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Wilkiemeyer MB Bieligk SC Ashfaq R Jones DB Rege RV Fleming JB 《Surgical endoscopy》2004,18(5):852-856
Background Laparoscopy identifies metastatic disease in patients with upper gastrointestinal malignancies; however, it has been suggested that cytological examination of peritoneal washings may increase the diagnostic yield. We hypothesize that the addition of cytologic washings to a standardized staging laparoscopy is unnecessary for the identification of intraabdominal metastasis in patients with gastric/esophageal cancer.Methods Forty patients with gastric/esophageal cancer were prospectively evaluated. Patients successfully underwent a diagnostic laparoscopy protocol (with biopsies) during which peritoneal washings were obtained and processed for cytologic analysis. Laparoscopic versus cytologic identification of intraabdominal metastasis were compared.Results Forty patients successfully completed laparoscopy with collection of peritoneal washings. Laparoscopic examination of the peritoneal cavity upstaged 21 (52.5%) patients. Laparoscopic examination consistently identified a statistically significant higher number of positive patients than cytologic examination of peritoneal washings (p = 0.001) and examination of cytologic washings alone failed to identify 45% of patients with positive findings and laparoscopy. The addition of cytologic examination added no additional stage IV patients to the laparoscopy-negative group.Conclusion A standardized laparoscopic examination alone is sufficient for the identification of intraabdominal metastatic disease in patients with gastric and esophageal cancer.Paper presented at the ninth World Congress of Endoscopic Surgery/Society of American Gastrointestinal Endoscopic Surgeons (SAGES), Los Angeles, CA, USA, March 2003 相似文献
3.
Importance of positive peritoneal lavage cytology findings in the stage grouping of gastric cancer 总被引:11,自引:0,他引:11
Suzuki T Ochiai T Hayashi H Nakajima K Yasumoto A Hishikawa E Shimada H Horiuchi F Ohki S Isono K 《Surgery today》1999,29(2):111-115
(Received for publication on Oct. 29, 1997; accepted on July 7, 1998) 相似文献
4.
Shah D Fisher WE Hodges SE Wu MF Hilsenbeck SG Charles Brunicardi F 《The Journal of surgical research》2008,147(2):216-220
BACKGROUND: Accurate preoperative staging is essential in pancreatic cancer to select the 15% of patients who can benefit from surgery and avoid surgery in the 85% with advanced disease. With improvements in computed tomography (CT) scanning, the value of routine laparoscopy for preoperative staging of pancreatic cancer has been questioned because it changes the preoperative plan in less than 20% of unselected cases. METHODS: We retrospectively reviewed our experience with preoperative staging in 88 consecutive patients with pancreatic cancer. All patients had preoperative CT scans, and selective criteria were used to determine which patients would also undergo preoperative staging laparoscopy. Patients were categorized preoperatively as resectable or not resectable (locally advanced or metastatic). Medical records, operative, and pathology reports were reviewed to determine the accuracy of preoperative predictions. RESULTS: Thirty patients were deemed resectable based on CT alone and 27 (90%) were resected (25 R0, 2 R1). Two (7%) had metastatic disease discovered at laparotomy and one (3%) had a R2 resection. Only 19 patients (39%) of 49 patients deemed resectable by CT met our selective criteria for preoperative staging laparoscopy. Laparoscopy changed the treatment plan in 11 (58%) of these patients. Eight were still deemed resectable after staging laparoscopy and 7 (88%) were resected (6 R0, 1 R1). One patient (12%) had metastatic disease diagnosed at laparotomy. If selective staging laparoscopy were eliminated from our algorithm, 49 patients would have been deemed potentially resectable based on CT alone, 34 (69%) would have been found to be resectable at laparotomy (31 R0, 3 R1), and 15 (31%) would have been found to be unresectable at laparotomy (positive predictive value of 69%). The addition of selective staging laparoscopy avoided unnecessary laparotomy in 11 patients and increased the positive predictive value to (34/38) 89%. CONCLUSION: Selective use of laparoscopy increases the positive predictive value of preoperative staging in pancreatic cancer and avoids unnecessary laparoscopy in the majority of patients. 相似文献
5.
Staging systems for pancreatic cancer: Differences between the Japanese and UICC systems 总被引:2,自引:0,他引:2
Differences between the clinical staging system of the Japan Pancreas Society (JPS) and the Union Internationale Contre le
Cancer (UICC) stage classification may account for reported differences in the prognosis of pancreatic carcinoma between Japan
and the West. In the review, we compared the characteristics of the JPS and UICC staging in 1689 patients, registered with
the JPS from 1981 to 1990, who underwent resection for carcinoma of the pancreatic head. The survival rates correlated well
with the JPS stage classification. The UICC staging did not reflect differences in prognoses among the stages. The current
JPS staging system, introduced in 1993, still differs from that of the UICC. To compare the results of treatment for patients
with pancreatic cancer it is important to establish a more practical and universal staging system for carcinoma of the pancreas.
Received for publication on Sept 8, 1997; accepted on March 25, 1998 相似文献
6.
Laparoscopy has emerged as an important staging procedure for determining resectability of pancreatic cancer. However, a small
fraction of patients with pancreatic cancer benefit from its use and therefore the routine application of laparoscopy remains
controversial. We hypothesized that serum CA 19-9 levels may identify patients who will or will not benefit by laparoscopy.
We retrospectively reviewed our database of 63 patients with pancreatic adenocarcinoma who underwent staging laparoscopy and
correlated findings with CA 19-9 levels. Overall, laparoscopy identified metastatic disease in 12 patients (19%). None of
those required any further operation. The resectability rate (patients who underwent resection after laparoscopy) was 73.5%.
There was one false-negative laparoscopy (1.6%). Patients with higher CA 19-9 levels had significant higher odds of having
metastasis identified by laparoscopy (odds ratio, 1.83; 95% confidence interval, 1.03-3.24; P = .04). There was no patient with CA 19-9 levels below 100 U/ml in whom metastatic disease was identified during laparoscopy:
18 patients (28.6%) with CA 19-9 levels below this cutoff point had negative laparoscopy and could have avoided the procedure
had this cutoff been used for screening. This would have increased the laparoscopy yield to 26.7%. In patients with adenocarcinoma
of the pancreas, low CA 19-9 levels predict low probability of metastatic disease; in those patients, laparoscopy can be spared.
On the contrary, patients with elevated CA 19-9 have an increased probability of metastatic disease, and these patients may
benefit from diagnostic laparoscopy.
Presented at the Forty-Sixth Annual Meeting of The Society for Surgery of the Alimentary Tract, Chicago, IL, May 14–18, 2005
(poster presentation). 相似文献
7.
Background: The influence of peritoneal cytology on survival of patients with gastric cancer has not been consistent. This study was to identify risk factors for positive peritoneal cytology and to evaluate the predictive value of positive cytology among Chinese patients with advanced gastric cancer. Methods: The study included 139 patients with gastric cancer macroscopically invading the serosa, who underwent gastrectomy and intra‐operative peritoneal cytological examination. In these patients, the relationship between cytological positivity and various clinicopathological features was analysed, and survival analysis was performed to identify independent prognostic factors of significance. Results: Thirty‐eight (27.3%) of 139 patients had positive peritoneal cytology. Although tumour size, lymphovascular invasion, depth of tumour invasion, lymph node metastasis and peritoneal metastasis were correlated with positive cytology, multivariate analysis revealed the depth of tumour invasion and peritoneal metastasis as the independent features affecting the cytology. Patients with a positive cytology result were confirmed to have a greater risk for recurrence in the pattern of peritoneal carcinomatosis and a significant inferior prognosis. Multivariate analysis indicated that positive peritoneal cytology was an independent prognostic factor among the curatively resected patients with advanced gastric cancer and was the prognostic factor most predictive of death for these patients (risk ratio = 2.74). Conclusions: Positive peritoneal cytology correlated with advanced features of gastric cancer. It is an independent poor prognostic factor, and it may serve as a guide for adjuvant therapeutic options to improve the survival of gastric cancer. 相似文献
8.
Objective: To review the role of diagnostic laparoscopy (DL) for staging of malignant diseases of the liver and biliary tract. Methodology: Critical review of the current literature. Results: Analysis of the utility of DL in hepatobiliary cancers depends on several criteria, particularly in the era of high quality prelaparotomy and pre‐DL imaging. Selection criteria for DL, selection criteria for resection, definition of resectability, patterns of intra‐ and extrahepatic spread, association with underlying liver disease and frequency of indications for palliative laparotomy impact the utility of DL depending on the disease studied. Conclusions: DL has a very limited role for staging patients with colorectal liver metastases as a result of expanding definitions of resectability, multistage approaches to bilateral metastases, and methods to increase resectability such as portal vein embolization and preoperative chemotherapy. For hepatocellular carcinoma, DL can be useful for staging patients with advanced tumours and cirrhosis, and might have an emerging role for the evaluation of transplant candidates with equivocal imaging findings. For biliary cancers, DL is indicated for patients with advanced stage hilar cholangiocarcinoma and gall bladder carcinoma. 相似文献
9.
Koea J Rodgers M Thompson P Woodfield J Holden A McCall J 《ANZ journal of surgery》2004,74(12):1056-1059
BACKGROUND: This investigation was undertaken to define the value of laparoscopy in the staging of patients with colorectal carcinoma metastatic to the liver. METHODS: The clinical details of 59 consecutive patients with colorectal liver metastases undergoing laparoscopy prior to planned hepatectomy were entered prospectively on a computerized database. All patients were staged preoperatively with thin slice (5-7 mm) helical computed tomography chest, abdomen and pelvis. Synchronous metastases were defined as those found during, or on imaging carried out within 1 month of, colorectal resection. Criteria for laparoscopic unresectability were: (i) histologically proven extrahepatic disease; (ii) bilateral inflow or outflow involvement; (iii) the presence of cirrhosis in patients requiring an extended resection (lobectomy or greater); or (iv) hepatic metastases involving more than six hepatic segments. RESULTS: In 24 patients with synchronous metastases (median age 65 years, range 32-81 years) all were resectable on laparoscopic criteria, of whom 21 were resected. Extrahepatic disease was found at laparotomy in three patients. In 35 patients with metachronous metastases (median age 64 years, range 32-81 years) laparoscopy could not be performed in five patients because of adhesions, and three patients were deemed unresectable on laparoscopic criteria. Of the remaining 27 patients, 25 underwent resection while two proved unresectable. Overall eight of 54 evaluable patients had unresectable disease and laparoscopy correctly identified three patients. CONCLUSIONS: Following computed tomography scan, 15% of patients with metastatic colorectal carcinoma will be found to have unresectable disease. Laparoscopy will identify approximately half. Laparoscopy is of no greater value in staging synchronous versus metachronous metastases. 相似文献
10.
The effects of staging laparoscopy on trocar site and peritoneal recurrence of pancreatic cancer 总被引:3,自引:2,他引:1
Velanovich V 《Surgical endoscopy》2004,18(2):310-313
Background: Staging laparoscopy (SL) has been used to assess resectability of patients with pancreatic cancer. It has lead to increased resectability rates and decreased morbidity. However, experimental data suggests that laparoscopy and peritoneal insufflation can promote tumor growth and potential recurrence. Few clinical data exist to allow assessment of whether these theoretical concerns translate into clinical problems. The purpose of this study was to determine if SL increases the incidence of trocar-site and peritoneal recurrence of pancreatic cancer. Methods: A retrospective review of all patients evaluated for pancreatic cancer from 1996 to 2001, inclusive, was included in this study. Patients were divided into five groups: nonoperative management (NM), SL followed by resection (SL-R), SL without resection (SL-NR), exploratory laparotomy with resection (EL-R), and exploratory laparotomy without resection (EL-NR). Patient records were assessed for postoperative occurrence of carcinomatosis and/or malignant ascites, trocar- or incisional-site recurrence, use of postoperative chemotherapy or radiation therapy, and survival. Results: A total of 235 patients were included. Peritoneal progression of disease: NM 15.9%, SL 24.2%, EL 31.6% (p = 0.03). Trocar/incisional recurrence: SL 3.0%, EL 3.9% (p = NS). Use of chemotherapy/radiotherapy: NM 29.4%, SL-R 76.5%, SL-NR 62.5%, EL-R 69.6%, EL-NR 41.5%. Median survival (months): NM 3; SL-R 15, EL-R 10 (p = NS); SL-NR 6, EL-NR 5 (p = NS). Conclusion: SL does not increase the occurrence of trocar-site disease or peritoneal disease progression of pancreatic cancer. Patients who are found not to be resectable by SL are more likely to receive postoperative treatment. However, this does not appear to affect survival greatly. Nevertheless, avoidance of nontherapeutic laparotomy is worthwhile in these patients.
Presented at the annual meeting of the Society of American Gastrointestinal Endoscopic Surgeons (SAGES), Los Angeles, CA, USA, 12–15 March 2003 相似文献
11.
Francesco Frattini Stefano Rausei Corrado Chiappa Francesca Rovera Luigi Boni Gianlorenzo Dionigi 《World journal of gastrointestinal surgery》2013,5(5):135-137
Positive peritoneal cytology in gastric cancer is classified as M1 disease by the 7thEdition of American Joint Committee on Cancer staging system.With the introduction of laparoscopy and peritoneal washing cytology in the staging of gastric cancer a new category of patients has been identified.These are patients with no macroscopic peritoneal metastases but with peritoneal cytology positive(P0C1).Prognosis and treatment of such patientsrepresent a controversial issue.We evaluate the state of the art of staging system in gastric cancer and discusss tandardisation in staging and treatment procedures.There is still a lack of uniformity in the use of laparoscopy with peritoneal cytology in clinical decision making and in the surgical treatment for gastric cancer.Survival of this patient subset remains poor.Multimodal therapies and new therapeutic strategies are required to improve the survival of these patients. 相似文献
12.
Is there a role for staging laparoscopy in patients with locally advanced,unresectable pancreatic adenocarcinoma? 总被引:6,自引:0,他引:6
Shoup Margo Winston Corinne Brennan Murray F. Bassman Diane Conlon Kevin C. 《Journal of gastrointestinal surgery》2004,8(8):1068-1071
The study objective was to determine the incidence of laparoscopically detected metastasis in patients with radiographically
staged locally advanced adenocarcinoma of the pancreas. Patients with locally advanced pancreatic cancer are considered candidates
for novel treatment protocols. Stratification of patients into locally advanced disease versus metastatic disease is imperative
to accurately evaluate treatment outcome. Between 1994 and 2000, 100 consecutive patients undergoing staging laparoscopy with
radiologic evidence of unresectable locally advanced pancreatic cancer were identified from a prospective database. All patients
had preoperative contrast-enhanced, thin-cut computed tomography scanning or magnetic resonance imaging and had no evidence
of detectable metastatic disease. There were 53 men and 47 women, with a median age of 64 years. The disease site was the
pancreatic head in 69 cases and the body or tail in 31. Radiographic assessment of nonresectability was due to encasement
of the celiac or hepatic artery in 37 patients, of the portal vein and superior mesenteric vessels in 56, and extrapancreatic
extension in 7. Laparoscopy identified metastatic disease in 37% of patients, not seen on preoperative imaging. Peritoneal
disease was noted in 12 cases and liver metastasis in 18 cases, and 7 patients had both. Neither the primary tumor size nor
location influenced the incidence of metastatic disease. Standard imaging modalities failed to detect metastatic disease in
37% of patients who were considered to have locally advanced pancreatic cancer. Patients considered for treatment protocols
for locally unresectable pancreatic cancer should be staged laparoscopically before initiation of therapy.
Presented at the Forty-Third Annual Meeting of The Society for Surgery of the Alimentary Tract, San Francisco, California,
May 19–22, 2002. 相似文献
13.
L. William Traverso 《Journal of Hepato-Biliary-Pancreatic Surgery》1998,5(2):138-142
Modern surgical therapy of pancreatic cancer has resulted in few long-term survivors. There are several reasons. First, most
patients are not diagnosed in an early tumor stage, resulting in a minority of patients undergoing surgical resection. A breakthrough
in screening methodology is required until this most major of obstacles can be overcome. Second, inaccurate clinical tumor
staging is all that is available for the majority of patients, since most patients are not resected. Imaging techniques used
for clinical staging require anatomic verification before clinical staging can be reliable. Then adequate comparison of treatments
for patients who never receive anatomical staging can accomplished. Postoperative tumor staging using anatomical methods from
intraoperative findings and examination of a surgical specimen require a staging system that is simple and directly correlates
with survival. The best staging system can be developed only with international cooperation. An adequate comparison of the
results of treatment will then be possible. Two broad treatment areas that are most promising are surgical (extending resections
to yield negative surgical margins) and adjuvant protocols (beginning with a variety of radio sensitizing chemotherapeutic
agents).
Received for publication on Sept. 29, 1997; accepted on Nov. 15, 1997 相似文献
14.
Laparoscopy in the staging of pancreatic cancer 总被引:15,自引:0,他引:15
Pisters PW Lee JE Vauthey JN Charnsangavej C Evans DB 《The British journal of surgery》2001,88(3):325-337
BACKGROUND: Over the past decade, laparoscopy has emerged as a popular method of detecting extrapancreatic metastatic disease in patients presumed to have localized pancreatic cancer. METHODS AND RESULTS: The English language literature on laparoscopic staging of pancreatic cancer was reviewed. Interpretation of this literature on staging laparoscopy is difficult because (1) there has been inconsistent use of high-quality computed tomography (CT) in prospective studies, (2) many studies have included patients with locally advanced disease, and (3) the R0/R1/R2 resection rates among patients staged by laparoscopy have not been reported, making it impossible to correlate laparoscopic findings with the R0 resection rate. Laparoscopy may prevent unnecessary laparotomy in a proportion of CT-staged patients presumed to have resectable pancreatic cancer. However, routine laparoscopy is performed on patients judged to have resectable disease by high-quality CT, this fraction of patients is between 4 and 13 per cent. CONCLUSION: When state-of-the-art CT is available, the routine use of staging laparoscopy may not be easily justified from the data in the recent literature. Selective use of laparoscopy may be more appropriate and will probably be a more cost-effective staging approach. Criteria are presented for the selective use of laparoscopy in the staging of patients with localized pancreatic cancer. 相似文献
15.
术前诊断为胰腺癌术中细针穿刺细胞学检查阴性结果病例分析 总被引:2,自引:0,他引:2
目的 探讨术前诊断为胰腺癌术中细针穿刺细胞学(FNAC)检查阴性结果病例的临床意义和提高诊断准确性的方法。方法 回顾性分析1995年12月至2006年6月中国协和医科大学肿瘤医院术前诊断为胰腺癌,术中FNAC结果阴性的33例病人的临床特点、影像表现、实验室检查结果和随访资料。结果33例均获得随访,时间3个月至8年,其中30例为真阴性病例,肿物为慢性肿决型胰腺炎所致;3例为假阴性病例,术后出现肿决增大,肿瘤多发转移。结论慢性胰腺炎(CP)是出现阴性结果的主要因素,肿瘤体积大小、生长方式和术者取材技术决定FNAC的准确性。应提高对慢性胰腺炎临床特点的认识及术前诊断的准确性,改进穿刺取材和制片技术可以降低假阴性率。 相似文献
16.
A L Warshaw 《American journal of surgery》1991,161(1):26-9; discussion 29-30
Cytologic examination of peritoneal washings was performed in 40 patients with pancreatic ductal adenocarcinoma (35 head, 5 body) whose tumors had been selected as potentially resectable by computed tomographic (CT) findings. Saline (100 mL) was instilled and aspirated at laparoscopy in 27 patients and at laparotomy in 13. Malignant cells were found in the peritoneal washings in 12 of 40 patients (30%): 29% in cancers of the pancreatic head versus 40% in the body; 33% at laparoscopy versus 23% at laparotomy; and in 4 of 8 patients with ascites versus 8 of 32 without ascites. The cytology was positive in 6 of 8 patients (75%) who had a prior percutaneous needle biopsy versus 6 of 32 (19%) of those who did not (p less than 0.01). Liver metastases were found in six patients, all with negative cytology. One of 10 pancreatic head cancers with positive cytology was resectable versus 13 of 25 with negative cytology (p less than 0.05). Survival was significantly longer in patients with negative cytology. We conclude that (1) pancreatic cancer sheds malignant cells into the peritoneum early and commonly; (2) laparoscopic lavage is an effective means of cytologic study; (3) ascites is not a precondition for cytologic study, nor does its presence necessarily imply carcinomatosis; (4) intraperitoneal spread of cancer cells may be promoted by tumor biopsy; (5) cytologic findings provide an additional index of resectability; and (6) cytologic findings appear to correlate with duration of survival. This study shows that even "localized" pancreatic cancer is often not contained and suggests caution with biopsy of potentially curable lesions. 相似文献
17.
Diagnostic laparoscopy for periampullary and pancreatic cancer: What is the true benefit? 总被引:5,自引:2,他引:3
Christopher J. Barreiro M.D. Keith D. Lillemoe M.D. Leonidas G. Koniaris M.D. Taylor A. Sohn M.D. Charles J. Yeo M.D. JoAnn Coleman R.N. C.R.N.P. Elliot K. Fishman M.D. John L. Cameron M.D. 《Journal of gastrointestinal surgery》2002,6(1):75-81
The role of diagnostic laparoscopy in patients with periampullary and pancreatic malignancies is controversial. A retrospective
review was performed including all patients (n = 188) with a periampullary or pancreatic malignancy who underwent both CT and laparotomy at our institution between January 1997 and December 1999. The overall resectability rate for all periampullary
cancers was 67.3% (115 of 171 patients). This compared favorably with the resectability rate for cancers of the pancreatic
body and tail (3 of 17 patients, 17.6%; P < 0.01 vs. periampullary cancers). Fifty percent of patients with periampullary cancers were unresectable because of metastatic
disease, whereas metastatic disease precluded resection in 64.3% of patients with cancers of the pancreatic body and tail.
After patients undergoing operative palliation were eliminated, a nontherapeutic laparotomy would have been precluded by the
use of diagnostic laparoscopy in only 2.3% of patients with periampullary cancers (4 of 171 patients). In contrast, 6 (35.3%)
of 17 patients with cancers of the pancreatic body and tail underwent a nontherapeutic laparotomy (P < 0.01 vs. periampullary cancers). One hundred fifty-eight (84%) of the 188 CT reports reviewed could be definitively categorized
as either “likely to be resectable” or “likely to be unresectable.” The remaining 16% were equivocal. Of the 107 patients
categorized as likely to be resectable, 89 were actually resected (83.2%). In contrast, only 10 of the 51 patients categorized
as likely to be unresectable could be resected (19.6%).
Presented at the 2001 Meeting of the Americas Hepato-Pancreato-Biliary Association, Miami Beach, Fla., Feb. 24, 2001. 相似文献
18.
Rebekah R. White M.D. Erik K. Paulson M.D. Kelly S. Freed M.D. May T. Keogan M.D. Herbert I. Hurwitz M.D. Catherine Lee M.D. Michael A. Morse M.D. Marcia R. Gottfried M.D. John Baillie M.D. Malcolm S. Branch M.D. Paul S. Jowell M.D. Kevin M. McGrath M.D. Bryan M. Clary M.D. Theodore N. Pappas M.D. Douglas S. Tyler M.D. 《Journal of gastrointestinal surgery》2001,5(6):626-633
Neoadjuvant chemoradiation therapy is used at many institutions for treatment of localized adenocarcinoma of the pancreas.
Accurate staging before neoadjuvant therapy identifies patients with distant metastatic disease, and restaging after neoadjuvant
therapy selects patients for laparotomy and attempted resection. The aims of this study were to (1) determine theutilityof
staging laparoscopy in candidates for neoadjuvant therapy and (2) evaluate the accuracy of restaging CT following chemoradiation.
Staging laparoscopy was performed in 98 patients with radiographically potentially resectable (no evidence of arterial abutment
or venous occlusion) or locally advanced (arterial abutment or venous occlusion) adenocarcinoma of the pancreas. Unsuspected
distant metastasis was identified in 8 (18%) of 45 patients with potentially resectable tumors and 13 (24%) of 55 patients
with locally advanced tumors by CT Neoadjuvant chemoradiation therapy and restaging CT were completed in a total of 103 patients.
Thirty-three patients with potentially resectable tumors by restaging CT underwent surgical exploration and resections were
performed in 27 (82%). Eleven (22%) of 49 patients with locally advanced tumors by restaging CT were resected, with negative
margins in 55%; the tumors in these 11 patients had been considered locally advanced because of arterial involvement on restaging
CT Staging laparoscopy is useful for the exclusion of patients with unsuspected metastatic disease from aggressive neoadjuvant
chemoradiation protocols. Following neoadjuvant chemoradiation, restaging CT guides the selection of patients for laparotomy
but may overestimate unresectability to a greater extent than does prechemoradiation CT.
Presented at the 2001 Americas Congress of the American Hepatopancreatobiliary Association, Miami, Fla., February 25, 200l. 相似文献
19.
The staging of lung cancer is a continuously progressing field, with advances in technology not only improving prognostic accuracy, but fundamentally changing pre-operative investigation algorithms. Noninvasive staging is currently undergoing revolutionary developments with the advent of Positron Emission Tomography, whereas Video-Assisted Thoracic Surgery has already been established as an essential, minimally invasive diagnostic tool for invasive histological staging. Molecular staging may transform future lung cancer staging, promising extremely accurate substaging, and potentially prompting a revision of our anatomically based conceptualization of lung cancer spread. This review presents an appraisal of current lung cancer staging modalities, and presents an overview of recent developments in molecular staging. 相似文献
20.
William F. Regine William J. John Mohammed Mohiuddin 《Journal of Hepato-Biliary-Pancreatic Surgery》1998,5(3):227-234
Only 5%–15% of patients with pancreatic adenocarcinoma undergo potentially curative resection. Evidence that postoperative
adjuvant therapy improves outcome is limited to a single randomized trial utilizing split-course chemoradiation. More aggressive
regimens have developed and are associated with, at best, a modest improvement in patient outcome. The potentially significant
morbidity associated with pancreaticoduodenectomy, which can compromise the delivery of postoperative chemoradiation, has
led to the investigations of preoperative regimens. Although such an approach is feasible, its ultimate impact warrants further
evaluation. Among the 4% of patients who present with unresectable or locally advanced disease, combined modality therapy
has produced the most promising results. However, only modest improvements in survival have so far been achieved. Combined
modality therapy with radioisotope implantation appears to have the greatest potential for improving local control and survival
in these patients. Intraoperative radiation therapy (IORT) may be associated with lower morbidity than radioisotope implantation,
but its impact may be limited by radiobiological disadvantage associated with single-dose boost therapy. The problem of distant
metastasis remains significant. New chemotherapeutic agents have the potential to produce better results than those achieved
with 5-fluorouracil. Continued advances in surgery, radiation, and systemic therapy should lead to the increased use of modern
combined modality interventions with an associated further improvement in patient outcome.
Received for publication on June 17, 1998; accepted on July 30, 1998 相似文献