血清同型半胱氨酸检测在首发精神分裂症患者中的临床意义

目的:探讨血清同型半胱氨酸(Hcy)检测在首发精神分裂症患者中的临床意义。方法:选取100例首次发病的精神分裂症患者作为研究组,选取同期100名接受体检的健康者作为对照组。比较两组不同性别、不同临床症状亚组Hcy水平及高同型半胱氨酸血症发生率。结果:两组男性Hcy水平均高于女性。研究组高同型半胱氨酸血症发生率和Hcy水平均显著高于对照组,阳性亚组患者Hcy显著低于阴性亚组患者。不同PANSS总分亚组间的Hcy水平与阴性总分亚组间和性别呈显著正相关。结论:首发精神分裂症患者的Hcy水平及高同型半胱氨酸血症发生率均显著高于健康者,且男性高于女性,并与病情程度呈正相关。     

血清ALT、AST和GGT水平检测在肝脏疾病诊断中的应用价值

目的探讨血清ALT、AST、GGT水平检测在肝脏疾病诊断中的应用价值。方法选取2015年9月至2016年10月郑州人民医院门诊部收治的126例肝脏疾病患者为疾病组,同时选取70例同期入院行健康体检的患者为对照组,抽取患者静脉血,检测血清肝功能指标ALT、AST、GGT水平。观察并比较两组患者各指标水平;比较不同类型肝疾病患者肝功能指标水平。结果肝癌患者GGT水平高于其他肝脏疾病,急慢性肝炎患者血清中AST、ALT水平较其他肝脏疾病高,差异有统计学意义(P<0.05);对照组肝功能指标ALT、AST、GGT水平低于疾病组,差异有统计学意义(P<0.05)。结论血清ALT、AST、GGT水平能判断肝脏损伤情况以及损害程度。     

冠心病合并高血糖高血脂与同型半胱氨酸(Hcy)的相关性分析

目的 探究冠心病合并高血糖高血脂与同型半胱氨酸(Hcy)的相关性.方法 选取2018年9月至2019年9月于本院慢性病科室参与体检的200例冠心病患者作为研究对象,根据患者血压情况分为单纯冠心病组和合并高血压组,每组100例,另选取100名健康体检者作为对照组,检测所有患者体内血脂及血清同型半胱氨酸表达量并进行相关性分...     

脂肪肝患者肝功能、血脂及血糖变化分析

目的探讨脂肪肝患者肝功能、血脂及血糖等指标的变化。方法比较分析脂肪肝患者(观察组,206例)和健康体检者(对照组,210例)的血脂指标甘油三酯(TG)、总胆固醇(TC),肝功能指标丙氨酸氨基转移酶(ALT)、天门冬氨基转移酶(AST)、谷氨酰转肽酶(GGT)、总胆红素(TBIL)及空腹血糖含量(GLU)。结果观察组TG、TC、ALT、AST、GGT、TBIL及GLU水平均高于对照组(均<0.05)。观察组检测指标水平异常比例亦均高于对照组(均<0.05)。结论肝功能、血脂及血糖等指标的检测对脂肪肝诊断具有指导作用。     

同型半胱氨酸血症与脑梗塞关系的探讨

目的探讨同型半胱氨酸血症与脑梗塞的关系。方法选取该院收治的脑梗塞患者76例进入实验组,及同期进行健康体检的健康者76例进入对照组,分别测量两组的空腹血浆同型半胱氨酸浓度,进行logistic回归分析。结果实验组空腹血浆同型半胱氨酸浓度明显高于对照组（P〈0．01）,高同型半胱氨酸血症与脑梗塞相关,相对危险度OR为9．225（95％CI2．50—34．35）。结论高同型半胱氨酸血症是脑梗塞发生的独立危险因素。     

2型糖尿病和糖耐量受损与同型半胱氨酸的关系研究

目的:探讨高同型半胱氨酸与2型糖尿病及糖耐量受损的关系,探求2型糖尿病的干预和治疗方案。方法:选取64例初诊2型糖尿病患者(DM组),41例糖耐量受损患者(IGR组)与25例正常健康者作对照(NGT组),行口服葡萄糖耐量试验(OGTT),探讨同型半胱氨酸与血糖、胰岛素和HOMA-IR的关系。结果:2型糖尿病患者和糖耐量受损患者血HCY水平高于正常健康组,HCY与TC、TG、Hb Alc、HOMA-IR呈正相关;与HOMA-B呈负相关。结论:初诊2型糖尿病患者和糖耐量受损患者血清HCY水平高于正常对照组,高同型半胱氨酸血症是2型糖尿病患者产生胰岛素抵抗的相关因素。     

血清同型半胱氨酸与C反应蛋白在急性脑血管病诊断中的应用

目的探究血清同型半胱氨酸与C反应蛋白在急性脑血管病诊断中的应用价值。方法选取脑出血患者50例作为A组,同时选取脑梗死患者50例作为B组,同时选取50例健康体检者作为对照组,这3组人员均给予血清同型半胱氨酸与C反应蛋白检测,对比3组受检人员的检查结果。结果 A组脑出血患者、B组脑梗死患者的C反应蛋白以及同型半胱氨酸水平明显高于对照组健康体检者(P0.05)。A组脑出血患者的C反应蛋白以及同型半胱氨酸水平与B组脑梗死患者存在一定的差异性(P0.05)。结论急性脑血管病患者的血清同型半胱氨酸与C反应蛋白水平明显高于健康人员,血清同型半胱氨酸与C反应蛋白可作为诊断急性脑血管病的指标。     

脑梗死与高同型半胱氨酸的相关性分析

目的:对脑梗死和高同型半胱氨酸的相关性进行分析。方法:选取我院于2010年1月~2013年3月收治脑梗死患者84例作为观察组,同时选取至我院体检的健康人群84例作为对照组。2组均展开血浆同型半胱氨酸水平测定并进行对比。结果:经测定,观察组与对照组血浆同型半胱氨酸整体水平分别为16.9±3.4μmol/L、10.0±1.9μmol/L,观察组患者血浆同型半胱氨酸水平显著高于对照组(P0.05);在观察组中,男性患者血浆同型半胱氨酸水平显著高于女性患者(P0.05),差异具有统计学意义。结论:在脑梗死患者中,血浆同型半胱氨酸水平显著高于健康人群,且男性血浆同型半胱氨酸水平显著高于女性。     

6项肝功能指标联合检测在肝病诊断中的应用价值分析

目的 探讨6项肝功能指标联合检测在肝病诊断中的应用价值.方法 选取我院2014年10月—2016年10月期间的150例肝病患者为研究组,并选取同期来我院进行体检的150例健康体检者为对照组.检查2组血清白蛋白(ALB)、前白蛋白(PA)、丙氨酸转氨酶(ALT)、谷氨酰转肽酶(GGT)、天冬氨酸转氨酶(AST)以及胆碱酯酶(ChE)水平.分析6项指标联合检测对肝病诊断的临床意义.结果 研究组的36例急性肝炎患者中AST、ALT以及GGT水平显著高于对照组,ALB、PA水平显著低于对照组(P<0.05);33例慢性肝炎患者中,ALB、PA及ChE水平显著低于对照组,组间比较差异有统计学意义(P<0.05);40例重型肝炎者及41例肝硬化患者中,AST、ALT以及GGT水平显著高于对照组,ALB、PA及ChE水平显著低于对照组(P<0.05).结论 ALB、PA、ALT、GGT、AST以及ChE联合检测可明确诊断各类肝病,为治疗提供可靠依据,具有重要的临床应用价值.     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

Development on Adjustable Calibration Marker for Shock Wave Focus

Shock wave lithotripsy （SWL） is a treatment of choice for upper urinary stones. However, this procedure is inappropriate for obese patients because the focus is often unable to reach the target owing to the limited focal distance in shock wave source. Although treating such patients in a blast path may increase the application length of shock wave source, it＇s difficult to find this path on the lithotripter monitor. For this reason, we invented an adjustable calibration marker in order to set an effective focus in the shock wave hath.     

Study on the TCM Pathogenesis of Angiopathic Complications of Type II Diabetes

Excess production of reactive oxygen species(ROS)of mitochondrion mediated by hyperglycemia is the common pathogenesis of angiopathic complications of diabetes.TCM holds that the damp from the dysfunction of spleen.kidney and liver is the causative factor of complications of diabetes.This is similar to the mechanism of Ros resulting in angiopathic complications of diabetes.When the angiopathic complications of type II diabetes mellitus(T2DM)are difierentiated as caused by turbid damp in TCM can be explained as ROS.Since the obstruction of pathogenic damp in channels and collaterals is said to be the main pathogenesis,the treating principle should be dissolving the damp to remove the obstruction.     

Leptin, Ghrelin and TNF-α before and after Hypo-caloric Traditional Chinese Diet and Auricular Acupuncture

INTRODUCTION Obesity is a complex emergent problem, which can be possibly solved not only by the diet but also by the life style and promotion of a constant physical exercise. 1, 2 No doubt careful attentions must be given to the nutritional condition of obese people, the dietary habits, the somatic build (i.e. distribution of fat mass) and the organic functions linked to formation of the fat mass. All the parameters should be constantly monitored before, during and after a diet treatment. 3, 4, 5     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

Relationship between Dysglycemia and Carotid Atherosclerosis in Tibetan Population

People with dysglycemia are at high risk for atherosclerotic diseases. This study aims at investigating the atherosclerotic vascular damage in dysglycemia and its metabolic origin in Tibetan population.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

CLINICAL SIGNIFICANCE OF SERUM CYTOKINES IL-1β,sIL-2R,IL-6,TNF-α,AND IFN-v IN ACUTE CORONARY SYNDROME

Objectives To explore serum cytokines levels (including IL-1 β, sIL-2R, IL-6, TNF-α, and IFN-v) and their significance in patients with acute coronary syndrome (ACS) and the subsequent follow-ups, with attempt to estimate the role of various serum inflammatory markers in the diagnosis and assessment of ACS.Methods The study population include 40 patients with acute myocardial infarction (AMI), 40 patients with unstable angina pectoris (UAP), and 40 controls. Among the 80 patients, 60 patients attended a follow up 4 months later. Serum inflammatory markers including IL-1 β, sIL-2R, IL-6, TNF-α, and IFN-v were measured by enzyme linked immunosorbent assay.Results Serum IL- 1 β, sIL-2R, IL-6, TNF-α were significantly higher in AMI group or UAP group compared to the control group and became significantly lower 4 months later in the follow-up patients. Serum levels of IFN-v shows no significant difference between AMI group or UAP group and controls, also showing no significant change when measured in follow up patients. There was no correlation between serum creatine kinase-MB isoenzyme levels and serum inflammatory markers either in UAP or AMI group. Furthermore, when divided into two subgroups using Wagner's QRS scoring system in the AMI group, there is no difference of each serum inflammatory marker between ≤ 6 scores group and ＞ 6 scores group.Conclusion Serum levels of certain inflammatory markers may have some diagnostic value for ACS, and can be a useful marker reflecting disease stability.     

Possible Spread of adenovirus type 3 from poultry to humans ：indirect evidence from an outbreak in China

Objective:To explore the epidemiology and etiology for an outbreak of acute respiratory tract infection that occurred in one county of Jiangsu Province, China 2004. Methods: Only cases meeting the case definition were included in the study. We reviewed the medical records of the cases who were admitted to the local hospitals, interviewed cases by a standard questionnaire, and then described the epidemiotogic features and analyzed risk factors by means of a case-control study. We collected pharyngeal swab specimens and sent them to different laboratories for isolation and culture. The laboratory used different detection methods such as DIP, PCR, electron microscope examination and microneutralization assay, to identify and then type the positive specimens. Results:A total of 871 cases were reported during the period from April 18 to July 4,2004. The distribution of onset times presented two peaks, one in late May and another in middle June. The epidemic occurred mainly in the elementary and junior high schools in ten townships of one county, and the mean age of the cases was 12 years (range 7 months to 18 years). The course of the disease was acute, and was characterized by fever accompanied with sore throat and tonsillitis. The WBC count of cases was normal or elevated. The mean duration of illness was 5 days (range 2 to 12 days). No fatalities from illness were reported. A case-control study indicated that the possible risk factors were close contact with a case and/or poultry before onset and sharing of towels among members of the family. The typical CPE was observed through inoculating pharyngeal swab specimens into the HEP-2 cell cultures in different laboratories. An infection of adenovirus type 3 was verified by detecting positive specimens in different methods. Conclusion:This investigation demonstrated that the acute respiratory infection in cases was caused by adenovirus type 3. Cases occurred in over 70 schools in ten townships in 2004, and the route of transmission was possibly close contact with cases or droplet transmission.