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1.
Background We investigated factors affecting 5-year survival in patients undergoing hepatic resection for colorectal cancer metastases,
including events long after initial hepatectomy. Although retrospective studies have demonstrated survival benefit of hepatectomy
for metastatic colorectal cancer, few have included sufficient 5-year survivors to identify survival-related factors throughout
the clinical course.
Methods We divided 156 patients with hepatectomy for colorectal cancer metastases into 5-year survivors (n = 64) and patients dying
before 5 years after hepatectomy (n = 92). Clinicopathologic data were compared retrospectively with respect to long-term
outcome.
Results By multivariate analysis, large liver tumors (adjusted relative risk, 2.029; P = .011), short tumor doubling time (1.809; P = .026), and origin from poorly differentiated primary adenocarcinoma (12.632; P = .001) compromised survival, whereas initial treatment-related variables did not. Although no difference was seen in initial
treatment-related variables between 5-year survivors with recurrence after hepatectomy and patients dying before 5 years,
repeat surgery was used more frequently in survivors (P < .001), typically with adjuvant chemotherapy.
Conclusions Reoperations for each recurrence of metastases, followed by additional chemotherapy, frequently resulted in long survival. 相似文献
2.
Background Hepatic resection for metastatic colorectal cancer (CRC) with concomitant extrahepatic disease (EHD) is controversial. Earlier
reports of the results of liver resection for metastatic CRC identified patients with EHD as a group with poor outcomes, suggesting
that the presence of EHD was an absolute contraindication to resection. This has recently been challenged in several reports
due to advances in systemic chemotherapy, surgical technique, and patient selection.
Methods This review was restricted to published data in the English language identified by searches of MEDLINE and Pubmed databases
as well as reference lists of recent review articles on subjects of surgery for metastatic colorectal cancer.
Results Five-year survival after resection is worse than patients with liver-only disease but approximates the survival rates seen
in patients with resected liver-only metastases in the era prior to the use of modern chemotherapy. Recurrence occurs in the
great majority of patients.
Conclusions At this time, there appears to be a role for surgery in highly selected patients with a single site of EHD amenable to complete
resection. Unlike patients with liver-only disease, however, the goals of surgery must not be viewed as potentially curative. 相似文献
3.
Journal of Gastrointestinal Surgery - 相似文献
4.
Five-Year Survival Following Hepatic Resection After Neoadjuvant Therapy for Nonresectable Colorectal [Liver] Metastases 总被引:9,自引:0,他引:9
Adam R Avisar E Ariche A Giachetti S Azoulay D Castaing D Kunstlinger F Levi F Bismuth F 《Annals of surgical oncology》2001,8(4):347-353
Background: Surgical resection is the most effective treatment for colorectal liver metastases but only a minority of patients are candidates for a potentially curative resection. Our experience with neoadjuvant chemotherapy followed by resection and five years survival analysis of the patients treated is presented.Methods: Between February of 1988 and September of 1996, 701 patients with unresectable colorectal liver metastases were treated with neoadjuvant chemotherapy. Four categories of nonresectable disease were defined: large size, ill location, multinodularity, and extrahepatic disease. Liver resection was performed in those patients whose disease became resectable. After resection, the patients were followed up every 3 months. A 5-year survival analysis by the different categories described was performed.Results: Ninety-five patients (13.5%) were found to be resectable on reevaluation and underwent a potentially curative resection. There was no perioperative mortality, and the complication rate was 23%. As of December of 1999, 87 patients have completed 5 years of follow-up. The overall 5-year survival is 35% from the time of resection and 39% from the onset of chemotherapy. Respective 5-year survival rates are 60% for large tumors, 49% for ill-located lesions, 34% for multinodular disease, and 18% for liver metastases with extrahepatic disease. In this latter category, however, a 35% 5-year survival was found when all the patients with extrahepatic disease were analyzed rather than only those for whom extrahepatic disease was the main cause of nonresectability.Conclusions: Neoadjuvant chemotherapy enables liver resection in some patients with initially unresectable colorectal metastases. Long-term survival is similar to that reported for a priori surgical candidates. 相似文献
5.
Arru M Aldrighetti L Castoldi R Di Palo S Orsenigo E Stella M Pulitanò C Gavazzi F Ferla G Di Carlo V Staudacher C 《World journal of surgery》2008,32(1):93-103
Background The aim of this study was to analyze the prognostic factors associated with long-term outcome after liver resection for colorectal
metastases. The retrospective analysis included 297 liver resections for colorectal metastases.
Methods The variables considered included disease stage, differentiation grade, site and nodal metastasis of the primary tumor, number
and diameter of the lesions, time from primary cancer to metastasis, preoperative carcinoembryonic antigen (CEA) level, adjuvant
chemotherapy, type of resection, intraoperative ultrasonography and portal clamping use, blood loss, transfusions, complications,
hospitalization, surgical margins status, and a clinical risk score (MSKCC-CRS).
Results The univariate analysis revealed a significant difference (p < 0.05) in overall 5-year survival rates depending on the differentiation grade, preoperative CEA >5 and >200 ng/ml, diameter
of the lesion >5 cm, time from primary tumor to metastases >12 months, MSKCC-CRS >2. The multivariate analysis showed three
independent negative prognostic factors: G3 or G4 grade, CEA >5 ng/ml, and high MSKCC-CRS.
Conclusions No single prognostic factor proved to be associated with a sufficiently disappointing outcome to exclude patients from liver
resection. However, in the presence of some prognostic factors (G3–G4 differentiation, preoperative CEA >5 ng/ml, high MSKCC-CRS),
enrollment of patients in trials exploring new adjuvant treatments is suggested to improve the outcome after surgery. 相似文献
6.
Raphael Araujo MD Mithat Gonen PhD Peter Allen MD Leslie Blumgart MD Ronald DeMatteo MD Yuman Fong MD Nancy Kemeny MD William Jarnagin MD Michael D’Angelica MD 《Annals of surgical oncology》2013,20(13):4312-4321
Background
Additional chemotherapy in patients with resectable colorectal liver metastases (CRLM) likely improves outcomes. Whether to administer chemotherapy as perioperative or adjuvant therapy remains controversial. We analyzed outcomes between these two treatment strategies.Methods
Patients were identified from a prospective CRLM database and studied retrospectively. Patients with extrahepatic disease or initially unresectable CRLM were excluded. Only patients receiving oxaliplatin- and/or irinotecan-containing chemotherapy regimens were included. Univariate and Cox regression models were developed for recurrence and death.Results
Between 1998 and 2007, 236 patients (57.4 %) in the adjuvant group and 175 patients (42.6 %) in the perioperative group were compared. The perioperative group was younger and had more tumors, shorter disease-free intervals, and higher clinical risk scores (CRS), but had smaller tumors. The overall survival was similar between the groups (perioperative 72.9 months vs. adjuvant 71.5 months; p = 0.48). When the comparison was adjusted for other clinicopathologic factors and CRS, the differences remained insignificant. On univariate analysis, there was a significant difference in recurrence-free survival between the groups (perioperative 17.2 months vs. adjuvant 27.4 months, p = 0.036). However, when the recurrence-free survival was adjusted for other clinicopathologic factors and the CRS, differences were not significant.Conclusions
The timing of additional chemotherapy for resectable CRLM is not associated with outcomes. Trials comparing adjuvant and perioperative chemotherapy would have to be powered for small differences in outcome. 相似文献7.
Takakura Y Okajima M Kanemitsu Y Kuroda S Egi H Hinoi T Tashiro H Ohdan H 《World journal of surgery》2011,35(10):2275-2282
Background
Two nomograms are available for predicting patient survival after hepatic resection for metastatic colorectal cancer (CRC). However, they have not been externally validated using other databases, and so their universal applicability has not been established. We aimed to examine the validity of these nomograms for predicting patient survival after hepatic resection for metastatic CRC in different institutions. 相似文献8.
Akio Saiura Junji Yamamoto Rintaro Koga Yu Takahashi Michiro Takahashi Yosuke Inoue Yoshihiro Ono Norihiro Kokudo 《Annals of surgical oncology》2014,21(13):4293-4299
Background
The rate of recurrence after liver resection for colorectal liver metastases (CLM) is high, and repeat resection (RR) is reserved with curative intent in selected patients. This study evaluated the benefit of RR for recurrence after liver resection for CLM.Methods
Data were collected on 287 consecutive patients who underwent primary curative hepatectomy between January 1999 and October 2008 for CLM at our institution.Results
After median follow-up of 63 months, 211 patients (73 %) developed recurrence and RR was conducted in 102 (48 %) patients. Five-year overall survival (OS) was significantly higher in the RR group than in those patients not selected for RR (70 vs. 45 %, P = 0.002). On multivariate analyses, RR was identified as an independent factor for good prognosis. According to the first recurrence sites, 5-year OS after recurrence was significantly better in patients with liver or lung only recurrence (55, 51 %, respectively) than in locoregional/lymph node metastases and other/multiple sites recurrence (33, 9.0 %, respectively). In patients with liver- or lung-only recurrence, 5-year OS after recurrence was significantly higher in RR patients than in those without RR (liver; 67 and 0 %, lung; 88 and 24 %, respectively; P < 0.001).Conclusion
Given similar indication criteria as the primary CLM, nearly half of all recurrence cases after liver resection for CLM could be salvaged by RR. In patients with liver-or lung-only recurrence, RR warrants a favorable outcome. 相似文献9.
Determinants of Survival following Hepatic Resection for Metastatic Colorectal Cancer 总被引:13,自引:1,他引:12
Efthimios A. Bakalakos Julian A. Kim Donn C. Young Edward W. Martin Jr. 《World journal of surgery》1998,22(4):399-405
p
= 0.0001), resected versus nonresected (
p
< 0.0001), and tumor-free surgical margins versus positive margins (
p
= 0.001). Surprisingly, the disease-free interval and the original stage of the primary tumor did not predict survival (
p
= not significant). Other factors that had no influence on survival were type of resection, size and number of liver metastases,
ABO blood group, and the number of perioperative blood transfusions. For those patients who underwent resection of unilobar
metastases with tumor-free margins, the 5-year survival rate was 29% with a median survival of 35 months and eight survivors
> 7 years. In addition, one patient with bilobar disease had survival > 7 years and five patients who had resection of hepatic
metastases and extrahepatic cancer simultaneously had survival > 3 years. Our data support the concept that patients with
unilobar metastatic disease who undergo surgical resection with tumor-free surgical margins can be afforded a significant
opportunity at long-term survival with acceptable morbidity, mortality, and hospital stay. Also, certain patients with bilobar
or extrahepatic disease (or both) who undergo complete resection can enjoy a long-term survival. In these subgroups of patients
resection should be considered on an individual basis. 相似文献
10.
Butte Jean M. Gönen Mithat Allen Peter J. Peter Kingham T. Sofocleous Constantinos T. DeMatteo Ronald P. Fong Yuman Kemeny Nancy E. Jarnagin William R. D’Angelica Michael I. 《Annals of surgical oncology》2015,22(8):2761-2771
Annals of Surgical Oncology - Patients with recurrence after complete resection of colorectal liver metastases (CLM) are considered for repeat resection as a potential salvage therapy (PST).... 相似文献
11.
Bridget N. Fahy MD 《Annals of surgical oncology》2014,21(3):738-746
Of the 13.7 million cancer survivors living in the United States as of January 2012, 1.2 million, or 9 %, were colorectal cancer (CRC) survivors. Determining an optimal surveillance for CRC survivors is necessary because of the significant burden follow-up poses to patients, physicians, and the health care system. Currently, there is no consensus regarding optimal follow-up in CRC patients. Current literature and published guidelines related to CRC follow-up were reviewed to examine the evidence for the surveillance strategies and specific tools demonstrated to improve outcome after curative CRC resection. An intensive surveillance strategy results in increased identification of recurrences amenable to curative resection but does not result in reduced overall or CRC-specific mortality. Patients most likely to benefit from surveillance include younger patients, those with earlier tumors, locoregional recurrences, longer time to recurrence, lower carcinoembryonic antigen (CEA) levels before reoperation, and those with isolated recurrence. Complete resection of recurrence is the only factor consistently associated with improved survival. CEA, colonoscopy, and liver-focused imaging surveillance appear to have the greatest impact on mortality after curative CRC resection. A CRC surveillance strategy is recommended that includes tumor risk stratification, that provides a focus on identifying recurrences amenable to complete resection, and that utilizes those modalities demonstrated to be most effective at improving outcome after CRC resection. 相似文献
12.
Andrea Muratore Dario Ribero Giuseppe Zimmitti Alfredo Mellano Serena Langella Lorenzo Capussotti 《Annals of surgical oncology》2010,17(5):1324-1329
Background
Optimal margin width is uncertain because of conflicting results from recent studies using overall survival as the end-point. After recurrence, re-resection and aggressive chemotherapy heavily affect survival time; the potential confounding effect of such factors has not been investigated. Use of recurrence-free survival (RFS) may overcome this limitation. The aim of this study is to evaluate the impact of width of resection margin on RFS and site of recurrence after hepatic resection for colorectal metastases (CRM). 相似文献13.
14.
15.
Chuang SC Su YC Lu CY Hsu HT Sun LC Shih YL Ker CG Hsieh JS Lee KT Wang JY 《World journal of surgery》2011,35(2):424-429
Background
Metachronous liver metastasis (MLM) occurs in 20–40% of colorectal cancer (CRC) patients following surgical treatment. The aim of the present study was to determine the risk factors affecting the development of MLM in CRC patients following curative resection. 相似文献16.
17.
18.
Background This study aimed to review the outcomes of laparoscopic colorectal resection for patients with stage IV colorectal cancer.
Methods From the prospectively collected database for patients who underwent surgery for colorectal cancer in our institution, those
with stage IV colorectal cancer who underwent elective resection of tumor during the period from January 2000 to June 2006
were included. The outcomes of those with laparoscopic resection were reviewed and comparison was made between patients with
laparoscopic and open resection.
Results A total of 200 patients (127 men) with median age of 69 years (range: 25–91 years) were included, and 77 underwent laparoscopic
resection. Conversion was required in ten patients (13.0%) and all except one conversion were due to fixed or bulky tumors.
There was no operative mortality in the laparoscopic group. The complication rate was 14% and the median postoperative hospital
stay was 7 days. When patients with laparoscopic resection were compared with those with open operations, there was no difference
in age, gender, comorbidity, or tumor size between the two groups. However, the complication rate was significantly lower
in those with laparoscopic resection (14% versus 32%, P = 0.007) and the median hospital stay was significantly shorter (7 days versus 8 days, P = 0.005).The operative mortalities and the survivals were similar in the two groups.
Conclusions Colorectal resection can be performed safely in patients with stage IV colorectal cancer. The operative outcomes in terms
of complication rate and hospital stay compare favorably with patients with open resection.
Presented in the Scientific Meeting of the Society of American Gastrointestinal and Endoscopic Surgeons on 18–22 April 2007
in Las Vegas, Nevada, USA. 相似文献
19.
Sulaiman Nanji MD PhD Sean Cleary MD MSc Paul Ryan MD Maha Guindi MD Subani Selvarajah MD Paul Grieg MD Ian McGilvary MD PhD Bryce Taylor MD Alice Wei MD MSc Carol-Anne Moulton MD PhD Steven Gallinger MD MSc 《Annals of surgical oncology》2013,20(1):295-304
Background
Hepatic metastasis from colorectal cancer (CRC) is best managed with a multimodal approach; however, the optimal timing of liver resection in relation to administration of perioperative chemotherapy remains unclear. Our strategy has been to offer up-front liver resection for patients with resectable hepatic metastases, followed by post–liver resection chemotherapy. We report the outcomes of patients based on this surgical approach.Methods
A retrospective review of all patients undergoing liver resection for CRC metastases over a 5-year period (2002–2007) was performed. Associations between clinicopathologic factors and survival were evaluated by the Cox proportional hazard method.Results
A total of 320 patients underwent 336 liver resections. Median follow-up was 40 (range 8–80) months. The majority (n = 195, 60.9 %) had metachronous disease, and most patients (n = 286, 85 %) had a major hepatectomy (>3 segments). Thirty-six patients (11 %) received preoperative chemotherapy, predominantly for downstaging unresectable disease. Ninety-day mortality was 2.1 %, and perioperative morbidity occurred in 68 patients (20.2 %). Actual disease-free survival at 3 and 5 years was 46.2 % and 42 %, respectively. Actual overall survival (OS) at 3 and 5 years was 63.7 % and 55 %, respectively. Multivariate analysis identified four factors that were independently associated with differences in OS (hazard ratio; 95 % confidence interval): size of metastasis >6 cm (2.2; 1.3–3.5), positive lymph node status of the primary CRC (N1 (2.0; 1.0–3.8), N2 (2.4; 1.2–4.9)), synchronous disease (2.1; 1.3–3.5), and treatment with chemotherapy after liver resection (0.42; 0.23–0.75).Conclusions
Up-front surgery for patients with resectable CRC liver metastases, followed by chemotherapy, can lead to favorable OS. 相似文献20.
Saiura A Yamamoto J Koga R Kokudo N Seki M Oya M Ueno M Kuroyanagi H Fujimoto Y Natori T Yamaguchi T Muto T 《World journal of surgery》2007,31(12):2378-2383
Background The prognosis of solitary liver metastasis involving the caudate lobe is unclear. This study analyzed the outcomes after resection
of the caudate lobe for solitary colorectal liver metastasis.
Methods We reviewed the records of 114 cases in which potentially curative hepatectomy were performed for solitary colorectal liver
metastasis. Solitary liver metastasis involving the caudate lobe was seen in 14 cases (Caudate group). The outcomes were compared
with those of the remaining 100 cases with metastasis in a site other than the caudate lobe (Other group).
Results No hospital deaths occurred. The 5-year survival rate for all cases was 61%. Recurrence-free and cumulative survivals were
similar in the two groups, as were the intraoperative blood loss, duration of operation, and postoperative hospital stay.
The distance of the surgical margin was significantly shorter in the Caudate group than in the Other group (0.6 mm vs. 6.6
mm; p = 0.001). A concomitant resection of the inferior vena cava was performed in four patients in the Caudate group but in no
patients in the Other group (p < 0.001).
Conclusions Despite a minimal surgical margin, the resection of solitary colorectal liver metastasis offers favorable short- and long-term
outcomes comparable to those for colorectal liver metastasis at other sites. 相似文献