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Kojima M Motoori T Iijima M Ono T Yoshizumi T Matsumoto M Masawa N Nakamura S 《Pathology, research and practice》2006,202(12):877-882
A pale ring of medium-to-large cells surrounding the follicles, namely a marginal zone distribution pattern, is the key criterion for diagnosing nodal marginal zone B-cell lymphoma (NMZBL). The tumor cells of NMZBL occasionally exhibit the morphology of monocytoid B-cells (MBC). However, this condition can be difficult to distinguish from MBC hyperplasia in reactive conditions. We describe the histopathological and immunohistochemical findings of four cases exhibiting florid MBC hyperplasia and resembling NMZBLs. The patients consisted of three males and one female (age range 48–64 years) who had asymptomatic lymphadenopathy in the head and neck area. Histologically, a pale ring surrounding more than 75% of the lymphoid follicles characterizes the lesion. The lymphoid follicles usually had hyperplastic germinal centers, and progressive transformation of germinal center was noted in two cases. The pale ring was composed of medium-to-large cells with indented or round nuclei and relatively abundant pale clear cytoplasm. Numerous plasma cells were observed in one case. The overall histomorphological findings in these four cases were similar to those of NMZBLs. However, immunohistochemical investigations demonstrated that MBCs were CD43− and bcl-2−. Moreover, immunohistochemistry, polymerase chain reaction, and flow cytometry studies demonstrated the polytypic nature of B-lymphocytes. Recognition of this unusual MBC hyperplasia in reactive lymph node lesions is important to avoid confusion with NMZBLs. 相似文献
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Correlation of intraoperative cytological and final histological diagnoses: A retrospective 10‐year study of neurosurgical cases from Ibadan,Nigeria
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A. Salami M.B.B.S. A. Azeez M.B.B.S. A. Malomo M.B.B.S. A. Oluwasola M.B.B.S. A. Adeleye M.B.B.S. G. Ogun M.B.B.S. A. Adeoye M.B.C.H.B. A. Adeolu M.B.C.H.B. C. Okolo M.B.B.S. U. Eze M.B.B.S. Y. Abdullahi M.B.B.S. A. Lawan M.B.B.S. J. Ogunbiyi M.B.B.S. E. Akang M.B.B.S. M. Shokunbi M.B.B.S. 《Diagnostic cytopathology》2015,43(3):195-201
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Aki Tanaka Mitsuyoshi Hirokawa Ayana Suzuki Miyoko Higuchi Akira Miyauchi Takashi Akamizu 《Pathology international》2023,73(8):351-357
A preoperative diagnosis of metastatic renal cell carcinoma to the thyroid (MRCCT) is important for determining clinical management but is challenging even in cases with a clinical history of renal cell carcinoma (RCC). This study aimed to elucidate the clinical, cytological, and pathological characteristics of MRCCT. Fourteen MRCCT cases extracted from 18 320 malignant thyroid tumors were included in this study. Twelve MRCCT (85.7%) occurred as solitary lesions and the most frequently suspected lesions on ultrasonography were follicular tumors. On cytology, 46.2% of cases were reported as RCC or suspected RCC; a medical history of RCC and immunocytochemistry were helpful in interpretation. RCC metastasized to a follicular adenoma in 50.0% of the solitary lesions. MRCCTs with a long interval from the initial presentation, solitary lesion, and Ki-67 labeling index <10% showed significantly longer disease-free survival. MRCCT is characterized by a long interval from the initial presentation of RCC, appearance as a solitary nodule, ultrasonographic similarity to follicular tumors, sharing cytological findings with primary thyroid tumors, and high frequency of metastasis within follicular adenoma. A long interval from the initial presentation, occurrence as a solitary lesion, and low Ki-67 labeling index may be favorable prognostic factors. 相似文献
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