Mycobacteria Induces Pleural Mesothelial Permeability by Down-Regulating β-Catenin Expression

Patients with pulmonary tuberculosis develop pleural effusions with a high protein content. Pleural mesothelial adherens junctions promote mesothelial cell-cell adhesion and contribute to pleural integrity. In the present study we have investigated the effect of mycobacterium (BCG) on mesothelial cell adherens junction proteins and pleural permeability. BCG enhanced pleural mesothelial cell (PMC) release of vascular endothelial growth factor (VEGF), and decreased electrical resistance across the PMC monolayer. Neutralizing antibodies to VEGF significantly restored the drop in PMC electrical resistance caused by BCG. BCG infection down regulated -catenin (adherens junction protein) expression and caused increased permeability across confluent mesothelial monolayer. Our results suggest that in TB pleurisy, mycobacteria cause VEGF release from mesothelial cells and leads to protein exudation by altering mesothelial adherens junction proteins.     

Call for Abstracts

The organizers of SC-ICC welcome the submission of abstracts. Submissions covering all aspects of cardiovascular disease are welcome. All accepted abstracts will be published in supplement(s) of the South China Journal of Cardiology. The excellent abstract will be selected for presentation at the session on the 10th SC-ICC. Be aware that your accepted abstract(s) will be published and your copyright transferred to SC-ICC on publication.     

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<正>Hepatobiliary & Pancreatic Diseases International Copyright 2023, Hepatobiliary & Pancreatic Diseases International. All rights reserved.www.hbpdint.com General information Hepatobiliary & Pancreatic Diseases International is a journal published bimonthly in the English language by the First Affiliated Hospital,Zhejiang University School of Medicine, Hangzhou, China. We welcome original research articles, review articles, editorials,     

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Aims and Scope Hepatobiliary & Pancreatic Diseases International publishes peer-reviewed     

Regulatory disincentives for developing antibiotics for common indications?

Pediatric and adult community-acquired respiratory tract infections remain some of the most common reasons for visits to primary care practitioners, and the antibiotics used to treat them are historically highly profitable for their manufacturers. Despite these facts and the continued evolving need for new treatments for these infections, virtually no new agents have been developed in the past decade. This review explores some regulatory guidelines that could potentially explain the dearth of development, and it provides some practical answers for resolving them.     

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Hepatobiliary & Pancreatic Diseases International(HBPD INT)Copyright 2007, Hepatobiliary & Pancreatic Diseases International. All rights reserved. www.hbpdint.comHepatobiliary & Pancreatic Diseases International (HBPD INT) is a journal published bimonthly (since 2007) in English language by the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. We welcome original articles from any part of the world; no charge is made for review. The papers are re…     

Information for Readers

Hepatobiliary & Pancreatic Diseases International (HBPD INT) Copyright 2007, Hepatobiliary & Pancreatic Diseases International. All rights reserved.     

Instructions for Authors

Hepatobiliary & Pancreatic Diseases International (HBPD INT) is a journal published bimonthly (since 2007) in English language by the First Affiliated Hospital     

Information for Authors

Hepatobiliary & Pancreatic Diseases International(HBPD INT)Copyright 2009, Hepatobiliary & Pancreatic Diseases International. All rights reserved. www.hbpdint.com Hepatobiliary & Pancreatic Diseases International (HBPD INT) is a journal published bimonthly in English language by the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. We welcome original