恶性疟对喹啉类抗疟药多药耐药现象及基因的研究进展

氯喹(CQ)的抗药性在东南亚的泰-柬边境和南美洲的哥伦比亚出现,从这两个地区开始蔓延,至今在世界大多数的疟疾流行区氯喹已失去其一线抗疟药的地位,更令人失望的是对氯喹产生抗药的疟原虫对其它含有喹啉环的抗疟药如甲氟喹、氨酚喹以及奎宁均产生抗药性(Wernsdorfer,1994a...     

抗疟药可降低系统性红斑狼疮患者的癌症风险

西班牙Basque Country大学的Ruiz-Irastorza博士及其同事在6月的《风湿病年鉴》（Ann Rheum Dis，2007；66：815—817．）上报道，使用抗疟药似乎可降低系统性红斑狼疮（SLE）患者发生恶性肿瘤的风险。     

抗疟药氯喹可能抑制某些癌症的发生

上个世纪70年代—年代,坦桑尼亚的研究者给儿童分发了上百万剂疟疾特效药氯喹作为5年疟疾预防工作的一部分。然而该研究未能得出明确的结论,但研究人员在注意到有一种称之为伯吉特淋巴瘤的血癌病例却显著下降了。小鼠实验证明了氯喹真的可能防止伯吉特淋巴瘤以及一种罕见的叫作     

抗疟药硝喹的研究进展

硝喹(NQ)是70年代合成的一个有效抗疟药,其化学结构为2,4二氨基-6-[(3、4二氯苄基)亚硝基胺基]喹唑啉醋酸盐,经临床应用无论对恶性疟或间日疟,甚至抗氯喹的恶性疟都有很高的疗效,并且在疟疾流行区还有预防疟疾的作用。该药合并氨苯砜能显著加强其抗疟作用,合并喹哌或咯萘啶治疗恶性疟,药物剂量仅为正常各药治疗量60％左右即可达到同等疗效。治疗氟喹敏感的恶生疟,用50～75mg/d×3的剂量,无性期原虫消除时间平均为47.6±20.9小时,氟喹对照组为49.5±11.9小时;治疗抗氯喹的恶性疟,NQ组原虫清除时间为56.2±11.0小时,而氯喹组为70.2±22.6小时,两组有显著差别。在云南疟疾流行区连续两年以NQ预防,在流     

确定HCMV抗药性实验方法研究进展

ＨＣＭＶ感染免疫妥协的机体，通常是无症状的，但在ＡＩＤＳ和骨髓，实质器官移植病人，是引起发病和死亡的主要原因之一，确定有毒力，对抗病毒药物产生抗性的ＨＣＭＶ株，对临床治疗ＨＣＭＶ感染引起的相关疾病很有必要，目前实验室用来确定ＨＣＭＶ抗药性敏感性实验方法有多种，且在不断改进和更新。本文对这些实验方法在临床上应用及其研究进展予以综述。     

转基因植物疫苗的研究进展

用转基因植物作生物反应器生产药用蛋白是一个新兴的研究领域，本文就用转基因植物生产疫苗的研究进展进行简要综述，并对其优缺点及发展方向进行了分析。     

维生素D研究进展

维生素Ｄ与甲状旁腺激素和降钙素共同组成体内钙代谢的主要调节系统。特别是对维持血钙平衡，维生素Ｄ起着关键作用。作者曾在１９８６年于本刊发表一篇有关维生素Ｄ研究进展的综述。时过１２年后，维生素Ｄ的研究在许多方面又取得很大进展，现作部分简介。一、１，２５一...     

多向耐药基因研究进展

恶性肿瘤严重危害人类健康，联合治疗仍是目前的主要方法，其中化疗是绝大多数患者（包括手术后患者）的主要疗法或辅助疗法，然而大多数患者常常化疗失败，其主要原因是肿瘤产生了耐药性。研究发现，肿瘤产生耐药性与多种因素有关，如多向耐药基因（MDRI），谷眈甘肽一S一转移酶，拓扑异构酶等，其中最重要的是MDRI表达增高及其编码产物P一塘蛋白（PPP）增多。许多肿瘤在化疗前即有MDRI表达增高，在化疗后比例更高。因此MDRI及其产物PPP耐药机制的研究对提高临床化疗效果，恢复耐药肿瘤细胞药物敏感性具有极其重要的意义。其研究…     

人类DNA分型研究进展

聚合酶链式反应技术克服了以往ＤＮＡ多态性检测技术的缺点，引起了ＤＮＡ多态性检测的一次革命。本文从扩增片段碱基序列多态性、扩增片段患联重复序列多态性和随机扩增的多态性ＤＮＡ等多方面，系统地综述了近年来聚合酶链式反应技术在ＤＮＡ分型研究中的进展。     

MESENCHYMAL CHONDROSARCOMA A CASE REPORT WITH AN ULTRASTRUCTURAL STUDY and REVIEW OF JAPANESE LITERATURES

A case of mesenchymal chondrosarcoma occurring in the left maxilla of a 30-year-old Japanese male was reported. Electron microscopic observation confirmed transition of undifferentiated cells to chondrocytes and calcification in similar manner as previously described with physiological processes. Matrix vesicles were thought to be the cytoplasmic products of tumor chondrocytes. Electron-dense finely granular deposits resembling the organic matrix of cartilagenous calcification were seen within the intercellular matrix. Matrix vesicles were also closely related to these deposits. Japanese cases of this rare tumor were reviewed and 8 cases, Including the present case as 6th among them, were accepted. Clinical characteristics were similar to those of a series reported by SALVADOR et al.     

INFANTILE DIGITAL FIBROMATOSIS HISTOPATHOLOGICAL and ELECTRON MICROSCOPIC STUDY WITH A REVIEW OF THE LITERATURE

Five cases of Infantile digital fibromatosis were described. Three were male and two were female. Multiple lesions were noted in two cases. The lesions were Intradermal and had a peculiar histologic pattern with intracytoplasmic inclusions. By electron microscopy, the inclusions were composed of a meshwork of both fibrils and fine granules and have no limiting membrane. No virus-like particle could be identified in the proliferating cells. Follow-up information was available in all five cases; one had recurring tumors.     

膝关节生物力学模型研究现状

膝关节是人体最重要的关节之一。对膝关节的生物力学性质和行为的正确认识有助于临床上各类膝关节伤病的治疗。模型是研究生物力学系统的有效手段，本文回顾了近年来国内外学者提出的若干膝关节力学模型，分析了其优点及局限性。提出了膝关节模型的发展趋势，为进一步探讨膝关节模型提供了参考和借鉴。     

叮咬蜱的摘除方法

蜱叮咬人,不但可以给人类带来直接的伤害,同时可以将其携带的病原感染给人,给人类健康带来危害。本文对国内外蜱摘除方面的进展进行了综述,人一旦被蜱叮咬,应尽早摘除,理想的方法是尽可能靠近皮肤夹住蜱的假头,用稳定向上的力进行果断摘除。     

A CLINICOPATHOLOGICAL REVIEW OF 12 AUTOPSIED CASES OF ADULT T-CELL LEUKEMIA

Twelve autopsied cases with adult T-cell leukemia (ATL) were reviewed clinicopathologically. The prognosis of three cases who had suffered from severe cutaneous lesions was much better than that of the other nine cases with no or negligible cutaneous lesions. The surface marker of leukemic cells from six cases was ordinary inducer/helper phenotype (OKT4+ and 8^-), but in one case leukemic cells showed OKT4+ and 8+. In another case, a significant amount of leukemic cell infiltration was found in the thymic cortex. Calcium content in the bone of ATL cases was lower than that of the patients without ATL (control group), and six cases with ATL (50%) were complicated by severe hypercalcemia. Neither adenoma nor hyperplasia of the parathyroid glands was found in any case. In most severely hypercalcemic patients, bone trabeculae were actively absorbed by numerous osteoclasts and partly replaced by fibrous tissues. In two normocalcemic patients, skeletal calcium content was also markedly reduced by osteoporosis, but the activation of osteoclasts was inconspicuous. It was speculated that the manner of bone resorption in ATL cases was diverse and there were some clinicopathological subtypes in ATL from the viewpoints of cutaneous lesions, hypercalcemia, and bone lesions.