各期高血压患者血液流变学改变及其相关因素的研究

本文采用系统的血液流变学研究方法,观察了245例各期高血压患者的血液流变学改变,同时观察其甲皱微循环和血脂的变化,并与116例正常人作对照。结果表明:高血压患者存在着显著的血液高粘滞状态,表现为全血粘度、血浆粘度和全血还原粘度均明显升高(P<0.001)。这种改变在高血压Ⅰ期即已存在,随着病情发展而加重。同时伴有HCT、EER及红细胞变形能力的明显异常(P<0.01)各期高血压患者均出现明显的甲皱微循环障碍,主要表现为毛细血管袢的严重畸型及其内血流速度缓慢。本结果证实了高血压病理过程中存在着血液流变学异常及微循环障碍。这种改变与病情发展有关。提示其对高血压病理过程的影响。     

突发性耳聋、梅尼埃病的甲皱微循环和血液流变学初步观察

选择突发性耳聋（突聋）患者４０例，梅尼埃病３０例，均于清晨空腹抽血作血液流变学检查，同时观察其甲皱微循环情况。选择１２５例健康人作为对照组，均作甲皱微循环和血液流变学的各项检查。结果显示：突聋和梅尼埃病组的甲皱微循环血管袢与对照组相比，最有意义的是袢顶明显增宽及异常袢出现比率明显增加（Ｐ＜０．００１），并且有２／３患者的血管袢属于重度异常；血流状态二者均属于粒流或粒缓流，红细胞呈粒团或絮团状，所以导致血流速度变慢，与正常人相比差异明显（Ｐ＜０．００１）。说明该类患者微血管与正常人相比有明显异常。…     

巯甲丙脯氨酸对心脏负荷及微循环的影响

观察了20例慢性心衰患者口服疏甲丙脯氨酸前后的血液动力学及甲皱徽循环的变化,发现用药前后患者的心功能改善,MAP、PWP、LVEOp、TPR、HR、HRP、肺血管阻力明显下降(P<0.01),以反映左室前负荷的LVEOP、PWP下降为突出。sv、co、EF、sw增加(P<0.01～0.05)。甲皱微循环血流速度加快(P< 0.05),血流状态,管袢颜色改善。     

中西医结合治疗血栓闭塞性脉管炎临床及实验研究

对55例血栓闭塞性脉(管支(TAO)患者进行了血液流变学8项指标及甲皱微循环检测，并以健康者作对比观察。结果：①TAO组多项流变学及甲皱微循环指标高于健康人组(P<0．05)；②TAO临床分期之间其流变学各值亦有明显差别(P<0．05)，③治疗前后血液流变学及甲皱微循环各值亦存在明显差异(P<0．05)。总有效率92．7％，截肢率为7．3％。表明血液流变学检测能反映临床病情轻重，可作为临床分期、中西医辨证分型的客观参考指标。血液流变学及甲皱微循环的检测为活血化瘀治疗、判定疗效及预后提供科学依据。     

舌诊与甲皱微循环关系

对比观察26例淡红舌与35例青紫舌患者舌象与甲皱微循环,结果青紫舌组的血管张力、管袢流态、袢顶血流的异常率均显著高于淡红舌组(P<0.05)。认为舌色与甲皱微循环的密切关系有助于诊断及辨证用药。     

肺心病患者甲皱微循环和肺动脉压的同步观察研究

对17例肺心病患者和10例慢性阻塞性肺疾病患者的甲皱微循环和肺动脉压进行同步观察。结果慢性阻塞性肺疾病患者甲皱微循环视野清晰,血管排列整齐,异形管袢出现率较低(5.8％);肺心病患者有半数甲皱微循环视野不清晰,异形管袢出现率较高(29.5％)管袢数减少;甲皱微循环的变化与肺动脉压之间呈明显的负相关(γ=-0.8095)。     

125例尿毒症肾阳虚患者舌象与血透前后舌、甲皱微循环观察

用WZD-1型微循环显微镜,观察尿毒症肾阳虚患者同一次血透前、后的舌尖和甲皱微循环。结果表明:微循环障碍、代谢产物含量升高和水潴留是尿毒症肾阳虚的病理基础;舌尖微血管管袢渗出是舌胖大有齿痕的形成原因之一;血透前甲皱微血管管袢流态明显异常,血透后微循环障碍明显好转,甲皱微循环加权积分值由中度异常(4.99±1.52)下降到大致正常(1.98±0.97)范围(P<0.01)。微循环是反映尿毒症肾阳虚病理变化的敏感指标。     

脑血栓患者甲襞微循环及血液流变学分析

<正> 脑血栓是中老年人的常见病,本文就30例脑血栓患者进行甲襞微循环及血液流变学检测,发现微循环障碍、血液流变学的改变(如凝固性、高粘滞状态)是疾病发生发展的主要因素。为了探讨对脑血栓的预测、诊断、早期     

2型糖尿病周围神经病变患者甲襞微循环变化特点

目的探讨2型糖尿病(T2DM)周围神经病变(DPN)患者甲襞微循环的变化特点。方法住院T2DM患者600例,根据肌电图结果分为DPN组488例和无DPN(NDPN)组112例,另选择30例正常人作为健康对照组,检查3组的甲襞微循环形态、流态、血管周围状态等指标,并进行比较。结果 (1)微循环特征:与健康对照组比较,DPN组和NDPN组甲襞微循环形态和袢周积分明显升高(P<0.01);与NDPN组比较,DPN组袢周积分和总积分升高(P<0.01)。(2)甲襞微循环表现:与健康对照组比较,2组患者袢周渗出、出血积分升高,DPN组管袢数、乳头积分升高,袢顶直径减小(P<0.05,P<0.01),且DPN组袢顶直径和乳头积分与NDPN组比较差异亦有统计学意义(P<0.05)。(3)病变程度:2组患者甲襞微循环正常者比例明显低于健康对照组(P<0.01),DPN组中度异常的比例高于NDPN组(52.9%vs 19.6%,P<0.01),正常者和轻度异常者比例低于NDPN组(分别为13.5%vs 31.2%,25.0%vs 43.8%,P<0.01)。结论 T2DM患者均存在甲襞微循环异常,DPN患者甲襞微循环异常更为严重,可能是DPN的病因之一。     

64例寒冷性荨麻疹患者甲襞微循环及血液流变学关系的研究

目的；探讨寒冷性荨麻疹患微循环及血液流变学之间的关系。方法；采用微循环测定仪血液粘度计，血栓形成等仪器观察血管袢数管径，管袢的形态，血液流变学等近20项指标。结果；甲襞微循环16项指标明显增高，血液流变学，血比粘度等四项指标也明显增高，与正常人相比差异非常显．P<0.01。结论：寒冷性荨麻疹与微循环障碍及血液流变的高凝状态密切相关。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

Development on Adjustable Calibration Marker for Shock Wave Focus

Shock wave lithotripsy （SWL） is a treatment of choice for upper urinary stones. However, this procedure is inappropriate for obese patients because the focus is often unable to reach the target owing to the limited focal distance in shock wave source. Although treating such patients in a blast path may increase the application length of shock wave source, it＇s difficult to find this path on the lithotripter monitor. For this reason, we invented an adjustable calibration marker in order to set an effective focus in the shock wave hath.     

Study on the TCM Pathogenesis of Angiopathic Complications of Type II Diabetes

Excess production of reactive oxygen species(ROS)of mitochondrion mediated by hyperglycemia is the common pathogenesis of angiopathic complications of diabetes.TCM holds that the damp from the dysfunction of spleen.kidney and liver is the causative factor of complications of diabetes.This is similar to the mechanism of Ros resulting in angiopathic complications of diabetes.When the angiopathic complications of type II diabetes mellitus(T2DM)are difierentiated as caused by turbid damp in TCM can be explained as ROS.Since the obstruction of pathogenic damp in channels and collaterals is said to be the main pathogenesis,the treating principle should be dissolving the damp to remove the obstruction.     

Leptin, Ghrelin and TNF-α before and after Hypo-caloric Traditional Chinese Diet and Auricular Acupuncture

INTRODUCTION Obesity is a complex emergent problem, which can be possibly solved not only by the diet but also by the life style and promotion of a constant physical exercise. 1, 2 No doubt careful attentions must be given to the nutritional condition of obese people, the dietary habits, the somatic build (i.e. distribution of fat mass) and the organic functions linked to formation of the fat mass. All the parameters should be constantly monitored before, during and after a diet treatment. 3, 4, 5     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

Relationship between Dysglycemia and Carotid Atherosclerosis in Tibetan Population

People with dysglycemia are at high risk for atherosclerotic diseases. This study aims at investigating the atherosclerotic vascular damage in dysglycemia and its metabolic origin in Tibetan population.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

CLINICAL SIGNIFICANCE OF SERUM CYTOKINES IL-1β,sIL-2R,IL-6,TNF-α,AND IFN-v IN ACUTE CORONARY SYNDROME

Objectives To explore serum cytokines levels (including IL-1 β, sIL-2R, IL-6, TNF-α, and IFN-v) and their significance in patients with acute coronary syndrome (ACS) and the subsequent follow-ups, with attempt to estimate the role of various serum inflammatory markers in the diagnosis and assessment of ACS.Methods The study population include 40 patients with acute myocardial infarction (AMI), 40 patients with unstable angina pectoris (UAP), and 40 controls. Among the 80 patients, 60 patients attended a follow up 4 months later. Serum inflammatory markers including IL-1 β, sIL-2R, IL-6, TNF-α, and IFN-v were measured by enzyme linked immunosorbent assay.Results Serum IL- 1 β, sIL-2R, IL-6, TNF-α were significantly higher in AMI group or UAP group compared to the control group and became significantly lower 4 months later in the follow-up patients. Serum levels of IFN-v shows no significant difference between AMI group or UAP group and controls, also showing no significant change when measured in follow up patients. There was no correlation between serum creatine kinase-MB isoenzyme levels and serum inflammatory markers either in UAP or AMI group. Furthermore, when divided into two subgroups using Wagner's QRS scoring system in the AMI group, there is no difference of each serum inflammatory marker between ≤ 6 scores group and ＞ 6 scores group.Conclusion Serum levels of certain inflammatory markers may have some diagnostic value for ACS, and can be a useful marker reflecting disease stability.     

Possible Spread of adenovirus type 3 from poultry to humans ：indirect evidence from an outbreak in China

Objective:To explore the epidemiology and etiology for an outbreak of acute respiratory tract infection that occurred in one county of Jiangsu Province, China 2004. Methods: Only cases meeting the case definition were included in the study. We reviewed the medical records of the cases who were admitted to the local hospitals, interviewed cases by a standard questionnaire, and then described the epidemiotogic features and analyzed risk factors by means of a case-control study. We collected pharyngeal swab specimens and sent them to different laboratories for isolation and culture. The laboratory used different detection methods such as DIP, PCR, electron microscope examination and microneutralization assay, to identify and then type the positive specimens. Results:A total of 871 cases were reported during the period from April 18 to July 4,2004. The distribution of onset times presented two peaks, one in late May and another in middle June. The epidemic occurred mainly in the elementary and junior high schools in ten townships of one county, and the mean age of the cases was 12 years (range 7 months to 18 years). The course of the disease was acute, and was characterized by fever accompanied with sore throat and tonsillitis. The WBC count of cases was normal or elevated. The mean duration of illness was 5 days (range 2 to 12 days). No fatalities from illness were reported. A case-control study indicated that the possible risk factors were close contact with a case and/or poultry before onset and sharing of towels among members of the family. The typical CPE was observed through inoculating pharyngeal swab specimens into the HEP-2 cell cultures in different laboratories. An infection of adenovirus type 3 was verified by detecting positive specimens in different methods. Conclusion:This investigation demonstrated that the acute respiratory infection in cases was caused by adenovirus type 3. Cases occurred in over 70 schools in ten townships in 2004, and the route of transmission was possibly close contact with cases or droplet transmission.