人工心脏起搏在治疗阿—斯综合征中的应用（附41例报告）

用人工心脏起搏治疗阿一斯综合征41例,其中临时起搏24例,永久起搏17例,除1例在心脏手术中行右心室心肌临时起搏和1例经胸壁穿刺右室起搏外,余39例均为右室心尖部心内膜起搏。结果39例起搏成功,24例临时起搏中有13例据病情改为永久起搏,认为人工心脏起搏治疗阿-斯综合征效果满意。     

经股静脉临时心脏起搏在心律失常病人手术时的应用

目的 探讨经股静脉临时心脏起搏对手术病人心脏的保护作用。方法 对40例合并缓慢心律失常需外科手术病人的临床资料进行回顾性研究。结果 40例经股静脉临时起搏全部成功,手术过程无1例心脏停跳事件发生。结论 经股静脉临时心脏起搏在手术过程中很好地起到预防性心脏起搏作用,安全可靠,无并发症。     

紧急经静脉心内膜临时起搏24例分析

经静脉紧急心内膜临时起搏抢救24例心脏病人,成功22例,失败2例,成功率91%.在X线透视引导下起搏的20例均成功,而盲目插管起搏4例,成功2例,失败2例,说明紧急心内膜起搏是心脏急症抢救的一项重要措施.在X线透视引导下进行临时起搏可提高起搏的成功率和起搏效果.对病情十分紧急的病例,采取直接心脏穿刺起搏较经静脉起搏更为适用.     

经左锁骨下静脉床旁临时心脏起搏在非心脏手术中的应用

目的评价经左锁骨下静脉床旁临时心脏起搏治疗在非心脏手术中应用的效果与安全性。方法在无X线透视下,为216例非心脏手术患者经左锁骨下静脉床旁安置临时心脏起搏电极。结果216例患者左锁骨下静脉穿刺成功,顺利将临时起搏导管送至右室,3例失败;在起搏期间有8例患者发生电极脱位,重新调整后恢复正常。结论床旁经左锁骨下静脉插入电极导管至右心室起搏具有较高的成功率,安全、简便易行;术前安置临时心脏起搏器,可以提高手术安全性。     

临时心脏起搏器治疗缓慢型心律失常12例临床分析

目的 探讨临时心脏起搏器治疗缓慢型心律失常的方法学及应用。方法 对12例缓慢型心律失常的病人经静脉进行床旁及X线下临时心脏起搏,观察手术操作的方法学、起搏成功率、临时起搏器对血流动力学的影响及在围手术期的应用。结果 临时心脏起搏可以迅速改善患者的血流动力学,床旁安置临时心脏起搏器适用于病情重、不宜搬动患者,且临时心脏起搏对围手术期的心动过缓患者更为安全。     

心脏起搏治疗严重缓慢型心律失常12例次

报告心脏起搏技术治疗严重缓慢型心律失常10例(12次),其中临时起搏8例次(经胸壁穿刺心内膜起搏5例,经静脉心内膜起搏2例次,经心外膜起搏1例)、永久起搏4例次。结果表明:临时起搏为抢救急性严重缓慢型心律失常之简便而有效的方法,永久起搏能长期控制心律失常及改善血流动力学状态。     

临时心脏起搏在缓慢心律失常应用中的价值

目的 :探讨临时心脏起搏在缓慢心律失常中应用的价值。方法 :各种病因所致缓慢心律失常 (Ⅲ度或高度房室传导阻滞、显著心动过缓 ) 2 3例均采取临时起搏 ,其中 18例作为治疗应用 ,另 5例为预防性应用。结果 :治疗应用18例中 ,经临时心脏起搏后 17例度过濒危阶段 ,症状明显改善 ,其中 11例植入心室按需型 (VVI)永久性心脏起搏器 ;另5例作为预防性临时起搏 ,确保了诊断、治疗、手术稳妥进行。结论 :临时心脏起搏在缓慢心律失常中可作为急症抢救及预防性措施。     

非X线透视下床旁紧急临时心脏起搏技术的临床应用

X线透视下经静脉起搏是最常用的临时心脏起搏方法,然而在紧急情况下,且不具备X线下临时起搏条件时,需行非X线下床旁紧急临时起搏.我们于1996年2月至2006年4月,经锁骨下静脉途径行床边紧急临时心脏起搏治疗63例严重缓慢性心律失常,效果满意,报告如下.     

紧急临时心脏起搏抢救严重心律失常24例分析

紧急临时心脏起搏抢救严重心律失常２４例分析李慧娟孙琳卢伟增昆明铁路中心医院（昆明，６５００１１）关键词心律失常；心脏起搏中图号Ｒ５４２７３１９８０年我们开始用上海产ＡＸＱ—１起搏器及其配套的双极起搏导管电极（普通电极）行紧急临时心脏起博；以后采用美...     

200例临时心脏起搏临床应用疗效及并发症分析

临时心脏起搏是防治包括心脏停搏等多种继发或原发心肘病及心律失常的重要方法。本文２００例患者接受临时心脏起搏，其中１８例急性窦房结或房室结衰竭、３６例急性下壁或伴右室急性心肌梗塞、１２例药物所致严重窦性过缓、高度或Ⅲ房室传导阻滞及心脏停搏病人心脏起搏成功占８３．３３－１００％；而其他３６例晚期器质性心脏病、１４例急性广泛性心肌梗塞临时心脏起搏成功占１９．４４－５７．１４％，说明临时心脏起搏对心脏窦房     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.