Effect of Chinese drugs combining with chemotherapy on quality of life in 146 children with solid tumor

Objective:To explore the effect of Chinese drugs for supporting essence and strengthening Pi(脾, SESP) combining with chemotherapy on the quality of life(QOL) in the children with solid tumor.Methods:Using a digital table,146 children with solid tumor were randomized into two groups,77 in the control group and 69 in the treated group.They received conventional chemotherapy,but to the patients in the treated group,SESP were administered additionally.The patients' scores of QOL and adverse reaction occurred...     

Initial experiences with isolated limb perfusion for unresectable melanoma of the limb

Aims  

Our initial results with isolated limb perfusion (ILP) using melphalan ± TNF alpha in patients with unresectable melanoma of the limb were analyzed.     

Clinical observation on the treatment of chronic urticaria with total glucosides of paeony capsule combined with citirizine

<正>Objective:To assess the effect and adverse reaction of total glucosides of paeony capsule(TGPC)in combining with citirizine for the treatment of chronic urticaria.Methods:A total of 120 patients were assigned to two groups by lottery,65 in the treated group and 55 in the control group.They all were orally treated with citirizine tablet 10 mg per day,but to the treated group,additional 0.2 g TGPC was given three times per day,the therapeutic course for both groups was 4 weeks.The effectiveness of treatment was observed,and the changes of total symptom score,serum levels of interleukin-4(IL-4),and immunoglobulin E(IgE)were measured before and after treatment.Moreover,a followup was carried out one month after ending the treatment.Results:The dropped cases were two in the treated group and seven in the control group;so,the study was accomplished on 63 patients in the treated group and 48 patients in the control group.The total effective rate was assessed at 73.02%(46/63)in the treated group,which was significantly higher than 47.92%(23/48)in the control group(P0.01).After treatment,the total symptom score decreased in both groups,but the decrement in the treated group was more significant(P0.05).Serum levels of IL-4 and IgE in the treated group lowered significantly,while the changes in the control group were insignificant,so statistical significant differences were shown between groups(P0.01).A follow-up study showed that the relapse rate in the treated group was 30.00% (6/20),while that in the control group was 90.00%(9/10),and the former was lower than the latter(P0.01).Adverse reactions,revealed as drowsiness,dizziness,and weakness,were seen in eight cases and seven cases in the two groups,respectively.Besides,mild diarrhea occurred in two cases of the treated group.Condusioiis:The treatment of TGPC combining citirizine shows definite curative effect in treating chronic urticaria,with low relapse rate and without evident adverse reaction.Its therapeutic effect might be realized by means of regulating patients' immune function. Besides,the medication should be continued for a rather long period to achieve the full effect.     

Analysis of the prognostic factors of very severe aplastic anemia treated with Chinese Kidney-invigorating drugs in combination with anti-lymphocyte globulin or anti-thymocyte globulin

<正>Objective:To explore the prognostic factors for very severe aplastic anemia(VSAA) patients treated mainly with Chinese Kidney(Shen)-invigorating drugs(CKID) combined with anti-lymphocyte globulin (ALG) or anti-thymocyte globulin(ATG).Methods:Twenty-seven VSAA patients were treated with CSID+ALG/ ATG therapy in conjunction with cyclosporine A,androgen,hemopoietic growth factor,etc.The relationship of the effectiveness and some factors(age of patients,course of illness,blood and bone marrow figures, etc.) were analyzed.Results:In the 25 evaluated VSAA patients who had been followed up for over 1 year,9 patients(36.0%) were basically cured,5(20.0%) remitted,6(24.0%) were markedly improved,and 5(20.0%) were treated in vain,with the total effective rate of treatment being 80.0%(20/25).Better clinical therapeutic effects were shown in patients newly diagnosed with VSAA,of male sex(P=0.037),20 years old(P=0.045), with an illness course≤1 month(P=0.048),with peripheral neutrophil count0.1×10~9/L(P=0.023),and with reticulocyte count10×10~9/L(P=0.002).Platelet count(P=0.620) and bone marrow lymphocyte percentage (P=0.736) showed no correlation with the therapeutic effectiveness.Multi-factor analysis by the Kaplan-Meier procedure on the factors influencing survival showed that rather longer survival times occurred in patients20 years old,with peripheral neutrophil count≤0.1×10~9/L,reticulocyte count10×10~9/L,and platelet count10×10~9/L(all P=0.0001).Bone marrow lymphocyte percentage and the initiation time of ALG/ATG application (from onset of the illness) showed no significant influence on patients' survival time(P=0.085 and P=0.935, respectively).Conclusions:CSKD+ALG/ATG therapy for treatment of VSAA could enhance the current clinical therapeutic effects and elevate patients' survival rate.Conditions including male sex,age20 years,illness course1 month,neutrophil count0.1×10~9/L,and reticulocyte count10×10~9/L are the likely effective indices for predicting favorable therapeutic effectiveness in newly diagnosed VSAA patients.     

Clinical study on effect of shenlong oral liquid combined with radiotherapy in treating nasopharyngeal carcinoma

Objective  

To observe the effect of Shenlong Oral Liquid(SLOL)combined with radiotherapy in treating nasopharyngeal carcinoma (NPC).     

Development of clinical practice guidelines in 11 common diseases with Chinese medicine interventions in China

Objective:To analyze the clinical practice guideline(CPG) development on 11 common diseases with Chinese medicine(CM) interventions in China.Methods:The CPGs of 11 common diseases which could be treated effectively with CM had been published between 1980 and 2010 in China.The 11 diseases include coronary heart disease(angina pectoris),hypertension,chronic gastritis,rheumatoid arthritis,cerebral infarction,migraine,diabetes,primary osteoporosis,insomnia,common cold,and IgA nephropathy.The issuing organization,date of publication,development methods,and citation rate of the CPGs were analyzed.According to the development method,each guideline was categorized as consensus-based(CB),evidence-based(EB), or consensus based with no explicit consideration of evidence-based(CB-EB).Results:Thirty-three CPGs on the 11 common diseases were found:20 guidelines were classified as CB,13 as CB-EB and none as EB.Fifteen CPGs were issued by the China Association of Chinese Medicine,8 by professional working groups,and 4 by the State Administration of Traditional Chinese Medicine.Six guidelines were published between 1980 and 1990,9 between 1991 and 2000,and 18 between 2001 and 2010.Fifty-eight percent of these guidelines have not been amended timely.Only 54.5%(18/33) of the 33 guidelines were cited by other researchers and 45.5% (15/33) percent had never been cited.Conclusions:Most CPGs developed for 11 common diseases with CM approaches in China are consensus,and their citation rates are relatively low.The results suggest that more EB CPG or CPG strictly based on expert consensus could be developed,and great efforts should be made for future CM CPG application.     

Atrial fibrillation precipitated by carotid sinus massage in a patient with unexplained syncope

Background  

Carotid sinus massage (CSM) is a useful tool in the investigation of unexplained syncope, but is associated with risks.     

A comparison of papaveretum-promethazine with morphine-ondansetron for patient-controlled analgesia

Background  

Patient-controlled analgesia (PCA) with intravenous morphine is commonplace. Antiemetics are often added to reduce side-effects. In our institution an unusual combination of papaveretum-promethazine is in use.     

Effects of panax notoginoside on the nephropathy in rats with type 1 diabetes mellitus

Objective  

To explore the effects and underlying mechanisms of Panax notoginoside (PNS) on the nephropathy in rats with type 1 diabetes.     

Clinical effect of Astragalus granule of different dosages on quality of life in patients with chronic heart failure

Objective:To explore the dose-effect relationship of Astragalus granule(AG) on improving the quality of life(QOL) of the patients with chronic heart failure(CHF).Methods:Ninety CHF patients of Fei(肺)-qi deficiency and/or Xin(心)-Shen(肾) yang-deficiency syndromes were equally randomized divided with a random number table into three groups;they received the high(7.5 g),moderate(4.5 g),and low dosage(2.25 g) of AG orally taken twice a day,respectively,and 4 mg of perindopril tablet once a day for 30 successive days.The heart function grade,patients’ left ventricular ejection fraction(LVEF) and walking distance in 6 min(6mWD) were measured before and after treatment,and the patients’ QOL was scored by the Minnesota Questionnaire for QOL evaluation in the patients with CHF at the same time.Results:The heart function grades of all the three groups after treatment were improved compared with those before treatment,but the improvements in high-dose group and moderate dose group were better than that in the low dose group(P<0.05).LVEFs were increased significantly in all the three groups,but the improvements in the high-dose group(59.42%±7.50%) and moderate dose group(61.98%±6.82%) were better than that in the low dose group(51.45%±6.80%,P<0.01); the 6mWDs in the all groups were also significantly increased(P<0.01),up to 419.80136.23 m,387.15134.13 m, and 317.69±39.97 m,respectively;and Minnesota scores in them were lowered to 29.59±4.69 scores,35.74±5.89 scores,and 42.78±6.06 scores,respectively;comparisons in aspects on 6mWD and Minnesota score showed that the effectiveness with high dose is the most effective,moderate dose as the second,and low dose as the lowest(P<0.01).Conclusions:AG was sufficient to display an optimal effect on improving heart contraction at the moderate dose.In aspects of improving the QOL of CHF patients,the effectiveness of AG showed a dosedependent trend.It should be applied discriminatively depending on the actual condition of patients and the aim of treatment in clinic.     

Remitting seronegative symmetrical synovitis with pitting oedema associated with rifampicin

Background  

Remitting seronegative symmetrical synovitis with pitting oedema (RS3PE syndrome) is a very rare condition incorporating a tenosynovitis of the hands and wrists, as well as the feet, ankles and shoulders. The aetiology of RS3PE syndrome is unknown, although it has been linked with infectious agents (including mycobacteria), other rheumatological conditions, HLA serotypes and malignancies.     

Retrospective analysis of thrombolysis therapy for 64 cases of acute myocardial infarction with elevated ST segment

Objective:To explore the cardiac protective effect of integrative therapy in acute myocardial infarction(AMI) with elevated ST segment after reperfusion.Methods:Sixty-four AMI patients who having received decimalization by thrombolysis were assigned to two groups by retrospective analysis,36 patients in the treated group and 28 in the control group.Both were treated by intravenous administering of urokinase for thrombolysis,and to the treated group,intravenous dripping of Xueshuantong Injection(血栓通注射液,XS...     

Clinical study on the treatment of primary dysmenorrhea with preconditioning acupuncture

Objective:To observe the therapeutic effect of preconditioning acupuncture(PA) on the treatment of primary dysmenorrhea.Methods:Eighty patients suffered from primary dysmenorrhea were randomly assigned on the ratio of 1:1:2 into three groups,20 in Group A,20 in Group B,and 40 in Group C.Group A and B were treated with PA and immediate acupuncture(IA),respectively,while Group C received no acupuncture treatment and be taken as a blank control.The treatment was lasted for three menstrual cycles.The therapeutic effects were observed and compared.Results:Comparing the scores of the symptoms in the different groups, the therapeutic effect in different groups showed that the symptom scores in Group A at the second and third cycle of treatment,as well as at the first and third cycle of follow-up,were significantly lower than the scores in Group B,respectively(P<0.05 or P<0.01),and the duration of symptoms was shorter in Group A than in Group B at the third cycle of treatment and the first and third cycle of follow-up(P<0.05).Symptom scores in Groups A and B in the treatment and follow-up periods were all lowered as compared to those before treatment(P<0.01), and the scores were also lower than those in Group C measured at corresponding times(P<0.01).Conclusion: The therapeutic effect of PA,either the short-term or the long-term effect,was superior to that of IA in treating dysmenorrhea.     

Effect of once weekly pulmonary rehabilitation on exercise tolerance in patients with chronic lung disease

Background  

Pulmonary rehabilitation (PR) programmes improve exercise tolerance and reduce breathlessness in patients with chronic obstructive pulmonary disease.     

Clinical pathologic study on effect of Qianggan capsule in treating patients of chronic hepatitis B with liver cirrhosis

Objective  

To explore the clinical therapeutic effect of Qianggan Capsule (QGC) in treating chronic hepatitis B with liver fibrosis from the pathological aspect.     

Relationship of anxiety state with lymphocyte subsets and the effect of chinese medical treatment on anxiety in patients with chronic hepatitis B

Objective:To analyze the relationship of anxiety state with CD4~+ level and CD4~+/CD8~+ ratio and to observe the effect of Chinese medicine(CM) treatment on anxiety in chronic hepatitis B(CHB) patients. Methods:The anxiety state of 120 CHB patients was evaluated based on Hamilton Anxiety Scale(HAMA) scoring.According to the scores,63 patients with scores≥14 were classified to anxiety and 57 patients with scores<14 to non-anxiety.The differences in CD4~+ cells and CD4~+/CD8~+ ratio between patients with anxiety and non-anxiety were analyzed.Moreover,63 patients with anxiety were randomized into two groups:31 in the control group were treated with lamivudine(100 mg per day) alone and 32 in the observation group were given equal dosage lamivudine combined with CM treatment depending on syndrome differentiation,all for 12 weeks. The effects of treatment on anxiety state and T-lymphocyte subsets as well as its impact on some CHB-related indices were observed and compared.Results:The anxiety state of CHB patients was negatively correlated with CD4~+ and CD4~+/CD8~+;the level of CD4~+ in patients with anxiety was significantly lower than that in non-anxiety patients(P<0.01 or P<0.05).After treatment,anxiety state in the observation group was significantly improved, with their HAMA scores significantly lowered(P<0.01),and the levels of CD4~+ and CD4~+/CD8~+ were significantly higher than those in the control group(P<0.05 or P<0.01).Moreover,the alanine transaminase recovery rate and the HBV-DNA-negative conversion rate in the observation group were significantly higher than those in the control group,respectively(P<0.05).Conclusions:The anxiety state of CHB patients was related to CD4~+ and CD4~+/CD8~+ levels.CM treatment could improve the anxiety state and showed certain regulatory effect on the patients’ immune system.     

The incidence of postoperative venous thrombosis among patients with ulcerative colitis

Background  

Patients with Ulcerative Colitis (UC) have inherent prothrombotic tendencies. It is unknown whether this necessitates the use of additional perioperative anti-thrombotic prophylaxis when such patients require major surgery.     

Clinical study on treatment of infantile cytomegalovirus hepatitis with integrated Chinese and Western medicine

<正>Objective:To evaluate the efficacy and safety of Chinese medicine(CM) in treating infantile cytomegalovirus hepatitis(ICH).Methods:A total of 100 infant ICH patients were randomly assigned to two groups,60 in the treatment group and 40 in the control group.Ganciclovir was administered to all patients via intravenous dripping at dose of 5 mg/kg every 12 h for 2 weeks,followed by 5 mg/kg once a day for 5 days every week;the whole treatment course lasted 8 weeks.Besides,the patients in the treatment group were treated with CM of Qinggan Lidan Decoction(清肝利胆汤,QLD) during icteric stage,and Yigan Jiangmei Decoction(益肝降酶汤,YJD) in non-icteric hyper-aminotransferase stage by oral medication,while for those in the control group,glucurolactone 50 mg was given three times per day.The efficacy of treatment was evaluated at the ends of 2nd,4th and 8th weeks,respectively.And a follow-up study was carried out for 6-24 months.Results: The total effective rate was 95.0%(57/60) in the treatment group and 77.5%(31/40) in the control group;the overall curative effect in the former was superior to that in the later,showing a significant difference(P=0.021). Cholestasis and liver function were Improved in both groups,and the effect of reducing serum bilirubin level in the treatment group was more rapid and extensive than that in the control group,which could reduce the post-hepatitis cirrhotic risk caused by long-term cholestasis and liver cell damage.Conclusion:The therapeutic efficacy of integrated CM and Western medical drug therapy,by using QLD during icteric stage and YJD in nonicteric hyper-aminotransferase stage,was significantly higher than that of routine Western medical treatment alone;it was an ideal project for the treatment of infantile cytomegalovirus hepatitis.     

Effects of Repeated Electroacupuncture on β-Endorphin and Adrencorticotropic Hormone Levels in the Hypothalamus and Pituitary in Rats with Chronic Pain and Ovariectomy

<正>Objective:To explore the mechanism of electroacupuncture(EA)-induced cumulative analgesic effects on chronic pain in rats with or without ovariectomy(OVX).Methods:A total of 110 female Wistar rats were randomized into normal control(n=10),chronic constrictive injury(CCI,n=10),CCI+EA(n=30),OVX+CCI (n=30),and OVX+CCI+EA(n=30)groups.Each of the latter 3 groups was further divided into 2 days(2d),2 weeks(2 W)and 3 weeks(3 W)subgroups,respectively(n=10 in each subgroup).The CCI pain model was established by ligature of the right sciatic nerve,and the memory impairment model duplicated by OVX.The paw withdrawal latency(PWL,pain threshold)of the bilateral footplates was detected by radiant heat irradiation,and the bilateral difference in PWL(PWLD)was used to evaluate changes in the pain reaction.Morris water maze test was conducted for evaluating the rats' learning-memory ability.EA was applied to bilateral Zusanli(ST36) and Yanglingquan(GB34)for 2 d,2 W and 3 W,respectively.Pituitary and hypothalamic p-endorphin(EP)and adrenocorticotrophic hormone(ACTH)contents were detected by immunoradioassay.Results:Compared with the CCI group,PWLD of the CCI+EA-3 W group decreased significantly(P0.05).Compared with the OVX+CCI group,PWLD of the OVX+CCI+EA-3 W group was lowered considerably(P0.05),but the value was markedly higher than its basal value and those of the normal control and CCI+EA groups(P0.05).In comparison with the sham-OVX group,the escape latency,swimming distance(SD)in the target quadrant and total SD were increased remarkably in the OVX group(P0.05),while the number of target platform crossings was decreased significantly(P0.05),suggesting an impairment of the OVX rats' learning-memory ability.In simple CCI rats, bothβ-EP and ACTH contents of the pituitary increased markedly(P0.05),and those of the hypothalamus decreased obviously compared to the normal control group(P0.05).After EA,pituitary and hypothalamic ACTH levels were significantly lowered at 2 d and hypothalamic ACTH andβ-EP contents increased obviously at 3 W in comparison with the CCI group(P0.05).In OVX+CCI rats,following EA,pituitaryβ-EP contents at 2 d,2 W and 3 W,and hypothalamicβ-EP and ACTH contents at 2 W and hypothalamic ACTH levels at 3 W increased significantly(P0.05),but hypothalamicβ-EP level at 3W decreased markedly(P0.05).The effects of repeated EA in lowering pituitary ACTH and raising hypothalamicβ-EP and ACTH levels disappeared after OVX+CCI. Conclusions:Repeated EA has a cumulative analgesic effect,which is closely associated with its effects in regulating pituitary and hypothalamicβ-EP and ACTH levels.OVX may weaken the analgesic effect of EA by affecting hypothalamic-pituitary axis activity.     

Gianotti-Crosti syndrome associated with HBV infection in an adult

Background  

Gianotti-Crosti Syndrome (GCS) is a characteristic cutaneous eruption following a viral infection. Incidence peaks in early childhood and the syndrome rarely occurs in adulthood. Hepatitis associated with GCS is usually anicteric and acute form.