6442例麻风畸残者自我护理3年效果评价

目的 探讨麻风畸残患者的自我护理效果。方法 经过培训的医务工作者教6442例麻风畸残者做眼手足的自我护理，免费提供防护器材，连续观察随访3年。结果 3年坚持自我护理的患者占72．52％；红眼减少76．82％，手部、足部皲裂分别减少93．61％和90．68％，足部溃疡减少48．34％，手部、足部的骨缺失数无明显增加。结论 麻风畸残患者坚持自我护理和简单的防护措施可以防止或减少眼手足畸残的加重及继发性的损害。     

74例麻风畸残康复观察

目的:分析通过特别护理、安全生活及体育疗法对74例麻风手、足畸残者感觉恢复和溃疡痊愈的效果。方法:对74例麻风手、足畸残者通过辅导护理、安全及体育疗法等知识，以提高其自我护理水平。结果:1年后Ⅰ级手及足畸残者感觉恢复各为3只，部分恢复分别为2只和6只，手部溃疡痊愈1只，手部有效率为14．3％(6／42)，足部为14.8％(9／61)；对18例(21处)足底溃疡的预防效果较显著，有效率为47．6％(10／21)。Ⅱ～Ⅲ级畸残未见加重。结论:对麻风畸残者进行预防性护理效果明显能有效防止Ⅰ级畸残的加重。     

168例住院麻风畸残自我护理3年效果分析

为提高麻风畸残患者的生活质量 ,以自我护理预防畸残和阻止畸残加重 ,是目前乃至今后麻风防治的重要任务 [1 ] 。1 996年 3月至 1 999年 3月我院对 1 6 8例住院麻风畸残患者进行自我护理教育培训和督导实施 ,已连续观察 3年 ,现报告分析如下。1　临床资料1 .1　一般资料 :选择有一定劳动能力的、较年轻的、生活能自理并愿意积极配合的住院畸残者 1 6 8例作为自我护理对象。男 1 1 3例 ,女 5 5例 ,I级畸残 38例 (2 2 .6 % ) ,II级以上畸残 1 30例 (77.4 % ) ;共有 335个畸残部位 ,其中 :眼残疾 5 4只 (视力损害 30只 ,红眼 2 4只 ) ,手畸残…     

肇庆市麻风病愈后存活者畸残情况及其生存质量

目的了解肇庆市麻风病愈后存活者畸残情况及其生存质量,为麻风病痊愈患者健康管理提供依据。方法 2016-2017年,采用自编的一般问卷和世界卫生组织生存质量简表对肇庆市麻风病愈后存活者进行入户调查。结果应调查505人,实际获得有效问卷497份,有效应答率为98.4%。调查对象平均年龄(66.36±11.25)岁,男女比例为3.2∶1。497例中有80例为畸残者(占16.1%),其中74例为2级畸残者(92.5%),6例为1级畸残者(占7.5%),畸残者中以足部、手部居多。畸残者与非畸残者在年龄、性别和医保上差异无统计学意义(P0.05),在学历、收入、职业和婚姻等方面差异有统计学意义(P0.05)。畸残者与非畸残者相比较,其生理、心理、社会和环境四个领域评分和自我感受(自评分)得分均低于非畸残者,差异有统计学意义(P0.05)。结论畸残是影响麻风病愈后存活者生存质量的重要因素,应给予更多的社会支持。     

麻风足病患者自我护理的4年随访

目的 评价麻风足病患者自我护理的效果。方法 经过培训的医务工作者指导198例麻风足病患者做足部的自我护理，免费提供防护器材，连续观察随访4年。结果 4年坚持足部自我护理的患者占74．24％，足部皲裂减少97％、溃疡愈合66．67％、骨缺失数无明显增加。结论 麻风足病患者坚持自我护理和简单的防护措施可以防止或减少足畸残的加重及继发性的损害。     

基于Orem自理理论的护理对麻风治愈畸残患者的干预效果

目的:探讨基于Orem自理理论的护理对麻风治愈畸残患者的干预效果.方法:选择2017年1月—2019年4月我院收治的麻风治愈畸残患者96例,根据随机数字表法分为两组,每组48例.对照组采用常规麻风护理,研究组予以基于Orem自理理论的护理.比较两组患者畸残改善率、心理状态.结果:研究组第1年、第2年的畸残总改善率均高于...     

28例麻风反应的观察与护理体会

目的:通过对麻风患者在治疗过程中麻风反应的观察和护理,减少麻风反应对患者机体的损害,避免畸残的发生.方法:对发生麻风反应的患者从心理、临床、皮肤、神经、眼的症状进行施护.结果:结果28例麻风反应患者,无1例发生可见性畸残.结论:通过严密的病情观察及护理措施的实施,减轻了患者反应期间身体和心理上的痛苦,缩短了麻风反应时间,降低反应程度.预防了畸残的发生.     

麻风反应的观察及护理

目的探讨20例麻风反应患者的病情观察方法及护理措施的制定。方法心理护理,皮肤反应的观察及护理,神经痛的观察及护理,眼部症状的观察及护理,用药的观察及护理,健康教育。结果20例麻风反应患者,无1例发生可见性畸残。结论通过严密的病情观察及护理措施的实施,减轻了患者反应期间身体和心理上的痛苦,缩短了麻风反应时间,预防了畸残的发生。     

麻风畸残愈后11例足底溃疡疗效观察

１９９５年６月至１９９８年５月,我县皮防站和县人民医院、解放军三Ｏ三医院进行技术协作,成立了麻风畸残康复医疗组,对全县现存的２０８例麻风畸残愈者的１１例２１处足底溃疡进行了系统治疗,收到了较好的效果。１９９８年５月,通过自治区卫生厅组织的专家考核组检...     

麻风及畸残患者防治的依从性分析

目的:分析麻风及畸残患者防治的依从性。方法:以该地区2004~2014年发现的14例麻风病新发病例作为调查对象,分析防治依从性的影响因素,并提出干预措施进一步提高麻风及畸残患者防治的依从性。结果:影响患者防治依从性的因素较多,针对具体情况实施干预措施,矫治患者畸残情况,恢复受损器官功能,其心理状况及社会适应能力明显改善。结论:提高麻风及畸残患者防治的依从性,加强综合干预措施,对患者生活质量及社会效益的提高具有明显效果。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.