Posterior interosseous nerve neuropathy. Clinical and electromyographical aspects.

A clinical-EMGraphic examination was carried out in 37 patients with posterior interosseous nerve neuropathy: 5 cases had a traumatic origin, 4 iatrogenic, and 28 non-traumatic. One of the non-traumatic cases had a lipoma, and another had chondroma. In the other cases, nerve entrapment at the level of the arcade of Frohse could be presumed. Acute or chronic onset of the deficit was probably due to repeated pronation-supination hand movements. A motor deficit in finger extension together with a radial deviation of the wrist, was typical. Surprisingly about 50% of the non-traumatic cases showed some sensory disturbance at the forearm, wrist or hand. EMG examination was useful to establish the entity and topography of the deficit. Follow-up was carried out in 27 cases (3 traumatic, 2 iatrogenic and 22 non-traumatic). Even if spontaneous recovery is possible, though infrequent, in non-traumatic cases with marked deficit surgery gave the most satisfactory results, especially when onset had been acute and operation was performed within nine months of onset.     

McBurney's button-hole to the posterior interosseous nerve

McBurney's button-hole is an exposure technique for the posterior interosseous nerve quoted in Anrold Kirkpatrick Henry's famous book Extensile Exposures. This short article discusses the overlap between three historical surgeons, Thompson, Henry and McBurney to discover the meaning of the reference and technique, which is used by surgeons to this day.     

Hyperalgesia due to nerve injury: role of neutrophils

The hypothesis that the early inflammatory cell, the neutrophil, contributes to the hyperalgesia resulting from peripheral nerve injury was tested in rats in which the sciatic nerve was partially transected on one side. The extent and time-course of neutrophilic infiltration of the sciatic nerve and innervated paw skin after partial nerve damage was characterized using immunocytochemistry. The number of endoneurial neutrophils was significantly elevated in sections of operated nerve compared to sections of sham-operated nerve for the entire period studied, i.e. up to seven days post-surgery. This considerable elevation in endoneurial neutrophil numbers was only observed at the site of nerve injury. Depletion of circulating neutrophils at the time of nerve injury significantly attenuated the induction of hyperalgesia. However, depletion of circulating neutrophils at day 8 post-injury did not alleviate hyperalgesia after its normal induction.It is concluded that endoneurial accumulation of neutrophils at the site of peripheral nerve injury is important in the early genesis of the resultant hyperalgesia. The findings support the notion that a neuroimmune interaction occurs as a result of peripheral nerve injury and is important in the subsequent development of neuropathic pain.     

Hyperalgesia due to nerve injury: role of prostaglandins

The hypothesis that prostaglandins contribute to hyperalgesia resulting from nerve injury was tested in rats in which the sciatic nerve was partially transected on one side. Subcutaneous injection of indomethacin (a classic inhibitor of cyclo-oxygenase) into the affected hindpaw relieved mechanical hyperalgesia for up to 10 days after injection. Subcutaneous injection of meloxicam or SC-58125 (selective inhibitors of cyclo-oxygenase-2) into the affected hindpaw also relieved mechanical hyperalgesia, but with a shorter time-course. Subcutaneous injection of SC-19220 (an EP1 prostaglandin receptor blocker) into the affected hindpaw produced significant relief of mechanical and thermal hyperalgesia. Comparable injections into the contralateral paw or abdomen had no effect on mechanical or thermal hyperalgesia, suggesting that the effects we observed were local rather than systemic. We conclude that prostaglandins, probably prostaglandin E1 or E2, contribute to the peripheral mechanisms underlying hyperalgesia following nerve injury. These data provide further evidence that inflammatory mediators contribute to neuropathic pain, and may warrant further study of peripherally administered non-steroidal anti-inflammatory drugs as a possible treatment for such pain in patients.     

The risk injury to the posterior interosseous nerve in standard approaches to the proximal radius: a cadaver study

Purpose  

The aim of this study was to provide guidance on the safe zones for the exposure of the proximal radius by measuring the distance from the PIN to various anatomical landmarks in the proximal forearm in pronation and supination.     

骨间前神经综合征解剖学基础

目的 :探讨骨间前神经综合征发病解剖基础。方法 :48侧 (左右各 2 4侧 )成人防腐固定标本在肉眼或双目放大镜下解剖观察可能构成对骨间前神经卡压的解剖结构。结果 :有 6 6 .6 %的拇长屈肌副头由内上至外下斜过骨间前神经主干前方。横过骨间前神经的结构还有 :尺侧副血管 (48.3% ) ,指浅屈肌发出至拇长屈肌的小肌束或纤维束 (10 .4% )。骨间前神经与桡、尺骨的关系 :77%骨间前神经走在桡骨颈前方下行一段 ,长为 3.9cm(37侧 ,) ;16 .7%骨间前神经在桡、尺骨之间走行 ;6 .3%隔指深屈肌走在尺骨的前方。结论 :拇长屈肌副头、横过骨间前神经的肌束和纤维等结构可能是致骨间前神经综合征的解剖基础。     

Possible transmission of HIV Infection due to human bite

The potential risk of HIV-1 infection following human bite although epidemiologically insignificant, but it is biologically possible. There are anecdotal reports of HIV transmission by human bites particularly if saliva is mixed with blood. The oral tissues support HIV replication and may serve as a previously unrecognized HIV reservoir. The HIV infected individuals have more viruses in blood than saliva, possibly due to the potent HIV-inhibitory properties of saliva. The case presented here is of a primary HIV infections following a human bite where in the saliva was not blood stained but it got smeared on a raw nail bed of a recipient. The blood and saliva of the source and blood of the recipient showed a detectable viral load with 91% sequence homology of C2-V3 region of HIV gp120 between the two individuals. The recipient did not receive PEP [post exposure prophylaxis] as his family physician was unaware of salivary transmission. The family physician should have taken PEP decision after proper evaluation of the severe and bleeding bite. Hence it is necessary to treat the HIV infected human bites with post exposure prophylaxis.     

骨间后神经受压的解剖学基础

目的阐明骨间后神经(PIN)卡压的原因及其手术治疗提供解剖基础。方法30侧尸体上肢标本,将PIN分为3段(即桡管段、旋后肌管段和旋后肌管后段)观察其肌支的分支情况;用卡尺对桡管(RT)、旋后肌管(ST)和桡侧腕短伸肌腱弓(AECRM)的形态和大小进行了观测,并对ST入口和出口的体表投影定位。结果ST入口和出口的宽度分别为(14.1±2.1)mm和(6.2±1.7)mm,长度为(35.0±6.9)mm。PIN从桡骨头至旋后肌腱弓(AF)和PIN从旋后肌穿出处的长度分别为(19.3±4.4)mm和(53.4±5.2)mm。AF的53.3%由肌性加腱性组织构成,23.3%由腱性组织构成,23.3%由肌组织构成。70%旋后肌远侧缘由腱性组织构成,所有AECRM均是腱性。桡骨背侧桡骨头下方1示指宽和3示指宽分别为ST的入口和出口的体表投影。结论本文提供的RT、ST和AECRM详细形态资料,对于PIN卡压的诊断和手术治疗具有指导意义。     

Human infection due to Mycobacterium marinum after a dolphin bite

A young man employed at the local aquarium was bitten by a bottlenose dolphin (Tursiops truncatus) during a training session, receiving a slight injury which healed rapidly. Some two months later fluctuant swellings appeared in the region of the bite, which developed into indolent ulcers which have not completely healed seven months after the original bite. Cultures taken on two occasions have yielded a pure growth of Mycobacterium marinum.     

Posterior parietal projections to the intraparietal sulcus of the rhesus monkey

Summary A cyto- and myeloarchitectonic parcellation of the intraparietal sulcus in the rhesus monkey was correlated with the pattern of afferent connections from the parietal lobe as determined by autoradiographic techniques. Area PEa in the upper bank receives topographically-organized input from the ventral and caudal superior parietal lobule and the medial surface of the parietal lobe. Area POa in the lower bank is the recipient of a projection from the rostral inferior parietal lobule. Area IPd, situated in the depth of the intraparietal sulcus, receives converging input from the caudal superior parietal lobule, medial surface of the parietal lobe, and mid-and caudal inferior parietal lobule. Finally, intrinsic sequences of connections, directed from rostral to caudal and caudal to rostral, exist within both areas PEa and POa, each having a distinctive laminar pattern of origins and terminations.Preliminary results of this investigation were presented at the meeting of the Society for Neuroscience, Boston, November 1983     

骨间后神经及其拇示指肌支的解剖学特征

目的　观察前臂骨间后神经及其拇示指肌支的解剖学特征。 方法　解剖43具尸体的86侧上肢部桡神经深支及其分支到腕背部,观测骨间后神经的行程与投影及其拇示指肌支起始部位横径、长度和骨性标志线与神经干间夹角关系等参数。 结果　骨间后神经及其各分支均呈扁薄的窄带状神经束,其主干和多数肌支都走行在前臂后面中2/4段浅、深层肌之间,终末支止于腕背侧的梭形膨大部;主干起始处横径为（3.79±0.64）mm,各分支在起始部的平均横径（除指伸肌支约2.0 mm外）均小于1.0 mm;在旋后位,它呈向桡侧开放的弓形线段投影在肱骨外上髁至尺骨茎突连线的尺侧,半旋前位时则投影于该连线上或其桡侧。 结论　前臂后面中2/4段是骨间后神经主干及其大多数拇示指肌支在临床上易被损伤、误伤发生的高风险区域。     

小腿骨间膜神经的走行及其与经络穴位的关系

目的：研究国人小腿骨间膜神经的走行、分支及其与局部经络穴位的关系。方法：用改进Sihler法染色显示成人小腿骨间膜神经,结合手术显微镜观测神经。结果：小腿骨间膜神经干白骨间膜上缘近腓骨侧斜行向内下,至骨间膜下部则近胫骨侧;神经干外径0．75—0．91mm;在骨间膜上1／3处,神经干常发一分支在骨间膜胫侧份下行。结论：补充了国人小腿骨间膜神经的解剖学数据,提示该神经可能在针刺足阳明胃经和足少阳胆经小腿穴位时被波及。     

骨间前神经综合征的局部解剖学研究

目的 搪塞骨间前神经综合征的解剖学基础。方法 解剖４８例（左右各２４侧）成人防固定标本。结果 骨间前神经主干邻近腱性结构有旋前圆肌纤维桥（５８．３％），尺骨头浅面腱膜（９３．７％），联合腱板（８３．３％）和指浅屈肌纤维弓（９１．２％），横过骨间前神经的拇长岂副头（６６．７％），及少 尺侧血管、小束肌肉或纤维结构。７７％骨间前神经干走在桡骨颈前方结论 骨间的神经主干邻近的腱性结构及距离桡骨颈近可能是     

Fibre composition in the interosseous nerve of the pigeon

The interosseous nerve of birds innervates a string of Herbst corpuscles located near the interosseous membrane between the tibia and fibula. Fibre composition of this nerve was assessed including both myelinated and unmyelinated axons. The diameter of the whole nerve is ∼100 μm. Complete data were obtained for 3 nerves. The mean total number of myelinated fibres and unmyelinated axons was 2872±53. The mean number of myelinated fibres was 280±20 and that for unmyelinated axons was 2600±47. There was a broad distribution of diameters for myelinated fibres ranging from ∼2 μm to 10 μm with a distinct peak at ∼3–5 μm and a less prominent second peak at 6–8 μm. Similarly, myelin sheath thickness distribution showed 2 peaks, one at 0.6–0.8 μm and another at 1.4–1.6 μm. It is suggested that the group represented by the second peak innervates the Herbst corpuscles. The group of smaller myelinated fibres and the unmyelinated axons are assumed to innervate other types of receptors, some of which may be nociceptors.     

骨间背侧神经的解剖学特征及其临床意义

目的　研究前臂骨间背侧神经及其肌支的解剖学特征,为体表定位提供形态学基础。 方法　解剖 30具成人防腐尸体的60侧上肢骨间背侧神经及其肌支,观察骨间背侧神经的行程与神经分叉点,测量分叉点分别至肱骨外上髁（LHE）、桡骨Lister结节（LTR）、尺骨茎突（SPU）的距离等参数,通过三圆交汇法及神经分段法来确定神经的体表位置。 结果　骨间背侧神经在发出指伸肌支、小指伸肌支及尺侧腕伸肌支后,主干有4个主要分叉点（O、O1、 O2、 O3）;以分叉点分别至LHE 、LTR 、SPU 的平均距离为半径,LHE 、LTR 、SPU为圆心,绘制3个圆,三圆交汇的点或区域可作为神经的体表定位;4个分叉点又可将骨间背侧神经分为7段（O点上段、OO1段、O1点下段、OO2段、O2点下段、O2O3段、O3点下段）。 结论　骨间背侧神经分叉点结合三圆交汇定位及神经分段法,根据神经损伤的临床表现,可明确神经损伤的位置。