共查询到20条相似文献,搜索用时 0 毫秒
1.
Two new steroidal saponins from the biotransformation product of the rhizomes of Dioscorea nipponica
Li-Juan Zhang He-Shui Yu Li-Ping Kang Bing Feng Bo Quan Xin-Bo Song 《Journal of Asian natural products research》2013,15(7):640-646
Two new steroidal saponins, dioscins E (1) and F (2), along with nine known steroidal saponins, were isolated from the biotransformation product of the rhizomes of Dioscorea nipponica using Aspergillus oryzae. The structures of new compounds were established as 25(R)-spirost-5-en-21β-methyl-3β-ol-3-O-α- l-rhamnopyranosyl-(1 → 4)-β-d-glucopyranoside (1) and (25R)-spirost-5-en-3β-ol-7-one 3-O-α- l-rhamnopyranosyl-(1 → 4)-β-d-glucopyranoside (2) by detailed spectroscopic analyses including 1D and 2D NMR spectral data (1H–1H COSY, HSQC, and HMBC) and MS spectrometry. 相似文献
2.
Two new steroidal saponins from the rhizomes of Dioscorea panthaica and their cytotoxic activity. 总被引:3,自引:0,他引:3
Two new steroidal saponins, dioscoresides C (1) and D (2), along with a new natural product, pregnadienolone 3-O-beta-gracillimatriose (3), and two known compounds, pregnadienolone 3-O-beta-chacotrioside (4) and pseudoprotodioscin (5), were isolated from the rhizomes of Dioscorea panthaica Prain et Burkill. On the basis of extensive NMR studies and chemical evidence, dioscoresides C and D were determined to be 26-O-beta-D-glucopyranosyl-3 beta,26-dihydroxy-23(S)-methoxy-25(R)-furosta-5,20(22)-dien-3-O-alpha-L-rhamnopyranosyl-(1-->2)-[alpha-L-rhamnopyranosyl-(1-->4)]-beta-D-glucopyranoside and 26-O-beta-D-glucopyranosyl-3 beta,26-dihydroxy-20,22-seco-25(R)-furosta-5-en-20,22-dine-3-O-alpha-L-rhamnopyranosyl-(1-->2)-[alpha-L-rhamnopyranosyl-(1--> 4)]-beta-D-glucopyranoside. These compounds showed mild cytotoxicity against the cancer cell lines, A375, L929, and HeLa, in a dose-dependent manner. 相似文献
3.
4.
Lan Su Sheng-Guang Feng Li Qiao Yu-Zhi Zhou Rui-Ping Yang 《Journal of Asian natural products research》2013,15(1):38-43
Two new steroidal saponins and two known flavonoid glycosides were isolated from the fruits of Tribulus terrestris. Their structures were assigned by spectroscopic analysis and chemical reaction as 26-O-β-d-glucopyranosyl-(25R)-5α-furostan-12-one-3β,22α,26-triol-3-O-β-d-glucopyranosyl (1 → 2)-β-d-glucopyranosyl(1 → 4)-β-d-galactopyranoside (1), 26-O-β-d-glucopyranosyl-(25S)-5α-furostan-22-methoxy-2α,3β,26-triol-3-O-β-d-glucopyranosyl(1 → 2)-β-d-glucopyranosyl(1 → 4)-β-d-galactopyranoside (2), kaempferol-3-gentiobioside (3), and isorhamnetin-3-gentiobioside (4). 相似文献
5.
Two novel steroidal saponins designated as spicatosidesA(1) andB(2) were isolated from the tubers ofLiriope spicata and their structures were clucidated as 25(S)-ruscogenin-1-O-β-D-glucopyranosyl (1→2)-[β-D-xylopyranosyl (1→3)]-β-D-fucopyranoside (1) and 26-O-β-D-glucopyranosyl 25(S)-22-O-methyl-furost-5-en-1β, 3β, 26-triol 1-O-β-D-glucopyranosyl (1→2)-[β-D-xylopyranosyl (1→3)]-β-D-fucopyranoside (2), respectively. 相似文献
6.
Jia-Chuan Liu Li-Li Yu Ming-Xu Tang Xiao-Jie Lu Dan Zhao Hai-Feng Wang 《Journal of Asian natural products research》2013,15(9):875-882
AbstractAs a part of our continuing research for bioactive constituents from Cynanchum limprichtii Schltr., two new C21 steroidal glycosides limproside A (1) and limproside B (2) were isolated from the roots of Cynanchum limprichtii. Their structures were elucidated on the basis of 1D- and 2D-NMR spectroscopic data as well as HR-ESI-MS analysis. The cytotoxicity of two compounds against two selected human cancer cell lines was assayed. 相似文献
7.
Tao Liu Xuan Lu Biao Wu Gang Chen Hui-Ming Hua 《Journal of Asian natural products research》2013,15(1):30-35
Two new steroidal saponins were isolated from the fruits of Tribulus terrestris L. Their structures were elucidated by spectroscopic and chemical analysis as (23S,24R,25R)-5α-spirostane-3β,23,24-triol-3-O-{α-l-rhamnopyranosyl-(1 → 2)-[β-d-glucopyranosyl-(1 → 4)]-β-d-galactopyranoside} (1) and (23S,24R,25S)-5α-spirostane-3β,23,24-triol-3-O-{α-l-rhamnopyranosyl-(1 → 2)-[β-d-glucopyranosyl-(1 → 4)]-β-d-galactopyranoside} (2). 相似文献
8.
知母中的两种新呋甾皂苷 总被引:5,自引:0,他引:5
目的研究知母根茎的化学成分。方法采用水煎提取、大孔吸附树脂SP825柱色谱、反相C18柱色谱等进行分离,并通过化学手段和光谱分析(FAB-MS,1H NMR,13C NMR,1H-1H COSY)鉴定其化学结构。结果从知母根茎中分离得到6种甾体皂苷,分别鉴定为:(25S)-26-O-β-D-吡喃葡糖基-22-羟基-5β-呋甾-2β,3β,26-三醇-3-O-β-D-吡喃葡糖基-(1→2)-β-D-吡喃半乳糖苷(知母皂苷N,1),知母皂苷El(2),(25S)-26-O-β-D-吡喃葡糖基-22-甲氧基-5β-呋甾-2β,3β,26-三醇-3-O-β-D-吡喃葡糖基-(1→2)-β-D-吡喃半乳糖苷(知母皂苷O,3),知母皂苷E2(4),(25R)-26-O-β-D-吡喃葡糖基-22-羟基-5α-呋甾-2α,3β,26-三醇-3-O-β-D-吡喃葡糖基-(1→2)-[β-D-吡喃木糖基-(1→3)]-β-D-吡喃葡糖基-(1→4)-β-D-吡喃半乳糖苷(purpureagitosid,5),marcogenin-3-O-β-D-glucopyranosyl-(1→2)-β-D-galactopyranoside (6)。结论化合物1和3为新化合物,命名为知母皂苷N和知母皂苷O,化合物5为首次从知母中分离得到。 相似文献
9.
《沈阳药科大学学报》2016,(6):438-443
目的对绵萆薢的化学成分进行研究。方法将大孔吸附树脂、硅胶、Sephadex LH-20、正相硅胶、ODS等柱色谱与制备型高效液相色谱法相结合进行化合物的分离制备,并通过理化性质与核磁共振波谱数据鉴定化合物的结构。结果从绵萆薢中分离鉴定了12个单体成分,分别鉴定为原薯蓣皂苷(protodioscin,1)、甲基原薯蓣皂苷(methyl protodioscin,2)、原纤细皂苷(protogracillin,3)、甲基原纤细皂苷(methyl protogracillin,4)、伪原薯蓣皂苷(pseudoprotodioscin,5)、伪原纤细皂苷(pseudoprotogracillin,6)、26-O-β-D-glucopyranosyl-3β,23,26-triol-25(R)-furosta-5,20(22)-dien-3-O-α-L-rhamnopyranosyl(1→4)-[α-L-rhamnopyranosyl-(1→2)]-β-D-glucopyranoside(7)、豆甾醇(stigmasterol,8)、β-谷甾醇(β-sitosterol,9)dioscoreavilloside A(10)、绵萆薢苷B(spongioside B,11)及粉背薯蓣G(hypoglaucin G,12)。结论在对绵萆薢的化学成分进行研究的过程中,分离鉴定了12个甾体类化合物。其中化合物5~8和10为首次从该种植物中分离得到,并首次对化合物7的核磁数据进行了报道。 相似文献
10.
Two new steroidal saponins, diosbulbisides D (1) and E (2), along with five known saponins (3- 7) were isolated from the rhizomes of Dioscorea bulbifera L. Their structures were elucidated on the basis of spectral data. Compounds 6 and 7, two 3- O-trisaccharides of diosgenin spirostanes, showed moderate cytotoxic activity against human hepatocellular carcinoma cells, with IC?? values of 3.89 μM and 7.47 μM on SMMC7721, and 10.87 μM and 19.10 μM on Bel-7402 cell lines, respectively. 相似文献
11.
Xiao-Liang Zhao Xiao-Jun Ma Wen-Guang Jing Qi-Wei Zhang Zhi-Min Wang 《Journal of Asian natural products research》2013,15(7):659-664
A new steroidal saponin and three known saponins were isolated from the rhizomes of Dioscorea panthaica. Their structures were elucidated as 3-O-[α-l-rhamnopyranosyl-(1 → 2)-β-d-glucopyranosyl]-26-O-β-d-glucopyranosyl-20,22-seco-25(R)-furosta-5-ene-20,22-dione-3β,26-diol (1), pregnadienolone-3-O-β-chacotriside (2), pseudoprotodioscin (3), and dioscoreside D (4) mainly by NMR techniques and chemical methods. The inhibitory activities of the saponins against α-glucosidase were investigated, and compound 2 was found to exhibit potent activity with IC50 values of 0.04 ± 0.01 mM. 相似文献
12.
A new steroidal saponin has been isolated from the rhizomes of Costus spicatus and its structure was elucidated as (3 beta, 22 alpha, 25R) -26-(beta-D-glucopyranosyloxy)-2-methoxyfurost-5-en-3-yl O-D-apio-beta-D-furanosyl-(1-->4)-O-[alpha-L-rhamnopyranosyl-(1--> 2)]- beta-D-glucopyranoside by means of IR, MS, NMR and chemical evidence. 相似文献
13.
Shuo Shen Chao-Jun Chen Ren Bu Lu Ga Guo-Yu Li Yong Tan 《Journal of Asian natural products research》2013,15(11):1014-1022
Three new steroidal saponins, pallidiflosides A (1), B (2), and C (3), have been isolated from the dry bulbs of Fritillaria pallidiflora Schrenk. Their structures were elucidated as 26-O-β-d-glucopyranosyl-(25R)-furost-5,20(22)-dien-3β,26-diol-3-O-β-d-xylopyranosyl(1 → 4)-[α-l-rhamnopyranosyl(1 → 2)]-β-d-glucopyranoside (1); 26-O-β-d-glucopyranosyl-3β,26-dihydroxyl-20,22-seco-25(R)-furost-5-en-20,22-dione-3-O-α-l-rhamnopyranosyl(1 → 2)-β-d-glucopyranoside (2); and (25R)-spirost-5-ene-3β,17α-diol-3-O-β-d-glucopyranosyl(1 → 4)-β-d-galactopyranoside (3) by spectroscopic techniques and chemical means. 相似文献
14.
Shen S Chen CJ Bu R Ga L Li GY Tan Y Li X Wang JH 《Journal of Asian natural products research》2011,13(11):1014-1022
Three new steroidal saponins, pallidiflosides A (1), B (2), and C (3), have been isolated from the dry bulbs of Fritillaria pallidiflora Schrenk. Their structures were elucidated as 26-O-β-d-glucopyranosyl-(25R)-furost-5,20(22)-dien-3β,26-diol-3-O-β-d-xylopyranosyl(1?→?4)-[α-l-rhamnopyranosyl(1?→?2)]-β-d-glucopyranoside (1); 26-O-β-d-glucopyranosyl-3β,26-dihydroxyl-20,22-seco-25(R)-furost-5-en-20,22-dione-3-O-α-l-rhamnopyranosyl(1?→?2)-β-d-glucopyranoside (2); and (25R)-spirost-5-ene-3β,17α-diol-3-O-β-d-glucopyranosyl(1?→?4)-β-d-galactopyranoside (3) by spectroscopic techniques and chemical means. 相似文献
15.
盾叶薯蓣难溶性甾体皂苷的提取及其抑制人肝癌细胞HepG2增殖的研究 总被引:1,自引:0,他引:1
目的 研究盾叶薯蓣水难溶性提取物的化学成分及对人肝癌细胞HepG2生长的抑制作用.方法 采用正、反相硅胶柱色谱方法分离纯化水难溶性提取物的单体化合物,并通过波谱学方法鉴定其结构;采用MTT法评价其体外抑制人肝癌细胞的增殖作用.结果 采用化学方法分离并鉴定了5个化合物,分别是薯蓣皂苷元(Ⅰ)、延令草皂苷(Ⅱ)、薯蓣皂苷元纤维二糖苷(Ⅲ)、三角叶皂苷(Ⅳ)和盾叶皂苷Ⅰ(Ⅴ);5个化合物对人肝癌细胞的增值具有明显的抑制作用,其中化合物V对人肝癌细胞HepG2的生长抑制作用最强.结论 盾叶皂苷Ⅰ具有明显的抗癌活性. 相似文献
16.
薯蓣属植物化学成分的研究——Ⅹ.蜀葵叶薯蓣中甾体皂甙和皂甙元的分离和鉴定 总被引:1,自引:0,他引:1
Four components were isolated from acid-treated rhizome of Dioscorea althaeoides Kunth. Their structures were identified as diosgenin (Ⅰ), β-sitosterol (Ⅱ), diosgenin palmitate (Ⅲ) and △3,5-deoxytigogenin (Ⅳ) on the basis of physical constants and spectral data.Two sparingly soluble steroid saponins were also isolated from this plant Their physicochemical constants showed that one of them is dioscin (Ⅴ) and the other graeillin (Ⅵ). 相似文献
17.
18.
薯蓣属植物化学成分的研究——Ⅱ.叉蕊薯蓣中甾体皂甙的分离和鉴定 总被引:6,自引:0,他引:6
从叉蕊薯蓣(D.collettii HooK.f.)根茎的乙醇提取物分离到四个甾体皂甙,根据理化性质、光谱数据,推定化学结构为3-O-(β-D-葡萄吡喃糖)-约莫皂甙元(3-O-(β-D-glucopyranosyl)-yamogenin)[Ⅰ];3-O-[α-L-鼠李吡喃糖(1→4)-β-D-葡萄吡喃糖]-约莫皂甙元(3-O-[α-L-rahmnopyranosyl(1→4)-β-D-glucopyranosyl]-yamogenin)[Ⅱ];3-O-{α-L-鼠李吡喃糖(1→4)-[α-L-鼠李吡喃糖(1→2)]-β-D-葡萄吡喃糖}-约莫皂甙元(3-O-{α-L-rhamnopyranosyl(1→4)-[α-L-rhamnopyranosyl(1→2)]-β-D-glucopranosyl}-yamogenin)[Ⅲ];3-O-{β-D-葡萄吡喃糖(1→3)-[α-L-鼠李吡喃糖(1→2)3-β-D-葡萄吡喃糖}-约莫皂甙元(3-O-{β-D-glucopyranosyl(1→3)-[α-L-rhamnopyranosyl(1→2)]-β-D-glucopyranosyl}-yamogenin)[Ⅳ]。其中Ⅰ为已知物,Ⅱ、Ⅲ、Ⅳ为首次从植物界得到的新甾体皂甙。 相似文献
19.
目的:建立穿山龙总皂苷的高效液相色谱(HPLC)指纹图谱,为其质量评价提供依据。方法:测定9批不同来源的穿山龙样品。色谱柱为Kromasil C8(250mm×4.6mm,5μm),流动相为水-乙腈(梯度洗脱),流速为1.0mL·min-1,检测波长为203nm,柱温为30℃。结果:共标示出穿山龙皂苷类化合物17个特征指纹峰;不同来源的穿山龙总皂苷色谱峰峰面积比值有一定的差异。结论:HPLC指纹图谱分析法能简便、快速地区分不同来源的穿山龙,为全面控制穿山龙药材的质量提供依据。 相似文献
20.
Xue-Yan Hu Yuan-Qiang Guo Tie-Jun Zhang Hai-Xia Chen 《Journal of Asian natural products research》2013,15(5):481-484
Two new triterpenoids, 25-anhydro-alisol F (1) and 11-anhydro-alisol F (2), were isolated from the rhizomes of Alisma orientalis. Their structures were elucidated by spectroscopic methods. 相似文献