14th International Isotope Society (UK group) symposium

Meeting Programme Prof David O'Hagan [University of St Andrews, UK]—Enzymatic C–¹⁸F Bond Synthesis: A New Strategy for PET Synthesis. Dr Michael Carroll [University of Newcastle, UK]—Studies Towards 6‐[¹⁸F]Fluoro‐m‐tyramine using Iodonium Salts. Dr John Gardiner [University of Manchester, UK]—Methods Towards Isotopomer‐Versatile Synthesis of ¹³C‐Labelled Carbohydrates. Prof William Lockley [University of Surrey, UK]—Some New Catalytic Systems for Isotope‐Exchange Labelling. Dr David Rustidge [Scynexis Europe, UK]—¹⁴C‐Synthesis—Not Always as Easy as it Looks. Dr Richard Hartley [University of Glasgow, UK]—The Potential for using Titanium Alkylidene Chemistry in Solid‐Phase Radiochemical Synthesis. Dr Ian Wilson [Turku Imanet, Finland]—Transition of PET Tracers from Clinical Research Tools to Commercial Diagnostics. Dr Simon Harwood [GlaxoSmithKline, UK]—The Synthesis of Stable Labelled Ketamine. Dr John Herbert [Sanofi‐Aventis, UK]—Towards Robust Conditions for Iridium‐mediated Exchange. Dr Conor Barry [University of Bristol, UK]—Total Synthesis of Clavosolide A.     

Abstracts of the 24th international isotope society (UK group) symposium: synthesis and applications of labelled compounds 2015

The 24th annual symposium of the International Isotope Society's United Kingdom Group took place at the Møller Centre, Churchill College, Cambridge, UK on Friday 6th November 2015. The meeting was attended by 77 delegates from academia and industry, the life sciences, chemical, radiochemical and scientific instrument suppliers. Delegates were welcomed by Dr Ken Lawrie (GlaxoSmithKline, UK, chair of the IIS UK group). The subsequent scientific programme consisted of oral presentations, short ‘flash’ presentations in association with particular posters and poster presentations. The scientific areas covered included isotopic synthesis, regulatory issues, applications of labelled compounds in imaging, isotopic separation and novel chemistry with potential implications for isotopic synthesis. Both short‐lived and long‐lived isotopes were represented, as were stable isotopes. The symposium was divided into a morning session chaired by Dr Rebekka Hueting (University of Oxford, UK) and afternoon sessions chaired by Dr Sofia Pascu (University of Bath, UK) and by Dr Alan Dowling (Syngenta, UK). The UK meeting concluded with remarks from Dr Ken Lawrie (GlaxoSmithKline, UK).     

15th International Isotope Society (UK group) Symposium

Meeting Programme Dr Nigel Botting [University of St Andrews, UK] – Isotopic Labelling of Lignan Phytoestrogens. Prof. Frédéric Dollé [CEA PET Centre, Orsay, France] – Fluorine‐18 Chemistry: A Selection of Recent Advances. Prof. Peter Scott [University of Warwick, UK] – Creating Chiral Metal Centres. Mr Laurent Brichard [WBIC, University of Cambridge, UK] – A Simple Device for the Radiosynthesis of [Carbonyl‐¹¹C]amides, Esters and Ketones using Carbon‐11 Monoxide. Dr Michael Hickey [AstraZeneca Charnwood, UK] – Tritium‐labelling via an Iridium‐based Solid‐phase Catalyst. Prof. Wolfgang Steglich [Ludwig‐Maximilians University, Germany] – Meroterpenoids from Mushrooms, A Colourful Group of Natural Products. Dr Joe Schofield [Sanofi‐Aventis, France] – Radio‐ and Stable‐isotope Labelling of SSR591813 – A Nicotinic Partial Agonist. Dr Nikolai Kuhnert [University of Surrey, UK] – Chiral Recognition in Ion Trap Mass Spectrometry using Isotopically Labelled Trianglamine Macrocycles. Dr Paul Watts [University of Hull, UK] – The Application of Micro Reactors for Radiochemical Synthesis. Dr Tony Gee [GlaxoSmithKline, UK] – PET in Drug Discovery and Development. Dr Alan Wadsworth [GlaxoSmithKline, UK] – Stable Isotopic Labelling of Heterocyclic Compounds     

Abstracts of the 12th IIS (UK Group) Symposium

“Synthesis & Application of Labelled Compounds 2002” Isotopes and Mass Spectrometry Carbon‐13 Labelling to Aid the Development of the Catalytic Alkenation of Carbonyls Production and Applications of ¹²⁴I for Positron Emission Tomography Organic Photochemistry: Synthetic Approaches to Alkaloids in a Reagentless Environment Fluorinaion for Positron Emission Tomography Synthetic Consequences of Kinetic Isotopes Effects: Synthesis of [¹³ C₆]‐SR31742A For Human Trail Purposes Tritio‐Dehalogenation: New Variants on an Old Theme The Synthesis of BOC‐L‐Proline‐[¹⁴C₂] Benzyl Ester Peptide Labelling with Fluorine‐18     

The 25th Scientific Conference of the Society on Neuroimmune Pharmacology: Program and Abstracts

Journal of Neuroimmune Pharmacology -     

10th Conference of the Central European Division e.V. of the International Isotope Society

Use of Microwaves in Organic Synthesis: Application in the Synthesis of Isotopically Labelled Compounds Preparation of Tritium‐Labelled BIIL 260 with High Specific Radioactivity Synthesis of [³H]‐, [¹⁴C]‐ and [¹³C,²H]‐labelled Org 12962 Derivatives Labeling of BAY 58‐2667, an Activator of sGC Preparation and Use of [¹⁴C]N,N′‐Carbonylditriazole in the Labelling of Urea Derivatives Efficient Carbon‐14 Labeling of 2‐(3‐Hydroxypropyl)‐1H‐benzimidazole Synthesis of Some ¹⁴C‐Labelled Fungicides C‐14 Labelling of NVP‐ABE651 and NVP‐ABE697 Synthesis of Carbon‐13,14 Isotopomers of a Novel 4‐Substituted‐2‐Carboxy Tetrahydroquinoline [¹⁴C]CH₂N₂: A Suitable Precursor for the Preparation of ¹⁴C‐Labelled Anthracyclines Preparative HPLC: a Useful Approach to Speed‐up the Purification of Labelled Compounds. Use of Stable Isotopes for the Biosynthesis and Biodegradation of Fosfomycin Metalloradiopharmaceuticals for Nuclear Medicine Strategic outlook: Future Methods in DMPK and subsequent requirements for isotopically labelled compounds Isotopic Imaging of Glass‐based cDNA Microarray Hybridization New Developments in Radiation Measuring Technique     

Abstracts presented at the International Society of Addiction Medicine (ISAM) 19th Annual Meeting,Abu Dhabi,United Arab Emirates,October 2017

ABSTRACT

The 19th Annual Meeting of the International Society of Addiction Medicine (ISAM) was held in Abu Dhabi, United Arab Emirates, in October 2017. Contained in this paper are the abstracts of scientific work presented at the conference.     

Abstracts of the 9th International Symposium on SHR and Cardiovascular Genetics

ORAL PRESENTATIONS: GENETIC MODELS OF HYPERTENSION: USE OF PHYSIOLOGY AND MOLECULAR GENETICS. ORAL PRESENTATIONS: GENETIC MODELS OF HUMAN CARDIOMYOPATHLES. ORAL PRESENTATIONS: APOPTOSIS IN THE FAILING HEART. ORAL PRESENTATIONS: VITAMIN E PREVENTS APOPTOSIS IN CORTICAL NEURONS ISOLATED FROM STROKE-PRONE SPONTANEOUSLY ORAL PRESENTATIONS: VASCULAR SMOOTH MUSCLE CELL APOPTOSIS IN GENETIC HYPERTENSION. ORAL PRESENTATIONS: INVOLVEMENT OF A NOVEL CARDIOVASCULAR-SPECIFIC HOMEOBOX GENE, GAX (GROWTH ARREST-SPECIFIC HOMEOBOX) IN HYPERTENSIVE CARDIOVASCULAR HYPERTROPHY ORAL PRESENTATIONS: MYOCYTE AND NON-MYOCYTE APOPTOSIS IN THE SUB-EPICARDIUM DURING CARDIAC REGRESSION INDUCED BY ANTIHYPERTENSIVE DRUG THEERAPY IN SPONTANEOUSLY HYPERTENSIVE RATS ORAL PRESENTATIONS: MOLECULAR CARDIOLOGY ORAL PRESENTATIONS: GENE-FUNCTION RELATIONSHIPS IN HYPERTENSION: A NOVEL PARADIGM ORAL PRESENTATIONS: A CENTRAL ANTIHYPERTENSIVE AGENT AMELIORATES INSULIN RESISTANCE AND HYPERPHAGIA IN THE OBESE SHR MODEL. ORAL PRESENTATIONS: A PHARMACOLOGICAL APPROACH TO BLOOD PRESSURE IN LYON HYPERTENSIVE RATS: A CHROMOSOME 2 LOCUS INFLUENCES THE RESPONSE TO A CALCIUM ANTAGONIST. ORAL PRESENTATIONS: VASCULAR CHANGES IN THE OCULAR FUNDUS OF SPONTANEOUSLY HYPERTENSIVE RATS TREATED WITH THREE KINDS OF ANTIHYPERTENSIVE AGENTS. ORAL PRESENTATIONS: THE RAT GENOME PROJECT: AN UPDATE ON PROGRESS. ORAL PRESENTATIONS: HYPERTENSION AND ENDOTHELIAL CELL FUNCTION ORAL PRESENTATIONS: CELLULAR SIGNALING VIA G-PROTEIN COUPLED RECEPTORS. ORAL PRESENTATIONS: MODULATORY ROLE OF Mg²⁺ ON VASOPRESSIN-INDUCED Ca²⁺ RESPONSES IN VASCULAR SMOOTH MUSCLE OF SHR ORAL PRESENTATIONS: GENETIC MECHANISMS OF THE ROLE OF KIDNEY IN HBP. ORAL PRESENTATIONS: DIFFERENCES IN SUSCEPTIBILITY TO RENAL DAMAGE AFTER UNILATERAL NEPHRECTOMY (UNX) IN RATS. ORAL PRESENTATIONS: ELIMINATION OF ADRENAL RENAL VASCULAR CONNECTION AND SIMULTANEOUS KIDNEY DENERVATION COMPLETELY PREVENT DEVELOPMENT OF HYPERTENSION IN SPONTANEOUSLY HYPERTENSIVE RATS ORAL PRESENTATIONS: THE SYMPATHETIC REFLEX REACTIVITY, CARDIAC B-ADRENERGIC PATHWAY AND VASCULAR REACTIVITY ARE IMPAIRED IN THE SHR BUT IMPROVED AFTER RENIN-ANGIOTENSIN BLOCKADE. ORAL PRESENTATIONS: INTERACTION BETWEEN SYMPATHETIC NERVOUS ACTIVITY AND RENIN. ANGIOTENSIN SYSTEM DURINO THE DEVELOPMENT OF HYPERTENSION IN SPONTANEOUSLY HYPERTENSIVE RATS. ORAL PRESENTATIONS: VASCULAR REMODELUNG IN RESISTANCE VESSELS. ORAL PRESENTATIONS: VASCULAR EFFECTS OF ANTIHYPERTENSIVE THERAPY ORAL PRESENTATIONS: VASCULAR REMODELING IN HYPERTENSION: WHAT DOES IT MEAN AND HOW SHOULD WE DEFINE IT? ORAL PRESENTATIONS: RADIO-TELEMETRY IN GENETIC AND PHARMACOLOGICAL STUDIES: NEW APPROACHES TO DATA ANALYSIS. ORAL PRESENTATIONS: CARDIAC SPECIFIC OVEREXPRESSION OF ANGIOTENSIN CONVERTING ENZYME IN TRANSGENIC RATS AUGMENTS LEFT VENTRICULAR HYPERTROPHY ORAL PRESENTATIONS: MARKEDLY ELEVATED AMNIOTIC FLUID RENIN AND REDUCED FETAL AND PLACENTAL WEIGHTS IN REN-2 TRANSGENIC RATS. ORAL PRESENTATIONS: AT₂ -NEW MECHANISMS ORAL PRESENTATIONS: ROLE OF ENDOGENOUS ANGIOTENSIN II IN THE BASAI GROWTH, THE EXPRESSION OF GROWTH FACTORS AND THI CELL CYCLE IN VASCULAR SMOOTH MUSCLE CELLS FROM SHR ORAL PRESENTATIONS: CHRONIC BLOCKADE OF THE AT, RECEPTOR IS ASSOCIATED WITH INHIBITION OF ENDOTHELIAL NITRIC OXIDE SYNTHASE GENE EXPRESSION IN THE AORTA OF SHR ORAL PRESENTATIONS: REGULATION OF ELASTASE AND FIBRONECTIN IN VASCULAR REMODELLING ORAL PRESENTATIONS: CLONING OF Kv CHANNEL PROTEINS IN TAIL ARTERY SMOOTH MUSCLE FROM NORMAL AND DIABETIC RATS. ORAL PRESENTATIONS: DECREASED NITRIC OXIDE PRODUCTION OF CULTURED ENDOTHELIAL CELLS IN SHR UNDERGOING CYCLIC STRETCHING AND RESTORATION OF ENDOTHELIAL FUNCTION BY ACE-I. ORAL PRESENTATIONS: NOREPINEPHRINE (NE)-INDUCED BIPHASIC RESPONSES IN PULMONARY ARTERIES (PA) OF YOUNG STROKE-PRONE SPONTANEOUSLY HYPERTENSIVE RATS (SHRSP): ROLE OF ENDOTHELIUM ORAL PRESENTATIONS: AFTER 38 YEARS WHAT IS THE ROLE OF SHR? FROM MOLECULAR GENETICS TO PREVENTION ORAL PRESENTATIONS: MICROGRAVITY, MINERAL METABOLISM, AND ARTERIAL FUNCTION: THE SHR IN OUTER SPACE. ORAL PRESENTATIONS: GENERATION OF FATLESS MICE OVEREXPRESSING LEPTIN: LONG-TERM EFFECTS OF LEPTIN ON GLUCOSE METAGOLISM ORAL PRESENTATIONS: NONSENSE MUTATION OF LEPTIN RECEPTOR AND ELEVATED PLASMA LEPTIN LEVELS IN OBESE SPONTANEOUSLY HYPERTENSIVE KOLETSKY RATS (OBESE SHR) ORAL PRESENTATIONS: CONTRIBUTION OF RECOMBINANT INBRED AND CONGENIC STRAINS FOR THE UNDERSTANDING OF CARDIOVASCULAR GENETICS ORAL PRESENTATIONS: CONSTRUCTION OF A DOUBLE CONGENIC STRAIN TO PROVE AN INTERACTION BETWEEN CHROMOSOMES 2 AND 10 ON BLOOD PRESSURE IN THE RAT. ORAL PRESENTATIONS: QTL OF THE STRESS RESPONSE BY TOTAL GENOME SCAN OF RAT RECOMBINANT INBRED STRAINS. ORAL PRESENTATIONS: DEATH PROPERTIES OF PLAQUE SMOOTH MUSCLE CELLS CRITICAL TO PATHOGENESIS OF ATHEROSCLEROTIC PLAQUE AND RESTENOSIS. ORAL PRESENTATIONS: ASSESSMENT OF APOPTOSIS IN CARDIOVASCULAR TARGET ORGANS OF HYPERTENSION. ORAL PRESENTATIONS: ARE NON-GENETIC MODELS STILL USEFUL FOR THE STUDY OF HYPERTENSION MECHANISMS? ORAL PRESENTATIONS: GENETIC vs NON GENETIC MODELS OF HYPERTENSION. ORAL PRESENTATIONS: GENETIC vs NON GENETIC MODELS OF HYPERTENSION. ORAL PRESENTATIONS: RECOMBINANT CONGENIC STRAINS AS A TOOL TO STUDY POLYGENIC DISEASES. ORAL PRESENTATIONS: SALT-SUSCEPTIBILITY MAPS IN THE SABRA RAT MODEL OF HYPERTENSION TO CHROMOSOMES 1 AND 17 WITH AN EPISTATIC EFFECT OF THE X CHROMOSOME ORAL PRESENTATIONS: EFFECT OF SA GENE LOCUS TRANSFER ON BLOOD PRESSURE AND BODY WEIGHT IN CONGENIC STRAINS DERIVED FROM SHR AND WKY STRAINS. ORAL PRESENTATIONS: ATRIAL NATRIURETIC PEPTIDE GENE AND SENSITIVITY TO CEREBRAL ISCHAEMIA ORAL PRESENTATIONS: TIME SERIES STUDY TO EVALUATE EFFECTS OF NON-GENETIC FACTORS ON BLOOD PRESSURE QUANTITATIVE TRAIT LOCI IN RATS ORAL PRESENTATIONS: NUTRITIONAL REGULATION OF BLOOD PRESSURE IN THE OBESE SHR: A ROLE FOR THE SYMPATHETIC NERVOUS SYSTEM. ORAL PRESENTATIONS: POST-EXERCISE HYPOTENSION IN SPONTANEOUSLY HYPERTENSIVE RATS: EFFECTS OF EXERCISE MODE AND TRAINING INTENSITIES. POSTER PRESENTATIONS: HIGH CALCIUM INTAKE IMPROVES BONE MINERAL DENSITY AND BLOOD PRESSURE (BP) IN DIABETIC C57BL/6J MICE. POSTER PRESENTATIONS: EFFECT OF ANGIOTENSIN CONVERTING ENZYME (ACE) GENE INSERTION (I) I DELETION (D) POLYMORPHISM AND LEFT VENTRICULAR FUNCTION ON CARDIAC ACE GENE EXPRESSION IN PATIENTS WITH ISCHAEMIC HEART DISEASE POSTER PRESENTATIONS: MAPPING AN INFERRED SINGLE MAJOR GENE LOCUS (HI) NEAR THE SA GENE LOCUS IN THE SPONTANEOUSLY HYPERTENSIVE RAT. POSTER PRESENTATIONS: ARE THERE POLYMORPHISMS DETECTABLE IN THE HUMAN α_1B-ADRENERGIC RECEPTOR GENE IN ESSENTIAL HYPERTENSION? POSTER PRESENTATIONS: DO POLYMORPHISMS DETECTABLE IN THE HUMAN β₂ ADRENERGIC RECEPTOR CONTRIBUTE TO HYPERTENSION? POSTER PRESENTATIONS: INTERSTRAIN DIFFERENCES IN TISSUE ANGIOTENSIN I-CONVERTINO ENZYME LEVELS BETWEEN THE STROKE-PRONE SPONTANEOUSLY HYPERTENSIVE RAT AND THE NORMOTENSIVE WISTAR-KYOTO RAT. POSTER PRESENTATIONS: ANALYSIS OF HEMODYNAMIC AND PLASMA RENIN ANGIOTENSIN SYSTEM PARAMETERS IN YOUNG CONSCIOUS HETEROZYGOUS TRANSGENIC TGR(mREN2)27 RATS POSTER PRESENTATIONS: QUALITATIVE TRAIT LOCI FOR BODY WEIGHT IN SHRSP POSTER PRESENTATIONS: MEDICAL-GENETIC CONSULTANCY OF PATIENTS WITH ARTERIAL HYPERTENSION IN MOSCOW POSTER PRESENTATIONS: ROLE OF Na*-Li⁺ COUNTERTRANSPORT AND ACTIVE CALCIUM TRANSPORT IN FAMILIAL OR NON-FAMILIAL HYPERTENSIVE DISEASE. POSTER PRESENTATIONS: PLEYOTHROPHIC EFFECT OF POLYMORPHIC GENES OF PREDISPOSITY TO ESSENTIAL AND SYMPTOMATIC HYPERTENSION. POSTER PRESENTATIONS: A METHOD OF GENOME SCREENING FOR SHR QUANTITATIVE TRAIT LOCI USING DNA POOLING OF PHENOTYPIC EXTREMES POSTER PRESENTATIONS: A PARADIGM FOR DETECTING CANDIDATE GENES FOR BLOOD PRESSURE QTL: USE OF RNA FINGERPRINTING WITH PANELS OF CONGENIC STRAINS POSTER PRESENTATIONS: GENETIC BASIS OF CONGENITAL CATARACTS IN THE DAHL-JR SALT-SENSITIVE RAT. POSTER PRESENTATIONS: QTL MAPPING USING GENETIC MARKERS GENERATED BY THE RAMP METHOD IN THE F2 BETWEEN SHRSP AND WKY POSTER PRESENTATIONS: TWO LOCI DETERMINE BASAL AND STRESS-DEPENDENT COMPONENT OF BLOOD PRESSURE IN INHERITED STRESS-INDUCED ARTERIAL HYPERTENSIVE (ISIAH) RATS. POSTER PRESENTATIONS: GENETIC DETERMINANTS OF SERUM URIC ACID: AN INTERMEDIATE PHENOTYPE OF HYPERTENSION. POSTER PRESENTATIONS: STRESS-SENSITIVE QTL OF BLOOD PRESSURE ON RAT CHROMOSOME 20. POSTER PRESENTATIONS: THE SEARCH FOR BLOOD PRESSURE CONTROLLING GENES IN SHR-RNO8 CONGENIC SUBLINES. POSTER PRESENTATIONS: Characterization of a polysomal RNA binding protein in normotensive (WKY) and spontaneously hypertensive rats (SHR) POSTER PRESENTATIONS: NON-DEPRESSOR DOSE OF CICLETANINE HAS RENO-PROTECTIVE EFFECTS IN STREPTOZOTOCIN DIABETIC SHR. POSTER PRESENTATIONS: GENETIC SUSCEPTIBILITY TO RENAL DAMAGE AFTER L-NAME-INDUCED HYPERTENSION IN UNINEPHRECTOMIZED RATS. POSTER PRESENTATIONS: EPOXYEICOSATRIENOIC ACIDS ARE INVOLVED IN THE RENAL ALTERATIONS OF THE LYON HYPERTENSIVE RAT POSTER PRESENTATIONS: EFFECTS OF CHRONIC CAFFEINE CONSUMPTION ON RENAL FUNCTION IN SPONTANEOUSLY HYPERTENSIVE HEART FAILURE (SHHF/Mcc-fa^cp) RATS. POSTER PRESENTATIONS: ROLE OF THE RENAL NERVES IN THE REGULATION OF RENIN SYNTHESIS POSTER PRESENTATIONS: RENAL VASCULAR RESPONSES TO ANGIOTENSIN H IN SPONTANEOUSLY HYPERTENSIVE (SHR) AND NORMOTENSIVE WISTAR-KYOTO (WKY) RATS. POSTER PRESENTATIONS: EFFECTS OF CYTOSOLIC Cs²⁺ ON MEMBRANE VOLTAGE AND CONDUCTANCE OF CULTURED MESANGIAL CELLS FROM STOROKE-PRONE SPNTANEOUSLY HYPERTENSIVE RATS AND WKY RATS POSTER PRESENTATIONS: AUGMENTATION OF THE GENE EXPRFSSION OF THE UNCOUPLING PROTEIN-2 IN: POSTER PRESENTATIONS: HEART FUNCTION IN ISIAH RAT STRAIN WITH INHERITED STRESS-SENSITIVE ARTERIAL HYPERTENSION POSTER PRESENTATIONS: A NEW COMPUTER METHOD FOR ANALYSING CONTRACTU. MOVEMENT OF SHR MYOCYTE POSTER PRESENTATIONS: FREE RADICAL INJURY IN SHRSP CEREBRAL CORTEX I. ROLE OF XANTHINE-XANTHINE OXIDASE SYSTEM FOR FREE RADICAL GENERATION IN HYPERTENSIVE CEREBRAL INJURY. POSTER PRESENTATIONS: FREE RADICAL INJURY IN SHRSP CEREBRAL CORTEX II. INCREASED EXPRESSION OF ADHESION MOLECULE IN LEUKOCYTES AND ENDOTHELIAL CELLS. POSTER PRESENTATIONS: FREE RADICAL INJURY IN SHRSP CEREBRAL CORTEX III. EFFECTS OF LEUKOCYTE ACTIVATION AND iNOS INHIBITION ON ENDOTHELIAL CELL FUNCTION POSTER PRESENTATIONS: FREE RADICAL INJURY IN SHRSP CEREBRAL CORTEX IV. EXPRESSION OF iNOS IN LEUKOCYTES AND ICAM-1 IN ENDOTHELIAL CELLS OF BRAIN MICROVESSELS POSTER PRESENTATIONS: CALCIUM/CALMODULIN DEPENDENT PROTEIN KINASE II CONTRIBUTES TO THE INCREASED EPINEPHRINE RELEASE FROM ADRENAL GLAND OF SPONTANEOUS HYPERTENSIVE RATS POSTER PRESENTATIONS: Relation of pathological change and EMG evoked by magnetic stimulation of spinal cord in M-SHRSP POSTER PRESENTATIONS: HYPERTENSION INDUCED BY PULSATILE COMPRESSION ON THE VENTRAL MEDULLARY SURFACE OF RAT. POSTER PRESENTATIONS: REDUCED AMOUNT OF LIVER MEVALONATE PYROPHOSPHATE DECARBOXYLASE IS RESPONSIBLE FOR REDUCED SERUM CHOLESTEROL IN STROKE-PRONE SPONTANEOUSLY HYPERTENSIVE RAT. POSTER PRESENTATIONS: Functional analysis of the muscarinic ml receptor promoter in normotensive (WKY) and spontaneously hypertensive rats (SHE.) POSTER PRESENTATIONS: INHIBITION OF ANGIOGENESIS: COMPARISON OF THE RELATIVE ACTIVITIES OF TRIFLAVEN, AN ARG-GLY-ASP-CONTAINING PEPTIDE AND ANTI-avp3 INTEGRIN MAB. POSTER PRESENTATIONS: EFFECT OF AT₁ AND AT₂ ANGIOTENSIN RECEPTOR ANTAGONISM ON BLOOD PRESSURE AND SMALL ARTERY STRUCTURE IN ANGIOTENSIN II-INFUSED RATS. POSTER PRESENTATIONS: INCREASED SUPEROXIDE IN GENETIC HYPERTENSION POSTER PRESENTATIONS: NITRIC OXIDE INHIBITION RAISES BP, AFFECTS CARDIOVASCULAR STRUCTURE AND CAUSES STROKE IN GENETICALLY HYPERTENSIVE RATS POSTER PRESENTATIONS: MECHANICAL PROPERTIES OF SMALL MESENTERIC ARTERIES FROM YOUNG SPONTANEOUSLY HYPERTENSIVE RATS POSTER PRESENTATIONS: ANGIOTENSIN II-INDUCED SMALL ARTERY CONTRACTION IN YOUNG SHR - ROLE OF AT₁ AND AT₂ RECEPTORS POSTER PRESENTATIONS: VASCULAR INJURY BY FUNCTIONAL DECLINE OF ERYTHROCYTES IN STROKE-FRONE SPONTANEOUSLY HYPERTENSIVE RATS (SHRSP POSTER PRESENTATIONS: CHANGES IN THROMBOTIC TENDENCY AND MICROCIRCULATION IN PIAL VESSELS OF STROKE-PRONE SPONTANEOUSLY HYPERTENSIVE RATS POSTER PRESENTATIONS: SCANNING ELECTRON-MICROSCOPIC STUDY OF GASTRIC VASCULAR CASTS IN HYPERTENSIVE RATS. POSTER PRESENTATIONS: THE REGULATION OF VASCULAR CONTRACTILITY BY NICOTINE IN NORMAL OR DIABETIC RATS POSTER PRESENTATIONS: EFFECT OF A PREPARED MEAL PLAN ON TRACE MNERAL STATUS IN PATIENTS WITH GENERALIZED CARDIOVASCULAR & METABOLIC DISEASE. POSTER PRESENTATIONS: INHIBITORY AND EXCITATORY EFFECTS OF GENISTEIN ON K CHANNEL CURRENT: THE CRITICAL ROLE PLAYED BY CALCIUM IN SMOOTH MUSCLE CELLS FROM RAT MESENTERIC ARTERY. POSTER PRESENTATIONS: AGE-RELATED EFFECT OF MELATONIN ON α₁-ADRENEROIC REACTIVITY OF MESENTERIC ARTERY IN SPONTANEOUSLY HYPERTENSIVE RATS. POSTER PRESENTATIONS: SSCP ANALYSIS DID NOT REVEAL MUTATIONS IN NHE1 cDNA FROM VASCULAR SMOOTH MUSCLE CELLS (VSMC) OF SHR SP WITH ENHANCED Na⁺/H⁺ EXCHANGE (NHE). POSTER PRESENTATIONS: CHARACTERISTIC CF INDUCIBLE NITRIC CKIDE SYNTASE IN VASCULAR SMCOIH MUSaE CELLS FRCM STROKE-PRCNE SPONTANEOUSLY HYPERTENSIVE RATS POSTER PRESENTATIONS: ROLE OF SUPEROXIDE ANION IN THE ENHANCED α-ADRENOCEPTOR INDUCED AORTIC CONTRACTION AND INOSITOL PHOSPHATE PRODUCTION IN VASCULAR SMOOTH MUSCLE CELLS FROM SHR POSTER PRESENTATIONS: THE EFFECT OF ET-1 ON CYCLIC NUCLEOTIDE LEVELS IN RAT PULMONARY ARTERIES. POSTER PRESENTATIONS: SUSTAINED CONTRACTION TO ANGIOTENSIN II AND IMPAIRED CALCIUM-PUMP ACTIVITY IN SMOOTH MUSCLE FROM SHRSP POSTER PRESENTATIONS: HYPERDMSULINEMIA AND IMPAIRED INSUUN SIGNALING IN OBESE SHR POSTER PRESENTATIONS: ANGIOTENSINS II INDUCED HYPERTROPHY AND ITS INTRACELLULAR SIGNAL TRANSDUCTION OF NEONATAL SHR/Izm CARDIAC MYOCYTE. POSTER PRESENTATIONS: MAPK KINASE INHIBITION ATTENUATES ANGII-INDUCED SIGNALING AND CONTRACTION IN SHR VASCULAR SMOOTH MUSCLE CELLS POSTER PRESENTATIONS: EFFECTS OF MECHANICAL STRETCH ON G-PROTEINS IN CULTURED RAT AORTIC SMOOTH MUSCLE CELLS OF SPONTANEOUSLY HYPERTENSIVE RATS. POSTER PRESENTATIONS: EVIDENCE FOR NON-AT1/AT2 RECEPTOR PATHWAY OF ALDOSTERONE SECRETION BY ANGIOTENSIN II IN TYPE 1 RECEPTOR-KNOCKOUT MICE POSTER PRESENTATIONS: TRANSIENT EXPRESSION OF ATRIAL NATRIURETIC PEPTIDE RECEPTOR-A (Npra) ATTENUATES THE MXTOGEN-ACTTVATED PROTEIN KINASE ACTIVITY IN HUMAN VASCULAR SMOOTH MUSCLE CELLS. POSTER PRESENTATIONS: GENE THERAPY FOR THE CARDIOVASCULAR ORGAN GROWTH IN SHR-SP BY ANTISENSE DNA TO PDGF A-CHAIN POSTER PRESENTATIONS: ANTISENSE ATTENUATION OF HYPERTENSION IN YOUNG SHR POSTER PRESENTATIONS: ANTISENSE INHIBITION OF ANGIOTENSINOGEN: TISSUE DISTRIBUTION AND ANTIHYPERTENSIVE EFFECTS IN THE SHR POSTER PRESENTATIONS: EFFECT OF ENDOTHELIN ANTAGONIST ON BLOOD PRESSURE IN PREGNANT RATS POSTER PRESENTATIONS: EFFECT OF AN ETA SELECTIVE ENDOTHELIN RECEPTOR ANTAGONIST ON BLOOD PRESSURE AND SMALL ARTERY STRUCTURE AND FUNCTION IN STROKE-PRONE SHR. POSTER PRESENTATIONS: A POSSIBLE ATTEMPT TO PROLONG LIFE SPAN OF SHRSP BY THE AGENTS WITH OXYGEN CONSUMPTION INHIBITING EFFECTS. POSTER PRESENTATIONS: SUPPRESSIVE ACTION OF ANGIOTENSINEII RECEPTOR ANTAGONIST ON REPERFUSION ARRHYTHMIAS IN SHR/Izm POSTER PRESENTATIONS: EFFECTS OF ADENOSINE DEAMINASE INHIBITION ON BLOOD PRESSURE IN SPONTANEOUSLY HYPERTENSIVE RATS. POSTER PRESENTATIONS: RECOVERY OF ALTERED ION TRANSPORT FUNCTION OF RBC MEMBRANE IN SPONTANEOUSLY HYPERTENSIVE RATS AFTER LOSARTAN TREATMENT. POSTER PRESENTATIONS: DECREASED PLASMA LEPTIN LEVEL IN STROKE-PRONE SPONTANEOUSLY HYPERTENSIVE RATS (SHR-SP/IZM) AND ITS REVERSAL BY ANTIHYPERTENSIVE AGENTS POSTER PRESENTATIONS: EFFECT OF EARLY TREATMENT OF ENALAPRIL ON THE EXPRESSION OF ANGIOTENSIN U AND ANGIOTENSINOGEN mRNA IN HYPOTHALAMUS IN SPOTANEOUSLY HYPERTENSIVE RATS POSTER PRESENTATIONS: INHIBITORY EFFECT OF ENALAPRIL ON THE PRESSOR RESPONSE OF ENDOGENEOUS ANGIOTENSIN H IN ROSTRAL VENTROLATERAL MEDULLA IN SHR POSTER PRESENTATIONS: INSULIN INCREASES BLOOD PRESSURE IN HYPERTENSION PRONE BUT NOT IN HYPERTENSION RESISTANT SABRA RATS. POSTER PRESENTATIONS: PHENOTYPE AND GENOTYPE VARIABILITY IN 4 STRAINS OF FAWN-HOODED (FH) RATS. POSTER PRESENTATIONS: ENDOTHELIN GENE EXPRESSION IN BLOOD VESSELS AND KIDNEY OF SHR, L-NAME-TREATED SHR, AND RENOVASCULAR HYPERTENSIVE RATS POSTER PRESENTATIONS: THE ENDOTHELIN SYSTEM IN THE (mRen2)27 TRANSGENIC RAT MODEL OF HYPERTENSION AND CARDIAC HYPERTROPHY. POSTER PRESENTATIONS: NITRO-ARGININE (L-NNA) ACCELERATES ARTERIAL OCCLUSION, INTIMAL THICKENING AND MYOCARDIAL FIBROSIS IN RESPONSE TO NECROSIS IN HYPERCHOLESTEROLEMIA SHRSP POSTER PRESENTATIONS: BLOOD PRESSURE FOLLOWING WITHDRAWAL OF ANTIHYPERTENSIVE DRUO TREATMENT IN SPONTANEOUSLY HYPERTENSIVE RATS (SHR). POSTER PRESENTATIONS: CARDIAC LEFT VENTRICULAR HYPERTROPHY (LVH) IN RECOMBINANT INBRED STRAINS DERIVED FROM SHR/WKY HYBRID CROSSES IS ACCOMPANIED BY DIFFERENT PATTERNS OF VENTRICULAR EXPRESSION OF THE ATRIAL NATRIURETIC FACTOR (ANF) GENE. POSTER PRESENTATIONS: SHROB: A MODEL FOR THE STUDY OF DIABETIC-LIKE MULTISYSTEM PATHOLOGIC CHANGES. POSTER PRESENTATIONS: RENAL FUNCTION FOLLOWING CENTRAL ADMINISTRATION OF IMIDAZOLINE COMPOUNDS IN SPRAGUE DAWLEY, WISTAR KYOTO AND SPONTANEOUS HYPERTENSIVE RATS POSTER PRESENTATIONS: CENTRAL ADMINISTRATION OF CLONUHNE IN SPONTANEOUS HYPERTENSIVE, WISTAR-KYOTO AND SPRAGUE DAWLEY RATS. POSTER PRESENTATIONS: EVALUATION OF SALT-ACCELERATED HYPERTENSION AND ITS VARIABILITY IN FEMALE SHRSP BY A TELEMETRY SYSTEM POSTER PRESENTATIONS: OXYGEN CONSUMPTION RATES IN VARIOUS TISSUES OF STROKE-PRONE SPONTANEOUSLY HYPERTENSIVE RATS (SHRSP). POSTER PRESENTATIONS: A MODEL COMBINING GENETIC HYPERTENSION WITH DIABETES: DIABETOGENIC EFFECT OF STREPTOZOTOCIN (STZ) IN SPONTANEOUSLY HYPERTENSIVE RATS. POSTER PRESENTATIONS: VASCCARE-THEAPY ATIENUATES TELEMETERED TEMPERATURE RESPONSE TO STRESS IN SPONTANEOUSLY HYPERTENSIVERATS (SHR) POSTER PRESENTATIONS: FIBROBLASTS' COLLAGENOSYNTHETIC FUNCTION IN FORMING OF POSTINFARCTION HEART. POSTER PRESENTATIONS: THE EFFECTS OF TREATMENT WITH VALSARTAN OR NIFEDIPINE ON APOPTOSIS IN THE GENETICALLY HYPERTENSIVE (GH) RAT. POSTER PRESENTATIONS: APOPTOSIS IN AORTA OF DOCA-SALT HYPERTENSIVE RATS: EFFECT OF ENDOTHEUN RECEPTOR ANTAGONISM. POSTER PRESENTATIONS: APOPTOSIS IN VASCULATURE OF SPONTANEOUSLY HYPERTENSIVE RATS: EFFECT OF ACE INHIBITORS AND CALCIUM CHANNEL BLOCKERS POSTER PRESENTATIONS: EXPRESSION AND ROLE OF LONG-FORM PDGF A-CHAIN IN THE GROWTH OF VASCULAR SMOOTH MUSCLE CELLS FROM SHR POSTER PRESENTATIONS: ABNORMAL REGULATION OF TGF-P RECEPTORS ON VASCULAR SMOOTH MUSCLE CELLS FROM SHR BY ANGIOTENSIN II POSTER PRESENTATIONS: Apoptosis in malignant hypertensive rats (M-SHRSP) POSTER PRESENTATIONS: ANGIOTENSIN H MAY BE INVOLVED IN APOPTOSIS OF LEFT VENTRICULAR CELLS IN ADULT SHR. POSTER PRESENTATIONS: ROLE OF ANGIOTENSIN II RECEPTOR SUBTYPES 1 AND 2 IN REGULATING APOPTOSIS IN THE HEART OF SPONTANEOUSLY HYPERTENSIVE RATS POSTER PRESENTATIONS: SELECTIVE INDUCTION OF APOPTOSIS IN THE HEART BUT NOT IN THE AORTA DURING 8-ADRENERGIC BLOCKADE IN THE SHR. POSTER PRESENTATIONS: DECREASED APOPTOSIS IN KIDNEYS MAY CONTRIBUTE TO NEONATAL RENAL HYPERPLASIA IN SHR. POSTER PRESENTATIONS: APOPTOSIS IN VASCULAR SMOOTH MUSCLE CELLS (VSMC): A KEY ROLE OF MODULATORS OF PROTEIN PHOSPHORYLATION POSTER PRESENTATIONS: CHROMATIN CLEAVAGE AND DNA DEGRADATION IN VASCULAR SMOOTH MUSCLE CELLS (VSMC) UNDERGOING APOPTOSIS: EFFECT OF E1A ADENOVIRAL PROTEIN AND Ca²⁺_i. POSTER PRESENTATIONS: MODULATION OF PROLIFERATION, NECROSIS AND AFOFTOSIS BY HEAT STRESS IN VASCULAR SMOOTH MUSCLE CELLS FROM SPONTANEOUSLY HYPERTENSIVE RATS POSTER PRESENTATIONS: Apoptotic events and phenotypic differences in left ventricular fibroblast populations isolated from normotensive and hypertensive rats POSTER PRESENTATIONS: THE HISTOLOGICAL STUDY OF ACUTE IRRADIATION INJURY IN SPONTANEOUSLY HYPERTENSIVE RATS.