缬沙坦联合贝那普利治疗慢性心力衰竭的疗效观察

Objective To observe the effect of valsartan combined with benazepril in treatment of patients with chronic heart failure. Methods 60 patients with heart failure of New York Heart Association (NYHA) class Ⅱ -Ⅳ and LVEF less than or equal 40% were selected and randomly divided into two groups. The patients in control group were given benazepril(10mg/d) alone,and the patients in treatment group were given valsartan(80mg/d) combined with benazepril(10mg/d). After 8 months therapy, the changes of the parameters of left ventriclular function and ventriclular dimension of the patients with chronic heart failure were compared before and after treatment. And the clinical efficacy was compared between two groups. Results The ventriclular dimension of the patients with chronic heart failure was decreased,and left ventriclular function was improved. The patients of the combination therapy group were improved especially after treatment. Conclusion Angiotensin-converting-enzyme(ACE) inhibitor could improve heart function of patients with chronic heart failure. Therapy of valsartan combined with benazepril was more effective.     

冠心病患者介入治疗前后焦虑抑郁障碍的心理干预与评价

Objective To discuss the effect of psychological intervention of depression in coronary heart disease after percutaneous coronary intervention (PCI). Methods The depression of 105 cases of coronary heart disease after PCI treatment was investigated. One hundred and five patients were randomly divided into intervention group and control group. The patientsin intervention group were treated with psychological intervention before and after PCI. The patients in control group were treated with normal treatment. Results There was not significant difference of incidence of depression an self-rating depression scale score between two groups. The depression in intervention group was less severe than that in control group ( P ＜ 0.01 ). Multivariate analysis showed: education level, the recent negative life events, household income, length of stay and sequelae of catheter intervention had significantly correlated with depression in coronary heart disease. Conclusion Psychological intervention can reduce the ratio of depression in coronary heart disease after PCI.     

前列腺素E1联合血浆置换治疗慢性重型肝炎的临床研究

Objective To investigate the curative effect, timing and feasibility of prostaglandin E1 combined plasma exchange in treatment of chronic severe hepatitis. Methods Eighty-eight patients with chronic severe hepatitis were randomly divided into treatment group and control group. The treatment group was given prostaglandin E1 combined plasma exchange treatment based on the comprehensive treatment of internal medicine. Control group only had given the internal medicine comprehensive treatment. Results The symptoms and signs of the treatment group were improved after treatments, especially with total bilirubin, cholinesterase, prothrombin activity, NH3 ( P ＜ 0.01,P ＜ 0.05 ). After treatment, except for albumin, the others indicators of the two groups had significant difference ( P ＜ 0.05). Follow-up for three months, the total effective rate of the treatment group was 69.6% ( 32cases ), early effective rate was 79.3% (23 cases), mid-term effective rate was 64.3% (9 cases) were all significantly higher than those of control group [47.6% (20 cases), 55.6% ( 15 cases), 38.5% (5 cases)] (P ＜ 0. 01 ).Conclusion Prostaglandin E1 combined with plasma exchange in treatment of chronic severe hepatitis can improve the liver function and survival rate significantly.     

前列腺素E1联合血浆置换治疗慢性重型肝炎的临床研究

Objective To investigate the curative effect, timing and feasibility of prostaglandin E1 combined plasma exchange in treatment of chronic severe hepatitis. Methods Eighty-eight patients with chronic severe hepatitis were randomly divided into treatment group and control group. The treatment group was given prostaglandin E1 combined plasma exchange treatment based on the comprehensive treatment of internal medicine. Control group only had given the internal medicine comprehensive treatment. Results The symptoms and signs of the treatment group were improved after treatments, especially with total bilirubin, cholinesterase, prothrombin activity, NH3 ( P ＜ 0.01,P ＜ 0.05 ). After treatment, except for albumin, the others indicators of the two groups had significant difference ( P ＜ 0.05). Follow-up for three months, the total effective rate of the treatment group was 69.6% ( 32cases ), early effective rate was 79.3% (23 cases), mid-term effective rate was 64.3% (9 cases) were all significantly higher than those of control group [47.6% (20 cases), 55.6% ( 15 cases), 38.5% (5 cases)] (P ＜ 0. 01 ).Conclusion Prostaglandin E1 combined with plasma exchange in treatment of chronic severe hepatitis can improve the liver function and survival rate significantly.     

冠心病患者介入治疗前后焦虑抑郁障碍的心理干预与评价

Objective To discuss the effect of psychological intervention of depression in coronary heart disease after percutaneous coronary intervention (PCI). Methods The depression of 105 cases of coronary heart disease after PCI treatment was investigated. One hundred and five patients were randomly divided into intervention group and control group. The patientsin intervention group were treated with psychological intervention before and after PCI. The patients in control group were treated with normal treatment. Results There was not significant difference of incidence of depression an self-rating depression scale score between two groups. The depression in intervention group was less severe than that in control group ( P ＜ 0.01 ). Multivariate analysis showed: education level, the recent negative life events, household income, length of stay and sequelae of catheter intervention had significantly correlated with depression in coronary heart disease. Conclusion Psychological intervention can reduce the ratio of depression in coronary heart disease after PCI.     

青鹏膏剂治疗肩关节周围炎临床疗效研究

Objective To investigate the clinical efficacy of Qingpeng ointment treating periarthritis.Methods Three hundred patients with periarthritis were randomly divided into two groups. Observed groups( 150 cases ) were given Qingpeng ointment, control group( 150 cases ) were given Guzhining liniment. Shoulder pain scores and shoulder joint function score of both group were compared. Results The total efficiency of observation group ( 85.3% ) was better than that of control group(72.7% ) ( P ＜ 0.05 ). After treatment, both groups activity in patients with shoulder pain score and functional activity score of comparison, the observation group were better than the control group ( P ＜ 0.01 ). Conclusion Clinical treatment of frozen shoulder by Qingpeng paste is better, is worthy of clinical.     

青鹏膏剂治疗肩关节周围炎临床疗效研究

Objective To investigate the clinical efficacy of Qingpeng ointment treating periarthritis.Methods Three hundred patients with periarthritis were randomly divided into two groups. Observed groups( 150 cases ) were given Qingpeng ointment, control group( 150 cases ) were given Guzhining liniment. Shoulder pain scores and shoulder joint function score of both group were compared. Results The total efficiency of observation group ( 85.3% ) was better than that of control group(72.7% ) ( P ＜ 0.05 ). After treatment, both groups activity in patients with shoulder pain score and functional activity score of comparison, the observation group were better than the control group ( P ＜ 0.01 ). Conclusion Clinical treatment of frozen shoulder by Qingpeng paste is better, is worthy of clinical.     

无创正压通气在老年慢性阻塞性肺疾病急性加重期患者中的应用效果分析

Objective To study the clinical effect of non-invasive positive pressure ventilation (NPPV) in elderly patients with acute exacerbation of chronic obstructive pulmonary diseases (AECOPD). Methods One hundred and Fourteen elderly patients with AECOPD were divided into two groups. The observed group of 58 patients was given oxygen, anti-inflammatory and other conventional treatment, at the same time NPPV treatment was given, But the control group of 56 cases was only given the conventional treatment. The difference of blood oxygen pressure ( PaO2 ), carbon dioxide partial pressure ( PaCO2 ), pH value, respiratory rate (RR) and heart rate (HR)between two groups were compared after 12 h. To compare two groups endotracheal intubation rate and mortality differences. Results The pH and PaO2 of the observation group were significantly higher than that before treatment , HR, RR and PaCO2 decreased significantly compared with before treatment, and the various indicators were better than the same period in the control group. The observation group endotracheal intubation rate and mortality were less than the control group ( all P ＜ 0. 05). Conclusions NPPV can effectively alleviate breathing difficulties of the elderly patients with AECOPD and correct hypoxia. NPPV can reduce the rate of endotracheal intubation and mortality.     

无创正压通气在老年慢性阻塞性肺疾病急性加重期患者中的应用效果分析

Objective To study the clinical effect of non-invasive positive pressure ventilation (NPPV) in elderly patients with acute exacerbation of chronic obstructive pulmonary diseases (AECOPD). Methods One hundred and Fourteen elderly patients with AECOPD were divided into two groups. The observed group of 58 patients was given oxygen, anti-inflammatory and other conventional treatment, at the same time NPPV treatment was given, But the control group of 56 cases was only given the conventional treatment. The difference of blood oxygen pressure ( PaO2 ), carbon dioxide partial pressure ( PaCO2 ), pH value, respiratory rate (RR) and heart rate (HR)between two groups were compared after 12 h. To compare two groups endotracheal intubation rate and mortality differences. Results The pH and PaO2 of the observation group were significantly higher than that before treatment , HR, RR and PaCO2 decreased significantly compared with before treatment, and the various indicators were better than the same period in the control group. The observation group endotracheal intubation rate and mortality were less than the control group ( all P ＜ 0. 05). Conclusions NPPV can effectively alleviate breathing difficulties of the elderly patients with AECOPD and correct hypoxia. NPPV can reduce the rate of endotracheal intubation and mortality.     

血液透析串联血液灌流对维持性血液透析患者微炎症及血管内皮功能的影响

Objective To investigate the effect of hemodialysis with hemo-perfusion on microinflammatory and vascular endothelial function of chronic hemodialysis patients. Methods Twenty hemodialysis patients were divided into two groups, 10 patients received hemodialysis therapy for four times (as control group), and 15 patients received hemodialysis with hemoperfusion(HD+HP) therapy for four times. The level of TNF-α and sVCAM-1 were detected before therapy and after therapy for four times. Results The level of TNF-α and sVCAM-1 in chronic hemodialysis patients were higher than that of control group; The level of TNF-α were positive correlated with the level of sVCAM-1 (r=0.674, P<0.05) before therapy; The level of TNF-α and sVCAM-1 in hemo-perfusion group patients decreased after therapy for 4 times. There was statistically difference between before and after therapy (P<0. 05); while in control group, both of them showed no statistically different (P>0.05). Conclusions Microinflammatory possibly lead to vascular endothelial function damage in chronic hemodialysis patients.Hemodialysis with hemo-perfusion could effectively reduce microinflammation and alleviate vascular endothelial function damage in chronic hemodialysis patients.