受虐待小学生自我概念的发展特点及与虐待经历的关系

目的 探讨受虐待小学生自我概念的发展特点及其与各种儿童虐待形式的关系.方法 对179例小学生进行了儿童期虐待史自评量表(PRCA)和Piers-harris儿童自我意识量表(PHCSS)测试.结果 受虐待组小学生PHCSS各因子分和总分均低于无虐待组:PHCSS总分[(53.56±13.12)分vs(63.11±8.68)分,P＜0.01],女生在行为和合群两个因子的得分高于男生[行为(11.68±3.34)分vs(13.13±2.23)分,P＜0.01;合群(8.05±2.16)分vs(9.14±1.82)分,P＜0.01],9～10岁组在总分和智力与学校表现两个维度的得分高于11～12岁组[总分(58.55±12 .17)分vs(54.68±12.90)分,P＜0.05;智力(11.56±3.54)分vs(10.38±3.47)分,P＜0.05].PRCA各因子分和总分与PHCSS各因子分和总分均呈负相关(r=-0.165～-0.524,P＜0.05或P＜0.01).情感虐待对行为、智力与学校表现、焦虑、合群、幸福与满足和总自我意识具有负向预测作用(Beta值=-0.263～-0.402,P＜0.01);忽视对行为、智力与学校表现、身体外貌与属性、焦虑、合群、幸福与满足和总自我意识具有负向预测作用(Beta值=-0.156～-0.359,P＜0.05或P＜0.01);性虐待对躯体外貌与属性和合群具有负向预测作用(Beta值=-0.158～-0.170,P＜0.05);本研究中未发现躯体虐待有任何预测作用.结论 儿童虐待可对小学生自我概念的发展造成不良影响,情感虐待、忽视和性虐待均可显著预测个体的自我概念发展水平.     

儿童虐待对小学生行为问题的影响

目的研究受虐待小学生的行为问题及其与各种儿童虐待形式的关系。方法对179例小学生进行了儿童期虐待史自评量表(PRCA)和Achenbach儿童行为量表(CBCL)测试。结果受虐待组小学生CBCL各因子分和总分高于无虐待:CBCL总分[男生(45.02±43.46)分vs(14.41±14.37)分,t=4.79,P<0.01;女生(37.16±28.34)分vs(17.73±14.58)分,t=4.39,P<0.01],女生中11～12岁年龄组的社交退缩因子分高于9～10岁组[(3.80±2.91)分vs(2.47±2.94)分,t=2.19,P<0.05]。除性虐待外,PRCA各因子分和总分与CBCL各因子分和总分呈正相关(r=0.213～0.513,P<0.05或P<0.01)。情感虐待、躯体虐待、性虐待和忽视对男生行为问题具有正向预测作用(Beta值=0.213～0.510,t=2.060～5.032,P<0.05或P<0.01);忽视和情感虐待对女生行为问题具有正向预测作用(Beta值=0.199～0.332,t=2.012～3.441,P<0.05或P<0.01)。结论儿童虐待可对小学生行为自我调节能力的发展造成不良影响,躯体虐待、情感虐待、忽视和性虐待可显著预测个体的行为问题。     

儿童虐待对小学生行为问题的影响

目的 研究受虐待小学生的行为问题及其与各种儿童虐待形式的关系.方法 对179例小学生进行了儿童期虐待史自评量表(PRCA)和Achenbach儿童行为量表(CBCL)测试.结果 受虐待组小学生CBCL各因子分和总分高于无虐待:CBCL总分[男生(45.02±43.46)分vs(14.41±14.37)分,t=4.79,P＜0.01;女生(37.16±28.34)分vs(17.73±14.58)分,t=4.39,P＜0.01],女生中11～12岁年龄组的社交退缩因子分高于9～10岁组[(3.80±2.91)分vs(2.47±2.94)分,t=2.19,P＜0.05].除性虐待外,PRCA各因子分和总分与CBCL各因子分和总分呈正相关(r=0.213～0.513,P＜0.05或P＜0.01).情感虐待、躯体虐待、性虐待和忽视对男生行为问题具有正向预测作用(Beta值=0.213～0.510,t=2.060～5.032,P＜0.05或P＜0.01);忽视和情感虐待对女生行为问题具有正向预测作用(Beta值=0.199～0.332,t=2.012～3.441,P＜0.05或P＜0.01).结论 儿童虐待可对小学生行为自我调节能力的发展造成不良影响,躯体虐待、情感虐待、忽视和性虐待可显著预测个体的行为问题.     

小学生冲动性人格与受虐待经历的关系

目的 研究受虐待小学生冲动性人格的发展特点及其与受虐待经历的关系.方法 采用儿童期虐待史自评量表(PRCA)和Barratt冲动性人格量表(BIS-11),对172名小学五、六年级学生进行测评,分别评估他们的冲动性人格和受虐待情况.结果 受虐待者的无计划冲动性、动机冲动性和冲动性总分均高于未受虐待者[冲动性总分(40.39±10.68)分vs(30.34±10.26)分,t =5.96,P ＜0.01],男生的动机冲动性明显高于女生[(28.98±14.42)分vs(24.46±11.52)分,t =2.28,P ＜0.05].躯体虐待、情感虐待和虐待总分与无计划冲动性、动机冲动性和冲动性总分呈正相关(r =0.337～0.514,P ＜0.01),忽视与冲动性人格所有因子和总分呈正相关(r =0.187～0.419,P ＜0.05或P ＜0.01),性虐待仅与动机冲动性呈正相关(r =0.192,P ＜0.05).情感虐待对无计划冲动性、动机冲动性和冲动性总分具有正向预测作用(Beta值=0.185～0.395,t =1.975～5.589, P ＜0.05或P ＜0.01),忽视对无计划冲动性、注意冲动性和冲动性总分具有正向预测作用(Beta值=0.272～0.294,t =3.037～3.756,P ＜0.01),躯体虐待和性虐待对动机冲动性具有正向预测作用(Beta值=0.213,t =3.025,P ＜0.01;Beta值=0.157,t =2.441,P ＜0.05).结论 小学生的冲动性人格与受虐待经历有关,儿童虐待对冲动性人格的形成具有预测作用.     

儿童期虐待史自评量表的信度与效度分析

目的 编制儿童期虐待史自评量表(PRCA),并对它进行初步的信度、效度分析.方法 对179例小学生进行了PRCA测试,分析PRCA的内部一致性,重测信度,内容效度及校标效度,并分析小学生的受虐待情况.结果 PRCA的虐待总分的cronbach's α系数为0.87,躯体虐待因子为0.85,情感虐待因子为0.73,性虐待因子为0.99,忽视因子为0.89.PRCA的重测信度为0.68,躯体虐待因子为0.46,情感虐待因子为0.56,性虐待因子为0.70,忽视因子为0.54.各因子之间相关系数为0.24～0.52,各因子与总分相关系数为0.53～0.77,与抑郁自评量表相关系数为0.35～0.77.受虐待组学生症自评量表总均分及各因子分均明显高于对照组[总均分:(1.84±0.61)分vs(1.59±0.57)分,t=2.84,P＜0.01].与女生相比,男生的受虐待程度较重,一年内受虐待次数较多[总分:(12.87±16.46)分vs(8.49±12.31)分,t=2.00,P＜0.05;频度:(1.72±1.71)分vs(1.16±1.16)分,t=2.53,P＜0.05].绝大部分虐待行为始发于10岁之前.结论 儿童期虐待史自评量表具有较好的信度、效度,可作为对儿童进行受虐待情况调查的自评工具.     

小学生攻击性人格与受虐待经历的关系

目的 研究受虐待小学生攻击性人格的发展特点及其与受虐待经历的关系.方法 采用儿童期虐待史自评量表(PRCA)、Buss和Perry攻击性人格量表,对172名小学五、六年级学生进行测评,分别评估他们的攻击性人格维度和受虐待情况.结果 与无虐待组相比,受虐待组小学生的攻击性人格各维度分和攻击性总分明显增高:攻击性总分[(32.60±8.01)分vs(19.28±4.97)分,t=11.51,P＜0.01],并且男生的攻击性高于女生:攻击性总分[(26.51±9.74)分vs(21.30±7.09)分,t=3.95,P＜0.01].躯体虐待、情感虐待、忽视和虐待总分与攻击性人格量表各因子分和总分呈正相关(r=0.287～0.797,P＜0.01),性虐待仅与躯体攻击、指向自我的攻击和攻击性总分呈正相关(r=0.159～0.181,P＜0.05).情感虐待能够正向预测躯体攻击、语言攻击、敌意、指向自我的攻击和总攻击性(Beta值=0.274～0.439,t=3.502～7.007,P＜0.01),躯体虐待能够正向预测攻击性人格的所有维度和总攻击性(Beta值=0.172～0.358,t=2.196～5.718,P＜0.05或P＜0.01),忽视能够正向预测愤怒和指向自我的攻击性(Beta值=0.203～0.235,t=2.770～3.207,P＜0.01),而性虐待对攻击性人格没有预测作用.结论 儿童虐待可对小学生的人格发展造成不良影响,使其形成高攻击性人格,躯体虐待、情感虐待和忽视对攻击性人格具有预测作用.     

儿童期虐待史自评量表的信度与效度分析

目的编制儿童期虐待史自评量表(PRCA),并对它进行初步的信度、效度分析。方法对179例小学生进行了PRCA测试,分析PRCA的内部一致性,重测信度,内容效度及校标效度,并分析小学生的受虐待情况。结果PRCA的虐待总分的cronbach’sα系数为0.87,躯体虐待因子为0.85,情感虐待因子为0.73,性虐待因子为0.99,忽视因子为0.89。PRCA的重测信度为0.68,躯体虐待因子为0.46,情感虐待因子为0.56,性虐待因子为0.70,忽视因子为0.54。各因子之间相关系数为0.24~0.52,各因子与总分相关系数为0.53~0.77,与抑郁自评量表相关系数为0.35~0.77。受虐待组学生症自评量表总均分及各因子分均明显高于对照组[总均分:(1.84±0.61)分vs(1.59±0.57)分,t=2.84,P<0.01]。与女生相比,男生的受虐待程度较重,一年内受虐待次数较多[总分:(12.87±16.46)分vs(8.49±12.31)分,t=2.00,P<0.05;频度:(1.72±1.71)分vs(1.16±1.16)分,t=2.53,P<0.05]。绝大部分虐待行为始发于10岁之前。结论儿童期虐待史自评量表具有较好的信度、效度,可作为对儿童进行受虐待情况调查的自评工具。     

受虐待小学生人格的人际关系维度分析

目的 研究小学高年级学生人格的人际关系维度及其与受虐待经历的关系.方法 采用儿童期虐待史自评量表(PRCA)和中国青少年人格量表(QZPS-Q),对172名小学五、六年级学生进行测评,分别评估他们的人际关系特质和受虐待情况.结果 女生的温和、谨慎和人际关系总分高于男生[温和(24.2±4.5)分vs(22.5±4.6)分,P＜0.05;谨慎(21.3±3.7)分vs(18.1±4.4)分,P＜0.01;人际关系(59.2±7.6)分vs(53.9±8.4)分,P＜0.01],受虐待者的谨慎因子分数低于未受虐待者[(18.3±4.6)分vs(20.6±4.0)分,P＜0.01].躯体虐待、忽视、情感虐待和虐待总分分别与谨慎、人际关系总分呈负相关(r=0.229～-0.393,P＜0.01).虐待对人际关系特质具有负向预测作用(Beta值=-0.237～-0.307,t=-3.314～-4.491,P＜0.01),女生对人际关系特质具有正向预测作用(Beta值=0.179～0.323,t=2.373～4.722,P＜0.05).结论 小学生人格的人际关系特质存在性别差异,人格特质的形成受受虐待经历的影响.     

综合干预对小学生受虐待现象和自我意识的影响

目的 探讨综合干预措施对小学生受虐待现象及其自我意识的影响作用.方法 采取整群抽样的方法对徐州市某区小学179名小学生进行儿童期虐待史自评量表(PRCA)和Piers-harris儿童自我意识量表(PHCSS)的调查.把179名小学生按班级随机分为干预组(88人)与对照组(91人).对干预组进行2个月的综合干预,干预结束半年后,对2组小学生重测儿童期虐待史自评量表和Piers-harris儿童自我意识量表.结果 与对照组相比,干预组小学生的躯体虐待、情感虐待、忽视和总受虐待率下降较明显:总受虐待减少率(45.3% vs 19.0%,χ2=18.90,P ＜0.01).重复测量的方差分析发现,干预后自我意识量表得分显著高于干预前(P ＜0.05),但是综合干预措施对自我意识量表得分的增高没有明显作用(P ＞0.05).回归分析表明,影响自我意识得分增长值的因素有:干预后虐待、干预前自我意识得分和性别,其中干预后虐待和干预前自我意识得分对自我意识得分的增长值有负向预测作用(Beta值=-0.123～-0.263,P ＜0.05;Beta值=-0.690～-0.790,P ＜0.01),女性对自我意识得分的增长值有正向预测作用(Beta值=0.086～0.166,P ＜0.05).结论 综合干预能减少小学生受虐待现象的发生,短期内难以显著改善小学生自我意识的发展状况.     

受虐待小学生人格的善良维度特点

目的 研究高年级小学生人格的善良维度特点及其与受虐待经历的关系.方法 采用儿童期虐待史自评量表(PRCA)和中国青少年人格量表(QZPS-Q),对172名小学五、六年级学生进行测评,分别评估他们的善良维度特质和受虐待情况.结果 ①女生的宽厚、利他、诚实和善良总分高于男生[(41.1±4.4)分,(37.6±6.6)分,(19.2±3.9)分,(17.1±4.6)分,(17.3±3.0)分,(15.3±3.5)分,(77.6±8.8)分,(69.9±12.6)分,F=9.379～15.709,P<0.01].②性虐待与善良维度无相关性,其它虐待形式与善良维度呈负相关r=-0.161～-0.369,P<0.05).③情感虐待对善良、宽厚和诚实具有负向预测作用,忽视对善良具有正向预测作用,女性对善良维度的所有因子具有正向预测作用(P<0.05).结论 小学生人格的善良特质存在性别差异,善良特质的形成受受虐待经历的影响.     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.