国产静脉注射免疫球蛋白治疗特发性血小板减少性紫癜的疗效和安全性

国产静脉注射免疫球蛋白治疗特发性血小板减少性紫癜的疗效和安全性贾苍松廖清奎罗春华马廉我们于１９９３年７月～１９９５年１月，应用中国医学科学院输血研究所生产的经加热灭活处理的静脉注射免疫球蛋白（ＩＶＩＧ）治疗小儿特发性血小板减少性紫癜（ＩＴＰ）２１例，...     

静注免疫球蛋白及地塞米松治疗特发性血小板减少性紫癜临床观察

探讨大剂量地塞米松及静注免疫球蛋白治疗特发性血小板减少性紫癜（ＩＴＰ）的疗效及其对血液粘稠度的影响。以ＤＥＸ、ＩＶＩＧ、ＩＶＩＧ加ＤＥＸ治疗ＩＴＰ患儿,观察其血小板数变化,并于治疗前后各抽取静脉血一次。结果显示：１。平均血小板计数升至正常时间：单纯ＤＥＸ治疗组为７天,单纯ＩＶＩＧ组及ＩＶＩＧ加ＤＥＸ组为４天;平均计数峰值;单纯ＩＶＩＧ组及ＩＶＩＧ加ＤＥＸ组高于ＤＥＸ缄,但单纯ＩＶＩＧ组与ＩＶＩＧ加     

关于静脉注射HCVAb阳性免疫球蛋白安全性的质疑

我们对中华儿科杂志１９９７年第３５卷第６期３２７页刊登的“国产静脉注射免疫球蛋白治疗特发性血小板减少性紫癜的疗效和安全性”一文，得出含有ＨＣＶ抗体ＨＣＶＡｂ的静脉免疫球蛋白（ＩＶＩＧ）经临床观察是安全的结论有不同看法。血清ＨＣＶＡｂ阳性者多伴有ＨＣＶ...     

静注丙种球蛋白加地塞米松治疗小儿ITP疗效观察

静脉注射人血丙种球蛋白 (ＩＶＩＧ)治疗特发性血小板减少性紫癜 (ＩＴＰ)的疗效已被公认 ,但单用ＩＶＩＧ治疗 ,血小板升高后在短时间下降。自 1 998年 1月以来 ,我们采用ＩＶＩＧ和地塞米松并用治疗 1 1例ＩＴＰ ,已获得满意效果 ,现报告如下。材料与方法1 .病例选择　 1 1例均为 1 998年 1月以来我科收治的ＩＴＰ患者 ,9例男性 ,2例女性 ,41 2 ～ 1 1 1 11 2 岁 ,平均 4 .8岁 ,病程最短 1天 ,最长 1年 ,其中急性ＩＴＰ 1 0例 ,慢性ＩＴＰ 1例 ,全部病例均符合全国小儿血液病学术会议拟定的“特发性血小板减少性紫癜诊疗常规 (草案 )”标…     

丙种球蛋白治疗新生儿血小板减少性紫癜20例

我们 1997～ 1999年对新生儿血小板减少性紫癜 (ＩＴＰ)采用静脉注射丙球蛋白 (ＩＶＩＧ)治疗 ,并与 1970～ 1996年新生儿ＩＴＰ对比 ,报告如下。资料与方法一、临床资料　随意抽取 1970～ 1996年新生儿ＩＴＰ 2 0例为对照组 ,1997～ 1999年新生儿ＩＴＰ 2 0例为治疗组 ;按1998年 6月特发性血小板减少性紫癜诊疗建议 (修订草案 )诊断[1] 。排除同族免疫性血小板减少及新生儿暂时性血小板减少。治疗组男 12例 ,女 8例 ;日龄未满 2 8ｄ。对照组男 14例 ,女 16例 ;日龄未满 2 8ｄ。二、治疗方法　治疗组用ＩＶＩＧ 40 0ｍｇ/ (ｋｇ·ｄ) (长春…     

静注免疫球蛋白及地塞米松治疗特发性血小板减少性紫癜临床观察

探讨大剂量地塞米松（ＤＥＸ）及静注免疫球蛋白（ＩＶＩＧ）治疗特发性血小板减少性紫癜（ＩＴＰ）的疗效及其对血液粘稠度的影响。以ＤＥＸ、ＩＶＩＧ、ＩＶＩＧ加ＤＥＸ治疗ＩＴＰ患儿,观察其血小板数变化,并于治疗前后各抽取静脉血一次。结果显示：１．平均血小板计数升至正常时间：单纯ＤＥＸ治疗组为７天,单纯ＩＶＩＧ组及ＩＶＩＧ加ＤＥＸ组为４天;平均计数峰值：单纯ＩＶＩＧ组及ＩＶＩＧ加ＤＥＸ组高于ＤＥＸ组,但单纯ＩＶＩＧ组与ＩＶＩＧ加ＤＥＸ组之间无显著差异。２．ＩＴＰ患儿治疗后骨髓成熟产板巨核细胞数比例由１．５６±２．５３％升至１３．３６±６．６８％,原幼巨核细胞数比例由４０．２０±１．８７％降至１３．３９±９．２８％,差异非常显著,治疗后各组间骨髓巨核细胞数比例无显著差异。３．ＩＴＰ患儿全血粘度值、血浆粘度值治疗前后三组均无显著变化。结论：ＩＴＰ患儿ＩＶＩＧ治疗较ＤＥＸ治疗血小板上升迅速,上升幅度大。１ＶＩＧ治疗的同时加大剂量ＤＥＸ治疗,未能进一步使血小板升高。     

旋甘口服液治疗儿童特发性血小板减少性紫癜疗效观察

旋甘口服液治疗儿童特发性血小板减少性紫癜疗效观察首都儿科研究所（１０００７０）陈静王天有廖斌牟京辉我院于１９９２年６月至１９９５年１２月应用中药旋甘口服液治疗儿童特发性血小板减少性紫癜（ＩＴＰ）取得良好效果，现报告如下。７７例ＩＴＰ患儿均系我院住院及...     

特发性血小板减少性紫癜患儿巨细胞病毒感染的初步研究

为探讨特发性血小板减少性紫癜（ＩＴＰ）与人巨细胞病毒（ＨＣＭＶ）活动性感染的关系，用聚合酶链反应（ＰＣＲ）技术检测了４４例临床确诊为特发性血小板减少性紫癜患儿外周血白细胞中ＨＣＭＶ－ＤＮＡ，同时作病毒分离及ＨＣＭＶ－ＩｇＧ、ＩｇＭ测定。结果表明：ＨＣＭＶ－ＤＮＡ阳性者１４例，阳性率为３２％；而病毒分离阳性者８例，阳性率为１８％；ＨＣＭＶ－ＩｇＧ、ＩｇＭ阳性率分别为３９％和２３％。提示：（１）部分ＩＴＰ患儿发病时有ＨＣＭＶ活动性感染；（２）ＰＣＲ技术特异、敏感、快速，对ＩＴＰ患儿的ＨＣＭＶ活动性感染的早期快速诊断有重要作用。     

大剂量地塞米松冲击疗法治疗小儿特发性血小板减少性紫癜

特发性血小板减少性紫癜（ITP）是小儿时期常见的出血性疾病，婴幼儿严重者易致颅内出血，首选糖皮质激素是快速有效经济的治疗方法，我院用大剂量地塞米松冲击疗法治疗小儿特发性血小板减少性紫癜（ITP），疗效较好，现总结我院5年来收治的100例特发性血小板减少性紫癜（ITP）患儿的治疗结果，报道如下：     

大剂量氢化考的松治疗急重型特发性血小板减少性紫癜

大剂量氢化考的松治疗急重型特发性血小板减少性紫癜空军４６３医院（１１００４２）王虹特发性血小板减少性紫癜（ＩＴＰ）是一种原因未明的自身免疫性疾病，伴有血小板相关抗体，主要为ＩｇＧ或ＩｇＭ升高，能特异地与巨核细胞相结合，抑制区核细胞产生血小板，使循环血...     

THE SECULAR TREND IN THE AGE OF MENARCHE IN AUSTRALIAN SCHOOLGIRLS

Statistics derived from a sample of 1391 schoolgirls drawn from both state and private schools showed the mean age of menarche to be 12.65 years. Selected schools were included to give a representative sample in terms of geographical and social class distribution. The onset of puberty was found to be normally distributed within the age range 9 years to 15 years 8 months. After an examination of the results of previous Australian studies, evidence was found which suggested a secular trend in the onset of puberty with fluctuations paralleling times of economic crisis.     

MYOELECTRICAL ACTIVITY IN EXPERIMENTAL AGANGLIONOSIS OF THE COLON IN THE RAT

ABSTRACT. Experimental aganglionosis of the colon was produced in rats by an experimental "aganglionosis producing" procedure. Radiological examination of the aganglionic colon showed a narrow segment distal to a dilated megacolon. Histologically, a transverse section of the aganglionic segment showed 3-4 ganglia in contrast to 32-40 ganglia per section in the normal colon. The myoelectrical activity of the normal colon presented two fast activities, a fast activity with a frequency of 25-40 cycles per sec superimposed over a medium-fast activity of 4-7 cycles per sec. However the aganglionic colon showed only the fast activity with complete absence of the medium-fast activity. Thus the experimental aganglionosis produced a characteristic alteration in the myoelectrical activity of colon. This confirms our earlier findings in children with Hirschsprung's disease. It also suggests that the causative mechanism for the production of a narrow segment in Hirschsprung's disease may not be the hyperactivity or the absence of any specific neuronal mechanisms as proposed earlier.     

ERYTHROPOIESIS IN THE NEWBORN

It has been shown that the diminished erythropoiesis occurring during the period from a few days to about six weeks after birth is associated with the presence of an inhibitor of erythropoiesis in the urine of infants at this time. Suggestions that the inhibitor might be an oestrogen or related compound are not supported by the observations recorded in this paper.     

ERYTHROPOIESIS IN THE NEWBORN

The normal newborn infant displays active erythropoiesis at birth. Within a few days erythropoietic activity is greatly reduced and remains so for several weeks. During this time the occurrence of anaemia does not evoke an erythropoietic response comparable with that seen in older children. It has been suggested that diminished production of erythropoietin by the infant following transition from the hypoxic intrauterine environment to the atmosphere accounts for these observations. Technical and ethical limitations on plasma erythropoietin assays have prevented adequate study of the mechanisms controlling erythropoiesis in this age group, and urinary erythropoietin assays appeared to offer a feasible alternative. This paper describes urinary assays in normal and anaemic infants, giving details of the technique. The results were inconclusive. The reasons for this are discussed and further studies proposed.     

THE MUCOSAL IMMUNE RESPONSE IN THE NEONATE

Hanson LÅ, Brinton C, Carlsson B, Dahlgren U, Mellander L, Sutton A and Söderström T. (Departments of Clinical Immunology and Paediatrics, University of Göteborg, Sweden, Bureau of Biologies, FDA, Bethesda, and Department of Life Sciences, University of Pittsburg, USA). The mucosal immune response in the neonate. Acta Paediatr Scand, Suppl. 296:53, 1982. — Human infants are relatively deficient in the IgA system defending mucosal membranes, but are provided via the maternal milk with considerable amounts of SIgA directed against microbes and food antigens to which both mother and infant are exposed. It is possible that serum antibodies may support the mucosal defense as do the lactoferrin, lysozyme and other defense factors present in the milk.