北京老年妇女脊椎骨折的流行病学研究

北京老年妇女脊椎骨折的流行病学研究徐苓ＣｕｍｍｉｎｇｓＳＲ秦明伟，田均平ＳｔｏｎｅＫ赵熙和，陈孝曙，余卫ＪｅｒｇａｓＭ摘要：脊椎压缩性骨折是老年妇女骨质疏松常见的并发症之一，严重影响老年妇女的健康和生活质量。本研究目的是要得出我国北京地区妇女脊椎骨折...     

太宁栓治疗Ⅰ度、Ⅱ度内痔的临床研究

目的 :研究太宁栓治疗 度、 度内痔的有效性和安全性。方法 :6 0例 度、 度内痔患者 ,其中太宁组和对照组各30例。太宁组使用太宁栓 ,对照组使用痔疮栓 ,每日 2次 ,连续使用 7d。结果 :1在治疗 2 d后 ,太宁组患者的出血和局部不适、瘙痒的平均积分较治疗前明显减少 (P <0 .0 1) ;2在治疗 7d后 ,太宁组患者的各项观察指标的平均积分较治疗前的减少值明显高于对照组患者 (P <0 .0 5 ) ,太宁组的显效率 (6 8%)总有效率 (85 %)均高于对照组 (37%,6 5 %) (P <0 .0 1,P <0 .0 5 ) ;3所有患者在治疗 7d后 ,未发现有不良反应的发生。结论 :太宁栓对治疗 度、 度内痔有明显的疗效且优于常规方法 ,未见明显不良反应。     

HALOTHANE HEPATITIS REVISITED IN WOMEN UNDERGOING TREATMENT OF CARCINOMA OF THE CERVIX

From 1964 to 1976, 238 patients with carcinoma of the cervixwere treated with irradiation and surgery. Their medical recordswere reviewed retrospectively. Three patients became jaundicedafter operation as a result of pigment overload and sepsis.Exposure to halothane did not appear to be a significant aetiologicalfactor.     

普鲁卡因对重症急性胰腺炎的治疗作用

目的观察普鲁卡因对重症急性胰腺炎(SAP)患者的治疗效果.方法将我院1993年3月至2001年4月收治行非手术治疗的SAP患者40例,分为普鲁卡因治疗组23例,非普鲁卡因治疗组17例.结果普鲁卡因治疗组治愈20例,死亡3例,死亡率为1 3.0%;非普鲁卡因治疗组治愈9例,死亡8例,死亡率为47.1%,普鲁卡因治疗组死亡率明显低于非普鲁卡因治疗组(P＜0.05).结论SAP的普鲁卡因治疗组效果优于非普鲁卡因治疗组,且患者痛苦小、并发症少、费用低,值得推广使用.     

全反式维甲酸联合化疗药物对胃癌的治疗作用

目的 探讨全反式维甲酸（ＡＴＲＡ）联合５Ｆｕ治疗裸鼠皮下ＳＧＣ７９０１胃腺癌的疗效。方法 以ＡＴＲＡ１０００μｇ／ｄ口服;５－Ｆｕ２７ｍｇ／ｋｇ腹腔注射,隔天给药;联合用药组剂量减半。结果 ５－Ｆｕ、ＡＴＲＡ及两者联合用均能抑制移植瘤生长,治疗７周后创面愈合的体积率分别为５６．８８％、４９．００％和７０．００％,瘤重抑瘤率分别为５１．６４％、５６．１０％６ ７６．９５％;ＡＴＲＡ与５－Ｆｕ的抑瘤作     

TREATMENT OF POSTOPERATIVE PAIN WITH DICLOFENAC IN UVULOPALATOPHARYNGOPLASTY

Diclofenac sodium suppositories 150–200 mg day^–1were compared with placebo in a double-blind study during thefirst 3 days after uvulopalatopharyngoplasty in 40 patientswith habitual snoring or obstructive sleep apnoea syndrome.Consumption of rescue analgesics (paracetamol suppositories)and pain assessed by a visual analogue scale were significantlyless in the diclofenac group. Bleeding time (modified Ivy'stest) and reported side effects did not differ between the twogroups.     

中国大陆地区妇女骨质疏松筛选工具探讨

目的建立适用于中国大陆地区40岁及以上妇女的骨质疏松（osteoporosis，OP）筛选工具。方法以20～39岁妇女腰椎骨密度的均数和标准差作为参考值计算T—score。以双能X线骨密度仪（dual—energy X—ray absorptiometry，DxA）的测量结果作为金标准，采用二分类的Bayes判别分析，建立判别函数。结果我国大陆地区40岁及以上妇女OP筛选工具（osteoporosis screening tool for Chinese，OSTC）为：体重-2×年龄＋50。判别准则为OSTC〉0为无OP危险性，OSTC≤0为有OP危险性。OSTC的正判率为75．78％，灵敏度为76．8％，特异度为75．1％，Kappa值为0．51（P=0．000），说明OSTC与DXA的判定结果一致性尚可。结论OSTC是一个简便的OP筛选工具。根据年龄、体重两个变量的简单计算，即可对我国大陆地区40岁及以上的妇女进行OP危险性的筛选。但OSTC没有得到外部数据的验证，其优劣还有待进一步评价。     

电灼加腐蚀治疗色痣效果观察

目的：观察治疗颜面色痣减少复发的效果。方法：用多功能治疗仪加石炭酸法治疗１００例共１５０颗色痣。结果：色痣经一次性治疗后美容效果好的１３５颗（９０％）。结论：多功能治疗仪加石炭酸法治疗色痣具有美容效果好、复发率低的优点。     

BLADDER MICROVASCULATURE IN WOMEN WITH INTERSTITIAL CYSTITIS

PURPOSE: A cardinal cystoscopic finding in women with interstitial cystitis is mucosal small vessel hemorrhage or glomerulations after hydrodistention. We quantified and compared microvascular density and endothelial proliferation in the bladder biopsies of women with interstitial cystitis and a control group of women who were undergoing incontinence or prolapse surgery. MATERIALS AND METHODS: We performed computer assisted image analysis and immunohistochemical studies to compare differences in the blood vessel count, and proportional area in the bladder suburothelium and deeper submucosa of bladder biopsies of 52 women, including 26 with interstitial cystitis. Routine light microscopy features were examined and correlated with microvascular density. RESULTS: In the bladder biopsies of women with interstitial cystitis there was a lower blood vessel count (p = 0.01), and a lower proportion of the total image consisted of blood vessel wall (p = 0.03) in the suburothelium than in control biopsies. We noted no difference in the blood vessel count of the deeper submucosa or in the degree of endothelial cell proliferation. Suburothelial blood vessel differences correlated with the degree of histological change, such as edema, inflammatory infiltrate and vascular congestion. CONCLUSIONS: We found decreased microvascular density in the suburothelium but not in the deeper submucosa in bladder biopsies of women with interstitial cystitis.     

全反式维甲酸诱导分化治疗对胃癌患者免疫功能的影响

目的 观察全反式维甲酸（all trans retinoic acid,ATRA)诱导分化治疗对胃癌患者免疫功能的影响。方法 对56例胃癌患者进行诱导分化测定，测定外周血T淋巴细胞亚群（T－Ls)和血清白细胞介素Ⅱ受体（sIL-2R)水平。结果 根治性手术组；CD3、CD4细胞数及CD4／CD8比值较对照组明显增高，sIL-2R水平明显降低；经ATRA治疗后，上述指标接近正常对照组；未手术或未根治性手术组：经ATRA治疗后，CD3、CD4细胞数及CD4／CD8比值也明显增高，sIL-2R水平明显降低。结论 ATRA诱导分化治疗有效提高胃癌患者的免疫功能。     

MANAGEMENT OF CYCLICAL MASTALGIA IN ORIENTAL WOMEN: PIONEER EXPERIENCE OF USING GAMOLENIC ACID (EFAMAST®) IN ASIA

Background : In most Western countries gamolenic acid is the first-line treatment for women with cyclical mastalgia. Methods : A prospective study was carried out in the breast referral clinic of the Department of Surgery, University of Hong Kong to evaluate the treatment of cyclical mastalgia using gamolenic acid provided in evening primrose oil (Efamast^®, Scotia Pharmaceuticals Ltd, Scotia House, Stirling, Scotland) as a pioneer experience in Asia. In addition, the features of cyclical mastalgia in Oriental women were studied by conducting a survey using anonymous questionnaires. Results : Sixty-six women with disturbing cyclical mastalgia seen by one breast surgeon were followed up with a breast pain diary. Thirty-four women had persistently disturbing mastalgia and were commenced on Efamast^®. Responses were measured at 3 and 6 months according to a standardized protocol. An overall useful response rate of 97% was observed at 6 months. Side-effects were found in 12% but all were insignificant. Conclusions : Efamast^® may be recommended as a first-line specific treatment for Oriental women with disturbing cyclical mastalgia.