新型室内杀虫剂KR-100的药效、毒性测试及杀虫机制的初步研究

目的研制新型高效长效的室内卫生害虫杀虫剂KR-100。方法科学配伍拟除虫菊酯类药物、控制药物释放物质、增效剂等,在一定条件下按照一定的工序制备KR-100,测试其药效、毒性、稳定性和长效性,并在扫描电镜下观察KR-100的成膜形态。结果杀虫剂KR-100具有良好的杀虫效果,且药效稳定、持久,在电镜下显示为多孔样膜状结构。结论新型杀虫剂KR-100 杀虫效果好,药效持久,安全,有良好的开发应用前景。     

新型高效长效室内卫生害虫杀灭剂“KR-100”的初步测试

将拟除虫菊酯类药物、高分子控制药物释放物质等经过科学配伍制成“KR-100”,经实验室测试该产品对主要室内卫生害虫具有良好的杀灭作用,且药效持久,有希望成为一种新型杀虫剂。     

测试杀虫气雾剂药效方法的探讨

<正> 近年来,卫生杀虫气雾剂在我国发展很快,新的品种日益增多,由于它携带、使用方便、用量少、杀灭快,颇受人们的欢迎。在评价新产品药效优劣时,我们常用OTA或其它商品化气雾剂进行比较测定。但由于各种气雾剂所使用的抛射剂及其与药液比例、罐内压力、喷咀孔径大小等等不同,在单位时间喷出的药量差异很大(见表一)。所以当我们在测试比较不同气雾剂药效时,用手动控制气雾剂喷雾就很难得到不同气雾剂喷出预想的相同或近似的药量进行药效比     

提高卫生杀虫剂稳定性与药效方法的探讨

<正> 随着对卫生害虫生物学及其防治研究的大量开,卫生杀虫剂成为剂型最为丰富的一类杀虫剂。由于杀虫剂原药开发的难度和费用不断加大,剂型开发     

醒脑注射液的毒性作用及药效研究

本研究以腹腔或肌肉注射的方法给动物不同剂量的醒脑注射液，探讨其毒性作用。     

室内杀虫剂杀灭蚊虫的现场药效试验

<正> 我们经多次筛选配制的室内杀虫剂经实验室试验研究具有高效、持效和使用方便等特点,为进一步验证其效果,我们于2003年8月在陕西某部队进行了现场杀灭蚊虫的药效试验,现将结果报告如下。     

肝炎灵的动物药效与毒性研究

肝炎灵对四氯化碳(Ccl_4)和硫代乙酰胺(TAA)所致的动物肝损害有保护作用,使升高的谷丙转氨酶(SGPT)降低和肝糖原增多,并促进坏死的肝组织再生与修复。小鼠、大鼠和狗的急性、亚急性与慢性毒性试验表明肝炎灵毒性低、安全范围大。静脉注射有明显的降压反应.     

高效灭蚊灵的药效与毒性实验研究

高效灭蚊灵的药效与毒性实验的结果表明，高效灭蚊灵对毛皮害虫具有预防和杀来作用。杀虫率在９９．４７％，防蚊效果达４５个目，对人安全。适用仓库、宾馆、家庭等使用。     

都梁软胶囊的药效及毒性试验

OBJECTIVE: To study the analgesic efficacy, toxicity and impact of Duliang capsule (DLC) and Duliang pill (DLP), different dosage forms of a patent Chinese herbal medicine, on the hemodynamics in mice and rats. METHODS: In hotplate and writhing tests in mice, the effects of both drugs on the latency of paw-licking response and the writhing number of times were observed. The changes of blood viscosity in rat models of blood stasis were measured with Viscometer-R80, and acute and chronic toxicity of DLC observed. RESULTS: DLP at the dose of 5 g/kg.b.w. and DLC at 10, 5 or 3 g/kg.b.w. significantly prolonged the latency of paw-licking response and reduced writhing times. The analgesic effects of DLC and DLP occurred 0.5 and 1 h respectively after the administration, and they could both lower the viscosity of the whole blood and hematocrit level in the blood-stasis rat models. Toxicity of the drug was not observed in acute or chronic toxicity tests. CONCLUSIONS: Both DLC and DLP possess strong analgesic effect and can lower blood viscosity and hematocrit, but DLC takes effect sooner than DLP as analgesics and can be effectively and safely applied clinically.     

100例系统性红斑狼疮患者的肺间质病变初探

目的　调查系统性红斑狼疮 (SLE)患者肺间质病变 (ILD)的发生率及临床表现 ,并根据临床、影像学及肺功能检查制定新的分型方法。方法　随机对 10 0例SLE患者进行胸片 ,高分辨CT扫描 (HRCT) ,肺功能和动脉血氧分压的同步测定。结果　HRCT诊断SLE患者的ILD阳性率为 77% (77/10 0 ) ,其敏感性高于胸片(38% )。 77例HRCT有ILD者肺功能和动脉血氧分压异常 ,分别为 35 .1%和 6 %。提出SLE合并ILD的临床分型新方法。分 3型 :临床前期型 ,急性肺泡炎型和慢性肺间质病变型。 77例HRCT阳性者分型分别为 92 .2 %(71/77) ,2 .6 % (2 /77) ,5 .2 % (4/77)。结论　SLE患者进行肺HRCT的检查 ,结合肺功能检查能发现早期ILD。     

全反式维甲酸致高白细胞症作用机理的初步研究

目的探讨全反式维甲酸（ＡＴＲＡ）在体内促外周血白细胞增高作用的细胞生物学机制。方法用３ＨＴｄＲ掺入,祖细胞培养和脾集落形成单位（ＣＦＵＳ）测定等方法,观察在ＡＴＲＡ作用下ＢＡＬＢ／Ｃ小鼠造血功能的动态变化。结果ＡＴＲＡ可以增加小鼠外周血细胞计数,第８天白细胞计数上升,第１６天为对照的１８３％。骨髓细胞增殖活性增加,３ＨＴｄＲ掺入增多,掺入高峰第８天,为对照的１９０％,ＣＦＵＳ增殖,１２天为对照２００％。造血祖细胞粒巨噬细胞集落（ＣＦＵＧＭ）增殖,第１２天为对照的２１５％。结论ＡＴＲＡ在小鼠体内具有致白细胞增高作用,这可能与其在体内促ＣＦＵＧＭ和ＣＦＵＳ增殖并定向粒系分化有关,与其作用于体内释放造血活性物质如粒细胞集落刺激因子有关。     

改良的两次屏气扫描方案联合100 kV管电压行减影CCTA的临床可行性

 目的  探讨一种改良的两次屏气减影扫描方案行减影冠状动脉CT血管造影(coronary CT angiography,CCTA)以及联合使用100 kV管电压行低剂量扫描在屏气受限的患者中的临床可行性。方法  对于钙化积分＞400且体重指数＜25 kg/m2,同时伴有屏气受限的患者纳入本研究;本研究共纳入17人。心脏平扫容积数据及增强容积数据在两次屏气中采集完成;且两次扫描保持相同的时间窗,即位于R-R间期的65%～80%。采用4分法对目标钙化节段行图像质量评估。结果  共53个目标钙化节段纳入本研究。较常规CCTA相比,减影CCTA的目标钙化节段的图像质量明显改善(3.36±0.92 vs.2.51±0.95,P<0.01)。不可评估冠脉节段数在常规CCTA中共23(43.4%)个节段,在减影CCTA中,共6个冠脉节段(11.3%);行减影CCTA扫描后,严重钙化节段的可评估性明显提高(P=0.02)。行减影CCTA扫描总的有效辐射剂量为(2.80±0.64)mSv。结论  这种改良的两次屏气扫描方案在屏气受限患者中行减影CCTA的临床可行性,即通过降低甚至消除钙化斑块伪影的不良影响,提高严重钙化冠脉节段的图像质量以及临床可评估性。通过联合使用100 kV扫描管电压,对于体重指数＜25 kg/m2的患者,可以显著降低扫描的总的有效辐射剂量。     

2.0版人工智能自动检测系统对甲状腺结节术前超声评估效能的初步探讨

目的 探讨升级后人工智能(AI)自动检测系统AI-SONIC_^TM Thyroid(2.0版)在甲状腺结节术前超声评估中的的辅助诊断效能,并与不同年资超声医师主观诊断结论进行比较,进一步探讨升级后AI自动检测系统在甲状腺结节良恶性鉴别诊断中的应用价值。     

Recovery after childbirth: a preliminary prospective study

This prospective study examined the time for 93 women to cease to feel discomfort in their perineal areas after the births of their first babies. Sixty-two of the women had experienced a spontaneous delivery that did not require forceps assistance. In 58 patients, an episiotomy was performed. Of the 35 women in whom an episiotomy was not performed, 24 women required sutures and only four women did not suffer any perineal damage. The median time for perineal comfort in general (including walking and sitting) was one month (range, zero to six months); 20% of women took more than two months to achieve general perineal comfort. For comfort during sexual intercourse, the median time was three months (range, one to more than 12 months); 20% of women took longer than six months to achieve comfort during sexual intercourse. Factors that were associated with discomfort for longer than the median time were delivery by forceps; spontaneous vaginal (not perineal) tears; and, in the three to four days after the birth, oedema and the breakdown of muscle or skin sutures. There was no significant difference in these times between patients who did not undergo an episiotomy and those who underwent an episiotomy without a forceps delivery.     

胸内心脏挤压器的初步研究

为取得心脏直接挤压的良好复苏效果，同时避免常规开胞手术，我们设计了胸内心脏挤压器。该挤压器可经剑突下小切口放到民心包前、胸骨后，用外接驱动囊控制挤压器的张驰，使心脏受压和舒张。在６只幼猪室颤模型中，与常规闭胸心肺复苏比较。结果：室颤前放入挤压器，对自主循环没有显著影响。