替格瑞洛对STEMI患者急诊PCI治疗前后Tp-e、Tp-e/QTc比值影响的研究

目的探讨急性ST段抬高型心肌梗死(STEMI)患者急诊行经皮冠状动脉介入治疗(PCI)术前给予负荷剂量的替格瑞洛口服及术后给予维持剂量口服治疗对T波峰末间期(Tp-e)、Tp-e/校正QT间期(QTc)比值的影响及临床意义。方法入选68例明确诊断为STEMI的患者并随机分为两组,即替格瑞洛组(n=34)与氯吡格雷组(n=34),观察两组在治疗前及治疗后24 h的Tp-e、Tp-e/QTc比值变化。结果 68例患者中,急诊PCI治疗前有22例出现室性心律失常,急诊PCI后无室性心律失常出现,Tp-e、Tp-e/QTc比值在室性心律失常组较非室性心律失常组明显延长(P0.05);氯吡格雷组PCI术后Tp-e、Tp-e/QTc比值较术前有明显缩短(P0.05),替格瑞洛组PCI后Tp-e、Tp-e/QTc比值较术前有明显缩短(P0.01),与氯吡格雷组比较,替格瑞洛组Tp-e、Tp-e/QTc比值缩短更明显(P0.05)。结论STEMI患者急诊PCI术前给予负荷剂量的替格瑞洛及术后给予维持剂量口服,Tp-e、Tp-e/QTc比值下降更明显;STEMI患者室性心律失常发生率与Tp-e、Tp-e/QTc比值延长有相关性。     

冠状动脉侧支循环及PCI治疗对CTO患者Tp-e间期、Tp-e/QT比值的影响

目的 探讨冠状动脉侧支循环（coronary collateral circulation,CCC）对冠状动脉慢性完全闭塞病变（chronic total coronary occlusion,CTO）患者Tp-e间期、Tp-e/QT比值的影响,以及经皮冠状动脉介入（percutaneous coronary intervention,PCI）治疗对CTO患者Tp-e间期、Tp-e/QT比值的影响及临床意义。方法 本研究选取邵阳市中心医院心内科2018年7月至2020年12月期间CTO患者共150例。CCC采用Rentrop评分进行分级,将入选患者分为CCC不良组（Rentrop 0级、1级组）,CCC良好组（Rentrop 2级、3级组）。测量各组患者心电图中Tp-e间期、Tp-e/QT比值。另从以上研究对象中按是否成功行PCI治疗分为PCI治疗成功组及PCI治疗失败组。观察两组患者PCI治疗前及治疗后心电图中Tp-e间期、Tp-e/QT比值的情况。结果 CCC良好组患者Tp-e间期、Tp-e/QT比值低于CCC不良组,差异有统计学意义（P<0.05）。PCI治疗成功组与PCI...     

心电图Tp-e间期和Tp-e/QT比值的影响因素分析

目的：探讨导致心电图Tp-e 间期和 Tp-e/QT比值大小变化的影响因素。方法选取我院2013年11月-2014年2月住院患者200例,记录12导联常规心电图,并分别测量和计算V2、V3、V4导联Tp-e间期和Tp-e/QT比值,按心电图指标Tp-e间期为100 ms和（或）Tp-e/QT 0.25为分界点,将其分为增大组（89例）和减小组（111例）,比较两组患者所患疾病分类、电解质及代谢紊乱等,分析其对Tp-e间期和Tp-e/QT比值大小变化的影响。结果心电图Tp-e 间期和 Tp-e/QT比值增大组中高血压左心室肥厚、肥厚性心肌病、急性心肌梗死、心力衰竭、急性脑血管疾病和低钾血症所占的比例明显大于减小组（P〈0.01）。结论高血压左心室肥厚、肥厚性心肌病、急性心肌梗死、心力衰竭、急性脑血管疾病和低钾血症均是心电图 Tp-e 间期和Tp-e/QT比值的影响因素。     

替罗非班联合血栓抽吸对ST段抬高型心肌梗死患者直接经皮冠状动脉介入治疗术后冠状动脉再灌注及心功能的影响研究

目的探讨替罗非班联合血栓抽吸对ST段抬高型心肌梗死(STEMI)患者直接经皮冠状动脉介入治疗(PCI)术后冠状动脉再灌注及心功能的影响。方法选取2010年6月—2016年6月在亳州市人民医院行直接PCI的STEMI患者60例,采用随机数字表法分为对照组和研究组,每组30例。两组患者均行常规直接PCI,对照组患者给予替罗非班治疗,研究组患者给予替罗非班联合血栓抽吸治疗。比较两组患者术后冠状动脉TIMI血流分级、术后30 d内主要心脏不良事件(MACE)发生率及术前、术后30 d心功能指标。结果术后研究组患者冠状动脉TIMI血流分级优于对照组(P0.05)。PCI术后30 d内两组患者MACE发生率比较,差异无统计学意义(P0.05)。两组患者术前和术后30 d脑钠肽(BNP)水平、左心室舒张末期内径(LVEDD)、左心室射血分数(LVEF)及术前左心室收缩末期内径(LVESD)比较,差异均无统计学意义(P0.05);研究组患者术后30 d LVESD短于对照组(P0.05)。术前两组患者T波峰末间期(Tp-e间期)和T波峰末与QT间期比值(Tp-e/QTc比值)比较,差异均无统计学意义(P0.05);术后30 d研究组患者Tp-e间期短于对照组,Tp-e/QTc比值低于对照组(P0.05)。结论替罗非班联合血栓抽吸能有效改善STEMI患者直接PCI术后冠状动脉再灌注和心脏收缩功能,降低恶性心律失常发生率,且未增加MACE发生风险。     

Tp-ec、Tp-e/QT对急性ST段抬高性心肌梗死恶性心电生理事件的预测价值

目的:观察急性ST段抬高性心肌梗死(STEMI)患者QT间期、Tp-ec(校正的T波的顶点到T波的终点的时间)和Tp-e/QT指标的变化及这些指标与恶性心电生理事件的相关性。方法:急性STEMI患者60例,测量并计算梗死相关和非梗死导联QT、QTc、Tp-ec、Tp-e/QT比值,记录1年内恶性心电生理事件。正常心电图60例作为对照。结果:①急性STEMI 12h内梗死和非梗死导联QTc明显延长(P<0.01),1周和1个月回复正常水平。梗死相关导联12h内Tp-ec间期比非梗死导联及对照组均明显延长(均P<0.01),1周和1个月逐渐回复正常。Tp-e/QT比值在梗死相关导联比其他导联明显增大(P<0.01),随之逐渐回复,但仍与对照组差异有统计学意义(P<0.01)。②QTc 440ms作为截点电生理事件发生差异无统计学意义(P>0.05),而分别以Tp-ec100ms和Tp-e/QT比值0.25作为截点恶性电生理事件发生差异有统计学意义(P<0.05)。结论:在心肌梗死急性期Tp-ec,尤其是Tp-e/QT比值增加,与恶性电生理事件相关,是预测急性STEMI后恶性电生理事件的指标。     

心肌梗死患者经皮冠状动脉介入治疗术后ST段回落与Tp-ec间期变化相关性与预测价值

目的 急性ST段抬高的心肌梗死(STEMI)患者动作电位2相折返引起ST段抬高和复极离散度变化,通过对STEMI患者经皮冠状动脉介入治疗(PCI)前后抬高的ST段回落(STR)、Tp-ec(校正的T波顶点到T波终点的时间)和Tp-e/QT的测算,分析其相关性,并评价这些指标对恶性心律失常事件(MAE)的预后价值.方法 ...     

糖尿病患者Tp-e间期和Tp-e/QT的临床观察

目的探讨糖尿病患者QT间期、QTc、Tp-e间期和Tp-e/QT检测的临床价值。方法随机选取糖尿病患者100例,年龄、性别与之匹配的正常人100例作对照组,分别测量两组V2导联QT间期、RR间期、Tp-e间期,计算QTc和Tp-e/QT。结果糖尿病组和对照组QT间期差异无统计学意义(P>0.05),而糖尿病组QTc、Tp-e间期和Tp-e/QT比值均显著高于对照组,差异有统计学意义(P<0.01)。结论 QTc、Tp-e间期和Tp-e/QT可作为糖尿病患者发生恶性心律失常的预测指标。     

血栓抽吸联合比伐卢定、替罗非班对急性ST段抬高型心肌梗死病人预后的影响

目的探讨血栓抽吸联合比伐卢定、替罗非班对急性ST段抬高型心肌梗死(STEMI)病人预后的影响。方法回顾性收集河南省三门峡市中心医院行经皮冠状动脉介入(PCI)治疗的198例急性STEMI病人(血栓积分≥2分)的临床资料,其中给予血栓抽吸联合替罗非班、比伐卢定治疗的108例病人作为观察组,给予血栓抽吸联合替罗非班治疗的90例病人作为对照组,比较两组心肌梗死溶栓试验(TIMI)血流分级、心功能指标、ST段回落率、全球急性冠状动脉事件注册评分(GRACE)和出血风险评分(CRUSADE)及主要不良心脏事件(MACE)发生率。结果两组术后TIMI血流分级均明显优于术前(P0.05),但观察组术后TIMI血流分级优于对照组(P0.05);术后30 d,两组T波峰-末间期(Tp-e)、Tp-e/校正QT间期(Tp-e/QTc)及血浆B型利钠肽(BNP)水平均明显低于术前(P0.05),且观察组Tp-e间期、Tp-e/QTc及血浆BNP水平均低于对照组(P0.05);观察组术后ST段回落率高于对照组(P0.05),GRACE、GRUSADE评分均低于对照组(P0.05);观察组术后30 d MACE发生率为12.96%,明显低于对照组的26.67%(P0.05)。结论血栓抽吸联合比伐卢定、替罗非班可有效改善急性STEMI病人行PCI术后TIMI血流分级和心功能,降低MACE发生率,改善病人预后。     

QTc、Tp-ec、Tp-e/QT对慢性肾功能衰竭患者恶性心律失常并发症的评估价值

目的 探索慢性肾衰竭CKD各期患者QTc、Tp-ec及Tp-e/QT指标的变化与恶性心律失常事件发生的关系。 方法 慢性肾衰竭患者258例,测量并计算慢性肾衰竭CKD各期患者QT间期、Tp-e间期及Tp-e/QT比值,记录住院2周内恶性心律失常事件。正常心电图99例作为对照。结果 (1) QTc、Tp-ec、Tp-e/QT在CKD1、2、3期与对照组之间无明显变化（P＞0.05）,而其在CKD4、5期与对照组之间差异均有统计学意义（P＜0.05）;QTc、Tp-ec、Tp-e/QT在CKD1、2期之间,CKD2、3期之间无明显变化（P＞0.05）,而其在CKD3、4期,4、5期之间差异有统计学意义（P＜0.05）。（2）恶性心律失常事件的发生在CKD1、2期之间,CKD2、3期之间无明显变化(P＞0.05),而其在CKD3、4期,4、5期之间差异均有统计学意义(P＜0.05);QTc以420ms,Tp-ec以100ms,Tp-e/QT以0.250为节点,恶性心律失常事件的发生有明显差异（P＜0.05）,慢性肾衰竭组患者的恶性心律失常事件的发生与QTc、Tp-ec、Tp-e/QT指标的延长明显相关。结论 慢性肾衰竭患者进入CKD4、5期后,QTc、Tp-ec、Tp-e/Q指标逐渐延长与恶性心律失常事件的发生明显相关,QTc、Tp-ec、Tp-e/QT有望成为评估慢性肾衰竭患者心血管损害的心电学指标。     

血栓抽吸在高血栓负荷患者急诊冠脉介入治疗中的应用

目的：探讨血栓抽吸在急性ST段抬高型心肌梗死（STEMI）患者急诊冠状动脉介入治疗（PCI）中对梗死相关动脉（IRA）高血栓负荷患者的临床效果。方法：71例STEMI患者急诊PCI时冠脉造影提示IRA高血栓负荷,其中40例应用Diver CE抽吸导管对IRA内血栓进行抽吸治疗为抽吸组,31例行标准PCI为PCI对照组;观察两组无复流现象、术后1h心电图ST段回落、肌酸激酶（CK）和肌酸激酶同工酶（CK-MB）的峰值、术后1周左心室射血分数（LVEF）及左心室舒张末期内径（LVEDd）、住院期间主要心脏不良事件（MACE）及出血并发症情况,并进行比较。结果：抽吸组无复流发生率明显低于PCI组（5.0%比22.6%,P〈0.05）,ST段回落率及LVEF明显高于PCI组[60.0%比32.3%、（58.0±6.4）%比（53.3±9.2）%,P均〈0.05];CK、CK-MB及LVEDd明显低于PCI组[（1692.9±394.5）U/L比（1995.1±571.5）U/L、（174.5±38.0）U/L比（203.7±65.2）U/L、（51.7±4.1）mm比（54.2±5.2）mm,P均〈0.05],两组住院期间MACE发生率差异无显著性（P〉0.05）。结论：在高血栓负荷的急性ST段抬高型心肌梗死患者急诊PCI中,应用Diver CE抽吸导管能有效减少梗死相关血管内血栓负荷,改善术后即刻心肌灌注,减少无复流现象的发生。     

Evaluation of Tp-e interval and Tp-e/QT ratio in patients with ankylosing spondylitis

Abstract

Objectives. Ankylosing spondylitis (AS) is a chronic multi-systemic inflammatory rheumatic disorder. Several studies have suggested that the interval from the peak to the end of the electrocardiographic T wave (Tp-e) may correspond to the transmural dispersion of repolarization and that increased Tp-e interval and Tp-e/QT ratio are associated with malignant ventricular arrhythmias. The aim of this study was to evaluate ventricular repolarization by using Tp-e interval and Tp-e/QT ratio in patients with AS, and to assess the relation with inflammation.

Methods. Sixty-two patients with AS and 50 controls were included. Tp-e interval and Tp-e/QT ratio were measured from a 12-lead electrocardiogram, and the Tp-e interval corrected for heart rate. The plasma level of high sensitive C-reactive protein (hsCRP) was measured. These parameters were compared between groups.

Results. In electrocardiographic parameters analysis, QT dispersion (QTd) and corrected QTd were significantly increased in AS patients compared to the controls (31.7 ± 9.6 vs 28.2 ± 7.4 and 35.8 ± 11.5 vs 30.6 ± 7.9 ms, P = 0.03 and P = 0.007, respectively). cTp-e interval and Tp-e/QT ratio were also significantly higher in AS patients (92.1 ± 10.2 vs 75.8 ± 8.4 and 0.22 ± 0.02 vs 0.19 ± 0.02 ms, all P values <0.001). cTp-e interval and Tp-e/QT ratio were significantly correlated with hsCRP (r = 0.63, P < 0.001 and r = 0.49, P < 0.001, respectively).

Conclusions. Our study revealed that Tp-e interval and Tp-e/QT ratio were increased in AS patients. These electrocardiographic ventricular repolarization indexes were significantly correlated with the plasma level of hsCRP.     

Evaluation of Tp-e interval and Tp-e/QT ratio in patients with non-dipper hypertension

Aims: Non-dipper hypertension is associated with increased cardiovascular morbidity and mortality. Several studies have suggested that the interval from the peak to the end of the electrocardiographic T wave (Tp-e) may correspond to the transmural dispersion of repolarization and that increased Tp-e interval and Tp-e/QT ratio are associated with malignant ventricular arrhythmias. The aim of this study was to evaluate ventricular repolarization by using Tp-e interval and Tp-e/QT ratio in patients with non-dipper hypertension.

Materials and method: This study included 80 hypertensive patients. Hypertensive patients were divided into two groups: 50 dipper patients (29 male, mean age 51.5?±?8 years) and 30 non-dipper patients (17 male, mean age 50.6?±?5.4 years). Tp-e interval and Tp-e/QT ratio were measured from the 12-lead electrocardiogram. These parameters were compared between groups.

Results: No statistically significant difference was found between two groups in terms of basic characteristics. In electrocardiographic parameters analysis, QT dispersion (QTd) and corrected QTd were significantly increased in non-dipper patients compared to the dippers (39.4?±?11.5 versus 27.3?±?7.5?ms and 37.5?±?9.5 versus 29.2?±?6.5?ms, p?=?0.001 and p?=?0.01, respectively). Tp-e interval and Tp-e/QT ratio were also significantly higher in non-dipper patients (97.5?±?11.2 versus 84.2?±?8.3?ms and 0.23?±?0.02 versus 0.17?±?0.02, all p value <0.001).

Conclusion: Our study revealed that QTd, Tp-e interval and Tp-e/QT ratio are prolonged in patients with non-dipper hypertension.     

Assessment of Tp-e interval and Tp-e/QT ratio in patients with human immunodeficiency virus

ObjectiveSudden cardiac death (SCD) plays an important part in all-cause mortality in patients infected with human immunodeficiency virus (HIV). The T-peak to T-end (Tp-e) interval, corrected Tp-e (Tp-ec) interval, and Tp-e/QT ratio on the ECG are parameters used to stratify risk for SCD. The objective of this study was to investigate the differences between HIV-infected patients and healthy individuals in terms of Tp-e interval, Tp-ec interval, and Tp-e/QT ratio, as well as other influencing factors.MethodsNinety-eight HIV-infected patients and 62 healthy controls were included in this prospective case-control study. Tp-e interval, Tp-ec interval, and Tp-e/QT ratio were measured in all participants. Echocardiographic examination and routine laboratory analysis were performed. In addition, CD4 T-cell count and HIV RNA levels were assessed in HIV-infected patients.ResultsAll baseline characteristics were comparable in both groups. The median survival of those living with HIV was 20.63 months; 53% of them had controlled viral load, and 74% were receiving antiretroviral therapy. Mean baseline CD4 T-cell count was 409. In HIV-infected patients, the Tp-e interval and Tp-ec interval were prolonged, and the Tp-e/QT ratio was higher (p<0.001, p<0.001 and p=0.021, respectively). In bivariate and partial correlation analyses, there was a negative correlation between CD4 T-cell level and Tp-e interval, Tp-ec interval, and Tp-e/QT ratio.ConclusionTp-e interval, Tp-ec interval, and Tp-e/QT ratio were greater in HIV-infected patients compared with healthy individuals. HIV-infected patients, particularly those with low baseline CD4 T-cell counts, should be closely monitored due to risk of SCD.     

The effect of moderate altitude on Tp-e interval,Tp-e/QT,QT, cQT and P-wave dispersion

Introduction

Long-time exposure to high altitude leads to changing at the respiratory, cardiovascular and hematological systems. There is no sufficient study about cardiovascular changes in moderate altitude. The distance between the peak and the end of the T wave (Tp-e) is a measure of transmyocardial distribution of repolarization and may be associated to dangerous rhythm disorders and ventricular arrhythmias. Again, P-wave dispersion (PWD) described as the extension of interatrial and intraatrial conduction time and inhomogeneous spread of sinus pulses are well recognized electrophysiologic features in patients with atrial fibrillation. We aimed to compare repolarization parameters (Tp-e interval, Tp-e/QT ratio, QT, cQT) and P wave dispersion between healthy people living at moderate altitude and sea level.

健康人Tp—e时间与Q—T间期比值的研究

目的观察健康人T波峰-末时间（Tp—e时间）与Q—T间期的比值（Tp—e／Q—T）,为临床Tp—e／Q—T的研究提供正常参考依据。方法选取1012例健康体检者,其12导联心电图T波在Ⅱ、V3、V4和V5直立,终末部清晰可辨,心率60～100次／min。分别测量Ⅱ、V3、V4和V5 Q—T间期、Q—TP间期,计算Tp—e时间、Tp—e／Q—T值。结果Tp—e／Q—T各导联总均值为022±0．03,95％可信区间0．16～0．28;V3、V。和V5Tp—e／Q—T总均值为022±0．03,95％可信区间0.16～0．28。当心率从60次／min至100次／min不等时,各导联间Tp—e／Q—T差异无统计学意义（P〉0．05）;各导联Tp—e／Q—T在不同性别和年龄间差异均无统计学意义（P〉0．05）;不同导联Tp—e／Q—T差异亦无统计学意义（P〉0.05）。结论得到了健康人Tp—e／Q—T的正常参考值。     

尿毒症患者Q—T离散度和T波峰末间期的研究

目的探讨行维持性血液透析的尿毒症患者是否存在区域性和跨心室壁复极离散度（TDR）增大。方法分别测量行维持性血液透析的尿毒症患者（尿毒症组,n=35例）和正常健康者（对照组,n=40例）体表心电图的Q—T间期、R—R间期、丁波峰末问期（Tp—e）,进而计算Q-T离散度（Q—Td=Q—Tmax—Q—Tmin）、心率校正的Q—T离散度（Q—Td／R√R--R）,心率校正的最大Tp—e间期（Tp—emax／√R-R）、T波峰末问期离散度（Tp—ed=Tp—emax—Tp—emin）、心率校正的Tp—e间期离散度（Tp—ed／√R—R）。结果尿毒症组的Q—T离散度及校正的Q—T离散度较对照组明显延长（66．3±15．9VS40．2±12．4,681±14．8VS44．5±13．1。均P〈0．05）;尿毒症组的最大Tp—e间期及最大校正Tp—e间期较对照组明显延长（98．34-14．6VS77．6±12．1,94．2±12．6VS72,54-11．4,均P〈O．05）,Tp—e间期离散度及校正的Tp—e问期离散度也较对照组明显延长（48．4±16．3VS32．1±12．3,44．3±12．2VS30．2±12．5,P〈0．05）。结论尿毒症患者的Q—T离散度和Tp—e间期及其离散度较正常者明显延长,表明尿毒症患者区域性和TDR增大。     

Tp-e间期的研究进展及其在冠心病中的临床应用

Tp-e间期和Tp-e/QT比值是新近提出的可以反映心室跨壁复极离散度(myocardial transmural dispersion of repolarization,TDR)的心电指标,其与恶性室性心律失常发生密切相关.冠心病是导致恶性室性心律失常甚至心源性猝死(sudden cardiac death,SCD)的最常见心脏结构异常,寻找冠心病患者恶性室性心律失常以及SCD的有效预测指标成为近些年临床上的研究重点.