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1.
G. S. Yakobson D. G. Sakharov A. L. Markel' 《Bulletin of experimental biology and medicine》1994,118(1):695-697
Analysis of ECGs recorded in 3 standard leads, 3 augmented limb leads, and 3 chest leads revealed typical signs of left ventricular
hypertrophy with a relative deterioration of coronary blood supply in NISAG rats, a new strain with hereditary arterial hypertension.
These signs are considered to be characteristic of an established arterial hypertension and may be taken as evidence that
the NISAG strain can serve as an adequate animal model of human hypertensive disease.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, N
o
7 pp. 17–18, July, 1994
Presented by V. A. Trufakin, Member of the Russian Academy of Medical Sciences 相似文献
2.
The effects of an infection with 200Trichinella spiralis larvae on the intestinal phospholipase B activity and bone marrow eosinophilia of congenitally athymic (nude) mice (BALB/c; NU/NU) were studied. Nude mice were used since it had been shown that they do not undergo a typical worm expulsion and also they lack a thymus. The results showed that nude mice do not develop either an increased bone marrow eosinophilia or an elevation in intestinal phospholipase B activity. The findings thus support the hypothesis that phospholipase B is involved in the expulsion of parasitic worms and that elevated enzyme levels and expulsion are thymus cell dependent. 相似文献
3.
R. Yu. Yukhananov P. M. Klodt A. Yu. Shemanov A. E. Rat'kin F. Nyberg A. I. Maiskii 《Bulletin of experimental biology and medicine》1993,116(2):976-978
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 116, N
o
8, pp. 177–178, August, 1993 相似文献
4.
Davydova TV Evseev VA Fomina VG Mikovskaya OI 《Bulletin of experimental biology and medicine》2000,129(6):522-523
Experiments on C57BI/6 mice kept under conditions of free choice between alcohol and water for 4 and 12 months showed that
adoptive transfer of splenocytes extracorporeally stimulated with arginine vasopressin suppressed alcohol intake.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 129, No. 6, pp. 617–619, June, 2000 相似文献
5.
G. S. Yakobson A. R. Antonov G. V. Petrova L. N. Maslova A. L. Markel' 《Bulletin of experimental biology and medicine》1996,121(5):449-451
Endocrine functions were investigated in normotensive (Wistar) and hypertensive (NISAG) rats before and on days 3, 7, and
21 after subcutaneous epinephrine administration. Rats of the NISAG strain are characterized by elevated plasma levels of
aldosterone and thyroxine and lowered plasma levels of immunoreactive insulin, and their endocrine system develops a much
stronger response to a single epinephrine injection than does that of Wistar rats. This is manifested in a still higher aldosterone
level, elevated corticosterone and insulin concentrations, and reduced thyroxine content in the plasma.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, No. 5, pp. 495–498, May, 1996 相似文献
6.
Whole exon 5 and intron 5 replaced by RHCE in DVa(Hus) 总被引:7,自引:0,他引:7
The DVa(Hus) was previously investigated through cDNA analysis, which revealed an RHD-CE(5)-D hybrid allele. However, the 5 and 3 breakpoints remain unknown. In this article, gene recombinations between the RHD and RHCE alleles were investigated by a combination approach of a sequence-specific primer PCR (PCR-SSP) and an RHD full-length coding region sequencing method on two Chinese subjects with weak D phenotypes. The hybrid Rhesus box of each individual was also investigated through an established PCR-based method. As a result, two partial D phenotypes, DVa(Hus) and DVI type III, were identified, each carrying one hybrid RHD-CE-D allele. The two samples were also serotyped with Rh phontypes of DccEe and DCcee, respectively. Other sequencing analyses of the DVa(Hus) sample showed that the sequence of intron 4 is identical with RHD, whereas the whole sequence of exon 5 and intron 5 is identical with RHCE except for seven polymorphisms in the intron 5. We may concluded that in the case of this Chinese DVa(Hus), the whole exon 5 and complete intron 5 of a total segment of 1801 nucleotides were replaced by RHCE suggesting that the breakpoints of the replaced region are the 5 end of the exon 5 and the 3 end of the intron 5. 相似文献
7.
Daily testing of SHR and C57Bl/6 mice during 3 days shows an increase of the number of mice with a high level of anxiety,
which was determined according to the ratio of the number of entries into the light arms to the total sum of entries into
the light and dark arms of an elevated T-maze. Such results were obtained after 3 testings every 3 days in C57Bl/6 but not
in SHR mice. This procedure is proposed for the selection of anxious individuals as objects for an anxiety model.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, N
o
3, pp. 355–356, March, 1996
Presented by S. N. Golikov, Member of the Russian Academy of Medical Sciences 相似文献
8.
E. R. Muldashev T. J. Wimen N. N. Kurchatova N. P. Zimina A. S. Gur'yanov K. S. Inchenko 《Bulletin of experimental biology and medicine》1994,117(1):78-83
Extract isolated from a collagen-containing transplant (series ALLOPLANTTM), which is used in the treatment of benign and malignant neoplasms of the eyelid, inhibits DNA synthesis in the cellin vitro. This effect is nonspecific, reversible, and dose-dependent. The extract is thermostable and resistant to proteolytic enzymes.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 117, N
o
1, pp. 75–79, January, 1994 相似文献
9.
David R. Harder Jane A. Madden 《Pflügers Archiv : European journal of physiology》1985,403(4):402-406
These studies were undertaken to determine the effect of reducing aPCO2 below physiological levels on cat middle cerebral artery. Upon reduction ofPCO2 from 37 to 14 torr (pH 7.4) we observed membrane depolarization and force development. ReducingPCO2 decreased the slope of theE
m vs. log [K]o curve and increased the slope of the steady-state I/V relationship suggesting that the change inE
m was due to reduction of outward K+ conductance (g
k). Elevation of pH from 7.37 to 7.6 had a very similar effect on these cerebral arterial muscle cells, depolarizing the muscle membrane (reducing theE
m vs. log [K]o curve) and increasing the slope of the I/V relationship to statistically equivalent values as reduction ofPCO2. ReturningPCO2 from 14 to 37 torr rapidly relaxed these preparations, but only transiently. This relaxation was followed by a rebound contraction within 3 min, demonstrating a transient nature for the action of elevatingPCO2 in cerebral arteries. The response to changing pHo followed a slower time course but did not change with time. These studies demonstrate that both elevated pHo and reducedPCO2 activate cerebral arterial muscle by a mechanism which includes reduction ing
k. However, it can not be determined if these similar responses and reduction, ofg
k are mediated by changing pHi or mediated through different mechanisms. It is possible that pHo andPCO2 can modify cerebral arterial tone by direct mechanisms and not necesarily by their effect on pHi. It is clear, however, that reduction ofPCO2 and elevation of pHo both activate cerebral arterial muscle by a mechanism which includes reduction ofg
k.This study was supported by NIH grant no. HL-32871. Dr. Harder is an established investigator of the American Heart Association 相似文献
10.
Human cytomegalovirus (HCMV) viral chemokine, UL146, and TNF alpha-like receptor UL144 genes show a high degree of hypervariability in clinical isolates. These proteins are predicted to be immune modulators and may contribute to the pathogenesis of HCMV infections. We analyzed the UL146 and UL144 genetic variation of 51 HCMV isolates from congenitally infected children and 13 isolates from children in childcare. There was no statistically significant correlation between UL146 and UL144 genotypes and HCMV disease and/or sequelae. However, there were some groups that had a relatively large proportion of asymptomatic outcomes. These included UL146 group 8 (7/8 asymptomatic) and UL146 group 10 (3/3 asymptomatic). UL144 group B had 11/15 (73%) asymptomatic. UL146 and UL144 genes remained stable in serial isolates from children in daycare for intervals up to three years. These results indicate that most UL146 and UL144 genotypes do not predict clinical sequelae following congenital HCMV infections. 相似文献
11.
G. V. Idova T. A. Pavina E. P. Alperina L. V. Devoino 《Bulletin of experimental biology and medicine》1997,124(5):1101-1103
Enhanced immune response of aggressive CBA mice after 10 daily confrontations in sensory contact on day 4 after immunization
with sheep red blood cells (5×108) is paralleled by an increase in the count of CD4+ T-cells in the bone marrow. Aggressive behavior, weight of the spleen, and count of CD4+ T-helpers in the bone marrow (which is increased only in aggressors with a history of at least 3 victories) are correlated.
The effect of aggressive behavior on immunity can be caused by changes of the neurochemical status of the brain and determined
by an increase in the CD4+ T-helper count.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 124, No. 11, pp. 544–546, November, 1997 相似文献
12.
A. I. Shapoval 《Bulletin of experimental biology and medicine》1993,115(1):60-63
Translated from Byulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 115, No. 1, pp. 57–59, January, 1993. 相似文献
13.
G. N. Kryzhanovskii T. V. Davydova V. G. Fomina K. D. Pletsityi V. A. Evseev N. A. Krupina V. G. Kucheryanu 《Bulletin of experimental biology and medicine》1994,117(3):232-234
Motor activity of C57Bl/6 mice is found to be decreased following syngeneic transfer to them of splenocytes from mice with
an MPTP-induced parkinsonian syndrome. The decrease in motor activity does not result from the transfer of MPTP and is apparently
associated with the transfer of B lymphocytes and with antibody production by these cells.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 117, N
o
3, pp. 232–234, March, 1994 相似文献
14.
In an effort to study a biologically important behavioral pattern in different naturally occurring populations of the same species, the copulatory behavior ofPeromyscus polionotus from South Carolina and from Santa Rosa Island, Florida, was compared with that ofP. polionotus from the Ocala National Forest, Florida. Twelve male and 16 female South Carolina mice received 71 tests, and five male and three female Santa Rosa mice received 18 tests. The basic pattern was identical across all three samples, being characterized by no lock, no intravaginal thrusting, multiple intromissions, and multiple ejaculations. Prolonged intromissions followed organized ejaculatory series. Quantitative differences among samples were found for several measures. Intromission Frequency appears particularly susceptible to local variation. Between-population differences in copulatory behavior appear to be of a quantitative rather than a qualitative nature. 相似文献
15.
Park JK Kim YC Sim JH Choi MY Choi W Hwang KK Cho MC Kim KW Lim SW Lee SJ 《Pflügers Archiv : European journal of physiology》2007,454(2):307-319
Employing microfluorometric system and patch clamp technique in rabbit basilar arterial myocytes, regulation mechanisms of
vascular excitability were investigated by applying intracellular pH (pHi) changers such as sodium acetate (SA) and NH4Cl. Applications of caffeine produced transient phasic contractions in a reversible manner. These caffeine-induced contractions
were significantly enhanced by SA and suppressed by NH4Cl. Intracellular Ca2+ concentration ([Ca2+]i) was monitored in a single isolated myocyte and based the ratio of fluorescence using Fura-2 AM (R
340/380). SA (20 mM) increased and NH4Cl (20 mM) decreased R
340/380 by 0.2 ± 0.03 and 0.1 ± 0.02, respectively, in a reversible manner. Caffeine (10 mM) transiently increased R
340/380 by 0.9 ± 0.07, and the ratio increment was significantly enhanced by SA and suppressed by NH4Cl, implying that SA and NH4Cl may affect [Ca2+]i (p < 0.05). Accordingly, we studied the effects of SA and NH4Cl on Ca2+-activated K+ current (IKCa) under patch clamp technique. Caffeine produced transient outward current at holding potential (V
h) of 0 mV, caffeine induced transient outward K+ current, and the spontaneous transient outward currents were significantly enhanced by SA and suppressed by NH4Cl. In addition, IKCa was significantly increased by acidotic condition when pHi was lowered by altering the NH4Cl gradient across the cell membrane. Finally, the effects of SA and NH4Cl on the membrane excitability and basal tension were studied: Under current clamp mode, resting membrane potential (RMP)
was −28 ± 2.3 mV in a single cell level and was depolarized by 13 ± 2.4 mV with 2 mM tetraethylammonium (TEA). SA hyperpolarized
and NH4Cl depolarized RMP by 10 ± 1.9 and 16 ± 4.7 mV, respectively. SA-induced hyperpolarization and relaxation of basal tension
was significantly inhibited by TEA. These results suggest that SA and NH4Cl might regulate vascular tone by altering membrane excitability through modulation of [Ca2+]i and Ca2+-activated K channels in rabbit basilar artery. 相似文献
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17.
T. V. Davydova V. G. Fomina G. N. Kryzhanovskii N. A. Krupina K. D. Pletsityi V. G. Kucheryanu 《Bulletin of experimental biology and medicine》1996,121(5):456-458
The administration of reaferon, a recombinant α-interferon preparation, hampers the development of parkinsonism caused by
MPTP administration in C57Bl/6 mice.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, No. 5, pp. 503–505, May, 1996 相似文献
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20.
A. A. Kubatiev I. A. Rud'ko V. M. Ermolenko 《Bulletin of experimental biology and medicine》1997,124(6):1167-1169
The study explores the effect of recombinant human erythropoietin and the rate of Na+,H+-exchange in erythrocytes from patients with chronic renal failure undergoing hemodialysis. The rate of Na+,H+-exchange in erythrocytes from patients was higher than in the control and remained unchanged after 24 months of treatment
with erythropoietin. Therapy with recombinant human erythropoietin does not normalize the Na+,H+-exchange mechanism. It is concluded that factors underlying disturbances of ion transport in erythrocytes from uremic patients
cannot be corrected with erythropoietin.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 124, No. 12, pp. 613–615, December, 1997 相似文献