中药药浴联合NB-UVB照射治疗寻常性银屑病疗效观察

目的观察中药药浴联合窄谱中波紫外线(NB-UVB)照射治疗寻常性银屑病的临床疗效。方法将入选的283例寻常性银屑病患者按门诊及住院顺序编号,采用随机数字表法分成3组。对照1组以NB-UVB全身照射;对照2组以中药煎液沐浴;治疗组为中药药浴联合NB-UVB照射,方法同前两组。3组均2周为1个疗程,2个疗程后判定疗效。结果治疗组有效率为94.38%,对照1组为84.38%,对照2组为69.89%,治疗组疗效优于对照组1组和2组,差异均有统计学意义(χ21组=4.8,P<0.05;χ22组=18.37,P<0.01)。治疗组复发率(10.81%)及不良反应(11.24%)低于对照组1组(分别为30.30%和23.96%),差异均有统计学意义(χ2=4.14,5.10;P均<0.05)。结论中药药浴联合NB-UVB照射治疗寻常性银屑病疗效较好,可缩短疗程,降低复发率及不良反应。     

中药浴及润肤剂治疗寻常性银屑病复发的观察

目的 观察中药浴及润肤剂对静止期寻常性银屑病复发的影响.方法 260例静止期寻常性银屑病患者,随机分为2组.治疗组130例,中药浴后外用润肤剂郁美净儿童霜;对照组130例,外用皮质类固醇激素乳膏.2组均口服复方甘草酸苷50～75 mg/次,3次/d,窄谱中波紫外线照射,疗程12周观察疗效;之后对临床痊愈患者随访2年,统计复发率及平均复发时间.结果 12周后治疗组与对照组总有效率分别为87.6％和85.3％,差异无统计学意义(P＞0.05).随访2年治疗组痊愈患者中(78/130),有10例复发,平均复发时间(21.25±7.5)个月;对照组痊愈患者中(82/130)有28例复发,平均复发时间(13.55±8.11)个月.差异具有统计学意义(P＜0.05).结论 中药浴及外用润肤剂辅助治疗寻常性银屑病,疗效满意,复发率低.     

中药药浴联合窄谱中波紫外线治疗寻常性银屑病疗效观察

目的评价中药药浴联合窄谱中波紫外线照射(NB-UVB)治疗寻常性银屑病的临床疗效。方法把140例患者随机分为两组,治疗组75例,对照组65例。两组均外用15%尿素霜,且在治疗的前7d同时外用卤米松乳膏,外用面积不超过体表面积的20%,均1次/d。治疗组加用我科协定方(参卿止痒方)中药浴,同时进行NB-UVB照射,对照组仅加用NB-UVB照射治疗,均隔日1次,10次为1个疗程,共治疗2个疗程。结果治疗组有效率78.67%,对照组为56.92%,差异有统计学意义(P<0.01)。两组患者未见严重不良反应。结论参卿止痒方中药浴联合NB-UVB治疗寻常性银屑病有效,值得临床应用。     

中药浴与光疗联合治疗银屑病的临床观察

我院于2002年3月-2004年6月采用中药洗浴与光化学疗法联合治疗各型银屑病患者1000例，取得良好疗效，现报道如下。     

中草药药浴治疗寻常型银屑病的疗效观察

我科自2004年11月-2005年10月采用中草药药浴等治疗寻常型银屑病，效果满意，现总结如下。     

NB-UVB治疗寻常型银屑病的临床研究

为评价NB—UVB治疗寻常型银屑病的疗效和安全性。将95例寻常型银屑病患者随机分成两组。一组用窄谱中波紫外线（NB—UVB）治疗，另一组用宽谱中波紫外线（BB—UVB）治疗，隔天一次，4周结束后。观察分析两组治疗效果。结果：4周治疗后，NB—UVB治疗组有效率85．4％，其中1例患者发生严重光毒反应。BB—UVB治疗组有效率51．1％，其中5例患者发生严重光毒反应。x^2检验显示有非常显著性差异（P〈0．01）。NB—UVB治疗寻常型银屑病具有良好疗效，与BB—UVB相比，不仅疗效好，而且副作用较少，照射时间缩短。     

NB-UVB照射治疗寻常性银屑病疗效及相关因素分析

目的观察窄谱中波紫外线NB-UVB治疗寻常性银屑病的疗效,并对相关因素进行探讨。方法104例寻常性银屑病患者予8周NB-UVB照射治疗,观察疗效及与年龄、性别等相关因素的关系。结果痊愈率28.85%,显效率为25.96%。不同年龄段患者有效率分别为≤20岁100%,21～50岁67.8%,>50岁28.2%,男性和女性患者疗效差异无统计学意义(P>0.05),治疗有效患者1年复发率为47.7%。结论NB-UVB是治疗寻常性银屑病的有效方法,疗效随年龄增加而下降,照射治疗不能防止复发。     

NB-UVB联合百癣夏塔热片治疗寻常型银屑病疗效观察

目的:观察NB-UVB联合百癣夏塔热片治疗寻常型银屑病的疗效及不良反应。方法:采用随机对照临床试验,将81例符合纳入标准的患者随机分为两组,治疗组45例,对照组36例。治疗组采用NB-UVB光疗,同时口服百癣夏塔热片,对照组单独采用NB-UVB光疗。结果:治疗组有效率为80.0%,对照组有效率为50.3%,治疗组有效率高于对照组,差异具有统计学意义(P<0.05)。结论:NB-UVB联合百癣夏塔热片治疗寻常型银屑病疗效明显,且不良反应小,安全性高,值得临床推广。     

窄谱中波紫外线联合中药浴治疗寻常型银屑病的疗效观察和护理

目的：观察窄谱中波紫外线（UVB）联合中药浴治疗寻常型银屑病的临床疗效和总结护理经验。方法：将79例银屑病患者随机分为两组,治疗组40例给予窄谱UVB联合中药浴治疗,对照组39例仅给予窄谱UVB治疗。两组均实施用药护理、心理护理、健康教育等。结果：经过3个月治疗和护理,治疗组和对照组有效率分别为75.00%和51.28%,两组比较差异有统计学意义。结论：窄谱UVB联合中药浴配合得当的护理措施,治疗寻常型银屑病疗效满意,值得临床推广。     

中药药浴联合NB-UVB照射治疗寻常性银屑病疗效及安全性的系统评价

目的系统评价中药药浴联合窄谱中波紫外线(NB-UVB)照射与单用NB-UVB照射治疗寻常性银屑病的临床疗效和安全性。方法计算机检索PubMed,EMBASE,Cochrane Library,CBM,CNKI,VIP和万方数据库1984年1月-2012年1月治疗组采用中药药浴联合NB-UVB照射、对照组单用NB-UVB照射治疗银屑病的随机对照试验(RCTs)。按照标准筛选资料和评价质量后,用RevMan5.0软件进行Meta分析或进行描述性分析。结果三个亚组共纳入12篇RCTs,共包括1875例患者。≥4分高质量文章3篇。纳入11篇RCTs评价有效率,6篇RCTs评价治疗前、后治疗组的PASI评分差值均高于对照组;10篇RCTs治疗组不良反应发生率低于对照组(P均<0.001)。治疗组复发率低于对照组。结论中药药浴联合NB-UVB照射较单用NB-UVB照射治疗寻常性银屑病的疗效好,并可减少不良反应和降低复发率。本次纳入试验方法学质量普遍较低,尚需开展科学而合理的高质量随机对照试验验证其确切疗效及安全性。     

Suberythemogenic narrow-band UVB is markedly more effective than conventional UVB in treatment of psoriasis vulgaris

Background: Narrow-band UVB (NB-UVB) is a new phototherapy option for psoriasis. Action spectrum studies previously done with different UVB wavelengths suggest that suberythemogenic doses of NB-UVB could be highly effective in treating psoriasis vulgaris. Even so, no comparative studies with suberythemogenic doses of NB versus conventional UVB have been performed previously. Objective: Our purpose was to compare conventional broad-band UVB (BB-UVB) with NB-UVB at suberythemogenic doses for the treatment of psoriasis vulgaris. Methods: Eleven patients were treated using a split-body approach for 6 weeks on a three-times-a-week basis. Outcomes were evaluated by means of Psoriasis Severity Index scores and quantitative histologic measures. Results: We were able to induce clinical clearing in 81.8% of patients after NB-UVB, but in only 9.1% of patients after BB-UVB (P < .01). Biopsy specimens obtained at the end of treatment revealed that keratin 16 staining was absent in 75% of patients on the NB side compared with none on the BB side, suggesting a reversal of regenerative epidermal hyperplasia by NB-UVB. Conclusion: NB-UVB is superior to UVB-BB in reversing psoriasis at suberythemogenic doses when given three times per week. This schedule was well tolerated by all patients.(J Am Acad Dermatol 1999;40:893-900.)     

窄谱中波紫外线治疗银屑病临床观察

目的:应用窄谱中波紫外线(NB-UVB)治疗337例银屑病患者,观察其治疗的有效性及安全性.方法:对银屑病患者进行全身NB-UVB照射,每周3次,应用银屑病皮损面积和严重程度指数(PASI)评分标准进行疗效评价.结果:痊愈所需治疗次数为12～62次,平均治疗次数为29.47次,照射累积剂量为8.24～126.18 J/cm2,平均累积剂量为53.3 J/cm2,未出现严重不良反应.结论:NB-UVB治疗银屑病具有效果好,安全性高的特点.     

青鹏软膏联合窄谱中波紫外线治疗寻常性银屑病的疗效观察

窄谱中波紫外线(NB-UVB)治疗银屑病具有疗效好,不良反应小的特点,但也不可避免地对患者造成各种不良反应.青鹏软膏是一种藏药,它由9味传统天然高原药材组方而成,经证实其具有抗炎、抑菌、止痒等作用.我们使用青鹏软膏联合窄谱中波紫外线(NB-UVB)治疗银屑病,疗效较为满意,现报告如下.     

Excimer laser versus narrow-band UVB (311 nm) in the treatment of psoriasis vulgaris

BACKGROUND: The excimer laser is a new therapeutic option in the treatment of psoriasis vulgaris. Objective: The purpose of this study was to determine the response of psoriasis lesions to the 308-nm excimer laser compared to 311-nm UVB phototherapy. METHODS: In this prospective right/left comparative, open, single-blinded trial, selected psoriasis plaques of 16 patients were treated with the excimer laser whereas the rest of the body was treated with UVB narrow-band phototherapy. A modified PASI score was used to evaluate the results. RESULTS: After 12 treatments, 15 patients were evaluated. In 2 patients no difference between the two body sides was observed. In 9 patients the laser-treated lesions showed better results, whereas in 4 patients the side treated with 311-nm UVB showed more clearing. The mean reduction in PASI score was 5.6 and 4.9, respectively (difference not significant). CONCLUSION: The use of the 308-nm xenon chloride excimer laser is an additional effective therapeutic option for the treatment of psoriasis vulgaris.     

他克莫司软膏联合窄谱UVB治疗白癜风的临床研究

目前对白癜风的治疗方法虽然有多种，但有各种局限性，而且疗效不确定，疗程长。他克莫司软膏是一种新型外用免疫抑制剂，有资料表明，其治疗白癜风的效果较好。我们采用外搽他克莫司软膏联合窄谱紫外线（NB—UW）的方法，治疗11例白癜风患者，并与单做光疗的10例患者作比较，观察联合治疗的疗效。     

氨基肽酶N抑制剂治疗寻常性银屑病的疗效

研究表明,微血管异常增生与银屑病发病有关,如血管内皮生长因子(VEGF)和促血管新生蛋白因子-2在慢性炎症阶段发挥一定作用.氨基肽酶(APN/CD13)抑制剂能抑制血管生成,可用于银屑病的治疗.现报告CD13抑制剂治疗银屑病疗效和安全性.     

311nm窄谱中波紫外线照射治疗寻常性银屑病疗效观察

目的观察311nm窄谱中波紫外线(NB-UVB)照射治疗寻常性银屑病的疗效及其影响因素。方法单独采用NB-UVB照射或联合糠馏油硼酸氧化锌软膏(PBZS)封包治疗寻常性银屑病87例,并以银屑病面积和严重度指数(PASI)评价疗效,分析性别、皮肤类型、临床分型及临床分期对疗效的影响,同时对采用其他方法治疗的30例寻常性银屑病患者进行回顾性的评价。结果在(17.60±4.42)d、(16.90±5.80)d、(25.80±6.67)d治疗后,NB-UVB组、NB-UVB+PBZS组及回顾分析组治疗前后PASI评分改善率分别为(76.3±24.6)%、(88.1±28.7)%、(76.5±26.2)%;与回顾分析组比较,NB-UVB组与其疗效相当(P>0.05),但治疗时间显著缩短(P<0.05),而NB-UVB+PBZS组则在更短的治疗时间(P<0.05)取得了更好的疗效(P<0.05);疗效相关因素分析表明,点滴状略优于斑块状、进行期略优于静止期(0.01相似文献   

Randomized half-side comparison of narrowband UVB and trimethylpsoralen bath plus UVA treatments for psoriasis

The efficacy of trimethylpsoralen bath PUVA and UVB TL01 were compared in chronic plaque psoriasis. Patients were randomly assigned to receive UVB TL01 on one side and bath PUVA on the contra-lateral side. Altogether 17 patients received treatments and 15 completed the trial. The decrease in the PASI score was greater with UVB TL01 than PUVA. At the end of the treatment period, the difference was highly significant (p < 0.001). The difference was already significant at week 3 (p = 0.014). The relative median decrease in the PASI score was 77% (24-100%) with UVB and 45% (8-100%) with PUVA. The median cumulative UVB dose was 39.92 (range 13.95-81.56) J/cm2 and the corresponding UVA dose was 8.06 (range 3.31-12.51) J/cm2. All patients relapsed within 4 months. Narrowband UVB improved psoriasis clinically and statistically more efficiently than trimethylpsoralen bath PUVA, and UVB was better tolerated.     

Clinical efficacy of narrow-band UVB (311 nm) combined with dithranol in psoriasis. An open pilot study

BACKGROUND: For UVB, the most effective wavelength in clearing psoriatic lesions was found to be of 313 nm. The efficacy of whole body exposure to narrow-band UVB (311 nm) combined with dithranol in psoriasis has not been evaluated to date. OBJECTIVE: Evaluation of the clinical efficacy of phototherapy with narrow-band UVB (311 nm) and dithranol for psoriasis by means of whole body exposures and analysis of the mean cumulative irradiation dose. METHODS: In this open pilot study, 13 patients were treated for 4-5 weeks. Evaluation of the therapeutic efficacy was performed by comparing the Psoriasis Area and Severity Index (PASI) scores at baseline and after 4 weeks of treatment. The cumulative irradiation dose was also calculated. RESULTS: Evaluation of the PASI scores showed a significant overall reduction of psoriatic lesions after 4 weeks of treatment. The cumulative irradiation dose was similar or lower to those found for phototherapy with narrow-band UVB alone. DISCUSSION: In patients with widespread psoriasis, treatment with narrow-band UVB (311 nm) combined with dithranol is safe and effective, allowing reduction of the cumulative irradiation dose. Copyright (R) 2000 S.Karger AG, Basel