Book Reviews

Book reviewed in this article: Endourologj: Principles and practice. Editor A.D. Smith, W.R. Casteneda-Suniga M.D. & J.G. Bronson. 1986. Plain X-ray Diagnosis of the Acute Abdomen, Second Edition. By M.H. Gough, M.W.L. Gear and A.S. Daar. A Practical Approach To Modern Imaging Equipment. Second Edition. By Thomas T. Thompson, M.D. DNA Content and Prognosis in Breast Cancer By Anders Fallenius Angiocardiography. Current Status and Future Developments. Edited by H. Just and P.H. Heintzen. Computed Tomography of the HEAD and Neck. Edited by Barbara L. Carter, M.D. The Tethered Spinal Cord. Edited by Robert N.N. Holtzman M.D. and Bennett M. Stein M.D. Ultrasound-Guided Biopsy and Drainage By G. Pedio, H.R. Burger, H.J. Einighammer and R. Hanke Multiple Choice Questions in Radiodiagnosis. By A. Crozier, D. Finlay and P. Paciorek. Paediatric Oncology an Illustrated Introduction W. R. McWhirter and J. P. Masel Williams & Wilkins. Guide to the Ultrasound Examination of the Abdomen. By Leon Skolnick.     

Book Reviews

Book reviewed in this article: X-ray Microscopy in Clinical and Experimental Medicine–by T. A. Hall, H. O. E. Rockert and R. L. deC. H. Saunders. Cisternography and Hydrocephalus–A Symposium. 559 pages. Edited by John C. Har-bert, David C. McFullough, Alfred J. Luessenhop & Giovanni Di Chiro. Modern Trends in Radiotherapy–2. Edited by-Thomas J. Deeley–Butterworths, 1972. “Computers in Radiotherapy.” British Institute of Radiology, 1971–Special Report Number 5. 187 pages. Radiographic Examination of the Urinary Tract. Howard M. Pollack, M.D. Roentgenography and Roentgenology of the Temporal Bone, Middle Ear and Mastoid Process. Fundamental Physics of Radiology. W. J. Meredith and J. B. Massey. Published by John Wright and Sons Ltd., Bristol, England. Practical Procedures in Diagnostic Radiology. By H. M. Saxton and Basil Strickland. Second Edition. Mammography. By Robert L. Egan. A Monograph in the Bannerstone Division of American Lectures in Roentgen Diagnosis. Acute Ureteric Obstruction. By P. M. Bret-land. Roentgenologic Diagnosis. Vol. 1 and 2. Radiological Diagnosis of Digestive Tract Disorders in the Newborn. Frontiers of Radiation Therapy and Oncology Vol. 7. The Interrelationship of the Immune Response and Cancer. Angiography of Trauma. Author: Whei-Rung Fu. Charles C. Thomas     

Book Reviews

Book reviewed in this article: Orthopaedic Radiology Edited by William M. Park and Sean P. Hughes An Introduction to Clinical Imaging. By D. Lloyd Dixon and Leslie M. Dugdale Orthopedic Radiology — A Practical Approach. By Adam Greenspan. Foreword by Michael W. Chapman Clinical Radiobiology by A.H.W. Nias. Self Assessment in Radiology and Imaging 4: Orthopaedics. By Dennis J. Stoker and Elisabeth A. Tilley. Magnetic Resonance Imaging of the Spine. By Michael T. Modic; Thomas J. Masaryk; and Jeffrey S. Ross. Self Assessment in Radiology & Imaging: Gastrointestinal Radiology. By M. Berger. “Emergency Radiology”. By Theodore E. Keats. Cross-Sectional Anatomy for Computed Tomography. By Michael L. Farkas. Contrast Media. By Ed. D.H. Carr. Manual of Oncologic Therapeutics 1989/90. By Robert E. Wittes. Clinical Radiation Oncology: Indications, Techniques and Results. By C.C. Wang MD. Biomedical Magnetic Resonance Imaging: Principles, Methodology and Applications. By Felix W. Wehrli; Derek Shaw; and J. Bruce Kneeland. The Physics of Medical Imaging. By Steve Webb. E.N.T. Radiology Textbooks Diagnostic Imaging of the Nose and Paranasal Sinuses. By Glyn A.S. Lloyd. Self Assessment in Radiology and Imaging — Ear, Nose and Throat. By Maurice Hawthorn & Richard Num. Self Assessment in Radiology & Imaging 5 Nuclear Medicine. By Shabu Karimjee, Adrian Thomas and Wendy Taylor.     

Book Reviews

Book reviewed in this article: The Visible Human Body - An Atlas of Sectional Anatomy. By Gunther Von Hagens, Lynn J. Romrell, Michael H. Ross and Klaus Tiedemann Liver Imaging: Current Trends and New Techniques. By Joseph T. Ferrucci and David D. Stark Which Tests For My Unborn Baby? A Guide to Prenatal Diagnosis. By Lachlan de Crespigny and Rhonda Dredge Ultrasound of Appendicitis and its Differential Diagnosis. By Julien B.C.M. Puylaert Normal and Abnormal Swallowing Imaging in Diagnosis and Therapy. By Bronwyn Jones and Martin W. Donner MCQ's - FRCR Part I. By Paul Butler, Charles Blakeney MRI of the Brain III: Neoplastic Disease. By Anton N. Hasso, Miyuki Shakudo and Edla Chidrychi Atlas of Anal Endosonography. By Clive I. Bartram and Sarah J.D. Burnett Urological Oncology - Dilemmas and Developments. By A.R. Alderson, R.T.D. Oliver, I.W.F. Hanham and H.J.G. Bloom Radioactive Heaven and Earth. A Report of the IPPNW International Commission to Investigate the Health and Environmental Effects of Nuclear Weapons Production and the Institute for Energy and Environmental Research Head and Neck Radiology. By Arnold Noyek Abdominal Sonography. By Mordecai Koenigsberg and Janet Hoffman-Tretin Radiology of the Extremities. By N. Baker Gastrointestinal Radiology. By Jack Farman Imaging of Orthopedic Trauma (Second Edition). By Thomas H. Berquist High-Resolution CT of the Lung. By W. Richard Webb, N.L. Muller and D.P. Naidich MRI of the Central Nervous System: A Pathology Atlas. By K. Mori (Ed.) Practical Radiotherapy Planning. Second Edition. By Jane Dobbs, Ann Barrett and Dan Ash Early Detection and Treatment of Liver Cancer. By K. Okuda, T. Tobe and T. Kitagawa Radiological, Clinical & Bio-mechanical Aspects of Chest Trauma. By S.A. Groskin Concomitant Continuous Infusion Chemotherapy and Radia tion. By Marvin Rotman and C. Julian Rosenthal Radiopathology of Organs and Tissues. By E. Schere, C. Streffer and K.R. Trott     

Book Reviews

Book reviewed in this article: Clinical Paediatric Uroradiology. By: Ian A. Aaronson FRCS, Head of Paediatric Urological Surgery, Red Cross Memorial Children's Hospital. The Clinical Neurosciences - Neuroradiology Irradiation Effects on Ascites Tumours as Related to Cell Cycle. By Sven Skog. Hand Trauma – A Practical Guide. By Dieter Buck-Gramicko, Ruimer Hoffmann, Rudiger Neumann. Joints and Vertebral Connections. By Wolfgang Dihlmann. Magnetic Resonance Imaging – Principles and Applications. By David Kean and Michael Smith. Functional Mapping of the Brain in Vascular Disorders. Wolf-Dieter Heiss. Conventional Radiological Study in Spine Injury. Jean-Claude Dosch. Studies in Cancer Epidemiology using both the Swedish Cancer Environment Registry and a traditional cohort approach. By Denny Vagero Diagnostic Imaging in Haemophilia. By Holger Pettersson and Marvin S. Gilbert. An Atlas of Normal Skeletal Scintigraphy. By James J. Flanagan and Michael N. Maisey. Atlas of Skeletal Dysplasias. Wynne-Davies, Hall & Apley. over 1900 illustrations. Review of Clark's Positioning in Radiography, edited by R.A. Swallow, and E. Naylor with Assistant Editors E.J. Roebuck and A.S. Whitley. Cervico-Ocdpital Joint (RX, CT). Auguste Wackenheim. Clinical Computed Tomography: Illustrated Procedural Guide. L.C. Chiu, J.D. Lipcamon and V.S. Yiu-Chiu. Skeletal Radiography. Sheila Bull.     

Book Reviews

Book reviewed in this article: Cardiac Imaging and Image Processing, S.M. Collins “Radiodiagnosis of the Skull”. The Cerebral Infarct Klaus-Joachim Lymphatic Imaging. Lymphography, Computed Tomography and Scintigraphy. Editors Melvin E. Clouse & Sidney Wallace. Golden's Diagnostic Radiology. Diagnostic Imaging of the Acutely Injured Patient. Radiological Physicists. Juan A. del Regato. “Atlas of Skeletal Dysplasias”. Wynne-Davies, Hall & Apley over 1900 illustrations. Clinical Diagnostic Ultrasound. Edited by E. Barnett and P. Morley. Recent Advances in Radiology and Medical Imaging. Edited by RE Steiner, Thomas Sherwood. Incidence and Cause of Femur Fractures by Rume Hedlund, Stockholm 1985. Protection of the Patient in Radiation Therapy. Publication No. 44 from the I.C.R.P. ‘Immune Variables in Breast Cancer Patients. Relation to Prognosis and Radiation Induced Long-term Effects’ An Atlas of the Breast Clinical Radio Diagnosis. Jean-Louis Lamarque. Essential Physics for Radiographers, J.A. BLOOMFIELD.     

Buchbesprechungen

Book reviewed in this article:
Arx, J. A. von, L. Rodrigues de Miranda, M. Th. Smith and D. Yarrow: The Genera of Yeasts and the Yeast-like Fungi. Studies in Mycology No. 14.
Soprunov, F. F.: Biochemie der Helminthen. I. Der Energiehaushalt der Helminthen.
Allergie—Theorie und Praxis. Von Prof. Dr. Hans Storck.     

Buchbesprechungen

Book reviewed in this article:
Smith, J. E., and D. R. Berry: The Filamentous Fungi. Vol. III: Developmental Mycology.
Hoog, G. S. de, and E. J. Hermanides-Nijhof: The black yeasts and allied hyphomycetes. Studies in Mycology No. 15.
Benirschke, K., F. M. Garner und T. C. Jones (Hrsg.): Pathology of Laboratory Animals.     

Book Reviews

Book reviewed in this article: Clinical Radiology Of The Lymphomas. By Henry Ngan and Keith W. James Clinical Cardiac Radiology. By Keith Jefferson and Simon Rees The Essentials Of Roentgen Interpretation. Third Edition. By Lester W. Paul and John H. Juhl The Radiology Of Joint Diseases. By Vassil Tzonchev, Kurt Seidel, Michail Dimitrov, Klaus Hermann Modern Thin-section Tomography. By Arnold Berrett, M.D.; Sam Brunner, M.D.; Gal-dino E Small Vessel Angiography: Imaging, Morphology, Physiology and Clinical Applications. Edited by Sadek K. Hilal Complications and Legal Implications of Radiographic Special Procedures. By Meaney, T. F., Lalli, A. F., Alfidi, R. J. 1973. C. V. Mosby Co., St. Louis Care of the Patient in Diagnostic Radiography–4th Edition. By D. N. and M. O. Chesney Planning of Surgical Centres. By Ervin Pütsep     

Corrigendum

M. Venturini, A. Michelotti, P. Papaldo, L. Del Mastro, M. Bergaglio,R. Lionetto, G. Lunardi, C. Sguotti, L. Frevola, S. Donati,R. Rosso & F. Cognetti. Identification of the highest doseof docetaxel associable with active doses of epirubicin. Resultsfrom a dose-finding study in advanced breast cancer patients.Ann Oncol 12 (8): 1097-1106. In the above-mentioned article. Table 5 was inadvertently omitted.The table has been printed below. The Publisher regrets anyinconvenience caused. Table 5. Objective responses     

Book Reviews

Book reviewed in this article: Mamography – A User's Guide. NCRP Report No. 85 “Iatrogenic Disorders of the Fetus, Infant and Child” By E.G. Kassner. Modulation Transfer Function of Screen-Film Systems. Diagnostic Procedures in Pancreatic Disease Edited By P. Malfertheiner and H. Ditschuneit Computed Tomography Of The Pituitary Gland By J.F. Bonneville, F. Cattin, & J.L. Diet-nam Pub. “Computed Tomography of the Cranial; Skeleton (Face and Skull)” Exercises in Radiological Diagnosis by Marcelle Megret Lung Cancer: Diagnostic Procedures and Therapeutic Management – with Special Reference to Radiotherapy. Practical Guide to Quality Assurance in Medical Imaging. By B.M. Moores, E.T. Henshaw, S.A. Watikinson and B.J. Pearcy.     

Antitumoral efficacy and pharmacokinetic properties of pirarubicin upon hepatic intra-arterial injection in the rabbit V x 2 tumour model.

To improve the efficiency of hepatic intra-arterial (h.i.a.) chemotherapy, we selected pirarubicin (THP) because it shows good properties for h.i.a. chemotherapy, such as fast and efficient cellular uptake, and used it for h.i.a. chemotherapy in rabbits with V x 2 tumour implanted in the liver. The anti-tumour effect of THP upon h.i.a. administration was compared with that upon intravenous (i.v.) injection and also with the anti-tumour activity of epirubicin (EPI) upon h.i.a. injection using optimal and maximal tolerated doses of each drug. When tumour growth rates and morphometric examinations were evaluated, it was found that THP and EPI were effective against V x 2 tumour when injected via the h.i.a. route. The activity of THP was stronger than that of EPI. As regards h.i.a. injection-related complication, plasma transaminase levels were temporarily elevated. To demonstrate higher anti-tumour activity and other advantages of h.i.a. injection of THP, plasma and tumour drug concentrations were determined by high-performance liquid chromatography after THP or EPI was administered at an equal dose to the rabbit V x 2 model. Hepatic intra-arterial injection of THP accomplished a selective and higher uptake into the tumour and lower effusion into the plasma than i.v. injection of THP or h.i.a. injection of EPL. Our findings indicate that THP is the better candidate of the two drugs tested for the h.i.a. chemotherapy because of its greater anti-tumour activity and the lower systemic drug exposure achieved upon h.i.a. injection.     

Buchbesprechung

Book reviewed in this article:
G. W. Korting: Praktische Dermatologie der Genitalregion
B. Krumke und G. Ehlers: Vergleichende cytophotometrische Untersuchungen an Condylomata acuminata.
G. T. Cole and R. A. Samson: Patterns of Development in Condidial Fungi.
D. G. Fleck and W. Kwantes: The Laboratory Diagnosis of Toxoplasmosis.
H. Zaun: Krankhafte Veränderungen des Nagels.     

Axl及其配体在乳腺癌组织中的表达及临床意义

目的 探讨Axl 及其配体Gas6蛋白在乳腺癌组织中的表达及其与临床病理特征的关系。方法 收集55例女性乳腺癌患者的新鲜癌组织及配对癌旁组织,另收集新鲜良性乳腺增生组织标本20例作为对照。Western blotting及免疫组化PV-9000法分别检测上述标本中Axl及其配体Gas6的表达情况,分析其表达在良恶性组织间的差异及与腋窝淋巴结转移的关系。结果 Axl在乳腺癌组织中的相对表达量和阳性表达率均高于癌旁组织及良性乳腺增生组织（0.272±0.052、0.134±0.008和0.116±0.007,60.0％、36.4％和40.0％）,差异有统计学意义（P＜0.05）;Gas6在乳腺癌组织中的相对表达量和阳性表达率均高于癌旁组织及良性乳腺增生组织（1.147±0.078、0.490±0.078和0.474±0.078,58.1％、21.8％和20.0％）,差异有统计学意义（P＜0.05）;癌旁组织及良性乳腺增生组织间Axl及Gas6蛋白表达的差异无统计学意义（P＞0.05）。淋巴结转移组中Axl和Gas6蛋白的相对表达量和阳性表达率均高于无淋巴结转移组（0.408±0.007 vs. 0.298±0.041,1.277±0.195 vs.0.880 ±0.037;80.0％ vs.48.0％,76.7％ vs.40.0％）,差异有统计学意义（P＜0.05）。乳腺癌组织中Axl 与Gas6蛋白表达呈正相关（r=0.612,P=0.041）。结论 乳腺癌组织中Axl 及Gas6蛋白表达与乳腺癌的发生、发展有关,两者表达促进了乳腺癌腋窝淋巴结转移。     

Body mass index,physical activity and the risk of pancreatic cancer in relation to smoking status and history of diabetes: a large-scale population-based cohort study in Japan–The JPHC study

Objective The effects of BMI and physical activity on the risk of pancreatic cancer were investigated in a large population-based cohort study in Japan (JPHC study). In particular, we explored how these effects were influenced by smoking status and a history of diabetes. Methods In total, 99,670 participants (47,499 men, and 52,171women) were followed for an average of 11 years through the end of 2003. Hazard ratios (HR) and their 95% confidence intervals (CI) were estimated by Cox proportional hazards models. Results A total of 224 incident cases (128 men, 96 women) of pancreatic cancer were identified. A statistically significant excess risk of pancreatic cancer was associated with current smoking (HR = 1.8, CI 1.1–3.0) and a history of diabetes (HR = 2.1, CI 1.3–3.5) among men. A similar increase in risk associated with current smoking (HR = 2.0, CI 0.9–4.4) and diabetes (HR = 1.5, CI 0.7–3.5) was also seen among women. BMI was inversely associated with risk of pancreatic cancer among men, especially among current male smokers or diabetes patients, but no association was found among women. Leisure-time physical activity was not associated with risk in either men or women. Conclusions Our study confirms the association between cigarette smoking, history of diabetes and increased risk of pancreatic cancer. However, our data suggest that the association between BMI and risk of pancreatic cancer in this Japanese population may be different from that in Western populations. Members of the JPHC Study Group (principal investigator: S. Tsugane): S. Tsugane, M. Inoue, T. Hanaoka and T. Sobue, National Cancer Center, Tokyo; J. Ogata, S. Baba, T. Mannami and A. Okayama, National Cardiovascular Center, Suita; K. Miyakawa, F. Saito, A. Koizumi, Y. Sano and I. Hashimoto, Iwate Prefectural Ninohe Public Health Center, Ninohe; Y. Miyajima, N. Suzuki, S. Nagasawa, Y. Furusugi and N. Nagai, Akita Prefectural Yokote Public Health Center, Yokote; H. Sanada, Y. Hatayama, F. Kobayashi, H. Uchino, Y. Shirai, T. Kondo, R. Sasaki, Y. Watanabe and Y. Miyakawa, Nagano Prefectural Saku Public Health Center, Saku; Y. Kishimoto, E. Takara, T. Fukuyama, M. Kinjo, M. Irei and H. Sakiyama, Okinawa Prefectural Ishikawa (Chubu) Public Health Centre, Ishikawa; K. Imoto, H. Yazawa, T. Seo, A. Seiko, F. Ito and F. Shoji, Katsushika Public Health Center, Tokyo; A. Murata, K. Minato, K. Motegi and T. Fujieda, Ibaraki Prefectural Kasama (Mito) Public Health Centre, Mito; K. Matsui, T. Abe and M. Katagiri, Niigata Prefectural Kashiwazaki Public Health Center, Kashiwazaki; M. Doi, A. Terao and Y. Ishikawa; Kochi Prefectural Tosayamada (Chuo-higashi) Public Health Center, Tosayamada; H. Sueta, H. Doi, M. Urata, N. Okamoto and F. Ide, Nagasaki Prefectural Arikawa (Kamigoto) Public Health Center, Arikawa; H. Sakiyama, N. Onga and H. Takaesu, Okinawa Prefectural Miyako Public Health Center, Hirara; F. Horii, I. Asano, H.Yamaguchi, K. Aoki, S. Maruyama and M. Ichii, Osaka Prefectural Suita Public Health Center, Suita; S. Matsushima and S. Natsukawa, Saku General Hospital, Usuda; S. Watanabe and M. Akabane, Tokyo University of Agriculture, Tokyo; M. Konishi and K. Okada, Ehime University, Matsuyama; H. Iso, Osaka University, Osaka; Y. Honda and K. Yamagishi, University of Tsukuba, Tsukuba; H. Sugimura, Hamamatsu University, Hamamatsu; Y. Tsubono, Tohoku University, Sendai; M. Kabuto, National Institute for Environmental Studies, Tsukuba; S. Tominaga, Aichi Cancer Center Research Institute, Nagoya; M. Iida and W. Ajiki, Osaka Medical Center for Cancer and Cardiovascular Disease, Osaka; S. Sato, Osaka Medical Center for Health Science and Promotion, Osaka; N. Yasuda, Kochi University, Kochi; S. Kono, Kyushu University, Fukuoka; K. Suzuki, Research Institute for Brain and Blood Vessels, Akita; Y. Takashima, Kyorin University, Mitaka; E. Maruyama, Kobe University, Kobe; M. Yamaguchi, Y. Matsumura and S. Sasaki, National Institute of Health and Nutrition, Tokyo; and T. Kadowaki, Tokyo University, Tokyo, Japan.     

Schedule-dependent drug effects of oral 5-iodo-2-pyrimidinone-2'-deoxyribose as an in vivo radiosensitizer in U251 human glioblastoma xenografts.

PURPOSE: 5-Iodo-2-pyrimidinone-2'-deoxyribose (IPdR) is an oral prodrug of 5-iodo-2'-deoxyuridine (IUdR), an in vitro/in vivo radiosensitizer. IPdR can be rapidly converted to IUdR by a hepatic aldehyde oxidase. Previously, we found that the enzymatic conversion of IPdR to IUdR could be transiently reduced using a once daily (q.d.) treatment schedule and this may affect IPdR-mediated tumor radiosensitization. The purpose of this study is to measure the effect of different drug dosing schedules on tumor radiosensitization and therapeutic index in human glioblastoma xenografts. EXPERIMENTAL DESIGN: Three different IPdR treatment schedules (thrice a day, t.i.d.; every other day, q.o.d.; every 3rd day, q.3.d.), compared with a q.d. schedule, were analyzed using athymic nude mice with human glioblastoma (U251) s.c. xenografts. Plasma pharmacokinetics, IUdR-DNA incorporation in tumor and normal proliferating tissues, tumor growth delay following irradiation, and body weight loss were used as end points. RESULTS: The t.i.d. schedule with the same total daily doses as the q.d. schedule (250, 500, or 1,000 mg/kg/d) improved the efficiency of IPdR conversion to IUdR. As a result, the percentage of IUdR-DNA incorporation was higher using the t.i.d. schedule in the tumor xenografts as well as in normal small intestine and bone marrow. Using a fixed dose (500 mg/kg) per administration, the q.o.d. and q.3.d. schedules also showed greater IPdR conversion than the q.d. schedule, related to a greater recovery of hepatic aldehyde oxidase activity prior to the next drug dosing. In the tumor regrowth assay, all IPdR treatment schedules showed significant increases of regrowth delays compared with the control without IPdR (q.o.d., 29.4 days; q.d., 29.7 days; t.i.d., 34.7 days; radiotherapy alone, 15.7 days). The t.i.d. schedule also showed a significantly enhanced tumor growth delay compared with the q.d. schedule. Additionally, the q.o.d. schedule resulted in a significant reduction in systemic toxicity. CONCLUSIONS: The t.i.d. and q.o.d. dosing schedules improved the efficiency of enzymatic activation of IPdR to IUdR during treatment and changed the extent of tumor radiosensitization and/or systemic toxicity compared with a q.d. dosing schedule. These dosing schedules will be considered for future clinical trials of IPdR-mediated human tumor radiosensitization.     

Book Reviews

Book reviewed in this article: Malignant Lymphoma: Nodal and Extranodal Diseases. Yeu-Tsu N. Lee and John S. Spratt, Jr. Modern Surgical Monographs, Grune & Stratton, Patient Care and Special Procedures in Radiologic Technology. By John C. Watson. Four Diagnostic Radiography. A Concise Practical Manual, by Glenda J. Bryan, Abdominal Echography, by E. Barnett and P Morley. Published by Butterworths Ultrasonics in Medicine, edited by M. de Vlieger, D. N. White and V. R. McCready.     

Effects of caffeine on pancreatic tumorigenesis by 4-hydroxyamino-quinoline 1-oxide in partially pancreatectomized rats

The effects of caffeine on pancreatic tumorigenesis by 4-hydroxyaminoquinoline1-oxide (4-HAQO) and on pancreatic DNA synthesis were studiedin partially pancreatec-tomized male Wistar rats. 4-HAQO wasinjected i.v. as a single dose of 7 mg/kg body weight 3 daysafter partial pan-createctomy. Caffeine was injected s.c. every12 h at the maximum tolerated dose (m.t.d.) of 120 mg/kg bodyweight, half the m.t.d., and one quarter the m.t.d. from 12to 72 h before and 0 to 72, 72 to 132, and 0 to 132 h after4-HAQO treatment. Post-treatment with caffeine from 0 to 132h had a dose-dependent biphasic effect on pancreatic tumorigenesis:post-treatment with the m.t.d. of caffeine decreased the totalnumber of nodules, whereas treatment with one quarter the m.t.d.of caffeine increased their number. Decrease in the number ofnodules was also observed on post-treatment with the m.t.d.of caffeine from 0 to 72 or from 72 to 132 h. Pre-treatmentwith the m.t.d. of caffeine had no significant effect on thenumber of nodules. Recovery of pancreatic DNA synthesis wasslower after simultaneous treatment with the m.t.d. of caffeineand 4-HAQO than after treatment with 4-HAQO alone. The possiblemechanism of the effect of caffeine on pancreatic tumorigenesisinduced by 4-HAQO in rats is discussed.     

Buchbesprechung

Book reviewed in this article:
Ergebnisse der experimentellen Medizin. Bd. 33: Struktur und Synthese von Immunglobulinen und die Bedeutung von Mediatoren bei Immunreaktionen. Hrsg. R. Dargel und D. Dettmer.
H. P. Molitoris, M. Hollings and H. A. Wood: Proceedings i n Life Sciences, Fungal Viruses.