茶色素改善甲襞微循环障碍78例临床观察

茶色素治疗微循环障碍者，结果评价按田牛甲襞微循环加权积分法 计算，并经统计学处理，测定数据以均值±标准差（ｘ±ｓ）表示，用ｔ检验，结果显 示，甲襞微循环障碍者应用茶色素治疗后，在血骨形态，血液流态及管周指标等方 面，差异有非常显著意义（Ｐ＜０．０１）。     

高血压患者血液流变性及甲襞微循环变化

本文对４５例高血压患者进行了血液流变学及甲襞微循环测定。结果表明，患者存在着明显的血液流变性异常及微循环障碍，与对照组之问有显著差异。     

糖尿病患者血液流变性与甲襞微循环相关性研究

目的：研究糖尿病（ＤＭ）患者血液流变与甲襞微循环的相关性。方 法收测３５例糖尿病患者血流变、甲襞微循环及部分生化指标，与３５例正常人对照。结果（１）非胰岛素依赖性糖尿病（ＮＩＤＤＭ）组全血高、低切粘度和高、低切还原粘度及血浆粘度均显著高于对照组（Ｐ＜０．０１～０．００１）．而胰岛素依赖性糖尿病（ＩＤＤＭ）组上述各粘度指标仅轻度增高（Ｐ＞０．０５）；（２）各ＤＭ组及不同并发症亚组均有红细胞刚性指数增高，微循环血流速度减慢，红细胞聚集性增强，白色微血栓等指标显著异常（Ｐ＜０．０５～０．００１）；（３）ＮＩＤＤＭ 组及并发症亚组，微血管畸形数增多，管禅长度增加，微血管周围有明显渗出及出血等形态和管围指标的改变（Ｐ＜０．０５～０．００１）；（４）直线相关分析显示各ＤＭ组全血高切还原粘度与红细胞刚性指数，血浆粘度与甘油三酯水平，微循环内红细胞聚集程度与白色微血栓数量均呈正相关（Ｐ ＜０．０５～０．００１）；空腹血糖与微循环内血流速度呈负相关（Ｐ＜０．０５），ＩＤＤＭ组血浆粘度与全血高、低切粘度、白色微血栓呈正相关（Ｐ＜０．０５）。结论：（１）各型 Ｄ Ｍ 患者均有不同程度血液流变性异常及微循环障碍。（２）Ｄ Ｍ患者血液流变与     

茶色素抗高血脂,异常血液变和微循环障碍的临床研究

采用自身对照法观察１００例高脂血症、服用茶色素１２５ＭＧ／次每日３次，疗程１个月。结果证明茶色素降低胆固醇有效率５１／５８例（８７．９３％）降低甘油三酯有效率５６／７７例（７２．７３％），提高高密度酯蛋白有效率５９／６５例（９０．７７％）。７８例脑梗塞、脑血栓、冠心病、糖尿病血流变异常甲襞微循环障碍双向指标观察均有明显改善。     

甲襞微循环与血液流变学双向指标检测诊断高粘滞血症的相关性分析

随机双盲检测１０２例中老年人甲襞微循环和血液流变学项目，各指 标值分别输入电脑，应用软件程序积分计值和分级评判，对诊断高粘滞血症作相关 性分析，相关系数ｒ＝０，５１８ Ｐ＜０．０１，两者相关具有十分显著意义。     

新正天丸对偏头痛患者血液流变性和甲襞微循环的影响

目的：探讨偏头痛患者血液流变学，甲襞微循环的改变及新正天丸对其的影响。方法：偏头痛患者１００例，随机分为２组，观察组５０例，口服新正天丸对照组５０例，口服氟桂嗪，疗程均为３０天。并进行治疗前后血液流变学和甲襞微循环的检测。结果：观察组血液流变性各项指标中除红细胞压积变化不明显外，其它各项均有显著改善（Ｐ＜０．０５或Ｐ＜０．０１），而对照组中只有血小板聚集率和血沉改变明显（Ｐ＜０．０５），观察组对甲襞四项积分示明显改善（Ｐ＜０．０５或Ｐ＜０．０１），而对照组改善不明显（Ｐ＞０．０５）。结论：血液流变性及甲襞微循环的改变是偏头痛的重要病理特征，新正天丸对偏头痛血瘀障碍可能有改善作用。     

活血化瘀中药对血液流变性及甲襞微循环改变的研究

目的 研究活血化瘀中药对患者血液流变性及甲襞微循环的改变.方法 用活血化瘀中药制剂(活脑丹、抗衰Ⅰ号),应用于血瘀气虚患者,观察用药前后患者血粘度及甲襞微循环的改变.结果 总结观察资料,说明用药后患者血粘度及甲襞微循环均有明显改善,与用药前比较,差异非常显著(P均＜0.01).结论 活血化瘀中药(活脑丹、抗衰Ⅰ号)均能降低患者血粘度,并能改善患者的甲襞微循环.为活血化瘀中药治疗心脑血管病急症的疗效观察,提供了一定依据.     

苦蝶子注射液对脑梗死患者血液流变性及甲襞微循环的影响

目的探讨苦蝶子注射液对脑梗死患者血液流变性及甲襞微循环的影响。方法将80例脑梗死患者随机分成治疗组和对照组,治疗组用苦蝶子注射液治疗,对照组用复方丹参、低分子右旋糖酐治疗,于治疗前后分别测定血液流变性与甲襞微循环指标。结果苦蝶子注射液能明显改善血液微循环障碍,在防治脑梗死中有重要价值。     

OSAHS患者甲襞微循环及血液流变学观察

目的探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者甲襞微循环的变化及血液流变学的改变。方法对11例OSAHS患者进行甲襞微循环和血液流变学的观察。结果OSAHS者存在微循环障碍,表现为甲襞微循环血流减慢,红细胞轻度至中度聚集,血流变学表现为红细胞压积增高。结论OSAHS患者微循环异常,血液粘度增加,血流缓慢,造成微血流滞缓形成为微血栓,是易发生脑血栓、冠心病的独立危险因素。     

茶色素对血液流变性影响的临床观察

观察茶色素对患者血液流变性的影响。１５２例不同患者分组，口服茶 色素胶囊，每次 ２５０ｍｇ，日服 ３次，３０天为一疗程。治疗前后检测 １４项血液流变指 标。结果：治疗前各组均有明显血流变异常，以肺心病组最为明显；治疗后，各组１４ 项血流变指标均得到改善，并有显著性差异（Ｐ＜０．０５），或非常显著性差异（Ｐ＜０．０１）；冠心、肺心、高血压病、高脂血症疗效明显，恶性肿瘤稍差。说明茶色素有显著改善患者血流变的作用。     

非典型抗精神病药对精神分裂症病人PRL和血脂影响

目的探讨4种非典型抗精神病药物对精神分裂症病人血清催乳素（PRL）和血脂水平的影响,以及药物疗效与PRL、血脂水平的相关性。方法将120例精神分裂症病人随机分为4组,分别给予利培酮、喹硫平、奥氮平、阿立哌唑治疗12周。于治疗前及治疗第12周末（治疗后）进行阳性与阴性症状量表（PANSS）评定,并测定血总胆固醇（TC）、三酰甘油（TG）、高密度脂蛋白（HDL）、低密度脂蛋白（LDL）及血PRL水平。结果治疗后4组病人的阳性症状分、阴性症状分、一般精神病理分、PANSS总分与治疗前比较差异均有显著性（t=10.01-17.38,P〈0.01）。4组间治疗后阳性症状分、阴性症状分、一般精神病理分、PANSS总分差异均无显著性（F=0.18-4.37,P〉0.05）。与治疗前比较,治疗后利培酮组TG、LDL显著升高（t=3.31、5.07,P〈0.01）,奥氮平组TG、TC、LDL显著升高（t=2.33-5.51,P〈0.05、0.01）,喹硫平组TC显著升高（t=5.94,P〈0.01）,阿立哌唑组LDL显著升高（t=2.21,P〈0.05）;利培酮组治疗后PRL水平明显升高（t=38.48,P〈0.01）。治疗后利培酮组TG水平显著高于喹硫平组和阿立哌唑组（F=13.00,q=5.21、5.17,P〈0.01）,奥氮平组显著高于喹硫平组和阿立哌唑组（q=7.05、7.01,P〈0.01）;奥氮平组和喹硫平组TC水平显著高于利培酮组（F=5.49,q=3.02、4.60,P〈0.05、0.01）,喹硫平组显著高于阿立哌唑组（q=4.78,P〈0.01）;利培酮组LDL水平显著高于其他3组（F=4.29;q=2.49-5.05,P〈0.05、0.01）,奥氮平组显著高于喹硫平组（q=2.18,P〈0.05）,喹硫平组显著高于阿立哌唑组（q=2.56,P〈0.05）。PANSS减分率与PRL、血脂水平变化情况均无相关（r=0.22、0.17,P〉0.05）。结论 4种药物均可升高血脂,利培酮可升高PRL;药物疗效与PRL、血脂水平无关。     

规律耐力运动对乳癌病人术前血压的作用

目的 探讨耐力运动对乳癌病人稳定术前血压的效果。方法 30例乳癌病人，每天进行慢跑运动，锻炼强度为每次运动后心率增加值不超过20min^-1，每天锻炼1次，每周锻炼3～4次，每次30min，连续锻炼2个月。用焦虑症状自评量表监测运动前后心理状态；比较病人运动前1d、运动后第20、40、60天血压、心率（HR）的变化。结果 运动后病人收缩压（SBP）、舒张压（DBP）显著降低，HR升高，差异有显著性（F=14．03～253．84，q=16．19～49．03，P〈0．05）；运动后第20、40、60天血压改善者不断增多（χ^2=20．00～40．00，P〈0．05）；运动后焦虑症状较运动前有显著改善。结论 耐力运动能改善乳癌病人焦虑状态，稳定术前血压。     

EFFECTS OF BLOOD FLOW RESTRICTION TRAINING ON HANDGRIP STRENGTH AND MUSCULAR VOLUME OF YOUNG WOMEN

Background:High-intensity training methods are generally recommended to increase muscle mass and strength, with training loads of 60-70% 1RM for novice and 80-100% 1RM for advanced individuals. Blood flow restriction training, despite using lower intensities (30-50% 1RM), can provide similar improvements in muscle mass and strength. However, studies commonly investigate the effects of blood flow restriction training in large muscular groups, whereas there are few studies that investigated those effects in smaller muscle groups, such as the muscles involved in grasping (e.g, wrist flexors; finger flexors). Clinically, smaller muscular groups should also be considered in intervention programs, given that repetitive stress, such as repeated strain injuries, affects upper limbs and may lead to chronic pain and incapacity for work. The purpose of the present study was to examine the effects of blood flow restriction training in strength and anthropometric indicators of muscular volume in young women.Hypothesis:The effect of blood flow restriction training in handgrip strength (HGS) and muscular volume of young women can be similar to traditional training, even with lower loads.Methods:Twenty-eight university students, 18 to 25 years of age, were randomly assigned into two groups, blood flow restriction training (BFR, n = 14) and traditional training (TRAD, n = 14). The anthropometric measures and maximum handgrip strength (MHGS) test were performed before and after the intervention. The participants did three weekly sessions of dynamic concentric contraction exercises on a dynamometer for four weeks (12 sessions). Each session had a time length of five minutes and the intensity was established from a percentage of MHGS at 30-35% in the first week, 40-45% in the second and 50-55% in third/fourth weeks. Three sets of 15-25 handgrip repetitions were performed until a failure with a 30 seconds rest for BFR training and three sets of 8-12 repetitions with one-minute rest for TRAD training.Results:A significant increase was found in the arm muscle circumference (20.6 ± 2.2 vs 21.6 ± 1.7cm) and right MHGS (32.7 ± 4.5 vs 34.3 ± 4.1 kgf) and left MHGS (28.0 ± 5.5 vs 30.9 ± 4.1 kgf) for the BFR training, and the left MHGS (27.6 ± 5.0 vs 31.0 ± 6.1 kgf) for the TRAD training.ConclusionDynamometer training with blood flow restriction, performed with low to moderate loads, was more effective than the traditional training in increasing HGS and muscle volume in young women.Level of evidence:2b     

全反式维甲酸对APL病人凝血和纤溶指标影响

目的了解急性早幼粒细胞白血病（APL）病人全反式维甲酸（ATRA）诱导缓解治疗过程中凝血和纤溶异常的变化及其与外周血白细胞（WBC）计数高低的关系。方法初治APL病人43例,其中外周血WBC计数≥10×109/L（高白细胞组）21例,WBC〈10×109/L（低白细胞组）22例。应用ATRA60 mg/d分3次口服治疗,外周血WBC〉4.0×109/L者给予柔红霉素20 mg/d×3 d＋阿糖胞苷100 mg/d×7 d方案小剂量化疗,血小板〈20×109/L伴出血倾向者给予血小板悬液输注,感染发热者给予抗生素等对症支持治疗。监测病人诱导缓解治疗前、治疗后1、2、4周外周血WBC及纤维蛋白原（FIB）、凝血酶原时间（PT）、部分凝血活酶时间（APTT）和骨髓常规变化。结果治疗前高白细胞组FIB低于低白细胞组（t=-3.082,P〈0.05）,而PT高于低白细胞组（t=3.720,P〈0.05）,APTT两组差异无统计学意义（t=-1.157,P〉0.05）。36例病人完全缓解,3例达部分缓解,1例未缓解,3例因脑出血死亡。APL病人治疗后第1周外周血WBC升高,至第4周逐渐恢复正常（F=9.041,q=2.825～6.786,P〈0.05）;病人的出血症状迅速得到改善;同时,血浆FIB、PT指标亦逐渐恢复,达到完全缓解时基本恢复至正常水平（F=15.346、37.147,q=4.012～13.673,P〈0.05）。结论 APL病人外周血WBC高低是有无DIC的一个重要危险因素,ATRA诱导缓解治疗后因出血所致的早期死亡率降低。     

A SYSTEMATIC REVIEW OF THE EFFECTS OF BLOOD FLOW RESTRICTION TRAINING ON QUADRICEPS MUSCLE ATROPHY AND CIRCUMFERENCE POST ACL RECONSTRUCTION

Background:ACL reconstruction often results in an extended period of muscle atrophy and weakness. Blood flow restriction (BFR) training is a technique that has been shown to decrease muscle atrophy in a variety of populations.Purpose:The purpose of this systematic review was to analyze the research presented on the effect of blood flow restriction training on quadriceps muscle atrophy and circumference post ACL reconstruction.Study Design:Systematic ReviewMethods:Articles were reviewed using the databases Google Scholar, PubMed, and EBSCO. Keywords included blood flow restriction training, ACL reconstruction, and quadriceps.Inclusion criteria included:English language, peer-reviewed journals; randomized control trials; and articles including blood flow restriction and measurement of quadriceps atrophy and circumference post ACL reconstruction. Exclusion criteria included non-English language publications; studies without a control group; and articles without sufficient data to evaluate the methodology. Four studies met the selection criteria and were assessed using the GRADE scale, which analyzes the strength of a study based on study limitations, precision, consistency, directness, and publication bias. After a GRADE designation was assigned, the following information was extracted from and compared across the studies: participant demographics, cuff used, graft used during ACL reconstruction, tool used to assess muscle atrophy, protocol used, and conclusions.Results:Three out of four studies showed some amount of an increase in femoral muscle cross sectional area after the use of BFR combined with low-intensity resistance training (LIRT). The strength of all four studies was moderate when assessed using the GRADE scale.Conclusion:This review of the available evidence yields promising results regarding the use of BFR and LIRT in the remediation of femoral muscle atrophy after an ACL reconstruction. Further research is necessary before BFR can be recommended for use in clinical settings.Level of evidence:3a