Glomerular disease

2007469 CD71 expression in renal tissue of IgA ne-phropathy.ZHANG Aiping (张爱平), et al. DeptNephrol, General Hosp, Jinan Command, PLA, Jinan250031. Chin J Nephrol 2007;23(10):631 -634. Objective To study the molecular pathologic fea-tures of CD71 and correlation between IgA deposits andCD71 expression in IgA nephropathy (IgAN),and to in-vestigate the role of CD71 in pathogenesis of IgAN.Methods According to clinical manifestations andpathological diagnosis, renal tissue sampl…     

Cerebrovascular disease

2005269 Electroencephalography grading standard research in severe cerebral dysfunction. WANG Xiao-mei(王晓梅)?, et al. Neuro ICU, Xuanwu Hosp, Cap Univ, Med Sci Beijimg 100053. Chin J Neurol 2005;38(2):104-107. Objective: To compare the predicting accuracy of different electroencephalography (EEG)grading standards in two different types of cerebral dysfunction.     

Glomerular disease

2005236 Pathological characteristics and outcome of IgA nephropathy presented with isolated hematuria. YANG Nian-sheng(杨念生),et al. Dept of Nephrol, 1st Affili Hosp, Sun Yat-sen Univ, Guangzhou 510080. Chin J Nephrol, 2005;21(1) :22-25. Objective: To study the pathological characteris-     

Muscular disease

2007498 Clinical, pathological and molecular bio-logical study on a family of autosomal dominant in-herited centronuclear myopathy.ZHANG Yongqing(张永庆), et al. Dept Neurol, Japan-China FriendshipHosp, Beijing 100029. Chin J Neurol 2007;40(10):663 -666. Objective To investigate the clinical, pathologicaland genetic features of the patients froma pedigree of au-tosomal dominant inherited centronuclear myopathy(CNM).Methods Clinical examinations were per-formed in patients and unaffecte…     

Autoimmune disease

2005164 Optimal cut-point of glutamic acid decar-boxylase antibody (GAD-Ab) for differentiating two subtypes of latent autoimmune diabetes in adults (LADA). LI Xia(李霞), et al. Dept Endocrinol, 2nd Xiangya Hosp, Central South Univ, Changsha, 410011. Chin J Diabetes, 2005;13(1) :34-38. Objective: To investigate the optimal cut-point of glutamate decarboxylase antibody (GAD-Ab) for differentiating two subtypes of latent autoimmune diabetes in adults (I. ADA). Methods: The frequency     

Cerebrovascular disease

2007493 Cerebral vascular accidents after cardiaccatheterization in patients with anamnesis of stroke.ZHANG Hua(张华), et al. Dept Neurol, Anzhen HospCapital Med Univ, Beijing 100029. Natl Med J China2007;87(37):2613 -2617. Objective To investigate the risk factors of relapse ofcerebral vascular accident (CVA) after cardiac catheter-ization (CC) in patients with anamnesis stroke.Meth-ods The clinical data of 892 patients with anamnesisstroke who received cardiac catheterization (CC) …     

Extrapyramidal disease

2005274 1H-MRS, immunohistochemistry and electronic microscopy study on frontal cortex in rat mod- el of Parkinson's disease. HOU Sch Med, Zhong-yu (侯中煜) ,et al. Center Sect & Imag Anat, Shandong Univ Jinan 250012. Chin J Radiol, 2005; 39 (2) 131-135. Objective:To investigate the pathological changes of the frontal cortex in Parkinson's disease (PD). Methods: Twenty rats were divided into 14 model     

Fungal disease

2005162 Analysis on partial sequence of ERG11 promoter region of Candida albicans. QIAO Jian-jun (乔建军) ,et al. Dept Dermatol 1st Affili Hosp,Jinan Univ,Guangzhou 510632. Chin J Dermatol. 2005;38 (3):160-162. Objective: To compare the difference of ERG11 partial promoter sequence ( - 440 - - 1) between yeast-form and hypha-form of Candida albicans,and the relation between the mutation of ERGll promot-     

Homocysteine – from disease biomarker to disease prevention

We have reviewed the literature and have identified more than 100 diseases or conditions that are associated with raised concentrations of plasma total homocysteine. The commonest associations are with cardiovascular diseases and diseases of the central nervous system, but a large number of developmental and age-related conditions are also associated. Few other disease biomarkers have so many associations. The clinical importance of these associations becomes especially relevant if lowering plasma total homocysteine by B vitamin treatment can prevent disease and so improve health. Five diseases can at least in part be prevented by lowering total homocysteine: neural tube defects, impaired childhood cognition, macular degeneration, primary stroke, and cognitive impairment in the elderly. We conclude from our review that total homocysteine values in adults of 10 μmol/L or below are probably safe, but that values of 11 μmol/L or above may justify intervention. Homocysteine is more than a disease biomarker: it is a guide for the prevention of disease.     

Behçet's disease associated with Crohn's disease

INTRODUCTION: The association of Beh?et's disease and of Crohn's disease is exceptional, and raises a nosological problem. CASE REPORT: A 24 year-old female developed since 1996 chronic diarrhea, abdominal pain, recurrent oral and genital ulcer and polyarthralgia. Endoscopic colonoscopy examination showed a diffuse colitis. Histological examination revealed epitheloid granuloma without vasculitis compatible with a Crohn's disease. The patient was treated with oral prednisone (1mg/kg/day). In November 1998, she was admitted for diarrhea. Many pseudofolliculitis lesions, uveitis and positive pathergy test were noted. The HLA was B 51. The diagnosis of Crohn's disease associated with Beh?et's disease was made. She was treated with high doses of prednisone (1mg/kg/day and 6 monthly intravenous pulses of cyclophosphamide). Skin lesions and diarrhea improved within few days, and cleared completely within five months. Presently, the patient remains clinically free of disease. CONCLUSION: While being of different pathogenic origin, Beh?et's disease and Crohn's disease may coexist within one and the same patient and cause diagnostic and therapeutic problems.     

Infectious heart disease

2007439 Association between myocardial AD-AMTS-1 expression and myocardial fibrosis in a mu-rine model of viral myocarditis.SHEN E(申锷), etal. Key Lab, Viral Heart Dis, Minist Public Health,Shanghai Cardiovasc Dis Instit, Zhongshan Hosp, FudanUniv, Shanghai 200032. Chin J Cardiol 2007;35(9):854 -858. Objective To investigate the association betweenmyocardial ADAMTS-1 expression and myocardial fibro-sis in coxsackie virus B3( CVB3)-induced acute andchronic murine mycarditis mod…     

Coronary heart disease

2005191 Characteristics of treadmill electrocar-diography and dipyridamole 201T1 myocardial perfu-sion imaging in patients with coronary artery spasm. XIANG Ding-cheng (向定成), et al. Dept Cardiol, Guangzhou Command General Hosp, PLA, Guangzhou 510010. Chin J Nucl Med, 2005; 25(1): 10-13. Objective: To investigate the characteristics of treadmill electrocardiography and dipyridamole 201T1 myocardial perfusion imaging in patients with coronary artery spasm, and to explore a non-invasive pro-