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1.
Abstract:  We report a 2-year-old boy with an elastic soft, flatly elevated, skin-colored nodule on his nasal ala. Histologic examination revealed numerous small hair follicles in several stages of maturation in the dermis. Serial sections did not show any cartilage or a central epithelial lined cystic structure. Based on clinico-pathologic findings, we diagnosed this lesion as a hair follicle nevus. Hair follicle nevus is quite rare. Histologically, it is very important not to find cartilage or a central epithelial lined cystic structure for distinction from an accessory auricle and from a trichofolliculoma, respectively. Awareness of the clinical and pathologic characterization of hair follicle nevus is an aid to a correct diagnosis.  相似文献   

2.
Hair-follicle nevus   总被引:1,自引:0,他引:1  
A case of a 5-year-old child with a rare nevus of a hair follicle is reported. Histologically it was characterized by many hair follicles within the dermis at the same level of maturation. This nevus must be differentiated from other hamartomas of hair follicles and from Becker's nevus.  相似文献   

3.
We present a case of hair follicle nevus, a rare hamartoma composed of vellus hair follicles. Hair follicle nevus should be differentiated from accessory auricle, trichofolliculoma and hair nevus.  相似文献   

4.
Hair follicle nevus with hyperplasia of smooth and striated muscle   总被引:1,自引:0,他引:1  
We report a peculiar nevus which occurred on the left side of the chin of an 18-year-old male. It had been present for four years and had grown rapidly during the last year. Histologically, many hair follicles, smooth muscles, and striated muscles were found within the reticular dermis. The hair follicles were accompanied by mature sebaceous glands; numerous eccrine glands were seen in the middle and deep dermis. Immunohistochemical stain and phosphotungstic acid hematoxylin stain supported the fact that the muscles seen between the follicles were both smooth and striated. This nevus was considered to be a hair follicle nevus accompanied by hyperplasia of smooth muscles and striated muscles.  相似文献   

5.
Hair follicle nevus (HFN) is a rare, benign, follicular hamartoma that most frequently presents as a congenital nodule on the face. We experienced a rare case of HFN on the neck of a 14-year-old boy and performed a pilot immunohistochemical study with cytokeratin 19 (CK19) to compare the staining pattern of hair follicles in HFN and its differential diagnoses, accessory tragus, cervical chondrocutaneous branchial remnants (CCBR) and trichofolliculoma. With hematoxylin and eosin stain, HFN showed numerous tiny hair follicles in the dermis with several sebaceous and eccrine glands, and perifollicular fibrous thickening. With CK19 stain, some hair follicles in HFN and CCBR showed positive expression, a few hair follicles in accessory tragus showed weak expression, and no hair follicles in trichofolliculoma showed expression. The present report supports the view that HFN, accessory tragus and CCBR are within the same spectrum of hamartomas.  相似文献   

6.

BACKGROUND

Hair follicle nevus is a rare, congenital hamartoma with follicular differentiation characterized histologically by numerous, tiny, mature hair follicles. Trichofolliculoma, the histopathological features of which are quite similar to those of hair follicle nevus, is also a hamartoma that differs from hair follicle. Accessory tragus is a relatively common, benign congenital abnormality of the external ear with an incidence rate of 1 to 10 per 1,000 live births.

OBJECTIVE

This study seeks to assess the discriminatory value of currently available, histological criteria in the differential diagnosis of hair follicle nevus, accessory tragi and trichofolliculoma.

METHODS

Twenty-one patients comprising 9 cases of hair follicle nevus, 8 accessory tragi patients and 4 trichofolliculoma cases, were recruited to perform the study.

RESULTS

There were 10 males and 11 females in the study group. No significant difference was observed between the three study groups in terms of age, gender or histopathological parameters such as density of hair follicles, subcutaneous fat score and presence of connective tissue framework. Cartilaginous component was seen in 8 cases that were diagnosed as accessory tragi, while central cyst and radiating hair follicles were seen in 4 cases which were diagnosed as trichofolliculoma.

CONCLUSION

The results of our study showed that diagnostic discrimination of these diseases could be made only with the clinicopathologic correlation because of their clinical and histopathological similarities.  相似文献   

7.
Porokeratotic eccrine ostial and dermal duct nevus is a rare hamartomatous malformation, histologically characterized by cornoid lamellae overlying dilated eccrine ostia. The nevus most commonly presents in the form of multiple filiform keratotic spines in a linear arrangement, usually on the distal extremities. Porokeratotic eccrine and hair follicle nevus is thought to be a variant of porokeratotic eccrine ostial and dermal duct nevus that additionally involves hair follicle infundibula. We report a case of widespread Porokeratotic eccrine and hair follicle nevus that developed in a 15-year-old woman with keratitis-ichthyosis-deafness syndrome.  相似文献   

8.
We report a rare hair follicle nevus that occurred in a three-month-old Japanese boy with mild frontonasal dysplasia. It had been present since birth. Histologically, numerous tiny vellus hair follicles were found within the dermis. The constituent cells of these follicles showed the features of follicular germ cells under the electron microscope. The fibroblasts around the follicles were active and merged with the colloid substance. Many myofibroblasts were found in a collagenous stroma in the atrophic lesion of the frontonasal dysplasia.  相似文献   

9.
A 2-year-old girl presented with ulnar-sided duplication of the left thumb distal to the interphalangeal joint and syndactyly of the first web space. She also had several asymptomatic pink-tan cutaneous papules, involving the first and second ray of the left hand and wrist, clinically resembling a linear epidermal nevus. Microscopically, the papules were composed of well-circumscribed aggregates of basaloid epithelium within the dermis. No normal hair follicles were identified. Follicular germ and papillae were identified, representing abortive attempts at hair follicle formation. The features were remarkably similar to a novel entity described by Finn and Argenyi as congenital panfollicular nevus. In our case, the congenital panfollicular nevus was associated with distal thumb polysyndactyly, which may suggest an important link between limb patterning and hair follicle development.  相似文献   

10.
毛囊痣   总被引:1,自引:1,他引:0  
报告1例毛囊痣。患者女,15岁。右颈前肤色丘疹15年,无自觉症状。皮肤科检查:右颈前一直径0.3cm肤色圆柱形丘疹,质地中等。组织病理检查示真皮内成熟毳毛毛囊明显增多,周围纤维组织鞘增厚,部分毛囊周围见皮脂腺结构,未见明显脂肪细胞和软骨结构。  相似文献   

11.
Abstract: Controversy exists about the histologic differences between hair follicle nevi and accessory tragi. We examined 10 congenital lesions histologicaiiy, possible diagnoses of which were hair follicle nevi or accessory tragi. Two specimens out of the 10 had tiny, mature hair follicles surrounded by thick fibrous root sheaths, a few fat cells, and no cartilage. The subcutaneous fat cells of their bases were segmented by a connective tissue framework. They had histologic features of hair follicle nevi. One specimen had cartilage and abundant fat cells with a connective tissue framework in the nodule, as well as a conglomeration of numerous well-differentiated hair follicles. It possessed both elements of a hair follicle nevus and an accessory tragus. Seven specimens had abundant subcutaneous fat and showed a prominent connective tissue framework. These were typical accessory tragi. The present study suggests that the number of fat cells in the nodule or papule differs between these two conditions. All the lesions studied revealed a connective tissue framework in the subcutaneous fat. Histologic features of both hair follicle nevi and accessory tragi can coexist in a single lesion. Hair follicle nevi may represent incomplete accessory tragi with scant fat cells.  相似文献   

12.
目的 探讨皮肤镜在面部光线性角化病鉴别诊断中的应用价值.方法 从北京大学第三医院皮肤镜数据库选取经病理确诊的面部光线性角化病皮损作为病例组,同时选取临床曾疑诊光线性角化病,但病理证实为其他疾病的面部皮损作为对照组,比较两组间各皮肤镜特征的差异,以病理为金标准,用诊断试验方法评价皮肤镜诊断面部光线性角化病的价值.结果 病例组43个皮损,对照组22个皮损.病例组中基底假网状红斑(38/43,88.37%)、毛囊口周围白晕(39/43,90.70%)、毛囊口黄色角栓(41/43,95.35%)、表面黄白色鳞屑或角化物团块(42/43,97.67%)、玫瑰花瓣征(26/43,60.47%)、毛囊口周围粗大的不规则线状血管(19/43,44.19%)、毛囊口周围细小、线状-波浪状血管(29/43,67.44%)及周边色素加深(14/43,32.56%)的出现频率显著高于对照组(均P<0.05).在这8个皮肤镜特征中,毛囊口周围白晕、基底假网状红斑、毛囊口黄色角栓及玫瑰花瓣征单独诊断面部光线性角化病的约登指数最高,分别为0.54、0.52、0.50和0.38,表面黄白色鳞屑或角化物团块灵敏度最高(97.67%),周边色素加深特异度最高(95.45%).基底假网状红斑、毛囊口黄色角栓及毛囊口周围白晕3个特征联合诊断价值最高,其灵敏度、特异度、阳性预测值、阴性预测值分别为90.70%、81.82%、90.70%、81.82%,约登指数为0.73,与病理诊断的符合率为80.00%.结论 面部光线性角化病具有较特异的皮肤镜表现,基底假网状红斑、毛囊口周围白晕、毛囊口黄色角栓3个皮肤镜特征联合诊断价值最高.  相似文献   

13.
The various forms of non-melanocytic nevi (hamartomas) are usually encountered in pediatric patients, and nevus sebaceous of Jadassohn is the most common to have undifferentiated pilosebaceous units. We report a unique congenital follicular nevus that fails to meet the criteria of any previously described follicular neoplasm, despite the plethora of alternatives. Clinically considered a syringocystadenoma papilliferum, the excised lesion contained multiple dermal nodules that exhibited nearly all stages of follicular differentiation. The periodicity of the follicular proliferations was akin to normal terminal hair, and a prominent perifollicular sheath surrounded each. This benign lesion of abortive hair follicles was unassociated with any established genodermatous syndrome or other adnexal neoplasm.  相似文献   

14.
BACKGROUND: Lichen planopilaris shows a perifollicular lymphocytic infiltrate at the level of infundibulum and the isthmus of the hair bulge resulting in necrotic changes within keratinocytes and eventually hair loss. OBJECTIVE: We present a 14-year-old black male with a history of a raised epidermal lesion on the scalp that was present at birth. Over the past few years, the patient developed gradual hair loss and increased verrucous changes of the skin within the original lesion. Histologic sections of the area showed features consistent with an epidermal nevus peripherally, with a central area showing some features characteristic of those seen in lichen planopilaris. In addition, there was marked hyperkeratosis with increased yeast and bacteria within the follicles. CONCLUSIONS: Initiating factors in lichen planopilaris are not well defined. Overgrowth of microorganisms with hyperkeratosis results in factors that disrupt the immune privilege of the hair follicle, leading to an immunologic reaction that is limited to the follicle and spares surrounding eccrine structures. This case suggests possible mechanisms involved in the induction of lichen planopilaris.  相似文献   

15.
Hair follicle nevi are rare, benign, congenital hamartomas that usually occur in the distribution of the first brachial arch. Histopathologically, the distinction between hair follicle nevus, trichofolliculoma, and accessory tragus has recently come into question, and it may be that they are all on a spectrum of the same condition. We report the case of a 7‐day‐old boy who presented with a “tag”‐like lesion on his midline chin that had been present since birth. Biopsy of the lesion proved it to be a hair follicle nevus.  相似文献   

16.
Trichofolliculoma is a rare follicular hamartoma whose dermoscopic features have been scarcely reported. On the other hand, reflectance confocal microscopy features have not been described yet. In the present study, the authors report reflectance confocal microscopy features in a case of trichofolliculoma as squamous hyperplasia forming irregular finger-like protrusions around the hair follicle and papillomatous hyperplasia of the hair follicle epithelium, which correlated with histopathology. This case suggests that reflectance confocal microscopy may help incorrect in vivo diagnosis of trichofolliculoma in cases difficult to diagnose by morphology and dermoscopy.  相似文献   

17.
Lesions developing in organ transplant patients may have a misleading clinical appearance. We report herein a case of Bowen's disease that developed within the epithelial wall of a hair follicle and masqueraded clinically as a banal follicular cyst in a renal transplant recipient. We speculate that this lesion developed from pre-existing Bowen's disease extending to the hair follicles.  相似文献   

18.
Cyclical changes in rat vibrissa follicles maintained In vitro   总被引:2,自引:0,他引:2  
In mammals hair growth is cyclical; however, the factors that regulate the hair growth cycle are still poorly understood. The recent development of methods for culturing hair follicles in vitro has proved an important tool to investigate many aspects of the regulation of hair follicle growth. At present, however, these models are based on the culture of anagen hair follicles and have only partially been used to address the cyclical nature of hair growth. In this study we have made use of the fact that in rodents the hair growth cycle is synchronized, well characterized, and relatively short. We have isolated vibrissa follicles from 12 d old rats and confirmed by histology that these follicles are in the anagen stage of their first hair growth cycle. We have then maintained these follicles in vitro, on Gelfoam supports, for up to 23 d (35 d of age) and compared their histology with in vivo follicles from equivalent age littermates. We observed that 12 d old follicles maintained in vitro for up to 23 d show changes in morphology that suggest that cultured rat vibrissa follicles retain cyclical activity in vitro. Cyclical changes in hair follicle morphology were only seen in follicles maintained on gelfoam supports and moreover, hair follicle size appears to be a key feature in determining the ability of the follicle to cycle in vitro. All follicles that showed cyclical changes in vitro, however, appeared to remain blocked in pro-anagen. These data suggest that the vibrissa follicle is a in vitro good model system with which to investigate hair cycle control. J Invest Dermatol 115:1152-1155 2000  相似文献   

19.
Gardner's syndrome is accompanied by numerous cutaneous neoplasias, cysts of hair follicles being the most frequent. We report a case of Gardner's syndrome with multiple hair follicle cysts. Histologically, parts of the cyst linings showed features of pilomatricomas. We discuss the histopathological findings and their significance as possible markers for the disease.  相似文献   

20.
Two patients having a localized plaque of alopecia on the scalp, and one with a systematized unilateral epithelial nevus exhibited a histologically distinctive form of follicular hamartoma. In the affected areas individual hair follicles were replaced, or were associated with solid strands and branching cords of undifferentiated basaloid cells, filled in between by fibrous stroma resembling either a miniature premalignant fibroepithelial tumor of Pinkus, a small trichoepithelioma, or a basal cell epithelioma. The relation between these 3 patients and cases reported as linear unilateral basal cell nevus with comedones and generalized hair follicle hamartoma associated with myasthenia gravis is discussed.  相似文献   

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