“双灌注”治疗转移性肝癌的疗效观察

经皮经导管肝动脉栓塞化疗术（TACE）是目前转移性肝癌的首选疗法之一。因门静脉供血、侧枝循环建立、肝动静脉瘘、门脉癌栓以及肝功能损害等不易控制因素影响,疗效不甚理想。国内外文献对此虽有许多报道,但疗效各不相同。为此我们采用肝动脉化疗栓塞＋间接门静脉化疗的方法治疗转移性肝癌,疗效较好,现报告如下。     

肝癌肝动脉—门静瘘并食管静脉曲张破裂大出血的TAE治疗

肝癌肝动脉－门静瘘并食管静脉曲张破裂大出血的ＴＡＥ治疗广西玉林市第一人民医院罗凤才黎显瑞陈文福原发性肝癌具有侵蚀周围血管的特性，常常侵及门静脉或肝静脉系统，形成动静脉瘘，尤以肝动脉－门静脉瘘多见。肝动脉－门静脉瘘一旦形成，将导致严重的门脉高压症，或使...     

原发性肝癌介入治疗的疗效分析

目的 总结原发性肝癌介入治疗的疗效.方法 对245例行肝动脉化疗、栓塞治疗的原发性肝癌患者进行了随访和回顾性分析,对其疗效及影响其疗效的相关因素进行了分析.结果 肝动脉化疗、栓塞治疗原发性肝癌疗效明显;肿瘤临床分期、肝功能Child-pugh分级,门脉癌栓、动静脉瘘、动门静脉瘘直接影响治疗的效果.结论 肝动脉化疗、栓塞是治疗原发性肝癌的有效治疗方法,对不同病期的肝癌采用不同的治疗方案,配合其他疗法能使疗效得以明显提高.     

原发性肝癌患者TACE治疗后预后和生存分析

回顾性分析接受经导管肝动脉化疗栓塞术( TACE)治疗的原发性肝癌( PHC)患者病史资料,对相关变量进行单因素和多因素回归分析,从而得出TACE治疗后肝癌患者预后和生存影响因素. 单因素分析中乙肝肝硬化背景、肿瘤分期、分型、肝功能分级、甲胎蛋白值、门静脉有无癌栓、有无动-静/门脉瘘、年龄对PHC行介入治疗患者生存时间有一定影响,Cox多因素回归分析显示肿瘤分期、门脉有无癌栓、年龄及乙肝肝硬化背景对患者生存期影响显著.     

原发性肝癌动静脉瘘的血管造影表现及介入治疗

分析原发性肝癌动静脉瘘的血管造影表现，介入及与临床预后的关系。方法对３７例原发性肝癌并动静脉瘘的血管造影表现进行了分析，并经导管动脉内药物灌注经导管动脉内栓塞术及防护。     

原发性肝癌并门脉癌栓的介入治疗体会

近年来我们两院对原发性肝癌并门脉癌栓患者 5 4例行介入治疗 ,现将治疗结果及体会报告如下。1 资料与方法5 4例原发性肝癌并门脉癌栓患者 ,男 43例 ,女 11例 ,年龄 2 8～ 6 1岁 ,平均 5 1岁。全部病例均作肝动脉造影 ,ＡＦＰ测定及ＣＴ或超声检查 ,证实为原发性肝癌。其中巨块型 2 4例、结节型 2 8例、弥漫型 2例 ,病灶最大约 15ｃｍ×2 5ｃｍ ,最小约 3ｃｍ× 3ｃｍ ,门脉主干癌栓 18例 ,以左支或右支为主 36例。所有病例均采用Ｓｅｌｄｉｎｇｅｒ经股动脉穿刺插管法作肝动脉造影 ,将导管超选择进入肝叶动脉或肝固有动脉 ,根据肝功能情况…     

肝血管影像与肝癌的介入治疗

分析了１７３例肝血管影像与肝癌的介入治疗资料，结果显示：（１）肝动脉起源及其分支走行形态与超选择性插管的成功密切相关；（２）肝动脉解剖变异２３例（１３．３％）主要为肠系膜上动脉供务型，其交伪胃左动脉供血型；（３）肝癌的动脉血供主要为规则性供血（１３６／１５７）变异性供血２１例（１３．４％）。（４）肝癌合并肝动静脉瘘２０例（１１．６％）（５）动脉性门脉造影可了解门脉内有无癌栓及门脉血流方向，可为选择     

“夹心蛋糕式”栓塞化疗治疗中晚期肝癌20例

本院自 1 997～ 1 998年用导管栓塞化疗治疗中、晚期肝癌 2 0例 ,取得较好的疗效 ,现报告如下。1　资料与方法1 .1　临床资料　 2 0例中、晚期肝癌病人 ,均为男性 ,年龄 45～ 60岁 ,平均 55.5岁。所有病人均符合WHO所制定肝癌诊断标准 ,其中结节型肝癌 1 5例 ,弥漫型肝癌 5例。1 .2　治疗方法　 2 0例病人均用股动脉穿刺法。将Yashir或 Simmons导管置于肠系膜上动脉 ,作间接门脉造影 ,观察是否有门静脉瘤栓形成。然后再做腹腔干动脉造影 ,观察癌肿供血动脉分支后 ,在 0 .0 35英寸超滑导丝引导下 ,将导管的头端尽量靠近癌肿边缘进行化疗加…     

原发性肝癌介入治疗对数字减影血管造影的影响及其意义

①目的探讨原发性肝癌首次治疗前后教字减影血管造影的（DSA）影像表现及其治疗意叉。②方法动态观察对比分析58例原发性肝癌首次介入治疗前后肿瘤双血供（肿瘤供血动脉、门静脉）血管形态学和血流动力学变化。③结果30例肿瘤血管丰富，无明显动、静脉瘘，栓塞后，肿瘤供血血管变细或闭塞，血流变慢，瘤血管减少或消失，实质期肿瘤染色变淡或不显示，肿瘤缩小明显；10例出现肝动脉-静脉或门脉瘘，9例用明胶海绵或钢固栓塞瘿口后动、静脉分流减轻，动脉造影肿瘤染色较好，栓塞后碘油沉积良好；3例有肝外侧支；6例有门脉癌栓。④结论分析原发性肝癌首次介入治疗的DSA表现，对制定介入治疗方案和疗效评价有重要意义。     

原发性肝癌肝动静脉瘘34例介入性诊断与治疗

原发性肝癌伴肝动脉 -门静脉瘘或肝动脉 -肝静脉瘘有其特殊性 ,今介绍 34例介入诊断与治疗。1　方法　 34例原发性肝癌伴有肝动静脉瘘 ,采用Seldinger技术将导管选择性插入肝固有动脉 ,造影与摄片 ,包括动、静脉期及实质期片。血管造影证实原发性肝癌后 ,如无栓塞禁忌证 ,行病变供血动脉化疗栓塞。常用化疗药有 :5 FU 10 0 0～ 15 0 0 mg,MMC 10 mg,EADM/ADM 6 0 m g 或CDDP6 0～ 80 mg,水化碘油 10～ 2 0 m l与化疗药液制成乳化剂。有肝动脉 -门静脉主干或分支瘘者先以明胶海绵颗粒或钢圈将瘘口栓塞 ,然后灌注化疗药液及碘油乳化剂 …     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.