Masquelet与Ilizarov技术修复感染性胫骨骨缺损比较

[目的]比较Masquelet技术与Ilizarov技术治疗胫骨感染性骨缺损的临床效果。[方法]回顾性分析2017年8月—2020年8月,本院治疗的胫骨感染性骨缺损60例患者的临床资料。依据术前医患沟通结果,35例采用Masquelet诱导膜技术,25例采用Ilizarov骨搬运技术。比较两组围手术期、随访及影像结果。[结果]两组均顺利完成手术,Masquelet组中透视总次数、手术切口愈合等级均显著优于Ilizarov组（P<0.05）。早期并发症方面,Masquelet为3/35 (8.57%),而Ilizarov组为9/25 (36.00%),两组差异有统计学意义（P<0.05）。两组平均随访时间（24.54±5.86）个月。Masquelet组恢复下地行走时间及完全负重活动时间显著早于Ilizarov组（P<0.05）。术后随时间推移,两组患者VAS评分均显著减少（P<0.05）,而Iowa膝关节评分、Iowa踝关节评分、SF-36得分均显著增加（P<0.05）。术后6个月和末次随访时,Masquelet组的VAS评分显著优于Ilizarov组（P<0.05）;相应时间点,两组Iowa膝关节评分、Iowa踝关节评分、SF-36得分差异均无统计学意义（P>0.05）。影像方面,Masquelet组骨缺损影像愈合时间显著早于Ilizarov组（P<0.05）。[结论] Masquelet技术与Ilizarov技术均可有效治疗胫骨感染性骨缺损,但本研究中Masquelet技术的临床效果优于Ilizarov技术。     

Masquelet技术与Ilizarov技术治疗成人胫骨慢性骨髓炎的早期临床疗效比较

目的 比较Masquelet技术与Ilizarov技术治疗成人胫骨慢性骨髓炎清创后大段骨缺损的早期临床疗效.方法 回顾性分析2011年1月至2015年5月我院收治的45例成人胫骨慢性骨髓炎病人资料,Masquelet技术治疗的27例纳入Masquelet组,男20例,女7例,骨缺损长度为(8.9±2.2)cm;Ilizarov技术治疗的18例纳入Ilizarov组,男12例,女6例,骨缺损长度为(8.3±2.1)cm.收集并比较两组病例的骨愈合时间、完全负重时间、术后并发症情况及末次随访时的Iowa膝关节评分、Iowa踝关节评分、SF-36量表得分.结果 45例病人的随访时间为12～38个月,平均(21.5±6.5)个月.Masquelet组与Ilizarov组的骨愈合时间分别为(20.85±4.31)周、(28.86±6.47)周,完全负重时间分别为(23.17±6.93)周、(32.87±6.79)周,两组间比较,差异均有统计学意义(t=4.944,P<0.0001;t=4.636,P<0.0001);两组末次随访时的Iowa膝、踝关节评分及SF-36量表总得分均较术前明显改善,但两组间比较,差异均无统计学意义(P均>0.05).结论 Masquelet技术与Ilizarov技术均可有效地解决成人胫骨慢性骨髓炎清创后大段骨缺损问题,但Masquelet技术能显著缩短治疗周期,完全负重时间早,是一种简单有效的手术方法.     

应用Ilizarov技术修复胫骨慢性骨髓炎并骨缺损

目的探讨应用Ilizarov技术治疗胫骨创伤后慢性骨髓炎并感染性骨缺损的临床疗效。方法对8例胫骨创伤后慢性骨髓炎并感染性骨缺损行清创、可延长外固定架固定、干骺端截骨及中间骨段逐步搬运。结果 8例均获随访6～40个月,平均31.5个月。骨与皮肤缺损得到修复,患侧肢体长度与健侧无明显短缩。结论应用Ilizarov技术治疗难治性胫骨骨髓炎合并骨缺损或皮肤软组织缺损创伤小,能够避免多次复杂手术,可简化治疗过程,疗效肯定。     

Ilizarov骨搬移技术修复胫骨创伤性骨髓炎大段骨缺损

目的探讨应用Ilizarov骨搬移技术治疗胫骨创伤性骨髓炎大段骨缺损的临床疗效。方法回顾性分析2010年6月至2014年9月在我科收治15例胫骨创伤性骨髓炎患者,其中男11例,女4例;年龄17~60岁,平均39.3岁。交通事故伤9例,重物压砸伤4例,高处坠落伤2例。根据Cierny-Mader解剖学分型:Ⅲ型6例,Ⅳ型9例。采用病灶骨段切除、Ilizarov骨搬移技术治疗,并记录骨段延长长度、外固定架时间、骨愈合及功能评价结果。结果 15例患者均获随访,随访时间18~40个月,末次随访时,骨缺损均得以重建。骨缺损长度6~13 cm,平均8.6 cm。外固定架固定时间为8.4~16.5个月,平均11.2个月。术后无一例出现深部感染、骨不连或关节僵直。根据改良ASAMI评定标准评定骨性结果:优12例,良1例,中1例,差1例,优良率为87.3%;功能结果:优10例,良2例,中3例,差0例,优良率为80.0%。结论应用Ilizarov骨搬移技术是治疗胫骨创伤性骨髓炎大段骨缺损的有效方法。     

改良Masquelet技术联合Ilizarov Mini-Fixator治疗掌指骨大段骨缺损的临床疗效

<正>（文接上期）3讨论手作为人类生产、生活的主要工具,是最常受伤的部位之一。随着工业化进程,目前临床各种严重手外伤较为常见,且常合并神经、血管、肌肉肌腱、皮肤软组织及骨缺损。其中骨缺损的重建是手外科与显微外科治疗、研究的热点及难点。骨缺损即骨骼结构完整性被破坏,分为容积性骨缺损和结构性骨缺损。     

改良Masquelet技术联合Ilizarov Mini-Fixator治疗掌指骨大段骨缺损的临床疗效

目的 探讨改良Masquelet技术联合Ilizarov Mini-Fixator外固定治疗掌指骨大段骨缺损的可行性、临床应用及疗效分析。方法 回顾性分析2019年11月-2021年10月符合手术适应证的掌指骨大段骨缺损17例患者的病历资料,均行改良Masquelet技术联合Ilizarov Mini-Fixator外固定治疗。⑴创伤性骨缺损：一期急诊行“地毯式”清创及相应修复手术,抗生素聚甲基丙烯酸甲酯（Polymethylmethacyrlate,PMMA）填充骨缺损,皮肤软组织缺损者同时给予骨水泥覆盖;二期：行带蒂皮瓣或植皮修复皮肤缺损创面,伤口愈合6～8周后去除骨水泥行自体骨移植联合Ilizarov Mini-Fixator外固定治疗;⑵感染性骨缺损：一期彻底清创、PMMA填充骨缺损,皮肤软组织缺损或皮肤软组织条件较差者给予彻底清创修复创面;二期方案同创伤性骨缺损。术后均给予预防或控制感染、观察患指（肢）及皮瓣血运等对症处理,均早期（2周）进行功能康复训练。结果 17例术后随访5～29个月,移植骨均愈合,平均愈合时间11.9周（10.5～14.0周）,术后均未出现伤口感染及皮瓣...     

应用Ilizarov技术修复胫骨长段骨髓炎骨缺损36例

[目的]探讨应用Ilizarov技术治疗胫骨长段骨髓炎骨缺损的临床疗效。[方法]自2010年1月²012年12月,应用Ilizarov技术治疗胫骨长段骨髓炎36例,其中GustiloⅡ型2例,ⅢA型8例,ⅢB型15例,ⅢC型11例。手术切除感染骨段,并彻底扩创,安装环形外固定架,干骺端截骨,应用Ilizarov骨搬移技术治疗。[结果]36例全部治愈,病骨切除后骨缺损82012年12月,应用Ilizarov技术治疗胫骨长段骨髓炎36例,其中GustiloⅡ型2例,ⅢA型8例,ⅢB型15例,ⅢC型11例。手术切除感染骨段,并彻底扩创,安装环形外固定架,干骺端截骨,应用Ilizarov骨搬移技术治疗。[结果]36例全部治愈,病骨切除后骨缺损8²2 cm,平均13.6 cm。随访时间为1822 cm,平均13.6 cm。随访时间为18³0个月,平均21.5个月。骨缺损愈合时间为830个月,平均21.5个月。骨缺损愈合时间为8¹5个月,平均11.4个月。延长指数2715个月,平均11.4个月。延长指数27⁵5 d/cm,平均42 d/cm。无感染复发,无再骨折,无小腿畸形等。[结论]手术切除长段慢性骨髓炎骨段,应用Ilizarov骨搬移技术修复胫骨长段骨缺损的临床疗效确切,避免多次复杂手术,是一种行之有效的方法。     

Masquelet技术在创伤后骨髓炎中的疗效观察

目的探讨Masquelet技术在创伤后骨髓炎中应用的疗效。方法采用Masquelet技术治疗15例创伤后骨髓炎患者,术后记录并发症、完全负重时间及骨缺损愈合情况。结果患者均获得随访,时间5～18个月。无取髂骨处并发症,无内(外)固定失效,无术后再发骨折。1例第1阶段术后3周感染复发,再次行第1阶段手术后感染得到控制。完全负重时间为14～32周。末次随访时根据Paley标准评定骨缺损愈合情况:优9例,良6例。结论 Masquelet技术可以有效治疗创伤后骨髓炎,操作简便,并发症少,疗效满意。     

Ilizarov技术治疗胫骨创伤性骨髓炎的临床研究

[目的]探讨Ilizarov技术治疗胫骨创伤性骨髓炎的临床疗效。[方法]2009年4月²012年12月应用Ilizarov技术治疗胫骨创伤性骨髓炎患者13例。男9例,女4例,年龄232012年12月应用Ilizarov技术治疗胫骨创伤性骨髓炎患者13例。男9例,女4例,年龄23⁶5岁,平均39.5岁。早期彻底清创并截除坏死骨段,安装外固定器在干骺端微创截骨,采用闭合灌洗负压引流或开放换药或VSD生物材料覆盖,二期移植中厚皮片。应用Ilizarov骨段滑移技术修复骨缺损。定期随访,根据X线片所示骨愈合情况及矿化情况逐步拆除固定组件。[结果]13例患者随访1265岁,平均39.5岁。早期彻底清创并截除坏死骨段,安装外固定器在干骺端微创截骨,采用闭合灌洗负压引流或开放换药或VSD生物材料覆盖,二期移植中厚皮片。应用Ilizarov骨段滑移技术修复骨缺损。定期随访,根据X线片所示骨愈合情况及矿化情况逐步拆除固定组件。[结果]13例患者随访12³2个月,平均18.4个月。不同程度的软组织缺损经个体化治疗后均愈合且无感染复发。扩创后骨缺损4.532个月,平均18.4个月。不同程度的软组织缺损经个体化治疗后均愈合且无感染复发。扩创后骨缺损4.5¹2 cm,平均6.1 cm,均实现骨愈合,恢复正常长度。1例发生滑移骨段轴向偏移,经截骨调整延长模块恢复正常力线;1例发生骨缺损处组织挛缩塌陷,经清创丝线牵拉固定后改善;1例发生轻度钉道感染,经清创换药联用抗生素治愈;所有膝、踝关节功能活动无明显影响。[结论]治疗创伤性骨髓炎的关键在于解决感染和骨缺损问题,而Ilizarov骨滑移技术不仅可在简化治疗程序的前提下安全有效控制感染、修复骨缺损,而且可根据骨愈合时段调整固定刚度消除应力遮挡,纠正畸形,避免二次手术且临床疗效优良,值得临床推广应用。     

Masquelet technique versus Ilizarov bone transport for reconstruction of lower extremity bone defects following posttraumatic osteomyelitis

ObjectiveThis study was to compare the effectiveness of Masquelet technique versus Ilizarov bone transport in the treatment of lower extremity bone defects following posttraumatic osteomyelitis.Patients and methodsWe retrospectively reviewed 39 patients who had been treated at our department for lower extremity bone defects following posttraumatic osteomyelitis. They were 30 males and 9 females with a mean age of 39.18 (range, 12–63 years). The infected bone defects involved 26 tibias and 13 femurs. The mean length of the bone defects after radical debridement was 6.76 cm (range, 2.7–15.7 cm). Masquelet technique (MT, group A) was used in 20 patients and Ilizarov bone transport (IBT, group B) in 19 ones. The measurements were bone outcomes (union, deformity, infection and leg-length discrepancy) and functional outcomes (significant limping, joint contracture, soft tissue dystrophy, pain and inactivity).ResultsThe mean follow-up after removal of the apparatus was 25.26 months (range, 14–51 months). The mean finite fixator time was 10.15 months (range, 8–14 months) in group A versus 17.21 months (range, 11–24 months) in group B. The bone outcomes were similar between groups A and B [excellent (5 vs. 7), good (10 vs.9), fair (4 vs. 2) and poor (1 vs. 1)]; group A showed better functional outcomes than group B [excellent (8 vs. 3), good (9 vs. 6), fair (3 vs. 8) and poor (0 vs. 2)].ConclusionsIn the treatment of segmental lower extremity bone defects following posttraumatic osteomyelitis, both IBT and MT can lead to satisfactory bone results while MT had better functional results, especially in femoral cases. IBT should be preferred in cases of limb deformity and MT may be a better choice in cases of periarticular bone defects.     

Role of Perforating Artery Pedicled Neurotrophic Flap in the Treatment of Compound Tissue Defect of Tibia Using the Ilizarov Technique

ObjectiveTo describe our experience with the combined use of pedicled neurotrophic flap and distraction osteogenesis in the management of complex lower extremity injuries with composite bone and soft tissue defects and assess the functional and cosmetic results of this method.MethodsA pedicled flap with a marked perforator artery was applied for soft tissue coverage after radical debridement and temporary external fixation. In the second stage, the Ilizarov external fixator was used in place of the temporary external fixator for reconstruction of the segmental bone defect by distraction osteogenesis. Twenty‐five patients (16 men and nine women; mean age, 39.2 years) were treated by using this combined technique between 2008 and 2016. All cases were graded initially as Gustilo–Anderson grade IIIB open fractures. The soft tissue defect after radical debridement ranged from 9 cm × 5 cm to 14 cm × 11 cm, and the average size of segmental defect was 5.2 (Range, 2.5–8.5) cm. Seventeen of these patients had a history of local infection. The bone structure and function were evaluated by two independent evaluators using Paley''s criteria.ResultsTwenty‐five patients were followed up for an average of 28.96 (Range, 15–48) months. The distally based sural neurovascular flap was applied in 13 patients, and the greater saphenous neurocutaneous perforator flap in 12 patients. The flap area ranged from 10 cm × 5 cm to 14 cm × 12 cm. Sufficient coverage of soft tissue defect was achieved in all cases. All flaps survived completely without complications. The bone defects were corrected by a mean lengthening of 6.94 (Range, 4.5–9.5) cm. The residual discrepancy was <1 cm in all cases, which was not clinically significant. The function was evaluated as excellent in 12 patients and good in 13 patients. Bone results were graded as excellent in 18 patients and good in seven patients. Complications during treatment included pain, pin tract infections, ankle midfoot joint stiffness, and docking site nonunion. No recurrence of infection was observed in infected patients. All cases achieved successful limb salvage and satisfactory function recovery without recurrence of infection.ConclusionsThe combined technique of a perforator artery pedicled neurotrophic flap and distraction osteogenesis is an effective alternative approach in the salvage treatment of massively traumatized and chronically infected lower extremities.     

骨髓间充质干细胞结合Masquelet技术治疗感染性骨缺损的临床疗效观察

目的 观察应用骨髓间充质干细胞(bone marrow mesenchymal stem cells,BMSCs)结合Masquelet技术治疗感染性骨缺损的临床疗效.方法 回顾性分析2016年6月至2019年1月河南省洛阳正骨医院采用BMSCs结合Masquelet技术治疗的30例感染性骨缺损病人的临床资料.其中男2...     

Three‐Dimensional Printing‐Assisted Masquelet Technique in the Treatment of Calcaneal Defects

ObjectiveThe aim of the present study was to summarize the clinical efficacy of three‐dimensional (3D) printing technology combined with the Masquelet technique in the treatment of calcaneal defects.MethodsFrom January 2018 to April 2019, 3D printing combined with induced masquelet technology was used to treat four patients with calcaneal defects, including two men and two women. The patients were aged 22–52 years old, with an average age of 36 years. There were two cases of traffic accident injuries, there was one case of a fall from height, and there was one case of crush injury. CT scans were used to reconstruct the bilateral calcaneus, mirror technology was used to construct the bone defect area, and Materialise 3‐matic software was used to design the calcaneus shaper mold and 3D print the mold. During the operation, the mold was used to shape the bone cement and fill the bone defect. In the second stage, the bone cement was removed and autologous bone was implanted to repair the bone defect. All patients were followed up to observe the effect.ResultsAll four patients were followed up for 14 months (range, 10–18 months). There were three cases of infectious bone defects: two cases of Escherichia coli and one case of Pseudomonas aeruginosa. The 3D printed mold was used to shape the bone cement. During the operation, it was found to have a high degree of matching with the defect area of calcaneus. There is no need to adjust it again, and the wound healed well after the first stage. In the second stage of surgery, it was found that the induced membrane formed was complete and of appropriate size; the bone cement was easily removed during the operation. The fracture healing time was 3–6 months, with an average of 4 months. At the last follow up, there was no pain and the patients walked with full weight bearing. The Maryland score was 94 points (range, 88–98 points); three cases were excellent and one case was good. The AOFAS score ranged from 86 to 98, with an average of 92.8 points; three cases were excellent and one case was good.ConclusionThree‐dimensional printing technology combined with induced membrane technology is an effective approach for treating calcaneal bone defects.