功能性便秘患者的精神心理状况及生活质量评估

目的 通过比较和分析功能性便秘(FC)患者与健康对照者的精神心理和生活质量状况,揭示FC患者的生活质量状况及其临床意义.方法 应用普适量表(SCL-90)和疾病特殊量表(PAC-QOL)对60例FC患者和性别、年龄相匹配的30例健康对照者进行问卷调查,并详细记录每天排便情况.对两者之间的一般资料、精神心理评分、生活质量评分进行比较,同时对FC患者的精神心理评分、便秘症状程度与生活质量评分进行相关性分析.结果 (1)FC患者与健康对照者在年龄、BMI、性别比例之问差异无统计学意义;而两组在大便性状评分、日均排便次数之间差异有统计学意义.(2)FC患者SCL-90评分的总分、总症状指数、阳性项日数、阳性症状痛苦水平、9个因子分除恐怖外的躯体化、强迫、焦虑、抑郁和精神病性等因子分显著高于健康对照组(P＜0.05).(3)FC患者PAC-QOL的4个部分得分及总平均分分别为:躯体不适(3.06±0.75)、心理社会不适(2.34±0.79)、担心焦虑(2.99±0.81)、满意度(3.22±0.40)、总平均分(2.85±0.50),均较基线水平明显升高.(4)SCL-90中的总分、总症状指数、阳性项目数、阳性症状痛苦水平、9个因子分中的躯体化、强迫、抑郁、焦虑、敌对等与PAC-QOL评分有显著相关性,尤其表现在焦虑和抑郁两方面.(5)FC患者腹胀、排便费力等症状程度与PAC-QOL总平均分及SCL-90评分有显著相关性.结论 FC患者存在明显的精神心理异常,便秘严重降低了患者的生活质量.生活质量评分的高低比实验室指标和便秘的严重程度更能反映患者的健康状况.     

生物反馈训练对功能性便秘患者临床症状、心理状况和生活质量的影响

目的 探讨生物反馈训练对功能性便秘(FC)患者临床症状、心理状况和生活质量的影响.方法 对49例符合FC罗马Ⅲ标准的患者进行生物反馈训练,应用临床症状积分量表、Zung焦虑自评量表(SAS)、抑郁自评量表(SDS)、汉化版简明健康调查量表(SF-36)评定患者治疗前后的临床症状、心理状况和生活质量的综合改善情况.结果 生物反馈训练后,FC患者临床症状显著改善,临床症状积分量表中排便间隔天数、费力程度、排便不尽和坠胀感、粪便性状、腹胀评分及总积分均有显著降低(临床症状改善).SF-36量表的8个维度(总体健康、生理功能、生理职能、躯体疼痛、活力、社会功能、情感职能和精神健康)的评分均显著提高(生活质量改善).患者治疗后与治疗前相比,SAS量表评分(41.0±8.1比46.5±11.9)和SDS量表评分(44.0±8.2比51.2±11.5)亦显著降低(焦虑、抑郁状况改善).结论 生物反馈训练不仅能有效改善FC患者的临床症状,还可提高患者的生活质量和心理健康水平.     

睡眠障碍对老年慢性功能性便秘患者焦虑抑郁情绪和生活质量的影响分析

背景随着饮食结构的改变和生活方式的快速变化,慢性便秘发病率呈逐渐上升趋势.睡眠障碍可增加胃肠道症状,也是焦虑、抑郁形成的一个危险因素.本研究旨在探讨睡眠障碍对老年慢性功能性便秘患者焦虑抑郁情绪和生活质量的影响进行分析,以期为治疗老年慢性功能性便秘患者的新思路提供客观依据.目的旨在探讨睡眠障碍对老年慢性功能性便秘患者焦虑抑郁情绪和生活质量的影响分析.方法选择2017-03/2019-09在我院就诊的126例老年慢性功能性便秘患者为研究对象,根据是否有睡眠障碍分为睡眠障碍组和睡眠正常组.对所有患者进行便秘评分系统(constipatipation scoring system, CSS)、便秘患者症状自评问卷(patient assessment of constipation symptom,PAS-SYM)、睡眠质量评估、焦虑自评量表(self-rating anxiety scale, SAS)、抑郁自评量表(selfrating depression scale, SDS)及生活质量量表评分.结果睡眠障碍组CSS评分为19.63分±3.36分, PAS-SYM评分为1.59分±0.52分,SAS评分为58.92分±6.72分, SDS评分为57.74分±6.38分,均高于睡眠正常组(P 0.05).睡眠障碍组患者社会功能评分为71.56分±3.38分、情绪评分为75.89分±2.95分、躯体角色评分为76.86分±2.92分、躯体健康评分为80.25分±3.35分、心理卫生评分为78.36分±3.65分、总健康评分为76.19分±2.56分,均低于睡眠正常组,差异有统计学意义(P0.05). CSS、PAC-SYM各维度评分以及总分均与SAS、SDS评分呈正相关(P0.05);生活质量量表中6个维度的得分与SAS、SDS评分均呈负相关(P0.05).结论睡眠障碍和焦虑、抑郁可能是影响老年慢性功能性便秘患者临床症状的重要因素,并影响患者生活质量.     

积极心理学视角下老年功能性便秘患者生活质量现状及影响因素分析

目的 探讨老年功能性便秘患者的生活质量现状,并探讨影响其生活质量的因素。方法 选取2022年7月—2023年6月在延安大学附属医院就诊的280例老年功能性便秘患者为研究对象,采用一般资料调查表、积极心理资本量表(PPQ)、便秘患者生活质量量表(PAC-QOL)对其进行横断面调查,采取单因素分析、相关性分析及多元线性回归,分析影响老年功能性便秘患者生活质量的相关因素。结果 老年功能性便秘患者PAC-QOL量表得分为(60.38±16.74)分。多元线性回归分析结果显示,性别、年龄、文化程度、症状持续时间、饮食量、心理资本水平是影响老年功能性便秘患者生活质量的独立影响因素(调整R²=0.844,P<0.001)。结论 老年功能性便秘患者生活质量水平较低,且除一般资料中性别、年龄、文化程度、症状持续时间、饮食量等因素影响外,心理资本水平也是其生活质量高低的重要预测因子。     

不同干预方案对老年缺血性脑卒中患者便秘的疗效

目的:研究不同干预方案对老年缺血性脑卒中(IS)患者便秘的疗效。方法:我院的150例老年IS合并便秘患者被随机均分为膳食纤维联合双歧杆菌组(A组)、球囊扩张训练联合盆底肌训练组(B组)与低频电穴位刺激组(C组),三组均在常规干预基础上接受对应治疗21d。比较三组干预前后便秘症状及疗效评估量表、焦虑自评量表(SAS)、抑郁自评量表(SDS)、便秘患者生活质量量表(PAC-QOL)评分及治疗总有效率。结果:干预后,与A组、B组比较,C组便秘症状及疗效评估量表中排便各项评分及总分[总分(9.92±2.83)分比(9.74±2.68)分比(8.94±1.99)分],SAS[(39.11±5.43)分比(41.72±6.42)分比(35.34±5.13)分]、SDS评分[(39.84±4.67)分比(41.95±5.03)分比(36.93±4.26)分],PAC-QOL生理、社会心理、担忧度、满意度维度评分均显著降低(P<0.05或<0.01)。与B组比较,干预后,A组SAS、SDS评分均显著降低(P均<0.05)。C组治疗总有效率显著高于A组、B组(92.00%比70.00%比72.00%,P均<0.01)。结论:低频电穴位刺激治疗可显著改善老年缺血性脑卒中患者便秘症状,提高生活质量,疗效显著。     

排便障碍的功能性便秘患者精神心理因素的研究

[目的]分析排便障碍的功能性便秘(FC)患者的精神心理因素特点。[方法]纳入符合罗马Ⅳ标准、有排便障碍的FC患者146例,以及25例健康对照者。所有入选者接受采用Zung的焦虑自评量表(self-rating anxiety scale,SAS)和抑郁自评量表(self-rating depressive scale,SDS)测试,评估其精神心理状况。分析排便障碍的FC患者精神心理因素的特点。[结果]FC组的SAS、SDS评分均明显高于健康对照组(P0.05),女性患者的SAS评分及SDS评分均高于男性患者(P0.05)。60岁与≥60岁患者的SAS、SDS比较差异无统计学意义(P0.05)。I、Ⅱ、Ⅳ型排便障碍的女性患者SAS评分高于男性(P0.05),Ⅱ、Ⅲ型排便障碍的女性患者SDS评分高于男性(P0.05)。[结论]排便障碍的FC患者具有较高的焦虑抑郁倾向,女性患者比男性患者更容易产生焦虑、抑郁情绪。     

功能性便秘动力学改变与情志因素的相关性

目的:分析功能性便秘(functional constipation,FC)肛肠动力学与患者生活质量及情志因素相关性.方法:患者进行肛肠动力学指标观察分析,采用生命质量调查问卷、精神心理状态评定量表问卷调查,进行动力学指标和情志因素相关性分析.结果:患者组生活质量所有8个维度的评分均低于健康对照组,存在明显的焦虑、抑郁情绪.焦虑、抑郁积分与生活质量负相关;肛肠动力学和精神心理因素相关(P<0.05),肛管缩榨压及其持续时间与抑郁自评量表(selfrating depression scale,SDS)、焦虑自评量表(selfrating anxiety scale,SAS)呈负相关;初始感觉阈值、排便感觉阈值和最大耐受容量与SAS、SDS呈正相关.结论:便秘显著损害患者的生存质量,易合并有焦虑、抑郁等情志因素的异常.焦虑、抑郁和生存质量相关,肛肠动力学和精神心理因素相关.     

基于“脑-肠轴”理论探讨老年慢性便秘患者睡眠障碍与焦虑抑郁和生活质量相关性

背景睡眠障碍可增加胃肠道症状发生率,而且长期睡眠质量的下降也是焦虑、抑郁形成的一个危险因素.本研究基于"脑-肠轴"理论探讨睡眠障碍是否加重老年慢性便秘患者的临床表现,是否影响患者心理情绪和生活质量.目的基于"脑-肠轴"理论探讨老年慢性便秘患者睡眠障碍与焦虑抑郁和生活质量相关性.方法选择2017-03/2019-09在我院住院治疗的126例老年慢性便秘患者为研究对象,对所有患者便秘评分系统,便秘患者症状自评问卷,睡眠质量评估,焦虑、抑郁量表及生活质量量表评分.结果睡眠障碍组便秘评分系统(constipatipation scoring system,CSS)评分为19.63分±3.36分,便秘患者症状自评问卷(patient assessment of constipation symptom,PAS-SYM)为1.59分±0.52分,焦虑自评量表(self-rating anxiety scale,SAS)评分为58.92分±6.72分,抑郁自评量表(self-rating depression scale, SDS)评分为57.74分±6.38分,均高于睡眠正常组(P <0.05).睡眠障碍组患者社会功能评分为71.56分±3.38分、情绪评分为75.89分±2.95分、躯体角色评分为76.86分±2.92分、躯体健康评分为80.25分±3.35分、心理卫生评分为78.36分±3.65分、总健康评分为76.19分±2.56分,均低于睡眠正常组,差异有统计学意义(P <0.05).CSS,PAC-SYM各维度评分以及总分均与SAS、SDS评分呈正相关(P <0.05);SF-36中6个维度的得分与SAS、SDS评分均呈负相关(P<0.05).结论脑-肠轴是沟通胃肠道与脑之间的桥梁,睡眠障碍和焦虑、抑郁可能是影响老年慢性便秘患者临床症状的重要因素,并影响患者生活质量.     

胃肠康复治疗对脑卒中后便秘患者生活质量以及P物质、5-羟色胺的影响

背景：脑卒中后便秘是一种常见的并发症,会降低患者的生活质量,故探讨脑卒中后便秘的治疗方法显得尤为重要。目的：探讨胃肠康复治疗（内脏筋膜手法+中频电刺激）对脑卒中后便秘患者生活质量、血清P物质（SP）和5-羟色胺（5-HT）水平的影响。方法：选择2020年10月—2021年10月上海市同仁医院收治的70例脑卒中后便秘患者,随机分为对照组（乳果糖治疗）和治疗组（胃肠康复治疗）。评估治疗前后蒙特利尔认知评估量表（MoCA）、Barthel指数评定量表（BI）、焦虑/抑郁自评量表（SAS/SDS）、胃肠道症状评定量表（GSRS）、Wexner便秘评分量表和便秘患者生活质量量表（PAC-QOL）,采用ELISA法检测血清SP、5-HT水平。结果：治疗后,两组MoCA评分无明显差异,SAS评分、SDS评分、GSRS评分、Wexner评分和PAC-QOL评分均显著下降（P<0.05）。重复测量方差分析结果显示两组SAS评分、SDS评分差异有统计学意义（P<0.05）,且治疗组SAS评分、SDS评分下降更明显;两组MoCA评分、BI评分、GSRS评分、Wexner评分和PAC-QOL评分无...     

老年功能性消化不良患者的SAS、SDS及SCL-90评分调查分析100例

目的:探讨临床中老年功能性消化不良患者的心理状况,并分析其护理干预措施.方法:选取郑州大学第五附属医院2011-01/2013-12间的100例老年功能性消化不良患者为研究组,并且选取同期体检健康的100名人员为对照组,采取问焦虑自评量表(selfrating anxiety scale,SAS)、抑郁自评量表(self-rating depression scale,SDS)、症状自评量表对两组的对象心理进行评估,了解心理状况.结果:研究组SAS评分和SDS评分分别为53.1分±5.4分、57.8分±4.3分;对照组SAS评分和SDS评分分别为32.7分±3.4分、33.5分±3.2分;研究组vs对照组,SAS评分和S D S评分差异有统计学意义(P0.05);研究组vs对照组,躯体化、强迫、抑郁、焦虑评分差异有统计学意义(P0.05).研究组中,干预后SAS、SDS评分较干预前有明显的降低,差异有统计学意义(P0.05).结论:临床老年功能性消化不良患者存在不同程度的焦虑和抑郁等不良情绪,临床中应实施针对性的护理干预措施,从而改善患者的不良情绪.     

The egogram is a potent, independent risk factor for hypertension in pregnancy

To assess the association between the egogram and hypertension in pregnancy (HP), a case-control study was carried out. Seventy-one HP cases, primiparous aged 20 to 34 years, and 109 controls, were enrolled among pregnant women who visited our hospitals for obstetrical care. Data from a self-administered questionnaire containing a Self Grow-Up Egogram (SGE) were subjected to univariate and multivariate analyses with prepregnancy body mass index (BMI) and angiotensinogen (AGT) genotype. The mean +/- standard error of total scores for the critical parent (CP) scale were 9.7 +/- 0.5 for cases and 8.3 +/- 0.3 for controls, those for the nurturing parent (NP) scale were 13.6 +/- 0.4 for cases and 13.4 +/- 0.3 for controls, those for the adult (A) scale were 11.3 +/- 0.5 for cases and 10.9 +/- 0.3 for controls, those for the free child (FC) scale were 12.3 +/- 0.3 for cases and 13.8 +/- 0.3 for controls, and those for the adapted child (AC) scale were 10.2 +/- 0.4 for cases and 8.5 +/- 0.4 for controls. A low FC scale score (FC < or = 10) and a high AC scale score (AC > 10) were significantly associated with HP ( p < 0.05; p < 0.01, respectively). In the multivariate analysis, FC < or = 10, AC > 10, prepregnancy BMI > or = 24, and homozygosity of the T235 allele genotype of the AGT gene were detected as the potent independent risk factors for HP. The odds ratios were 2.2, 2.8, 4.0, and 2.5, respectively. The present results suggest that a low FC score and a high AC score may be potent, independent risk factors for HP.     

Anomalous functional connectivity within the default-mode network in treatment-naive patients possessing first-episode major depressive disorder

Background and Objective:Previous studies have shown that the default-mode network (DMN) has a substantial role in patients with major depressive disorder (MDD). However, there is a shortage of information regarding variations in the functional connectivity (FC) of the DMN of treatment-naive patients with first-episode MDD. The present study aims to explore the FC of the DMN in such patients.Methods:The study population consisted of 33 patients and 35 controls, paired regarding age, gender, education level, and health condition. Depression severity was assessed through the Hamilton Depression Scale (HAM-D), and subjects underwent evaluation during the resting-state through functional magnetic resonance imaging (rs-fMRI). To assess the result, we used FC and ICA. We used Spearman''s correlation test to detect potential correlations between anomalous FC and severity of HAM-D scores.Results:We have found a decreased FC in the left medial orbitofrontal gyrus (MOFG) and right marginal gyrus (SMG) in depressive patients compared to controls. There was a negative correlation between abnormal FC in the right SMG and HAM-D scores. We have not found any increase in FC of the DMN in treatment-naive, first-episode of MDD patients.Conclusions:Our study provided evidence of a negative correlation between abnormal FC in the DMN and severity of depression symptoms measured by HAM-D in treatment-naive MDD patients. This finding could shed some light on the relevance of DMN for understanding the pathophysiology of cognitive impairment in MDD.     

Diagnostic value of faecal calprotectin in paediatric gastroenterology clinical practice

BACKGROUND: Faecal calprotectin (FC) is a new marker of intestinal inflammation. Data on FC in paediatric gastroenterology clinical practice are still scarce. AIMS: To assess FC values in different paediatric gastrointestinal diseases comparing them with those obtained in healthy children. PATIENTS: Two hundred and eighty-one children (age range 13-216 months) consecutively referred for gastrointestinal symptoms. Seventy-six healthy controls (age range 13-209 months). The exclusion criteria in healthy children were the following: any known underlying chronic disease or a history of abdominal pain, diarrhoea, acute respiratory tract infection, intake of non-steroidal anti-inflammatory drugs, gastric acidity inhibitors, antibiotics, drugs influencing gut motility, and menstrual or nasal bleeding in the last 3 weeks. METHODS: Stool samples stored, prepared and analyzed by an ELISA assay. RESULTS: In healthy children the median FC value was 28.0 microg/g (15-57 interquartile range) with a 95th percentile value of 95.3 microg/g. An increase in FC concentration was observed in all diseases characterized by gastrointestinal mucosa inflammation, and the active inflammatory bowel disease patients showed the higher FC values. All children affected by functional bowel disorders or by non-inflammatory diseases showed normal values. We calculated an optimized FC cut off value of 102.9266 microg/g (revealed by the receiver operating characteristic curve) to distinguish patients with active organic/inflammatory disorders from healthy subjects and from patients with functional bowel disorders. CONCLUSIONS: Calprotectin is a sensitive, but not disease specific, marker to easily detect inflammation throughout the whole gastrointestinal tract. It may help in identifying an organic disease characterized by intestinal mucosa inflammation and in the differential diagnosis of functional bowel disorders.     

Psychosocial stress in Hansen's disease: a comparison with other chronic illness patients

The present study investigated stress, as measured by a standardized life events scale, in Hansen's disease (HD) patients and as compared to renal patients and non-illness controls. Statistical analyses indicated that experimental groups were well matched on variables of age, sex, and marital status. Regarding analyses of the life events scale, significant differences were found across groups for negative change scores and total change scores. Post-hoc analyses revealed that the outpatient HD group and the renal group were significantly different from the non-illness controls. The results are viewed as support for the hypothesis that HD patients are similar to other chronic illness groups in terms of psychosocial characteristics.     

Serum osteocalcin levels in rheumatoid arthritis: a marker for accelerated bone turnover in late onset rheumatoid arthritis

Levels of serum osteocalcin (OC) are increased in diseases with high bone turnover. We determined OC levels in (1) 15 patients with definite rheumatoid arthritis (RA) in early stages according to Steinbrocker's functional class FC I-II, (2) 40 patients at advanced stages (FC III-IV) and (3) 17 patients with late RA (onset at age of 65 or more). Sixty-two healthy volunteers, divided into 3 subgroups corresponding to the patients, and 19 patients with primary fibromyalgia syndrome (FMS) served as controls. All patients were included in a short term as well as a longitudinal study over one year. Mean OC levels were significantly elevated in patients with late onset RA compared with healthy controls (p = 0.037), while the OC values in early RA FC I-II and advanced RA FC III-IV did not differ significantly from the corresponding control group and the patients with FMS. The late RA group showed a positive correlation between OC and the erythrocyte sedimentation rate (ESR) (r = 0.641, p = 0.007) with a significant decrease of OC (p less than 0.01) as well as ESR (p = 0.047) over one year. We conclude increased OC levels correlate with disease activity in older patients with active RA, suggesting impaired bone turnover. This finding supports the picture of heterogeneity in RA with more late onset patients displaying "high bone turnover."     

Fecal calprotectin is useful in predicting disease relapse in pediatric inflammatory bowel disease

BACKGROUND: Fecal calprotectin (FC) has been proposed as a noninvasive surrogate marker to determine the degree of intestinal inflammation and predicting relapse in patients with inflammatory bowel disease (IBD). The aim was to compare FC levels in IBD and healthy controls, to correlate FC levels with clinical disease activity, and to assess whether FC levels can be used to predict clinical relapse in children with IBD. METHODS: Enzyme-linked immunosorbent assay (ELISA) determined levels of FC were measured in more than 1 stool samples (n) from 32 IBD patients (n = 97) and from 34 healthy controls (n = 37). Disease activity was assessed by the Harvey-Bradshaw index in Crohn's disease (CD) and by Physician's Global Assessment (PGA) in both CD and ulcerative colitis (UC). Clinical events were recorded up to 9 months following stool collection in CD patients. Wilcoxon rank sum test and Fisher's exact tests were used to compare FC levels in IBD patients and in control. Kaplan-Meyer analysis was used to determine a risk of clinical relapse in relation to FC levels. RESULTS: The IBD group had higher FC levels (range 17-7500 g/g) compared with control (16-750 g/g, P < 0.0001). FC levels were higher during relapse (CD, 3214 +/- 2186; UC, 2819 +/- 1610) compared to remission (CD, 1373 +/- 1630; UC, 764 +/- 869; P < 0.0001). Among those with clinical relapse, 90% had FC levels more than 400 mug/g in CD. Eighty-nine percent of CD encounters with FC levels less than 400 mug/g remained in clinical remission. CONCLUSIONS: FC levels differentiate active IBD from controls. Among children with CD and in remission, FC levels may be useful in predicting impending clinical relapse.     

Fecal calprotectin in coeliac disease

We would like to share with the readers the results of our experience in 50 celiac disease(CD)patients,enrolled between September 2012 and April 2013,who were referred to our third-level CD Unit.The fecal calprotectin(FC)concentration of 50 adults with newly diagnosed CD was compared to that of a control group of 50 healthy subjects.FC level was determined by enzyme linked immunosorbent assay with diagnostic cutoff of 75μg/g.In addition,we tried to correlate the FC level with symptoms,histological severity of CD(Marsh grade)and level of tissue transglutaminase antibodies(aTg)in CD patients.Finally,FC level was increased in five CD patients and in four controls(10%vs 8%,P=NS);mean FC concentration of patients and controls were 57.7(SD±29.1)and 45.1(SD±38.4)respectively.Furthermore,no significant correlation was seen between FC levels and symptoms/Marsh grade/aTg.The five CD patients did not show inflammatory lesions(e.g.,ulcers,erosions)at upper endoscopy.The four healthy controls with positive FC were followed-up for further six months;in this observational period they did not show clinical signs of any underlying disease.On these bases,we think that FC is not able to investigate the subclinical inflammatory changes of active CD and FC should be considered a useless tool in the diagnostic work-up of uncomplicated CD but it should be accompanied by aTg when ruling out organic disease in patients with irritable bowel syndrome.