共查询到20条相似文献,搜索用时 15 毫秒
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D L Mager P S Henthorn 《Proceedings of the National Academy of Sciences of the United States of America》1984,81(23):7510-7514
We describe a 5- to 6-kilobase-pair repetitive family in human DNA. One member of this family is linked to the beta-globin gene cluster and is close to the 3' breakpoints of three different naturally occurring deletions involving this gene cluster. Sequence analysis indicates that this element includes terminal direct repeats of 415 base pairs that exhibit the features of long terminal repeats (LTRs) of retroviruses. A potential histidine tRNA primer binding site occurs just 3' to the 5' direct repeat. This retrovirus-like element interrupts a member of the Kpn I family of repeated DNA and is bracketed by a 5-base-pair directly repeated sequence. When attempts are made to clone the element in bacteriophage, homologous recombination between the LTR-like sequences is very frequently observed. Copy number estimates by two methods indicate that the element is repeated 800-1000 times in the human genome. We term this Homo sapiens family of retrovirus-like elements having a histidine tRNA primer binding site the hsRTVL-H family. 相似文献
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Cleavage of tRNA within the mature tRNA sequence by the catalytic RNA of RNase P: implication for the formation of the primer tRNA fragment for reverse transcription in copia retrovirus-like particles. 下载免费PDF全文
Y Kikuchi N Sasaki Y Ando-Yamagami 《Proceedings of the National Academy of Sciences of the United States of America》1990,87(20):8105-8109
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Reverse transcriptase of human immunodeficiency virus can use either human tRNA(3Lys) or Escherichia coli tRNA(2Gln) as a primer in an in vitro primer-utilization assay. 总被引:3,自引:0,他引:3 下载免费PDF全文
L A Kohlstaedt T A Steitz 《Proceedings of the National Academy of Sciences of the United States of America》1992,89(20):9652-9656
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Specific binding of tryptophan transfer RNA to avian myeloblastosis virus RNA-dependent DNA polymerase (reverse transcriptase). 总被引:38,自引:6,他引:38 下载免费PDF全文
A Panet W A Haseltine D Baltimore G Peters F Harada J E Dahlberg 《Proceedings of the National Academy of Sciences of the United States of America》1975,72(7):2535-2539
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Identification of a single transcriptional initiation site for the glutamic tRNA and COB genes in yeast mitochondria. 总被引:14,自引:2,他引:14 下载免费PDF全文
T Christianson J C Edwards D M Mueller M Rabinowitz 《Proceedings of the National Academy of Sciences of the United States of America》1983,80(18):5564-5568
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Mutations in the RNase H domain of HIV-1 reverse transcriptase affect the initiation of DNA synthesis and the specificity of RNase H cleavage in vivo 下载免费PDF全文
Julias JG McWilliams MJ Sarafianos SG Arnold E Hughes SH 《Proceedings of the National Academy of Sciences of the United States of America》2002,99(14):9515-9520
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Viral RNA annealing activities of human immunodeficiency virus type 1 nucleocapsid protein require only peptide domains outside the zinc fingers. 总被引:42,自引:2,他引:40 下载免费PDF全文
H De Rocquigny C Gabus A Vincent M C Fournié-Zaluski B Roques J L Darlix 《Proceedings of the National Academy of Sciences of the United States of America》1992,89(14):6472-6476
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Structure of Moloney murine leukemia viral DNA: nucleotide sequence of the 5'' long terminal repeat and adjacent cellular sequences. 总被引:26,自引:1,他引:26 下载免费PDF全文
C Van Beveren J G Goddard A Berns I M Verma 《Proceedings of the National Academy of Sciences of the United States of America》1980,77(6):3307-3311
Some unintegrated and all integrated forms of murine leukemia viral DNA contain long terminal repeats (LTRs). The entire nucleotide sequence of the LTR and adjacent cellular sequences at the 5' end of a cloned integrated proviral DNA obtained from BALB/Mo mouse has been determined. It was compared to the nucleotide sequence of the LTR at the 3' end. The results indicate: (i) a direct 517-nucleotide repeat at the 5' and 3' termini; (ii) 145 nucleotides out of 517 nucleotides represent sequences between the 5'-CAP nucleotide and 3' end of the primer tRNA (strong-stop DNA); (iii) an 11-nucleotide inverted repeat is present at the ends of the 5'-LTR and a total of 17 out of 21 nucleotides at the termini are inverted repeats; (iv) sequences CAATAAAAG (at positions -24 to -31) and CAATAAAC (at positions +46 to +53) resembling the hypothetical DNA-dependent RNA polymerase II promoter site can be identified in the 5'-LTR; (v) the sequence GAAA appears to be repeated on both sides of the junction of viral and cellular sequences; and (vi) in analogy with the bacterial transposons, the presence of an inverted repeat sequence at the termini of 5'-LTR suggests that M-MLV also has the integration properties of a transposon. 相似文献