共查询到20条相似文献,搜索用时 15 毫秒
1.
Novel trans-2,2-dimethylcyclopropyl nucleosides were synthesized as potential antiviral agents. The key intermediate, 3, was synthesized via five steps from ethyl chrysanthemate and condensed with purine bases using the Mitsunobu reaction to give six cyclopropyl nucleosides. These synthesized nucleosides did not show any significant antiviral activity against HSV-1, HSV-2, EMCV, Cox B3, or VSV, at concentrations up to 100 microM. 相似文献
2.
A series of novel cyclopropyl nucleosides was synthesized using the highly stereoselective Simmons-Smith reaction starting from 1,2:5,6-di-O-isopropylidene-D-mannitol. The structural assignments of these nucleosides were determined by NMR studies and X-ray crystallography. All the synthesized nucleosides were assayed against several viruses. 相似文献
3.
Sh. A. Samsoniya M. V. Trapaidze N. A. Kuprashvili 《Pharmaceutical Chemistry Journal》2009,43(2):92-94
We have synthesized a series of new phenylazo derivatives of 1H,10H-benzo[e]pyrrolo[3, 2-g]indole containing 3-(p-bromophenylazo) (II), 3-(p-iodophenylazo) (III), 3-(p-sulfamidophenylazo) (IV), 3-formyl (V), 3,8-diformyl (VI), 3-phenylazo (VII), 3-(p-chlorophenylazo) (VIII), 3-(p-nitrophenylazo) (IX), 2,9-di(adamantylaminocarbonyl) (X), 2,9-di(p-benzenesulfamidoaminocarbonyl) (XI), 2,9-di(isonicotinoylhydrazidecarbonyl) (XII), and 2,9-di(carbohydrazide) (XIII) substituents. The antimicrobial, antifungal, and antituberculosis activity was investigated in vitro with respect to various microorganisms including conditionally pathogenic mycobacteria and pathogenic fungi. It is established
that the tested compounds possess high antimicrobial activity. The synthesized compounds are of great interest for further,
more thorough investigations and experiments on animals with the corresponding infectious diseases.
Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 43, No. 2, pp. 23–25, February, 2009. 相似文献
4.
Ya. F. Kopyt’ko 《Pharmaceutical Chemistry Journal》2008,42(11):647-649
Methods of standardization and quality control of homeopathic matrix tinctures of Coffea arabica and Coffea tosta obtained using green and roasted coffee beans are described. They include the organoleptic characteristics, qualitative reactions,
TLC, quantitative estimation of caffeine and total phenolcarboxylic acids (calculated as caffeic acid), relative density,
and percentage of dry residue. The period of expiration on storage is established at two years. These methods are included
in drafts of pharmacopoeial monographs for homeopathic matrix tinctures of Coffea arabica and Coffea tosta.
Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 42, No. 11, pp. 45–48, November, 2008. 相似文献
5.
A. A. Glukhov N. F. Kirillov A. A. Potapova R. R. Makhmudov L. G. Mardanova 《Pharmaceutical Chemistry Journal》2010,44(9):483-485
A series of 4-aroyl-1H-benzo[c]oxepin-4-ones have been prepared by heating ethyl 2-aroyl-3-(2-bromophenyl)propenoates. The synthesized compounds possess
higher analgesic activity than the reference drug (analgin) and exhibit low toxicity. 相似文献
6.
Pawadee Noiarsa Qian Yu Katsuyoshi Matsunami Hideaki Otsuka Somsak Ruchirawat Tripetch Kanchanapoom 《Journal of natural medicines》2007,61(4):406-409
A new (Z)-3-hexenyl O-β-d-glucopyranosyl-(1→6)-β-d-glucopyranoside was isolated from the aerial part of Spermacoce
laevis, along with 17 known compounds: (6S,9R)-roseoside, (Z)-3-hexenyl O-β-d-glucopyranoside, (Z)-3-hexenyl O-α-l-rhamnopyranosyl-(1→6)-β-d-glucopyranoside, (Z)-3-hexenyl O-α-l-arabinopyranosyl-(1→6)-β-d-glucopyranoside, phenyethyl O-β-d-glucopyranoside, phenyethyl O-α-l-arabinopyranosyl-(1→6)-β-d-glucopyranoside, phenyethyl O-α-l-rhamnopyranosyl-(1→6)-β-d-glucopyranoside, benzyl O-α-l-arabinopyranosyl-(1→6)-β-d-glucopyranoside, benzyl O-β-d-xylopyranosyl-(1→6)-β-d-glucopyranoside, asperuloside, 6α-hydroxyadoxoside, asperulosidic acid, kaempferol 3-O-β-d-glucopyranoside, kaempferol 3-O-rutinoside, quercetin 3-O-β-d-galactopyranoside, quercetin 3-O-α-l-rhamnopyranosyl-(1→6)-β-d-galactopyranoside, and rutin. The structure determinations were based on physical data and spectroscopic evidence. 相似文献
7.
M. A. Iradyan N. S. Iradyan R. V. Paronikyan G. M. Stepanyan 《Pharmaceutical Chemistry Journal》2010,44(8):413-417
A series of substituted 6-alkyl(6H)-3-phenyl-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazines have been synthesized by reaction of 3-alkyl-4-amino-5-thio-1,2,4-triazoles with substituted phenacylbromides
in the presence of an equimolar amount of KOH. Mass spectra for the dissociative ionization by electron impact, antibacterial
activity, and antitumor properties of the synthesized compounds have been studied. It was established that some compounds
at doses of 50 – 100 mg/kg decrease the growth of sarcomas 45 and 37 by 35 – 47%. 相似文献
8.
Tetsuya Kodai Yoshinori Horiuchi Yasuhiro Nishioka Naoki Noda 《Journal of natural medicines》2010,64(2):216-218
A novel cycloartane-type triterpenoid was isolated from the fruits of Nandina domestica (Berberidaceae). The structure was characterized as 24-methylene-3-oxocycloartane 13-carboxylic acid on the basis of NMR
spectroscopic data. 相似文献
9.
Hardik S. Bodiwala Gaganmeet Singh Ranvir Singh Chinmoy Sankar Dey Shyam Sundar Sharma Kamlesh Kumar Bhutani Inder Pal Singh 《Journal of natural medicines》2007,61(4):418-421
The n-hexane, ethyl acetate, methanol, and acetone extracts of Piper cubeba Linn. and P. retrofractum Vahl. (Piperaceae) were evaluated in vitro against promastigotes of Leishmania donovani, and all exhibited significant in vitro activity at 100 μg/ml. Two lignans, cubebin and hinokinin, were isolated from the
hexane extract of P. cubeba; and one bis-epoxy lignan, (−)-sesamin, and two amides, pellitorine and piplartine, were isolated from the hexane and methanol
extracts of P. retrofractum. Cubebin and piplartine showed significant antileishmanial activity in vitro at 100 μM and were further tested in vivo in
a hamster model of visceral leishmaniasis. Piplartine showed activity at 30 mg/kg dose. This is the first report of antileishmanial
activity of these two plants and their isolated constituents.
NIPER Communication No. 395. 相似文献
10.
E. R. Kurbatov A. V. Kurochkin L. M. Korkodinova B. Ya. Syropyatov L. N. Markova 《Pharmaceutical Chemistry Journal》2008,42(12):674-676
A series of new 3,1-benzoxazin-4(3H)-ones were synthesized and N-acyl-5-iodoanthranilic acid amides derived from them were obtained in a search for new biologically active derivatives of
anthranilic acid. The anti-inflammatory activity of these compounds was evaluated. It is established that these classes of
compounds are promising for further research on biologically active substances possessing anti-inflammatory activity.
Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 42, No. 12, pp. 19–18, December, 2008. 相似文献
11.
Bohang Sun Bailing Hou Jian Huang Lijun Wu Masonori Kuroyanagi Huiyuan Gao 《Archives of pharmacal research》2008,31(12):1530-1533
Further chemical study led to two new A-seco-rearranged lanostane triterpenoid derivatives (1–2) and one known compound Abiesanolide C (3) from the ethyl acetate (EtOAc) soluble fraction of the MeOH extract of Abies sachalinensis needles. The new compounds were identified as 3,4-seco-8-(14→13R)abeo-17,13-friedo-9β-lanosta-4(28), 7, 14, 24-tetraen-26,23-olide-23-hydroxy-3-oic acid and methyl-3,4-seco-8-(14→13R) abeo-17,13-friedo-9β-lanosta-4(28), 7, 14, 24-tetraen-26,23-olide-23-hydroxy-3-oate, respectively. Structural determination of these compounds
were carried out by the spectral studies especially by the two digital (2D)-NMR and high-resolution (HR)-MS experiences. 相似文献
12.
E. A. Oganesyan I. I. Miroshnichenko N. S. Vikhrieva A. A. Lyashenko S. Yu. Leshkov 《Pharmaceutical Chemistry Journal》2010,44(2):74-76
Resveratrol is a substance of plant origin with antioxidant, anti-inflammatory, and chemoprotective properties used as a biologically
active supplement in the prophylaxis of myocardial infarction, types 1 and 2 diabetes, and tumors. The aim of the present
work was to develop and perform pharmacokinetic studies of a nanosomal form of resveratrol. The techniques described here
yield particles of submicron size, with resveratrol yields of 70–100% and resveratrol contents in lyophilized formulations
reaching 15–20%. After oral administration of unmodified resveratrol to mice, only 19% of the dose was taken up into the blood,
while use of nanosomal resveratrol formulations based on Eudragit RL and lecithin/chitosan increased bioavailability to 39%
and 61% respectively. Increases in the peak plasma resveratrol concentration by factors of 4–5 were also seen in mice given
nanoparticles. Thus, conversion of resveratrol to the nanosomal form leads to solubilization and resultant increases in absorption
into the bloodstream. 相似文献
13.
R. G. Glushkov S. D. Yuzhakov M. V. Alekseev L. N. Dronova E. N. Salin N. I. Andreeva V. V. Asnina 《Pharmaceutical Chemistry Journal》2011,45(3):131-136
It is established that succinic acid is capable of potentiating (synergism) the antihypoxic activity of 3-hydroxypyridine
derivatives such as the succinate (Ia) and hydrochloride (Ib) of 3-(N,N-dimethylcarbamoyloxy)- 2-ethyl-6-methylpyridine. This effect makes it expedient to create new drugs containing a mixture
of Ia or Ib and succinic acid derivatives that would possess antihypoxic, antiamnestic, and anticonvulsant activity. The antihypoxic
activity of 3-hydroxypyridine drugs increases in the order emoxypin < mexidol < proxypin < Ia + succinic acid < Ib + succinic
acid. 相似文献
14.
15.
Hitomi Sakai Rie Kakuda Yasunori Yaoita Masao Kikuchi 《Journal of natural medicines》2007,61(2):226-228
Seven secoiridoid glycosides, secologanin dimethyl acetal (1), n-butyl vogeloside (2), n-butyl epi-vogeloside (3), (7R)-n-butyl morroniside (4), hydrangenoside A (5), hydrangenoside C (6), and hydrangenoside A dimethyl acetal (7), have been isolated from the leaves of Hydrangea macrophylla subsp. serrata (Thunb.) Makino (Saxifragaceae). The structures were elucidated on the basis of spectral data. 相似文献
16.
F. A. Khaliullin Yu. V. Shabalina G. G. Davlyatova L. A. Valeeva 《Pharmaceutical Chemistry Journal》2018,51(12):1049-1052
17.
18.
19.
G. F. Krainova Yu. B. Vikharev L. V. Anikina E. V. Sivtseva V. A. Glushkov 《Pharmaceutical Chemistry Journal》2009,43(11):606-609
A series of substituted 5-dialkylaminoacetyl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolines were synthesized by amination of the corresponding 5-chloroacetyl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolines. The acute toxicity, analgesic activity, and influence of the obtained compounds on the locomotor and exploratory
activity in the open-field test were studied. 相似文献