Treatment of 54 cases of lactation insufficiency with acupuncture

针刺少泽、膻中、乳根、脾俞、足三里和三阴交,治疗乳汁不足妇女54例,42例显效,乳汁完全满足婴儿的需要,9例好转,3例治疗中断治疗.     

乳房局部推拿对产后泌乳的影响

目的:探讨推拿促进产妇泌乳的有效性,拟定促进产妇产后泌乳的有效推拿手法.方法:以84例足月初产妇为研究对象,随机分为推拿组(58例)和对照组(26例),推拿组以乳房局部推拿为主,配合经穴推拿;对照组予母婴同室常规护理.观察推拿对产妇始乳时间、产妇泌乳量、血清泌乳素等指标的影响,并与正常未推拿产妇进行比较对照.结果:推拿组产妇的泌乳量积分在治疗1次后、2次后、3次后分别为1.660±0.785、2.530±1.030、2.880±1.171,而对照组在相应时间段则分别为1.270±0.533、1.460±0.811、1.500±0.583,推拿组泌乳量积分高于对照组(均P＜0.01);两组始乳时间分别为(21.6±10.5)h和(22.5±9.8)h,差异无统计学意义(P＞0.05);推拿组治疗前血清泌乳素为(314.35±110.37)ng/mL,治疗后上升为(321.56±109.61)ng/mL,而对照组血清泌乳素前后分别为(385.78±85.19)ng/mL和(340.12±103.10) ng/mL,但两组前后比较差异均无统计学意义(均P＞0.05).结论:产后乳房推拿能明显增加产妇的泌乳量,能延缓血清泌乳素下降水平,有利于产妇早泌乳、多泌乳.     

针刺对360例子宫全切术后患者膀胱功能影响分析

ObjectiveTo analysis the clinical curative effect on bladder function recovery after radical hysterectomy with acupuncture and acu-physiotherapy.MethodsA total of 564 cervical cancer patients in the gynecology department who received radical hysterectomy from January 2011 to December 2017 in Qilu Hospital of Shandong University were collected. According to the inclusion and exclusion criteria, we studied 360 case records at last, with 120 cases respectively. Patients got treatment of acupuncture [acupuncture at Zhōngwǎn (中脘 CV12), Tiānshū (天枢 ST25), Shuǐdào (水道 ST28), Tàichōng (太冲 LI3), Sānyīnjiāo (三阴交 SP6), Zúsānlǐ (足三里 ST36) and Yīnlíngquán (阴陵泉 SP9)], or acu-physiotherapy with two large-size electrodes placed on the bladder area above the pubic symphysis besides acupuncture, from the 3rd day after operation once a day till the 14th day that removing the indwelling catheter. And the blank group got no other auxiliary treatment except scrubbed the meatus orifice with iodophor twice a day. We tested the residual urine volume 6 h later after removement of indwelling catheter. Residual urine volume more than 100 mL was defined as urinary retention, and the volume less than 50 mL was defined as adequate bladder emptying.ResultsWe analyzed patients’ age, the International Federation of Gynecology and Obstetrics (FIGO) stage, operation duration, amount of hemorrhage, depth of myometrium infiltration, cancer embolus, parametrium invasion, lymphatic metastasis, treating methods and residual urine volume recorded in case records, and there was no significant difference between every two groups (P >0.05). The incidences of urinary retention of the acupuncture group, the acu-physiotherapy group and the blank group were 24.17%, 21.67%, and 44.17%, indicating that both treating methods have significant effects (P <0.05), and acupuncture group was a little better than acu-physiotherapy group. The bladder function recovery rates of the 3 groups were 44.17%, 56.67%, and 40.83% correspondingly, which had significant difference between acu-physiotherapy group and blank group (P <0.05). Both acupuncture and acu-physiotherapy could reduce the incidence of urinary retention for the patients of Ib1 and IIa1 stages (P <0.01), whilst for patients of Ib2 and IIa2 stages, neither of the two methods was effective (P >0.05).ConclusionBoth acupuncture and acu-physiotherapy could prevent urinary retention after radical hysterectomy for local early cervical cancer (Ib1 and IIa1 stages) effectively, and acupuncture was a little more effective than acu-physiotherapy group. Acupuncture together with modulated medium frequency eletro-therapy could improve the cure rate of bladder function and minimize the residual urine volume.     

Treatment of 32 cases of bile reflux gastritis by embedding catgut in acupoints

在穴位胆俞、胃俞、梁门、中脘、上脘、足三里、内关、太冲和阳陵泉埋入羊肠线,1 d后取下.15-20 d埋线1次,治疗32例胆汁返流性胃炎患者,治疗4次后治愈20例,好转12例.     

胸背部平衡松解术配合推拿手法改善产后缺乳临床研究

目的:探究胸背部平衡松解术配合推拿手法应用于产后缺乳的效果.方法:选取产后缺乳产妇92例,按随机数字表法分为观察组和对照组,每组各46例.对照组行常规推拿治疗,观察组行胸背部平衡松解术配合推拿治疗;均隔天治疗1次,5次为1个疗程.观察两组泌乳指标(乳房充盈度与泌乳量)评分、不同时间点泌乳量、血清泌乳素水平及临床疗效.结...     

Electroacupuncture for postpartum sexual dysfunction with urinary incontinence: A prospective case series study电针治疗产后性功能障碍伴尿失禁：前瞻性病例系列研究

ObjectiveTo observe the clinical therapeutic effect of electroacupuncture on postpartum sexual dysfunction associated with urinary incontinence.MethodsThe prospective case-series study was adopted. A total of 36 patients with postpartum sexual dysfunction associated with urinary incontinence were included consecutively. Electroacupuncture was applied to Shènshū (肾俞BL23), Huìyáng (会阳BL35), Pángguāngshū (膀胱俞BL28), Shíqīzhuī (十七椎EX-B8), Cìliáo (次髎BL32), Zhōngliáo (中髎BL33), Qìh?i (气海CV6), Guānyuán (关元CV4), Zhōngjí (中极CV3), Qūg? (曲骨CV2), Shu?dào (水道ST28), Z?gōng (子宫EX-CA1), Zúsānl? (足三里ST36) and Sānyīnjiāo (三阴交SP6), once daily, 6 times a week. The treatment for 2 weeks was as one phase and it should be completed in one menstrual cycle. For the cases without menstrual cycle recovery, the treatment should be given for any two weeks in one menstrual cycle and for those with menstrual cycle recovery, the treatment should avoid the menstrual period. Totally, the treatment lasted for 3 menstrual cycles. Before and after treatment, the scores of postpartum female sexual dysfunction diagnostic scale (PFSDDS), sexual intercourse pain assessment scale (SIPAS) and pelvic floor muscle strength test (PFMST), as well as the results of urodynamic examination (UE) were observed before and after treatment in the patients.ResultsAfter treatment, the scores of PFSDDS, SIPAS and PFMST were all increased as compared with those before treatment separately, presenting the statistical significance (all P < 0.05). Regarding UE, after treatment, the maximum bladder capacity, detrusor pressure at maximum flow, maximum flow rate and maximal urethral closure pressure were increased and postvoiding residual urine volume was reduced obviously as compared with the values before treatment, respectively, indicating the statistical differences (all P < 0.05).ConclusionElectroacupuncture has the significant effect on postpartum sexual dysfunction associated with urinary incontinence.     

Xiong-gui-tiao-xue-yin (Kyuki-chouketsu-in), a traditional herbal medicine, stimulates lactation with increase in secretion of prolactin but not oxytocin in the postpartum period

The aim of the present investigation was to evaluate the clinical efficacy of Xiong-gui-tiao-xue-yin, a traditional Japanese herbal medicine, in stimulating lactation in the postpartum period. We enrolled 82 women who had a normal delivery in Osaka Medical College Hospital, and randomly assigned them to the following two groups: a group of 41 women who received Xiong-gui-tiao-xue-yin at a dose of 6.0 g/day (Group X), and a group of 41 women who received ergometrine (methylergometrine maleate) at a dose of 0.375 mg/day (Group E). Volume of lactation was determined daily until Day 6 postpartum. Plasma prolactin and oxytocin concentration were measured at Days 1 and 6 postpartum. The results showed that volume of lactation was significantly higher in Group X than in Group E at Days 4 (p = 0.042), 5 (p = 0.038), and 6 (p = 0.046). Significant differences between Groups X and E were noted in plasma prolactin concentration at Days 1 (157.9 +/- 78.2 ng/ml and 129.1 +/- 64.8 ng/ml; p = 0.037) and 6 (167.5 +/- 95.4 ng/ml and 117.1 +/- 53.6 ng/ml; p = 0.0042) postpartum. On the other hand, at Day 1, oxytocin concentration was significantly higher in Group E than in Group X (p = 0.0024). No adverse effects were observed in this study. The results of our study demonstrate the beneficial effects of Xiong-gui-tiao-xue-yin on lactation, with increase in prolactin level without increase in oxytocin level in the postpartum period. Therefore, Xiong-gui-tiao-xue-yin can be expected to improve lactation in women in the postpartum period. Further detailed bio-pharmacological studies and clinical trials to investigate the properties of this drug are warranted.     

敷胸方不同剂型的体外透皮吸收效果比较

目的：评价超滤工艺对注射用芪红脉通抗急性心肌缺血和被动皮肤过敏反应的影响。方法：选择舌静脉注射垂体后叶素（0.75 U·kg^-1）构建急性心肌缺血大鼠模型,以心电图ST段变化和血清超氧化物歧化酶（SOD）,丙二醛（MDA）的含量变化为药效学评价指标,比较注射用芪红脉通超滤前后对垂体后叶素致大鼠急性心肌缺血的影响,以大鼠被动皮肤过敏试验考察该制剂的安全性。结果：超滤前后注射用芪红脉通在成分上无明显变化;与模型组相比,超滤前后样品均能显著降低心电图ST段的抬升,超滤前中剂量及超滤后高剂量样品组均能显著提高血清SOD活性,各给药组均能显著降低血清MDA的产生,但超滤前后这些指标均无显著差异;超滤后样本的被动皮肤过敏呈阴性。结论：注射用芪红脉通具有显著的抗急性心肌缺血作用,超滤工艺提高了制剂的安全性,对药效无影响。     

Lithocarpus polystachyus(Sweet Tea) water extract promotes human hepatocytes HL7702 proliferation through activation of HGF/AKT/ERK signaling pathwayOA

Objective: Sweet Tea(ST), derived from the leaves of Lithocarpus polystachyus, is a Chinese folk medicine with wide pharmacological activities. However, the promotive effects of ST water extract on hepatocytes proliferation and its underlying mechanism remains still unknown. In the present study, the beneficial effects of ST water extract on human hepatocytes and its possible mechanism were investigated.Methods: MTT assay was used to detect the safety range of ST; HL7702 cells were divided into ...     

参归口服液联合缩宫素对自然分娩产后恢复状况的临床研究

目的:分析探讨参归口服液联合缩宫素对自然分娩产后恢复状况。方法:选择120例足月阴道分娩产妇随机分为2组,对照组和治疗组,对照组采用常规缩宫素治疗,治疗组采用参归口服液联合缩宫素,观察2组产妇产后3 d内宫底高度、产后24 h内阴道出血量、产后血红蛋白情况、产后24 h内泌乳率及产后恶露天数。结果:治疗组产妇产后第1、3 d子宫底高度,均明显低于对照组(P0.05),治疗组产后24 h内出血量少于对照组(P0.05)。治疗组产后3 d的血红蛋白浓度明显高于对照组(P0.05)。治疗组血性恶露持续时间明显短于对照组(P0.05),而产后24 h泌乳率明显高于对照组。结论:参归口服液联合缩宫素能促进产后子宫复旧,减少产后出血,提高血红蛋白含量,及早下奶,促进患者肌体功能恢复。     

疏风通络方对哮喘大鼠嗜酸细胞跨膜迁移 相关因子VCAM-1/PI3K/Rac-1/NOX2/ NOX4/SHP-2表达影响的研究

[目的]探讨疏风通络方对哮喘大鼠嗜酸细胞跨膜迁移的影响。[方法]选择SPF级雄性Wistar大鼠70只为研究对象,随机分为正常组、模型组、地塞米松组、DPI组、中药低、中、高剂量组,共7组,每组大鼠10只。第1天致敏:正常组给予生理盐水1 mL腹腔注射致敏,而其他6组给予1 mL造模液(含V级卵清蛋白100 mg,氢氧化铝100 mg和灭活百日咳杆菌6×109个)腹腔注射致敏;第15天开始激发:将各组大鼠分别置于相同大小的雾化箱内,正常组给予生理盐水6 mL雾化激发,其他6组给予5%的V级卵清蛋白溶液6 mL雾化激发,每次激发前2 h正常组给予生理盐水1 mL灌胃,而其他6组给予相应的药物灌胃。各组每天激发1次,每次激发30 min,连续激发10 d后处死大鼠,并采集相应标本,并进一步检测影响嗜酸细胞跨膜迁移的相关指标。[结果]模型组肺组织嗜酸细胞跨膜迁移相关调节因子血管内皮黏附分子-1(VCAM-1)、磷脂酰肌醇3激酶(PI3K)、Rac-1、NADPH氧化酶2(NOX2)、NADPH氧化酶4(NOX4)、酪氨酸磷酸酶(SHP-2)出现高表达,高于正常组(P<0.001);各治疗组与模型组相比,地塞米松组抑制上述因子表达的效果最好(P<0.001),中药高剂量组的抑制效果略差于地塞米松组,但两者差异无统计学意义(P>0.05),氯化二联苯碘(DPI)组、中药低、中剂量组抑制效果一般。[结论]疏风通络方对哮喘大鼠嗜酸细胞跨膜迁移有一定的阻抑作用,这可能是其平喘作用机制之一。     

Treatment of 30 cases of migraine by mind-regulating acupuncture

目的；探讨神庭、内关和三阴交穴在针刺治疗偏头痛中的作用。方法：在德国Aachen市门诊工作中，以神庭，双侧内关和三阴交为主穴，双侧合谷、太冲，患侧头维、阳白、攒竹、丝竹空、率谷、四白，耳穴交感、神门、心和内分泌为配穴（调神针刺法）治疗偏头痛患者30例，与常规针刺法治疗28例患者进行对照。观察两组疗效及即时止痛效果。结果：调神针刺法总有效率为90.0％，常规针刺法为75.0％，前者疗效好于后者（X^2=4．57，P〈0．05）。调神针刺法治疗24h后止痛效果远优于常规针刺法（X^2=10．11，P〈0．01）。结论：应用神庭、内关和三阴交穴治疗偏头痛可以取得较常规针刺方法更好的疗效。     

个体化灸法治疗产后身痛的临床研究

Objective:To evaluate the clinical therapeutic effect and safety of individualized moxibustion in treatment of postpartum pantalgia.Methods:A total of 99 patients with postpartum pantalgia were divided into three group at the ratio of 1:1:1 according to random number table,i.e.an individualized moxibustion group,a quantitative moxibustion group and a voltaren group.The same acupoints were selected in the individualized moxibustion group and the quantitative moxibustion group.With the patient in supine,Zhongwǎn(中脘CV12),Guānyuán(关元CV4),bilateral Tiānshū(天枢ST25),bilateral Xuèhǎi(血海SP10),bilateral Yanglingquan(阳陵泉GB34),bilateral Zúsānlǐ(足三里ST36) and bilateral Sānyīnjiāo(三阴交SP6) were selected.With the patient in prone,Dàzhuī(大椎GV14),bilateral Géshū(膈俞BL17),bilateral Píshū(脾俞BL20),bilateral Shènshū(肾俞BL23),Mìngmén 命门(GV4),bilateral Wěizhōng(委中BL40) and bilateral Yǒngquán(涌泉KI1) were selected.In the individualized moxibustion group,the moxibusion dose was determined by patient’s constitution and conditions as well as no occurrence of dry throat,thirst and local skin lesion.In the quantitative moxibustion group,the moxibustion dose was fixed as 1 cone at each acupoint in treatment.In these two groups,the treatment was given once every two days,three times a week and the treatment for 2 weeks was as 1 course.Totally,2 courses of treatment were required.In the voltaren group,voltaren ointment was used externally at the pain area,once a day,for 4 weeks totally.Separately,before treatment,at the end of treatment course and in follow-up,the symptom score of traditional Chinese medicine(TCM),pain score of visual analogue scale(VAS) and patient’s treatment satisfaction score were observed in the patients of the three groups.Results:In comparison within group,TCM symptom score,VAS score and the treatment satisfaction score at the end of treatment were all reduced obviously as compared with those before treatment in each of the three groups(P <0.05).In 4,12 and 24 weeks of followup after treatment,the differences in these data were not significant as compared with those at the end of treatment in the individualized moxibustion group and the quantitative moxibustion group respectively(all P> 0.05).In the voltaren group,these data were not different as compared with those at the end of treatment in 4 weeks of follow-up(all P> 0.05),but these data were all increased as compared with those at the end of treatment in 12 and 24 weeks of follow-up(all P <0.05).In comparison among three groups,at the end of treatment and in 4,12 and 24 weeks of followup,the above-mentioned three therapeutic effect indicators were all different significantly(all P <0.05).In comparison between two groups,in the individualized moxibustion group,TCM symptom score,VAS score and the patient’s treatment satisfaction score were all lower than those in the quantitative moxibustion group at the end of treatment and at each time point of follow-up successively,indicating the significant differences(all P <0.05).Conclusion:Individualized moxibustion and quantitative moxibustion improve the short-term and longterm therapeutic effect on postpartum pantalgia as compared with the external application of voltaren ointment.The therapeutic effect and patient’s satisfaction of individualized moxibustion for replenishing kidney and nourishing blood are better than the quantitative moxibustion.The individualized moxibustion therapy for replenishing kidney and nourishing blood achieves a satisfactory effect on postpartum pantalgia and is excelled to voltaren ointment that is strongly recommended in modern medicine.Individualized moxibustion is an external therapy of TCM with optimal short-term and long-term therapeutic effect and reliable safety.Hence,it deserves to be promoted in practice.     

Treatment of 130 cases of postpartum retention of urine by electroacupuncture

电针双侧三阴交和阴陵泉,治疗130例产后癃闭患者,经1～5次治疗后,130患者均能顺利排尿.     

益气化瘀方对血瘀证子宫复旧不全模型大鼠血液高凝状态的影响

目的:观察产后子宫复旧不全大鼠血液流变学和组织纤溶酶原激活物(t-PA)的含量变化,探讨血瘀证子宫复旧不全大鼠模型的构建及益气化瘀方对其干预机制。方法:50只妊娠大鼠被随机分为5组,分别为正常组、模型组、新生化组(5.4 g·kg-1)及益气化瘀低、高剂量组(4.68,18.72 g·kg-1)。各组产后予以大肠埃希菌宫腔内给药制备炎症产后子宫复旧不全模型(正常组不造模),并于造模后第1~7天分别ig给药,子宫组织常规苏木素-伊红(HE)染色观察子宫组织形态。采用血液流变仪测定血流变指标,采用双抗体夹心法测定血清t-PA的含量。结果:与正常组比较,模型组全血黏度和血浆黏度明显升高(P0.05);与模型组比较,新生化组、益气低、高剂量组明显降低全血黏度和血浆黏度(P0.05),益气高剂量组优于新生化组(P0.05)。模型组中t-PA水平高于正常组(P0.05);新生化组、益气低、高剂量组中t-PA水平较模型组降低(P0.01),且各组间比较无统计学意义。结论:子宫内膜炎所导致的产后子宫复旧不全大鼠模型满足血瘀证动物模型要求。益气化瘀方能改善产后血液的黏滞状态,加速血液循环,促进产后余血的排出。同时它通过降低t-PA高水平,降低血液黏滞程度,抑制瘀血形成,促进新血再生,帮助产后子宫复旧。     

Danggui injection plus vitamin B12 injection at Acupoints for hyperlipidemia

取膈俞、脾俞、足三里、丰隆和内关穴为主，注射当归注射液和维生素B12，治疗56例高血脂症患者，并与非诺贝特治疗45例相对照。治疗2个月后，两组疗效相近。     

乳房局部推拿对产后泌乳的影响

目的:探讨推拿促进产妇泌乳的有效性,拟定促进产妇产后泌乳的有效推拿手法。方法:以84例足月初产妇为研究对象,随机分为推拿组(58例)和对照组(26例),推拿组以乳房局部推拿为主,配合经穴推拿;对照组予母婴同室常规护理。观察推拿对产妇始乳时间、产妇泌乳量、血清泌乳素等指标的影响,并与正常未推拿产妇进行比较对照。结果:推拿组产妇的泌乳量积分在治疗1次后、2次后、3次后分别为1.660±0.785、2.530±1.030、2.880±1.171,而对照组在相应时间段则分别为1.270±0.533、1.460±0.811、1.500±0.583,推拿组泌乳量积分高于对照组(均P<0.01);两组始乳时间分别为(21.6±10.51)h和(22.5±9.76)h,差异无统计学意义(P>0.05);推拿组治疗前血清泌乳素为(314.35±110.37)ng/mL,治疗后上升为(321.56±109.61)ng/mL,而对照组血清泌乳素前后分别为(385.78±85.19)ng/mL和(340.12±103.10)ng/mL,但两组前后比较差异均无统计学意义(均P>0.05)。结论:产后乳房推拿能明显增加产妇的泌乳量,能延缓血清泌乳素下降水平,有利于产妇早泌乳、多泌乳。     

人参皂苷Rb1对异丙肾上腺素诱导大鼠急性心肌缺血影响的作用机制

目的:研究人参皂苷Rb1对异丙肾上腺素(ISO)致大鼠急性心肌缺血的影响。方法:75只SPF级SD大鼠随机分为正常组,模型组,葛根素组(10 mg·kg~(-1)),Rb_1低,高剂量组(10,20 mg·kg~(-1)),每组15只。正常组、模型组分别给予等量的生理盐水,各组均ip给药0.01 m L·g~(-1)体重。连续给药5 d,每天1次。开始给药后的第4天和第5天,除正常组外,其余各组连续2次皮下多点注射给予ISO 30 mg·kg~(-1),正常组给予等量生理盐水,给药体积均为0.01 m L·g~(-1)。观察人参皂苷Rb_1对大鼠心电图的影响,激光散斑检测心脏表面微循环,ELISA检测血清中乳酸脱氢酶(LDH),肌酸激酶(CK),谷胱甘肽合成酶(GSH),一氧化氮(NO),超氧化物歧化酶(SOD)和丙二醛(MDA)的含量。结果:与正常组比较,模型组大鼠心率明显升高,抗心电图ST段明显降低,心脏表面血流微循环明显降低,血清中LDH,CK的活性及MDA的含量明显升高,血清中SOD的活性及GSH,NO的含量明显降低(P0.01,P0.05);与模型组比较,人参皂苷素Rb_1能有效降低心率,对抗心电图ST段升高,同时能显著增强心脏表面血流微循环,显著降低血清中LDH,CK的活性及MDA的含量,升高血清中SOD的活性及GSH,NO的含量(P0.01,P0.05),同时减轻心肌损伤的程度。结论:人参皂苷素Rb_1对ISO所致大鼠急性心肌缺血有一定的保护作用,其可能与抗脂质过氧化,修复损伤有关。     

基于频谱分析的原穴部脉动变异特异性研究

[目的] 研究原穴部脉动变异(脉搏间期变异)能否反映内脏功能, 并且其反映能否显示经脉特异性。[方法]用压力传感器同时在原穴部位连续测定512个脉搏间期, 对获取的脉动变异时间序列数据进行频谱分析, 算出功率谱指标。在健康人组、浅表性胃炎组和萎缩性胃炎组进行上述的分析, 各原穴部位的指标值比较做配对t检验, 评价原穴部位之间的关系。[结果] 健康人太渊、冲阳和太冲穴的脉动变异指标, 冲阳和太冲穴的TF、LF和HF值高于太渊穴(P<0.01),但LF/HF值都低于太渊穴(P<0.01),冲阳穴和太冲穴之间差异无统计学意义(P>0.05).浅表性胃炎患者原穴部位之间的关系呈与健康人一样的趋势;但萎缩性胃炎患者, 冲阳穴的脉动变异指标值有明显的变化, 即冲阳穴值低于太冲穴值(P<0.01).[结论] 冲阳穴(胃经原穴)脉动变异能反映胃病证。     

Treatment of 15 cases of chronic pelvic inflammation by acupuncture plus herbal enema

针刺关元,气海,三阴交,中极,水道,地机,足三里,肾俞,大肠俞和次髎穴,同时用清热解毒和活血化瘀中药进行保留灌肠,治疗了15例慢性盆腔炎患者,经过2个疗程治疗,13例痊愈,2例有效.