A different mechanism of inhibition by buspirone and its camphorimide analogs of serotonin 5-HT3 effects

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 116, N ^o 8, pp. 167–169, August, 1993     

Effect of immune “sessile” receptors on the choline receptors of the lymphocyte membrane in mice immunized with certain antigens

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 115, N ^o 2, pp. 384–386, April, 1993     

Comparative analysis of progesterone and estradiol reception in human myoma

Cytosolic and plasma membrane receptors for progesterone and estradiol are studied in myomatous nodes (MN) and in histologically unaltered myometrium (HUM) against the background of myoma. The level of cytosolic receptors for both hormones is higher in the myoma cells than in the essentially healthy myometrium. In the plasma membranes the progresterone reception is reduced and the estradiol reception is unchanged compared with HUM. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, N ^o 7, pp. 33–34, July, 1994     

Effect of 3-orthocresylphosphate on the toxicity of GABA-lytics for mice

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 116, N ^o 10, pp. 396–397, October, 1993     

Role of intraosseous receptors in afferent and motor reaction modulation

Acute experiments on cats demonstrated facilitation effects of afferent reactions, and segmentary motor reactions during stimulation of sciatic nerves and inhibition of corticofugal motor reactions induced by electrical stimulation of ilium osteoreceptors. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, N ^o 7, pp. 40–41, July, 1995 Presented by N. A. Agadzhanyan, Member of the Russian Academy of Medical Sciences     

Effect of paraoxon and sulfhydryl reagents on3H-quinuclidinol benzoate and3H-methylscopolamine with synaptic membranes of rat brain

Paraoxon is shown to reduce the density of M-choline receptors in the cortex of rat brain. Inhibition of³H-QNB is noncompetitive and reversible in nature. Sulfhydryl reagents do not affect this process. The mechanism of action of PO is thought to include direct effects on brain muscarine receptors. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, N ^o 7, pp. 51–53, July, 1994     

Effect of salicylates on the toxicity of GABA-lytics in mice

Preliminary injection of aspirin and salicylic acid increases the toxicity of picrotoxin, but not of bicuculline. Aspirin inhibits binding of³H-diazepam and N-methyl-³H-methylphenazepam with membranes from the brain of intact mice. In view of the fact that salicylates reduce the content and sorption capacity of serum albumin, this protein can be assumed to be involved in the detoxication of picrotoxin. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, N ^o 6, pp. 619–620, June, 1995     

Impact of 8-isoestrone analogs on estradiol binding in uterine tissue from ovariectomized rats

8-Isoanalogs of estrone were studied for their ability to influence estradiol binding in the cytosolic fraction of uterine tissue from ovariectomized rats and for their uterotropic activity 24 h after injection into such rats. Two groups of estrone 8-isoanalogs with opposite biological effects were identified: those increasing estradiol binding in the cytosolic fraction of uterine tissue and those decreasing this binding. Uterogenic activity was exhibited by all of the compounds tested, with the exception of compound I. No correlation was found between the uterogenic activity of the isoanalogs and hormone-receptor interactions. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, N ^o 2, pp. 165–167, February, 1995     

Binding of3H-diazepam in rat brain eleven months after termination of corazole kindling

Binding of³H-diazepam in rat cerebellum decreases by 14% (p<0.05) 11 months after termination of kindling and one day after injection of a test dose of corazole (30 mg/kg), while it increases by 19.5% after a single injection of a convulsive dose of corazole (50–75 mg/kg). No changes are found in the cortex. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 117, N ^o 2, pp. 135–137, February, 1994 Presented by G. N. Kryzhanovskii, Member of the Russian Academy of Medical Sciences     

Vestibuloprotective activity of seal serum proteins

Cat and rat experiments show that the protein fraction isolated from blood serum of the Greenland seal has a protective activity against motion sickness. This activity is comparable to that of the classical vestibuloprotector scopolamine and is greater than that of diprazine. Radioligand assay of the receptor binding showed that the serum protein fraction has the highest affinity for α₂-adrenoceptors, μ-opioid, and benzodiazepine receptors. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol 117, N ^o 4, pp. 444–445, April, 1994     

On the involvement of endogenous μ- and δ-opiate receptor agonists in the antiarrhythmic effect of adaptation

Rats adapted to stress showed a decreased severity and incidence of cardiac arrhythmias induced by epinephrine, and these effects of adaptation were abolished by naloxone. It is suggested that stress adaptation mitigates arrhythmia by activating the endogenous opioid system and stimulating the μ-opiate receptors. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, N ^o 1, pp. 24–25, January, 1996 Presented by R. S. Karpov, Member of the Russian Academy of Medical Sciences     

Distribution of immunoregulatory carbohydrate receptors for lectins on membranes of neurons and syngeneic peripheral lymphocytes

Common immunoregulatory carbohydrate receptors on the membranes of neurons and sysngeneic peripheral lymphocytes of mice are detected by using lectins. Brain neuron membranes possess no receptors characteristic of immature lymphocytes. The common immunoregulatory receptors on brain neurons and mononuclear cells of peripheral immune organs are shown to represent one the mechanisms of integration of the nervous and immune systems. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 117, N ^o 2, pp. 155–157, February, 1994 Presented by A. P. Romodanov, Member of the Russian Academy of Medical Sciences     

Central opioid receptors in the pathogenesis of adrenal arrhythmias

The effect of intraventricular administration of opioid peptides on the frequency and severity of ventricular arrhythmias is studied after intravenous injection of epinephrine. It is found that the selective μ-agonist DAGO and the nonselective σ-agonist DADLE decrease the frequency and severity of arrhythmias. On the other hand, the selective σ-agonist DSLET and the κ-agonist dinorphine A 1–13 potentiate adrenal arrhythmias. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, N ^o 9, pp. 241–243, September, 1994 Presented by R. S. Karpov, Member of the Russian Academy of Medical Sciences     

Relative binding capacity of pentarane substances with plasma membrane receptors of uterine cells of oophorectomized rats

The relative capacity of substances of the pentarane group for binding with progesterone receptors of the plasma membranes of uterine cells of oophorectomized rats is studied. Introduction of an extra carbocycle D' in the progesterone molecule at the 16α and 17α sites and further modification of the molecule cause an increase of the relative binding capacity of these compounds. Analysis of the findings identifies substance III, showing the highest activity toward all the discussed parameters and a promising candidate for further preclinical studies. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol., 118, N ^o 7, pp. 31–32, July, 1994     

Adaptation of the membrane receptor apparatus of blood cells after the combined use of cryodestruction and plasma beam in experimental cirrhosis of the liver

It is shown that cryodestruction combined with resection with a plasma beam aggravates alterations of the functions of the blood cell receptor complex affected by cirrhosis, leading to hypoinsulinemia, inhibited capacity of cells to utilize glucose, a lowered metabolic activity of insulin receptors, and other changes. Three weeks after surgery the energy metabolism of the blood cells returns to the normal level, while the activity of insulin receptors and of hexokinase exceeds the control level. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, N ^o 6, pp. 647–650, June, 1995 Presented by V. N. Yarygin, Member of the Russian Academy of Medical Sciences     

Relationship between the antiaggressive properties of buspirone and the time of day

Buspirone administered in the morning or evening completely suppressed the interspecies aggressiveness of isolated rats expressed as attacks on and bites of mice; muricidal behavior (killing of mice) was blocked by the drug only if it was administered in the evening. Electrolytic destruction of serotonin-containing structures of the midbrain levels the phase dependence of the antimuricidal properties of buspirone. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, N ^o 3, pp. 291–294, March, 1996 Presented by P. V. Sergeev, Member of the Russian Academy of Medical Sciences     

Aldosterone binding with corticosteroid brain receptors in rats: Effect of behavioral typology and stress

Differences in³H-aldosterone binding with hippocampus cytosol receptors were found to be dependent on the behavioral type of male Wistar rats in the “emotional resonance” test. These differences were not observed in the cytosol analysis of the remaining part of the brain. Control rats and rats subjected to short-term stress by painful electrical stimulation showed a long-term drop of³H-aldosterone binding with hippocampus cytosol in active as compared to passive animals preferring a closed space. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, N ^o 7, pp. 49–51, July, 1995 Presented by I. P. Ashmarin, Member of the Russian Academy of Medical Sciences     

Impact of ADP on the contractility of intestinal smooth muscle from guinea pigs

Both ADP and adenosine were found to potentiate the anaphylactic contracture of isolated guinea pig ileum (smooth-muscle preparations). When ADP or adenosine was added after the induced anaphylactic reaction, a biphasic change in ileal tonus — relaxation followed by contraction — was noted. The contractile response was abolished by Dimedrol, but not by Troventol. ADP suppressed (or, in some ileal smooth-muscle preparations, reversed) the relaxation response to epinephrine and ocriprenaline and potentiated the naphazoline-induced smooth-muscle contraction. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, N ^o 10, pp. 361–365, October, 1995 Presented by Yu. A. Vladimirov, Member of the Russian Academy of Medical Sciences     

Role of estrogens in the regulation of prolactin receptors in liver cells of female rats

Strong expression of prolactin receptors in sinusoidal domains and cytoplasmic granules of hepatocytes, which is independent of cell location in the hepatic lobule and is positively regulated by estrogens, is revealed in pubertal female rats. In estrogen-treated animals, Prolactin receptors are also exposed in the perinuclear space of some hepatocytes surrounding the central veins. Estrogens regulate the intensity of prolactin receptors expression in hepatocytes, but not the number of cells containing these receptors. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, N ^o 9, pp. 264–267, September, 1994 Presented by I. P. Ashmarin, Member of the Russian Academy of Medical Sciences     

Tolerance for opiate analgesia: Complex effect of antagonists of receptors for excitatory amino acids

The effect of excitatory amino acid receptor antagonists on the development of the conditioned reflex component of the tolerance for morphine analgesia is studied. It is demonstrated that the antagonists of NMDA and non NMDA receptors reduce the development of associated component of the tolerance, while the magnitude of the nonassociative component changes after co-administration of morphine with NMDA receptor antagonists. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 117, N ^o 5, pp. 494–496, May, 1994 Presented by D. A. Kharkevich, Member of the Russian Academy of Medical Sciences