significantly improve the clinical and pathological changes in the precancerous lesions of CAG. The mechanism might be related to the inducing and promoting effect of WSC on the differentiation and maturity of IM cells and dysplasia cells. WSC could also inhibit and correct the abnormal proliferation of cells.     

Clinical study on the Piweiping capsule in treating patients with metaplasia of gastric mucosa

Objective: To evaluate the therapeutic effect of Piweiping capsule (PWPC) in treating patients with metaplasia of gastric mucosa and explore its mechanism.Method: One hundred and forty-three patients were diagnosed as chronic superficial atrophic gastritis of gastric antrum or with metaplasia by means of gastroscopic observation with pathological biopsy examination. They were divided into 4 types (type I - IV) according to Syndrome Differentiation of traditional Chinese medicine, and each type was subdivided according to treatment into 2 groups, 75 in the PWPC group and 68 in the Sanjiu Weitai ( ) group. Patients of PWPC group were in accordance with the type to which they belong treated with PWPC I, II, HI, IV respectively, while patients of SJWT group were all treated with SJWT. After 3 - 6 months of treatment, the clinical effect, pathological examination of gastric mucosa and some other parameters were observed.Results: The improvements of gastric mucosa cyclic adenosing monophosphate (cAMP), deoxyribonucleic acid (DNA),³H-thymopyrimidine nucleoside and lymphocyte transformation of the treatment group were all superior to those of SJWT group,P < 0.05-0.001. In the PWPC group, the curative rate and total effective rate on symptom were 49.3 % and 92.0% respectively, and the curative rate and total effective rate on intestinal metaplasia were 45.3 % and 62.7%. As for the SJWT group, they were 29.4%, 67.6%, 10.3% and 29.4% respectively. The difference between the two groups was significant,P < 0.001. Conclusion: PWPC could reverse the intestinal metaplasia through improving the gastric cAMP, DNA and strengthening the cellular immunity and the effect would be enhanced when the treatment was based on Syndrome Differentiation.