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1.
Irene Toldo Egle Perissinotto Francesca Menegazzo Clementina Boniver Stefano Sartori Leonardo Salviati Maurizio Clementi Pasquale Montagna Pier Antonio Battistella 《The journal of headache and pain》2010,11(3):235-240
The purpose of this study was to analyse the comorbidity between headache and epilepsy in a large series of children with
headache (1,795). Fifty-six cases (3.1%) suffered from idiopathic headache and idiopathic or cryptogenic epilepsy or unprovoked
seizures. There was a strong association between migraine and epilepsy: in migraineurs (46/56) the risk of epilepsy was 3.2
times higher when compared with tension-type headache, without significant difference between migraine with and without aura
(P = 0.89); children with epilepsy had a 4.5-fold increased risk of developing migraine than tension-type headache. In cases
with comorbidity, focal epilepsies prevailed (43/56, 76.8%). Migraineurs affected by focal epilepsies (36/56) had a three
times higher risk of having a cryptogenic epilepsy (27/36, 75%) than an idiopathic epilepsy (9/36, 25%) (P = 0.003). In migraine with aura, epilepsy preceded migraine in 71% of cases. Photosensitivity (7/56, 12.5%) and positive
family history for epilepsy (22/56, 39%) were frequent in cases with comorbidity. 相似文献
2.
Ravi Gupta Vivek Kumar Kalpana Luthra Basudeb Banerjee Manjeet Singh Bhatia 《The journal of headache and pain》2009,10(2):115-120
Nitric oxide plays an important role in the pathogenesis of migraine as well as tension-type headache. Studies suggest that
the expression of molecules involved in the pathogenesis of headache, i.e., nitric oxide and interleukin, is influenced by
apolipoprotein E (APOE) and is gene specific. Hence, we hypothesized that APOE polymorphism may be associated with migraine
as well as tension-type headache.The study sample comprised of three groups: migraineurs, tension-type headache subjects as
well as a healthy control group. A total of 50 subjects in each group were included after screening for the inclusion and
exclusion criteria. None of the subjects was a blood relative of any other subject included in the present study. Their venous
blood was drawn and stored at −20°C. Genomic DNA extraction was performed with a commercial kit and simple sequence-specific
primer PCR was performed to assess the APOE polymorphism. Data were analyzed with the help of SPSS V11.0 for Windows. χ2 test and logistic regression analysis were run. The results of the study showed that APOE ε2 gene increases the risk of migraine
as compared to the control group and the tension-type headache group (OR = 4.85; 95% CI = 1.92–12.72; P < 0.001 and OR = 2.31; 95% CI = 1.08–4.94; P = 0.01, respectively). Interestingly, APOE ε4 gene was protective against migraine as well as tension-type headache. This
study shows that APOE ε2 gene increases the risk of migraine, while APOE ε4 gene is protective against migraine and tension-type
headache. Further research is required to confirm the findings of the present study in a larger sample and to elucidate the
role of APOE polymorphism in headache. 相似文献
3.
Psychopathology and quality of life burden in chronic daily headache: influence of migraine symptoms
A. Autret S. Roux S. Rimbaux-Lepage D. Valade S. Debiais 《The journal of headache and pain》2010,11(3):247-253
The aim of this study is to compare the psychopathology and the quality of life of chronic daily headache patients between
those with migraine headache and those with tension-type headache. We enrolled 106 adults with chronic daily headache (CDH)
who consulted for the first time in specialised centres. The patients were classified according to the IHS 2004 criteria and
the propositions of the Headache Classification Committee (2006) with a computed algorithm: 8 had chronic migraine (without
medication overuse), 18 had chronic tension-type headache (without medication overuse), 80 had medication overuse headache
and among them, 43 fulfilled the criteria for the sub-group of migraine (m) MOH, and 37 the subgroup for tension-type (tt)
MOH. We tested five variables: MADRS global score, HAMA psychic and somatic sub-scales, SF-36 psychic, and somatic summary
components. We compared patients with migraine symptoms (CM and mMOH) to those with tension-type symptoms (CTTH and ttMOH)
and neutralised pain intensity with an ANCOVA which is a priori higher in the migraine group. We failed to find any difference
between migraine and tension-type groups in the MADRS global score, the HAMA psychological sub-score and the SF36 physical
component summary. The HAMA somatic anxiety subscale was higher in the migraine group than in the tension-type group (F(1,103) = 10.10, p = 0.001). The SF36 mental component summary was significantly worse in the migraine as compared with the tension-type subgroup
(F(1,103) = 5.758, p = 0.018). In the four CDH subgroups, all the SF36 dimension scores except one (Physical Functioning) showed a more than 20
point difference from those seen in the adjusted historical controls. Furthermore, two sub-scores were significantly more
affected in the migraine group as compared to the tension-type group, the physical health bodily pain (F(1,103) = 4.51, p = 0.036) and the mental health (F(1,103) = 8.17, p = 0.005). Considering that the statistic procedure neutralises the pain intensity factor, our data suggest a particular vulnerability
to somatic symptoms and a special predisposition to develop negative pain affect in migraine patients in comparison to tension-type
patients. 相似文献
4.
B. Petolicchio L. Di Clemente M. Altieri E. Vicenzini G. L. Lenzi Vittorio Di Piero 《The journal of headache and pain》2010,11(2):129-135
In 2003, we conducted a sensitisation campaign on migraine in the Casilino district of Rome, by sending a letter with the
ID Migraine test to all the households and placing posters in the GPs’ waiting room. Out of 195 headache patients recruited,
92% had migraine while 73% had never consulted a physician for headache. The aim of this study was to evaluate the long-term
impact of this campaign. The follow-up was performed by a telephone interview. The questionnaire considered the characteristics
of headache, quality of life, preventive and acute treatments, drug efficacy, comorbidity and subjective usefulness of the
campaign. Of the 179 migraineurs, 90.5% (mean age 40.7 ± 16.5, 139 females) were included in the follow-up. An improvement
was observed in mean pain intensity (−13.9%; p < 0.0001) and mean HIT-6 score (−6.1%; p = 0.0003). The campaign was considered to be useful by 63.6% of cases, while 66.1% reported an improvement in their clinical
status. Improved patients showed a decreased mean number of days with headache per month (−51.7%; p < 0.0001), pain intensity (−21.8%; p < 0.0001), headache duration (−18.1%; p = 0.0008) and HIT-6 score (−11.7%; p < 0.0001). Our data suggest that the effects of a “single shot” campaign are beneficial not only in a short-term perspective,
but even in the long term. Moreover, the lack of benefit in more severe cases suggests that such patients should not be treated
by GPs alone: patients in whom the HIT-6 score, frequency, severity or duration of headache worsen should be promptly referred
to the headache clinic. 相似文献
5.
The characteristics of
psychiatric comorbidity in migraine
have been studied in migraine with
aura (MA) and migraine without
aura (MO). Little information is
available concerning patients with
migraine aura without headache. In
a study of 201 patients with major
affective disorders (DSM–IV) we
have described the clinical characteristics
of patients with these three
sub–types of migraine (IHS criteria)
and compared the MA and migraine
aura without headache groups.
Compared to patients having MA
(n=57), the group with migraine
aura without headache (n=18) had a
higher age of onset of migraine
(28.5 vs. 19.2, p=0.001), significantly
lower prevalences of affective
temperaments (28% vs. 56%,
p=0.036), suicide attempts (17% vs.
53%, p=0.013) and Raynaud’s syndrome
(0% vs. 25%, p=0.017).
These results indicate that there
seem to be differences in the clinical
characteristics found in patients
with migraine with aura when compared
to those having the migraine
subtype without a headache phase.
This may convey new information
concerning the comorbid expression
of migraine and affective disorders
or concerning the processes that
differentiates the migraine types
with and without a subsequent pain
attack. 相似文献
6.
Gaul C van Doorn C Webering N Dlugaj M Katsarava Z Diener HC Fritsche G 《The journal of headache and pain》2011,12(4):475-483
This study investigated the outcome of a 5-day headache-specific multidisciplinary treatment program (MTP) and the adherence
to treatment recommendations in 295 prospectively recruited consecutive headache patients [210 migraine, 17 tension-type headache
(TTH), 68 combination headache, including 56 medication-overuse headache (MOH)]. Headache frequency decreased from 13.4 (±8.8)
to 8.8 (±8.0) days per month after 12–18 months. Forty-three percent of the participants fulfilled the primary outcome (reduction
of headache frequency of ≥50%), which was less likely in patients with combination of migraine and TTH compared to migraine
(OR = 3.136, p = 0.002) or TTH (OR = 1.029, n.s.). Increasing number of headache days per month (OR = 1.092, p ≤ 0.0001) and adherence to lifestyle modifications (OR = 1.269, p = 0.004) predicted primary outcome. 51 of 56 MOH patients were treated successfully. Thirty-five percent of the patients
were adherent to pharmacological prophylaxis, 61% to relaxation therapy, and 72% to aerobic endurance sports. MTP is effective
in headache treatment. Adherence to therapy was associated with better outcome. 相似文献
7.
de Tommaso M Federici A Serpino C Vecchio E Franco G Sardaro M Delussi M Livrea P 《The journal of headache and pain》2011,12(6):629-638
Our previous study assessed the prevalence of fibromyalgia (FM) syndrome in migraine and tension-type headache. We aimed to
update our previous results, considering a larger cohort of primary headache patients who came for the first time at our tertiary
headache ambulatory. A consecutive sample of 1,123 patients was screened. Frequency of FM in the main groups and types of
primary headaches; discriminating factor for FM comorbidity derived from headache frequency and duration, age, anxiety, depression,
headache disability, allodynia, pericranial tenderness, fatigue, quality of life and sleep, and probability of FM membership
in groups; and types of primary headaches were assessed. FM was present in 174 among a total of 889 included patients. It
prevailed in the tension-type headache main group (35%, p < 0.0001) and chronic tension-type headache subtype (44.3%, p < 0.0001). Headache frequency, anxiety, pericranial tenderness, poor sleep quality, and physical disability were the best
discriminating variables for FM comorbidity, with 81.2% sensitivity. Patients presenting with chronic migraine and chronic
tension-type headache had a higher probability of sharing the FM profile (Bonferroni test, p < 0.01). A phenotypic profile where headache frequency concurs with anxiety, sleep disturbance, and pericranial tenderness
should be individuated to detect the development of diffuse pain in headache patients. 相似文献
8.
Restricted neck mobility in children with chronic tension type headache: a blinded, controlled study
Daniel M. Fernández-Mayoralas César Fernández-de-las-Peñas Domingo Palacios-Ceña Irene Cantarero-Villanueva Carolina Fernández-Lao Juan A. Pareja 《The journal of headache and pain》2010,11(5):399-404
The main purpose of this study was to analyze the differences in neck mobility between children with chronic tension type
headache (CTTH) and healthy children, and to determine the influence of cervical mobility on headache intensity, frequency
and duration. Fifty children, 13 boys and 37 girls (mean age 8.5 ± 1.6 years) with CTTH associated to peri-cranial tenderness
(IHS 2.3.1) and 50 age- and sex matched children without headache (13 boys, 37 girls, mean age 8.5 ± 1.8 years, P = 0.955) participated. Cervical range of motion (CROM) was objectively assessed with a cervical goniometer by an assessor
blinded to the children’s condition. Children completed a headache diary for 4 weeks to confirm the diagnosis. Children with
CTTH showed decreased CROM as compared to children without headache for flexion (z = −6.170; P < 0.001), extension (z = −4.230; P < 0.001), right (z = −4.505; P < 0.001) and left (z = −4.768; P < 0.001) lateral-flexions, but not for rotation (right z = −0.802; P = 0.425; left z = −1.254; P = 0.213) and also for total range of motion for flexion-extension (z = −4.267; P < 0.001) and lateral-flexion (z = −4.801; P < 0.001), but not for rotation (z = −1.058; P = 0.293). Within CTTH children, CROM was not correlated with headache intensity, frequency or duration. Additionally, age
(P > 0.125) or gender (P > 0.250) did not influence CROM in either children with CTTH or without headache. Current results support the hypothesis
that the cervical spine should be explored in children with headache. Further research is also needed to clearly define the
potential role of the cervical spine in the genesis or maintenance of CTTH. 相似文献
9.
Arthur Filusch Derliz Mereles Ekkehard Gruenig Sebastian Buss Hugo A. Katus F. Joachim Meyer 《Clinical research in cardiology》2010,99(8):491-498
Optimizing the non-invasive imaging of right ventricular (RV) function is of increasing interest for therapy monitoring and
risk stratification in patients with idiopathic pulmonary hypertension (IPAH). Therefore, this study evaluated strain and
strain rate echocardiography as a tool for comprehensive assessment of RV function and disease severity in IPAH patients.
In 30 IPAH patients [WHO functional classes II–IV; mean pulmonary artery pressure (mPAP) 48.8 ± 12.5 mmHg; pulmonary vascular
resistance (PVR) 7.9 ± 5.3 Wood units] and in 10 matched healthy control subjects’ two-dimensional echocardiography, 6-MWD
and N-terminal pro-brain natriuretic peptide (NT-proBNP) levels were obtained. In IPAH patients when compared with controls,
RV systolic strain (−18.8 ± 4.3 vs. −34.5 ± 3.8%, p = 0.0016) and strain rate (−1.6 ± 0.6 vs. −2.7 ± 0.5 s−1, p = 0.018) were significantly altered and correlated significantly with elevated NT-proBNP levels (r = 0.73 and r = 0.62; p < 0.001, respectively) and reduced 6-MWD (r = −0.76 and r = −0.81; p < 0.001). In IPAH patients, reduced strain correlated with both mPAP (r = 0.61, p = 0.01 for strain; and r = 0.55, p = 0.04 for strain rate, respectively), and PVR (r = 0.84, p < 0.001 for strain; and r = 0.67, p < 0.001 for strain rate, respectively). This study gives first comprehensive evidence that strain echocardiography allows
accurate non-invasive assessment of RV function and disease severity in patients with IPAH. 相似文献
10.
Juliana Jensen Li-Ping Ma Michael L. X. Fu David Svaninger Per-Arne Lundberg Ola Hammarsten 《Clinical research in cardiology》2010,99(7):445-452
Plasma BNP and NT-proBNP are often regarded as interchangeable parameters in assessing heart failure (HF) severity and prognosis.
Renal failure results in disproportionate increases of NT-proBNP and an increased NT-proBNP/BNP ratio. Low kidney function
is therefore considered particularly when NT-proBNP is used to assess HF. The purpose of this study was to identify other
conditions affecting the NT-proBNP/BNP ratio. We examined the NT-proBNP/BNP ratio, 26 other lab parameters, and clinical factors
in 218 patients admitted to the HF ward. In addition to renal function, we also found significant correlations between the
NT-proBNP/BNP ratio and inflammation as measured by orosomucoid (r = 0.525, p < 0.0001), CRP (r = 0.333, p < 0.0001), haptoglobulin (r = 0.201, p = 0.02), and alpha1-antitrypsin (r = 0.223, p = 0.01). Reverse correlation was found with transferrin (r = −0.323, p < 0.0001), albumin (r = −0.251, p = 0.003), and S–Fe (r = −0.205, p = 0.02), parameters known to decrease during inflammation. Inflammation increased levels of NT-proBNP more than BNP, resulting
in an increased NT-proBNP/BNP ratio. Our findings indicate that NT-proBNP should be evaluated concomitantly with inflammatory
status to avoid overestimation of HF severity. 相似文献
11.
Giovanni Mazzotta Paola Sarchielli Andrea Alberti Elisabetta Cittadini Virgilio Gallai 《The journal of headache and pain》2003,4(1):24-30
We observed the occurrence of neuromuscular hyperexcitability, assessed with electromyographic ischemic tests, in headache
patients in relation to Mg++ levels in serum, red blood cells and mononuclear cells. Clinical symptoms most significantly associated with neuromuscolar
hyperexcitability and magnesium derangements were also investigated. A total of 36 patients with migraine without aura (MwoA),18
patients with episodic tension-type headache (ETTH) and 22 patients with chronic tension-type headache (CTTH) were examined
during interictal periods. The electromyographic (EMG) ischemic test was positive in 91.7% of MwoA patients, in 27.7% of ETTH
and in 13.6% of CTTH patients. In patients with MwoA, the Mg++ levels in red blood cells were significantly less than those in the other two groups of patients with tension-type headache
(ANOVA, p<0.00l). Positive EMG ischemic tests were significantly associated with decreased erythrocyte Mg++ levels in MwoA patients (χ2, p<0.01). The clinical symptoms in patients with MwoA most frequently suggest the presence of neuromuscular hyperexcitability
and are more strictly associated with reduced red blood cell Mg++ levels. They include fasciculations (91.7%), asthenia (91.7%), blepharospasm (75.8%) and paresthesiae (47.2%). Anxiety and
depression most often occurred in tension-type headache patients, but were not related to modifications in intra- and extracellular
Mg++ levels.
Received: 14 January 2002, Accepted in revised form: 22 July 2002
Correspondence to G. Mazzotta 相似文献
12.
Gabriel Bsteh PD MD PhD Stefan Macher MD PhD Nik Krajnc MD Philip Pruckner MD Wolfgang Marik MD Christoph Mitsch PD MD Klaus Novak MD Berthold Pemp PD MD Christian Wöber MD 《Headache》2023,63(5):601-610
Objective
To assess the prognostic impact of migraine headache in idiopathic intracranial hypertension (IIH).Background
Migraine headache is common in IIH, but it is unclear whether it has prognostic relevance.Methods
We investigated patients with IIH from the Vienna-IIH-database and differentiated migraine (IIH-MIG) from non-migraine headache (IIH-nonMIG) and without headache (IIH-noHA). Using multivariable models, we analyzed the impact of IIH-MIG on headache and visual outcomes 12 months after diagnosis.Results
Among 97 patients (89% female, mean [SD] age 32.9 [11.1] years, median body mass index 32.0 kg/m2, median cerebrospinal fluid opening pressure 310 mm), 46% were assigned to IIH-MIG, 37% to IIH-nonMIG (11% tension-type, 26% unclassifiable), and 17% to IIH-noHA. Overall, headache improvement was achieved in 77% and freedom of headache in 28%. The IIH-MIG group showed significantly lower rates for headache improvement (67% vs. 89% in IIH-nonMIG, p = 0.019) and freedom of headache (11% vs. 33% in IIH-nonMIG and 63% in IIH-noHA, p = 0.015). These differences persisted when only analyzing patients with resolved papilledema at follow-up. In contrast, visual worsening was significantly less common in IIH-MIG (9% vs. 28% in IIH-nonMIG and 31% in IIH-noHA, p = 0.045). In multivariable models, IIH-MIG was associated with a significantly lower likelihood of achieving headache improvement (odds ratio [OR] 0.57, 95% confidence interval [CI] 0.40–0.78, p < 0.001) and freedom of headache (OR 0.29, 95% CI 0.12–0.46, p < 0.001), but also a lower risk for visual worsening (OR 0.26, 95% CI 0.04–0.82, p < 0.001).Conclusions
In IIH, migraine headache is associated with unfavorable outcomes for headache, even when papilledema has resolved, and possibly favorable visual outcome. 相似文献13.
Ettore Beghi Gennaro Bussone Domenico D’Amico Pietro Cortelli Sabina Cevoli Gian Camillo Manzoni Paola Torelli Maria Clara Tonini Giovanni Allais Roberto De Simone Florindo D’Onofrio Sergio Genco Franca Moschiano Massimiliano Beghi Sara Salvi 《The journal of headache and pain》2010,11(2):141-150
The objective of this paper was to assess prevalence and characteristics of anxiety and depression in migraine without aura and tension-type headache, either isolated or in combination. Although the association between headache and psychiatric disorders is undisputed, patients with migraine and/or tension-type headache have been frequently investigated in different settings and using different tests, which prevents meaningful comparisons. Psychiatric comorbidity was tested through structured interview and the MINI inventory in 158 adults with migraine without aura and in 216 persons with tension-type headache or migraine plus tension-type headache. 49 patients reported psychiatric disorders: migraine 10.9%, tension-type headache 12.8%, and migraine plus tension-type headache 21.4%. The MINI detected a depressive episode in 59.9, 67.0, and 69.6% of cases. Values were 18.4, 19.3, and 18.4% for anxiety, 12.7, 5.5, and 14.2%, for panic disorder and 2.3, 1.1 and 9.4% (p = 0.009) for obsessive–compulsive disorder. Multivariate analysis showed panic disorder prevailing in migraine compared with the other groups (OR 2.9; 95% CI 1.2–7.0). The association was higher (OR 6.3; 95% CI 1.4–28.5) when migraine (with or without tension-type headache) was compared to pure tension-type headache. This also applied to obsessive–compulsive disorder (OR 4.8; 95% CI 1.1–20.9) in migraine plus tension-type headache. Psychopathology of primary headache can reflect shared risk factors, pathophysiologic mechanisms, and disease burden. 相似文献
14.
Tronvik E Zwart JA Hagen K Dyb G Holmen TL Stovner LJ 《The journal of headache and pain》2011,12(3):347-353
The relationship between blood pressure and headache in youth has not been explored and the objective of the present study
was to provide data on this association in an adolescent population. Cross-sectional data from a large population-based survey,
the Young-HUNT study, on 5,847 adolescents were used to evaluate the association between blood pressure (systolic, diastolic,
mean arterial and pulse pressure) and recurrent headache, including migraine and tension-type headache. Increasing pulse pressure
was inversely related to recurrent headache prevalence, and both tension-type headache and migraine. For systolic blood pressure
such an inverse relationship was present for recurrent headache and tension-type headache prevalence. For migraine, the results
were not significant, although there was a tendency in the same direction (p = 0.05). High-pulse pressure has previously been found to be inversely related to the prevalence of migraine and tension-type
headache in an adult population. This inverse relationship has now been demonstrated to be present among adolescents also,
supporting the results from a previous study in adults, that blood pressure regulation may be linked to the pathophysiology
of headache. 相似文献
15.
Yiannopoulou KG Efthymiou A Karydakis K Arhimandritis A Bovaretos N Tzivras M 《The journal of headache and pain》2007,8(6):329-333
Helicobacter pylori (H. pylori) infection has recently been associated with various extraintestinal pathologies and migraine. The aim of this study was
to investigate the correlation of the H. pylori infection with the pathogenesis of migraine without aura, especially in cases not affected by endogenous risk factors, like
hereditary pattern or hormonal fluctuations.
A total of 49 outpatients (37 females and 12 males; age range: 19–47 years; mean age: 31,±14 years) affected by migraine without
aura was evaluated. We divided them in 2 subgroups: a) with positive familial history, and/or with menstrual type of migraine
b) with negative familial history and with menstrual unrelated type of migraine. H. pylori infection was diagnosed by the 13 C- urea breath test (INFAI — test).
Control subjects consisted of 51 patients without any primary headache history (38 females; mean age of 32,±14,4 years; range
21–49 years), who underwent upper gastrointestinal (GI) endoscopy for investigation of anaemia or non ulcer dyspepsia. H. pylori detection was based on the histologic analysis of gastric mucosa biopsy.
The prevalence of H. pylori infection was significantly higher in the migraineurs without aura compared to controls (p=0.016).
The prevalence of H. pylori infection was significantly high in the mixed and in the female group of our patients without other predisposing factors
for migraine without aura (81 and 87% respectively), while in the same groups with predisposing factors (menstruation and/or
family history) the prevalence was only 36 and 37% respectively (p=0,001 for the first group and p=0,002 for the second group). Our results seem to highlight the role of H. pylori infection as a probable independent environmental risk factor for migraine without aura, especially in patients that are
not genetically or hormonally susceptible to migraine. 相似文献
16.
The objective of this study is to assess effects of beta-blocker migraine prophylaxis on cortical excitability determined
by transcranial magnetic stimulation (TMS). Phosphene and motor thresholds (PT, MT) were investigated in 29 patients with
migraine, in 15 of them prior to and following preventive medication with metoprolol and in 14 patients without prophylaxis.
Following prophylaxis headache frequency significantly decreased (p = 0.005) and mean PT were significantly increased (51.5 ± 7.5 vs. 63.6 ± 8.4%) compared to patients without preventive treatment
(53.7 ± 5.3 vs. 52.3 ± 6.3%; p = 0.040). Mean MT did not significantly differ either between groups or due to treatment. In the group of all patients, a
significant inverse correlation between headache frequency and the level of PT was found (R = −0.629; p < 0.01). There was, however, no significant correlation in the subgroups of patients. We conclude that (a) clinical efficacy
of beta-blocker treatment in migraine could be (at least partly) linked to its ability to modulate the excitability of the
visual cortex and (b) the PT determined by TMS appears suitable to assess the effects of prophylaxis on cortical excitability
in the individual patient. This may be useful in clinical trials investigating migraine preventive drugs. 相似文献
17.
Corletto E Dal Zotto L Resos A Tripoli E Zanchin G Bulfoni C Battistella PA 《Cephalalgia : an international journal of headache》2008,28(8):825-831
This study was planned to investigate the prevalence of osmophobia in juvenile headache sufferers and to analyse the diagnostic utility of osmophobia in order to distinguish migraine without aura from episodic tension-type headache. We examined 305 consecutive patients presenting at our Paediatric Headache Centre. A semistructured questionnaire was given to 275 selected patients affected by migraine or tension-type headache. The prevalence of osmophobia during attacks was 18.5%, mainly in migraine patients (25.1%) vs. those with tension-type headache (8.3%). Osmophobia showed more specificity than phonophobia or photophobia in the differential diagnosis between migraine and tension-type headache. In conclusion, this study demonstrates that osmophobia resulted in a symptom with poor sensitivity (27.1%) but high specificity (92%) that could become a supportive diagnostic criterion even in children for the differential diagnosis between migraine without aura and tension-type headache. 相似文献
18.
Russell MB 《The journal of headache and pain》2005,6(6):441-447
The aim of this study was to evaluate the one–year prevalence of tension–type headache in the general population. Three thousand
men and one thousand women aged 40 years from the Danish population were included. They received a mailed questionnaire and
the response rate was 87%. The selfreported one–year prevalence of tension– type headache was 84.7%. The one–year prevalence
of infrequent episodic, frequent episodic and chronic tension–type headache was 48.2%, 33.8% and 2.3%, respectively. No tension–type
headache and infrequent episodic tension–type headache was significantly more frequent in men than women (p<0.0005 and p=0.004), while frequent and chronic tension–type headache was significantly more frequent in women than men (p<0.0005 and p<0.0005). No tension– type headache and infrequent tension–type headache was significantly more frequent among those without
than with self–reported migraine (no headache, men, p<0.0005 and women, p=0.002 and infrequent, men, p<0.0005 and women, p<0.0005), while episodic frequent and chronic tension–type headache was significantly more frequent among those with than
those without self–reported migraine, with the exception of chronic tension–type in women (frequent episodic, men, p<0.0005 and women, p<0.0005 and chronic, men, p<0.0005 and women, p=0.08). Women are more prone to tensiontype headache than men and they have it more frequently than men. Self–reported migraine
increases the risk for frequent episodic and chronic tension–type headache. 相似文献
19.
Ilya Kister A. B. Caminero T. S. Monteith A. Soliman T. E. Bacon J. H. Bacon J. T. Kalina M. Inglese J. Herbert R. B. Lipton 《The journal of headache and pain》2010,11(5):417-425
The objectives of this study were: (1) to assess relative frequency of migraine in multiple sclerosis (MS) patients using
the validated self-administered diagnostic questionnaire, and to compare the migraine rates in MS outpatients to age- and
gender-matched historical population controls; (2) to compare clinical and radiographic characteristics in MS patients with
migraine and headache-free MS patients. We conducted a cross-sectional study to assess the demographic profiles, headache
features and clinical characteristics of MS patients attending a MS clinic using a questionnaire based on the American Migraine
Prevalence and Prevention (AMPP) study. We compared the relative frequency of migraine in MS clinic patients and AMPP cohort.
We also compared clinical and radiographic features in MS patients with migraine to an MS control group without headache.
Among 204 MS patients, the relative frequency of migraine was threefold higher than in population controls both for women
[55.7 vs. 17.1%; prevalence ratio (PR) = 3.26, p < 0.001] and men (18.4 vs. 5.6%; PR = 3.29, p < 0.001). In a series of logistic regression models that controlled for age, gender, disease duration, β-interferon use,
and depression, migraine in MS patients was significantly associated (p < 0.01) with trigeminal and occipital neuralgia, facial pain, Lhermitte’s sign, temporomandibular joint pain, non-headache
pain and a past history of depression. Migraine status was not significantly associated with disability on patient-derived
disability steps scale or T2 lesion burden on brain MRI. Migraine is three-times more common in MS clinic patients than in
general population. MS–migraine group was more symptomatic than the MS–no headache group. 相似文献
20.
Multi-echo T2 relaxation decay data was acquired for 5 preadolescent males (age range 9–12 years). A signal to noise filter appropriate for multi-exponential T2 analysis was then applied to remove voxels which did not accurately fit the modelled curve. The remaining voxels were designated “highly myelinated” if their myelin water fraction (MWF) was greater than a critical value. We investigated a range of signal to noise filter cut-off values and highly myelinated critical values and demonstrated a significant correlation (r = 0.990, p < 0.001) between verbal intelligence quotient scores on the Wechsler Intelligence Scale for Children — Revised and myelination of the corpus callosum in children. This relationship is supported by a growing number of studies showing a correlation between white matter development and cognitive ability. 相似文献