液氮冷冻疗法治疗增生性皮肤病855例体会

对855例增生性皮肤病采用液氮冷冻治疗,回顾性分析其治疗效果并与148例CO2激光治疗患者进行比较.结果液氮冷冻治疗增生性皮病效果确切,有效率99.42%,复发率0.58%;CO2激光治疗患者有效率87.84%,复发率12.16%.二者有效率和复发率比较差异均有统计学意义(P均＜0.01).认为液氮冷冻治疗增生性皮病方法简便、效果显著,无不良反应,适合于基层医院应用.     

CO2激光与液氮冷冻治疗扁平疣临床观察

目的比较CO2激光与液氮冷冻治疗扁平疣的疗效及并发症,为临床治疗提供依据。方法将50例扁平疣患者随机分为CO2激光组（A组）和液氮冷冻组（B组）,观察两组的近期和远期疗效及并发症出现情况。结果治疗1次,A组有效率（84%）与B组（80%）比较无统计学差异。治疗半年后随访,A组复发率（8.33%）低于B组（21.74%）,A组并发症发生率（8%）低于B组（24%）（P〈0.05）。结论CO2激光治疗扁平疣与液氮冷冻治疗相比近期疗效相近,但CO2激光远期疗效好于液氮冷冻,且并发症发生少。     

潘托拉唑加丽珠胃三联治疗难治性胃幽门螺杆菌感染40例

[目的]观察潘托拉唑加丽珠胃三联治疗难治性胃幽门螺杆菌(Hp)感染的疗效.[方法]80例经一线治疗失败的Hp感染患者,随机分为2组,治疗组予潘托拉唑加丽珠胃三联治疗,对照组予奥美拉唑、灭滴灵及克拉霉素治疗.[结果]治疗组Hp根除率为95.0%,对照组为51.4%,P＜0.05.治疗组不良反应显著优于对照组.[结论]潘托拉唑加丽珠胃三联治疗难治性Hp感染疗效确切,不良反应少.     

液氮冷冻疗法治疗肛周股癣疗效观察

目的观察液氮冷冻疗法治疗患者肛周股癣的疗效。方法将80例肛周股癣患者随机分为观察组和对照组,各40例。两组均给予常规药物治疗,治疗组在此基础上接受液氮冷冻治疗,比较两组患者的临床疗效及治愈时间。结果观察组、对照组治疗15 d后总有效率分别为87.5%、57.5%,观察组高于对照组(P<0.05)。观察组、对照组痊愈时间分别为(6.35±1.28)、(11.48±2.35)d,观察组少于对照组(P<0.05)。观察组患者治疗期间及治疗后3个月未发生明显不良反应。随访3个月,观察组、对照组复发率分别为5.0%、22.0%,观察组低于对照组(P<0.05)。结论液氮冷冻疗法治疗肛周股癣效果满意。     

5-氨基酮戊酸光动力疗法治疗扁平疣疗效观察

目的观察5-氨基酮戊酸光动力疗法(5-aminolevulinic acid photodynamic therapy,ALA-PDT)治疗扁平疣的临床疗效和安全性。方法选择2015-01~2016-10该院门诊就诊的扁平疣患者85例,随机分为两组,ALA-PDT组45例,采用ALA-PDT治疗,1次/7~10 d,视疣体脱落情况,治疗2~4次不等。冷冻组40例,采用液氮冷冻方法治疗,每2周1次,视疣体脱落情况,治疗2~4次不等。两组均在治疗期间和治疗3个月后,观察和记录临床疗效和不良反应。结果治疗3个月后,ALA-PDT组有效率(95.6%)明显高于冷冻组(80.0%),差异有统计学意义(P0.05)。ALA-PDT组治疗期间仅出现水肿性红斑、烧灼感、脱屑等不良反应,均为一过性,对症治疗1~3 d后即消退,未出现冷冻组治疗后普遍出现的疼痛、水疱、结痂和色素沉着、色素减退,无瘢痕形成。结论 ALA-PDT治疗扁平疣疗效高,不良反应轻微,安全性好。     

中西医结合治疗对尖锐湿疣患者的疗效及免疫指标影响

将100例女阴尖锐湿疣患者随机分成治疗组50例(口服外洗荡疣汤,并用CO2激光治疗)及对照组50例(肌注聚肌胞,并用CO2激光治疗),观察治疗前后临床痊愈率及免疫学指标的变化。结果治疗组痊愈率(84%)明显高于对照组(62%);与对照组比较,治疗组IL-2水平显著升高,CD8显著降低,CD4/CD8显著升高,差异有统计学意义(P<0.05)。认为中西医结合治疗能调节患者的免疫异常,从而提高临床疗效。     

CO_2激光联合包埋术治疗尖锐湿疣

目的观察自身疣体包埋术治疗尖锐湿疣临床效果及安全性。方法治疗组取患者自体新鲜疣体接种于上臂皮下组织内,同时局麻下用CO2激光1次性祛除所见全部疣体;对照组局麻下用CO2激光祛除全部疣体。两组患者均每周随访1次,了解创面愈合及疣体复发情况,观察3个月,按痊愈和复发两级来判断疗效。结果治疗组痊愈率为86%(43/50),复发率为14%(7/50);对照组痊愈率为67.35%(33/49),复发率为32.65%(16/49);两组比较差异有统计学意义(P0.05)。结论自体疣接种是一种理想的自体免疫疗法,该疗法与CO2激光配合治疗尖锐湿疣可显著降低其复发率,且无明显不良反应。     

5%咪喹莫特乳膏预防CO_2激光术后宫颈尖锐湿疣复发

目的观察5%咪喹莫特乳膏预防二氧化碳(CO2)激光治疗后宫颈尖锐湿疣(CA)的复发情况和对人乳头瘤病毒(HPV)的清除情况。方法对94例宫颈CA(HPV阳性)患者先进行CO2激光治疗,再随机分为观察组(46例)和对照组(48例),观察组给予5%咪喹莫特乳膏涂布宫颈及阴道后穹窿,每周2次,共12周。随访24周。对照组在CA复发时只进行激光治疗。两组患者均在CO2激光治疗后第12周、第24周进行HPV复查。结果两组在术后第12周、24周的疣体复发情况比较差异有统计学意义(P均0.05),观察组的复发率低于对照组。在12周及24周时观察组HPV清除率较对照组高,两者比较差异有统计学意义(P均0.05)。结论在CO2激光治疗后,5%咪喹莫特乳膏能有效预防宫颈尖锐湿疣的复发,对HPV有良好的清除作用。     

纳络酮配合红花注射液治疗急性一氧化碳中毒疗效观察

目的观察纳络酮配合红花注射液治疗急性一氧化碳(CO)中毒的疗效.方法将急性CO中毒的病人随机分为两组治疗.治疗组(32例)用纳络酮和红花注射液治疗,对照组(30例)用甘露醇、糖皮质激素及促进脑细胞代谢药物等常规方法治疗,观察两组疗效.结果纳络酮治疗组与对照组有效率分别为96.88%和83.33%,发生迟发脑病例数分别为1例和5例,两组比较均有统计学意义(P＜0.05).两组病人意识、血氧饱和度(SaO2)恢复时间比较有统计学意义(P＜0.01).结论纳络酮配合红花注射液治疗急性CO中毒,能显著提高总有效率,缩短意识恢复时间,减少迟发脑病的发生,且无不良反应.     

中医辨证治疗慢性胃炎48例

[目的]观察中医辨证治疗慢性胃炎的临床疗效.[方法]使用随机对照,开放试验方法,分为治疗组(48例)和对照组(30例),治疗组予中医辨证治疗,对照组予西药治疗.2组治疗前后均做胃镜检查,观察临床疗效.[结果]治疗组有效率为87.75%,对照组为86.67%(P＞0.05).治疗组对症状的缓解明显优于对照组(P＜0.01).[结论]采用中医辨证治疗慢性胃炎其疗效与对照组相当,但对症状的缓解优于对照组.     

State of knowledge of helminth fauna of freshwater fishes of Poland

A total 89 fish and lamprey species has been recorded from Polish freshwater habitats. Twenty-seven of them (30.3%) have not been surveyed for parasitic helminthes. Some of the latter fishes are either rare or not easily accessible. Other live only in specific habitats in scattered localities. An important obstacle for studying parasite faunas of some fishes may be their status on an endangered species. Among the non-surveyed fishes, are those which have been relatively recently introduced to Poland or migrated there on their own. The present paper attempts to review all hitherto not studied helminthologically fish species, their habitats, localities and current protection status.     

高血压降压治疗目标的再认识

根据传统的高血压水平的定义,1993年WHO高血压治疗指南提出血压控制目标为<140/90mm Hg(1mm Hg=0.133kPa),但是并非所有患者都必须将血压降至同一水平,而应根据患者情况进行个体化治疗。Framingham进行的一项长达10～12年的心血管事件研究发现,第5年后,正常上限血压[收缩压(SBP     

Lack of correlation of degree of villous atrophy with severity of clinical presentation of coeliac disease

BACKGROUND AND AIM: Both the clinical presentation and the degree of mucosal damage in coeliac disease vary greatly. In view of conflicting information as to whether the mode of presentation correlates with the degree of villous atrophy, we reviewed a large cohort of patients with coeliac disease. PATIENTS AND METHODS: We correlated mode of presentation (classical, diarrhoea predominant or atypical/silent) with histology of duodenal biopsies and examined their trends over time. RESULTS: The cohort consisted of 499 adults, mean age 44.1 years, 68% females. The majority had silent coeliac disease (56%) and total villous atrophy (65%). There was no correlation of mode of presentation with the degree of villous atrophy (p=0.25). Sixty-eight percent of females and 58% of males had a severe villous atrophy (p=0.052). There was a significant trend over time for a greater proportion of patients presenting as atypical/silent coeliac disease and having partial villous atrophy, though the majority still had total villous atrophy. CONCLUSIONS: Among our patients the degree of villous atrophy in duodenal biopsies did not correlate with the mode of presentation, indicating that factors other than the degree of villous atrophy must account for diarrhoea in coeliac disease.