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Malignant fibrous histiocytoma of bone is a highly malignant neoplasm similar to that found in soft tissues. It accounts for at least 5% of all primary malignant bone tumors. The majority of lesions are primary, but some arise in preexisting benign lesions. Definitive diagnosis is made on histologic examination, a storiform arrangement of spindly tumor cells being the classic finding. Radical resection combined with preoperative and postoperative chemotherapy is the treatment of choice.  相似文献   

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Malignant fibrous histiocytoma is a rare primary bone tumor, and there have been conflicting reports on its grades of malignancy. We are describing the cases of eight patients who were seen between 1977 and 1982. Four had pulmonary metastases and five, involvement of the lymph nodes. Five patients had a high level of serum alkaline phosphatase. None of the patients had a pathological fracture, an associated bone infarct, or Paget's disease. Seven of the eight patients died within one year after diagnosis.  相似文献   

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A 45-year-old male presented with a large calvarial mass caused by a malignant fibrous histiocytoma arising primarily from the frontal bone and extending into the intracranial space. Magnetic resonance imaging revealed a well-demarcated, mottled enhanced bulky tumor with several low-signal separations. He underwent extensive tumor and bone removal, followed by radiation therapy. Histological examination showed pleomorphic spindle cells in a storiform pattern. The tissue stained positive for alpha-1-antitrypsin and alpha-1-antichymotrypsin by immunohistochemical techniques.  相似文献   

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T F Breen  W L Healy 《Orthopedics》1987,10(8):1169-1173
Malignant fibrous histiocytoma arising in bone infarcts has only been recently recognized as a pathologic entity. Eighteen cases have been reported prior to this one. A case of a malignant fibrous histiocytoma developing in a 58-year-old man with idiopathic medullary bone infarcts in the distal femurs is presented along with a review of the literature.  相似文献   

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Malignant fibrous histiocytoma of the breast. A case report   总被引:1,自引:0,他引:1  
Primary malignant fibrous histiocytoma of the breast was diagnosed in a 45-year-old Indian woman. She presented with a large ulcerated lesion and had lung metastases. Treatment was by radiotherapy, toilet mastectomy and chemotherapy. The patient died of rapid extension of lung metastases 15 months after first being seen. Although this tumour has previously been considered to have a relatively good prognosis, this report emphasises its fully malignant metastatic potential.  相似文献   

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Malignant fibrous histiocytoma is a recently recognised common sarcoma of late adult life which, rarely, may arise in the heart. Unlike the atrial myxoma, which it may mimic clinically, malignant fibrous histiocytoma is a far more aggressive tumour with a greater tendency for local recurrence and infiltration. A case of a primary intracardiac malignant fibrous histiocytoma is reported and relevant published reports reviewed.  相似文献   

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Malignant fibrous histiocytoma (MFH) is a rare tumour of the spermatic cord. We present the second reported case in Australia and review the literature, discussing the recommended management and prognosis of this condition.  相似文献   

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Malignant change in Paget's disease of bone usually has the histological features of osteosarcoma, but follows a different clinical course from cases not associated with paget's disease of bone. Malignant fibrous histiocytoma is an uncommon neoplasm which may be associated with pagetic bone and its clinical course is not well defined. Seven cases of malignant fibrous histiocytoma in Paget's disease were reviewed from two Australian bone tumour registries. In stage IIB and III disease there was a three year survival rate of 57%, suggesting a better prognosis than for patients with other sarcomas in Paget's disease.  相似文献   

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Seven cases of malignant fibrous histiocytoma are reported. Two patients had tumour involving the scrotum and small-gut mesentery, which are unusual primary sites, while three others with pulmonary metastases are alive five years since the appearance of these metastases. A review of the histogenesis, biological behaviour and the treatment of these uncommon tumours suggests that the prognosis is good even in the presence of advanced local or metastatic disease. Radiotherapy controlled the primary lesion in one patient and was effective in treating pulmonary metastases in three, suggesting that these tumours do show a response to radiotherapy. The prophylactic use of radiotherapy and chemotherapy awaits further evaluation.  相似文献   

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Malignant fibrous histiocytoma of the clivus: case report   总被引:1,自引:0,他引:1  
A case of malignant fibrous histiocytoma of the clivus in a 2 1/2-year-old boy is reported. There are no prior reports of this tumor in this location. The child was treated with operation, radiation therapy, and chemotherapy. The tumor recurred locally 21 months later. The recurrence was palliated by operation and chemotherapy, permitting an additional 20-month survival.  相似文献   

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Summary Malignant fibrous histiocytoma only infrequently arises from structures of the head and neck. When it does, it most often originates in facial structures, particularly the maxilla.This case report details a malignant fibrous histiocytoma arising from the pericranium, and presenting clinically as a large indurated frontal calvarial mass. A CT scan showed its origin to be from the pericranium and demonstrated its intracranial extension.Radical excision presented a surgical challenge because of the extensiveness of the lesion. Yet, combined with post-operative teletherapy, a favourable outcome was obtained.  相似文献   

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