308 nm准分子光联合自体表皮移植术对稳定期白癜风的疗效观察

目的:探讨308 nm准分子光联合自体表皮移植术对稳定期白癜风疗效的影响,为白癜风的治疗提供更多的选择。方法:选取98例稳定期白癜风患者,随机分成3组:A组32例,单纯采用自体表皮移植术,共移植皮片83片;B组36例,采用自体表皮移植加308 nm准分子光治疗,共移植皮片106片;C组30例,采用自体表皮移植加NB-UVB治疗,共移植皮片78片。比较3组治疗3个月后的疗效。结果:3种治疗方法在疗效上存在差异,B组疗效优于A、C组(P0.01)。结论:308 nm准分子光联合自体表皮移植术对稳定期白癜风的治疗有较好的效果。     

自体细胞移植治疗稳定期白癜风疗效的Meta分析

目的 系统评价培养与非培养自体黑色素细胞移植及联合其他方法治疗稳定期白癜风的疗效。方法检索PubMed、Embase、Web of Science、The Cochrane Library、中国期刊全文数据库（CNKI）、维普中文科技期刊全文数据库（VIP）、万方数据库,纳入研究为自体细胞移植治疗稳定期白癜风的临床研究。计数资料以合并后相对危险度（RR）值为效应指标,用Revman5.4软件对符合分析的研究进行Meta分析。结果 最终纳入文献14篇,Meta分析显示：自体培养黑色素细胞移植（CMT）与黑色素细胞+角质细胞、CMT与自体非培养混悬液移植（NCES）治疗稳定期白癜风疗效差异无统计学意义（P>0.05）;CMT与CMT+光疗治疗稳定期白癜风疗效差异有统计学意义（P<0.01）;NCES与NCES+其他成分、NCES与NCES+其他疗法、NCES与NCES+光疗治疗稳定期白癜风疗效差异无统计学意义（P>0.05）;细胞移植与细胞移植+其他疗法、细胞移植与细胞移植+光疗、细胞移植与细胞移植+窄谱中波紫外线（NBUVB）治疗稳定期白癜风疗效差异有统计学意义（P&l...     

自体表皮移植联合窄谱UVB照射治疗白癜风临床观察

我们采用自体表皮移植联合窄谱中波紫外线(NB-UVB)照射治疗白癜风,取得较好临床效果,现报道如下.临床资料所有病例均为2004-2005年本所门诊诊治的稳定期白癜风患者共45例,疤痕体质及紫外线光疗禁忌证者除外,近3个月内未采用其它治疗.     

口服中药联合自体表皮移植治疗白癜风疗效观察

目的：中药对自体表皮移植治疗白癜风的治疗作用。方法：以口服中药联合自体表皮移植与单纯自体表皮移植治疗白癜风的疗效进行比较。结果：中药联合自体表皮移植与单纯自体表皮移植组（对照组）治疗白癜风的疗效比较差异有显著性意义（P＜0．05）,结论：提示中药能迅速控制病情,使白癜风进展期转为稳定期,提高自体表皮移植治疗白癜风的成功率。     

自体表皮移植治疗白癜风120例临床观察及其影响因素分析

目的评估白癜风行自体表皮移植术治疗后的长期临床疗效并分析其相关影响因素。方法采用薄层削片自体表皮移植术治疗白癜风,通过复诊、随访观察不同型别白癜风的长期疗效,并分析其与移植后时间长短及患者性别、年龄、治疗部位的相关性。结果接受自体表皮移植资料完整的稳定期白癜风患者120例,寻常型86例(男52例,女34例),节段型34例(男14例,女20例),共移植皮片828个,随访3个月~3年后的总有效率为76.33%,寻常型与节段型有效率分别为70.59%和82.90%。移植部位色素减退15例,原位复发7例,其他部位新发5例。对可能影响疗效的相关因素分析显示,自体表皮移植治疗白癜风后1年内尚稳定,随时间延长,疗效稍降低;移植疗效与白癜风型别、部位及患者性别、年龄有关(P0.05)。结论自体表皮移植治疗白癜风的长期疗效较好,患者性别、年龄及白癜风型别、移植部位、稳定期及病程长短为影响疗效的因素。     

自体培养黑素细胞治疗白癜风患者疗效观察

目的评价自体纯培养黑素细胞移植治疗白癜风的方法与疗效。方法采用从发疱壁上获取黑素细胞、纯黑素细胞培养与增殖、受皮区采用超脉冲二氧化碳激光磨削去表皮后进行黑素细胞移植治疗白癜风。结果共治疗43例白癜风患者,58.62%的皮损获得了90%以上的复色,85.05%的皮损获得了50%以上的复色。局限型白癜风患者移植痊愈率(73.33%)高于节段型(57.14%)和散发型白癜风患者(42.86%);面颈部白癜风患者的移植痊愈率(77.78%)高于四肢(57.78%)和躯干(45.83%)的白癜风患者。结论自体纯培养黑素细胞移植是治疗稳定期白癜风的有效方法,其移植疗效与白癜风类型和皮损部位密切相关。     

高频电刀去皮结合负压吸疱自体表皮移植治疗白癜风

目前国内外报道自体表皮移植法治疗白癜风取得明显疗效,但普遍存在的问题是吸杯之间空隙造成的白癜风皮损无法起疱进行表皮移植.     

自体表皮移植治疗唇红部稳定期白癜风

目的:评价自体表皮移植治疗唇红部稳定期白癜风的临床疗效。方法:将28例唇红部稳定期白癜风患者随机分成2组,治疗组16例,自体表皮移植拆线后1周,外搽祛白酊,每日两次及0.1%他克莫司,每晚1次;对照组12例,仅外搽祛白酊及他克莫司;3个月后评估疗效。结果:治疗组有效率93.75%,对照组有效率41.67%,两组有显著性差异(P0.05)。结论:自体表皮移植方法治疗唇红部稳定期白癜风疗效显著。     

自体表皮移植联合中药白斑颗粒剂Ⅰ方治疗白癜风的疗效及复发率的临床观察

正白癜风是一种获得性皮肤色素异常,表现为脱色性白斑,是皮肤科常见病,严重影响患者心理健康。自体表皮移植是治疗稳定期白癜风的一种较好方法,在我院开展近20年,疗效确切。上海最新的一次大样本流行病学调查显示自体表皮移植的总有效率为92.7%[1]。但少数患者移植治疗半年以后,原复色皮片再次脱色。笔者应用自制中药白斑颗粒剂Ⅰ方联合自体表皮移植术治疗白癜风,降低了移植区复色皮片的复发率,同时提高了疗效,取得满     

体外培养自体黑素细胞移植治疗白癜风78例疗效观察

目的评价自体黑素细胞培养移植治疗白癜风的疗效和影响因素。方法临床选择稳定期白癜风患者78例,采用自体黑素细胞培养与移植治疗方法,记录疗效和并发症,分析可能影响因素。结果 78例患者总计189处皮损,98处皮损(51.85%)获得了90%以上的复色,53处皮损(28.04%)获得了50%~90%以上的复色,总有效率达到79.89%;节段型白癜风患者有效率为86.04%,优于局限型白癜风患者(83.54%)和泛发型白癜风患者(71.64%)的治疗效果;面颈部位的皮损治疗效果最佳(有效率87.80%),要优于躯干部(83.67%)和四肢部位(80.39%),手足部位治疗效果最差(有效率68.75%),黑素细胞分裂时间≤3.5 d的移植有效率明显高于3.5 d者(P0.05)。结论自体培养黑素细胞移植是治疗稳定期白癜风的一种有效方法,其疗效与白癜风的分型、皮损的部位和黑素细胞的生物活性有关。     

New fillers for the new man

ABSTRACT:  Two new collagen-based lidocaine-containing dermal fillers, ArteSense™/ArteFill™ (Artes Medical, San Diego, CA) and Evolence® (Colbar LifeScience Ltd., Herzliya, Israel), have proved to be of particular interest to men, many of whom seek a long-lasting or permanent correction. ArteFill™ has been available in the United States since 2006, and it is expected that Evolence® will reach the American market in 2008. The properties of the two products will be described, and experience based on the administration of many hundreds of syringes of both products by a Canadian dermatologist will be detailed here, with tips and precautions to optimize patient outcomes.     

Outcomes and adverse effects of ablative vs nonablative lasers for skin resurfacing: A systematic review of 1093 patients

It is generally believed that ablative laser therapies result in prolonged healing and greater adverse events when compared with nonablative lasers for skin resurfacing. To evaluate the efficacy of ablative laser use for skin resurfacing and adverse events as a consequence of treatment in comparison to other modalities, a PRISMA‐compliant systematic review (Systematic Review Registration Number: 204016) of twelve electronic databases was conducted for the terms “ablative laser” and “skin resurfacing” from March 2002 until July 2020. Studies included meta‐analyses, randomized control trials, cohort studies, and case reports to facilitate evaluation of the data. All articles were evaluated for bias. The search strategy produced 34 studies. Of 1093 patients included in the studies of interest, adverse events were reported in a total of 106 patients (9.7%). Higher rates of adverse events were described in nonablative therapies (12.2% ± 2.19%, 31 events) when compared with ablative therapy (8.28% ± 2.46%, 81 events). 147 patients (13.4%) reported no side effects, 68 (6.22%) reported expected, transient self‐resolving events, and five (0.046%) presented with hypertrophic scarring. Excluding transient events, ablative lasers had fewer complications overall when compared with nonablative lasers (2.56% ± 2.19% vs 7.48% ± 3.29%). This systematic review suggests ablative laser use for skin resurfacing is a safe and effective modality to treat a range of pathologies from photodamage and acne scars to hidradenitis suppurativa and posttraumatic scarring from basal cell carcinoma excision. Further studies are needed, but these results suggest that ablative lasers are a superior, safe, and effective modality to treat damaged skin.     

Genetic alterations in RAS‐regulated pathway in acral lentiginous melanoma

Studies integrating clinicopathological and genetic features have revealed distinct patterns of genomic aberrations in Melanoma. Distributions of BRAF or NRAS mutations and gains of several oncogenes differ among melanoma subgroups, while 9p21 deletions are found in all melanoma subtypes. In the study, status of genes involved in cell cycle progression and apoptosis was evaluated in a panel of 17 frozen primary acral melanomas. NRAS mutations were found in 17% of the tumors. In contrast, BRAF mutations were not found. Gains of AURKA gene (20q13.3) were detected in 37.5% of samples, gains of CCND1 gene (11q13) or TERT gene (5p15.33) in 31.2% and gains of NRAS gene (1p13.2) in 25%. Alterations in 9p21 were identified in 69% of tumors. Gains of 11q13 and 20q13 were mutually exclusive, and 1p13.2 gain was associated with 5p15.33. Our findings showed that alterations in RAS‐related pathways are present in 87.5% of acral lentiginous melanomas.     

Self‐resolving superficial primary cutaneous mucormycosis in a 7‐week‐old infant

A 7‐week‐old girl, born at 30 weeks' gestational age, presented to clinic for evaluation of a crop of vesicular lesions that were noted after removal of a bandage that had been in place for 4 days. A punch biopsy of the lesion revealed fungal elements that were later identified as Rhizopus spp. The lesion began to self‐resolve, and no further treatment was needed, with full resolution of the lesion by 1 month after presentation. Clinicians should be aware of the variable presentations of mucormycosis and consider fungal infection in the differential diagnosis when evaluating vulnerable patients with skin eruptions.     

Multiple New-Onset Subcutaneous Nodules of the Upper Extremity Digits: Giant Cell Tumor of Tendon Sheath and Lipoma

A black woman with the concurrent onset of two subcutaneous nodules located on the digits of her upper extremities is described. Initially, a single systemic disorder was considered; yet, the lesions differed in morphology and consistency. Microscopic examination of the nodules showed a giant cell tumor of tendon sheath and a lipoma. Although Occam's “razor” suggests that multiple lesions in the same person are more likely to represent variable manifestations of a single disorder than several different diseases in that individual, the simultaneously appearing lesions in this patient represented two different conditions.