共查询到20条相似文献,搜索用时 93 毫秒
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从现代药剂学看药用辅料的发展 总被引:2,自引:0,他引:2
现代药剂学领域中药物传递系统的出现,是科学技术进步的结晶;新型药物剂型及制剂的问世是药剂学领域中突破性的进展。而这些成就的取得,离不开药用辅料的发展。 相似文献
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红细胞载体——一种新颖的药物传输系统 总被引:3,自引:0,他引:3
目的 介绍红细胞作为药物载体的传输系统。方法 通过对国内外研究的综述和总结,描述了红细胞作为药物载体的原理和特点。结果与结论 作为目前研究最深入的第三代生物反应器和药物载体,红细胞药物载体具有:①可极大的延长药物的体内半衰期;②降低外源性物质的免疫反应;③提高药物传输的靶向性;④红细胞代谢功能的可利用性等优点,具有深远的研究意义和广阔的应用前景。 相似文献
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在综合分析药物释放系统发展趋势、我国药物释放系统发展的实际水平及存在问题的基础上,提出我国药物释放系统发展的对策与建议。 相似文献
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Lei Xing Xin Chang Lijun Shen Chenglu Zhang Yatong Fan Chongsu Cho Zhiqi Zhang Hulin Jiang 《Asian Journal of Pharmaceutical Sciences》2021,(1):47-61
Fibrosis is a necessary process in the progression of chronic disease to cirrhosis or even cancer,which is a serious disease threatening human health.Recent stu... 相似文献
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利用互联网Medline数据库、清华全文数据库、欧洲专利数据库和中国知识产权局专利数据库,应用统计和情报分析的方法,对国内外近年来发表的有关药物释放系统(DDS)主题文献的论文进行文献数量、年代及研究内容的统计分析,同时对国内外药物制剂专利公布情况进行资料统计,对比分析国内外DDS的研究领域、研究重点变化及发展趋势,探讨我国未来DDS的研究重点与发展前景。 相似文献
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A study was made of the pharmacokinetic behaviour in plasma and urine of cefazolin in seven healthy volunteers following parenteral administration of sodium cefazolin (1250 mg) and a sustained release formulation containing sodium cefazolin: cefazolin-dibenzylamine (1:4) at a total dose of 1250 mg, both formulations being administered over 1 week by the i.m. route. Cefazolin concentrations in plasma and urine were determined by a HPLC technique. Kinetic analysis of the experimental results was performed using an open single-compartment kinetic model and a sustained release model for the drug administered as standard formulation and the sustained release formulation, respectively. The results obtained point to significant variations in the pharmacokinetic profile of the drug when administered in the DDS. The time of cefazolin at levels greater than 1 microgram ml-1 was 16.03 +/- 2.51 and 47.76 +/- 14.18 h-1 after administration of the standard formulation and the DDS, respectively. The urinary excretion rate curves also show the existence of sustained drug levels in the urine following administration of the DDS. The renal clearance of the drug did not show statistically significant differences between the two formulations administered. The process of release of cefazolin from the cefazolin-dibenzylamine complex proved to be a first order kinetic process. The release constant of the antibiotic was calculated according to three different methods: the Wagner-Nelson method; the statistical moments method; and the fitting of the plasma levels curves to a compartmental model considering release and absorption. The values obtained for this constant ranges from 0.026 +/- 0.02 h-1 calculated with the method of statistical moments to 0.094 +/- 0.03 h-1 as calculated by the equation derived for the plasma fitting of cefazolin administered as DDS. 相似文献