甲硝唑联合左氧氟沙星治疗急性盆腔炎的临床分析

目的甲硝唑联合左氧氟沙星治疗急性盆腔炎的临床分析。方法选取2010年9月~2013年8月本院收治急性盆腔炎80例患者为研究对象,并随机分成观察组和对照组两组,对照组采用甲硝唑联合氧氟沙星治疗,观察组采用甲硝唑联合左氧氟沙星治疗,分析对比两组疗效及不良反应发生率。结果观察组治疗总有效率高于对照组(P<0.05),观察组不良反应发生率低于对照组(P<0.05),两组对比差异有统计学意义。结论对于急性盆腔炎患者的治疗,采用甲硝唑静滴联合左氧氟沙星静滴可收获到满意疗效,且不良反应发生率低。值得临床推广应用。     

左氧氟沙星联合甲硝唑治疗急性盆腔炎疗效观察

目的观察为急性盆腔炎患者联合应用左氧氟沙星、甲硝唑治疗的实际效果。方法选取2012年8月~2014年5月收治的40例急性盆腔炎患者,按随机数字表法分组,20例实验组患者联合应用左氧氟沙星、甲硝唑治疗,20例对照组患者联合应用青霉素、甲硝唑治疗,观察盆腔炎治疗效果。结果两组患者均未出现严重不良反应,实验组体温降至正常时间、症状消失时间、治愈时间分别为(3.1±1.6)d、(3.7±1.8)d、(7.4±2.3)d,临床总有效率为95.0%,以上数据与对照组相比,差异具有统计意义(P<0.05)。结论为急性盆腔炎患者联合应用左氧氟沙星、甲硝唑治疗,效果显著,安全性高,值得各级医院应用、推广。     

盐酸左氧氟沙星对盆腔炎的治疗效果探讨

目的：探讨盐酸左氧氟沙星在盆腔炎治疗中的临床效果,对盆腔炎的治疗方法进行总结。方法将盆腔炎患者随机分成治疗组和对照组两组,两组都用基础的青霉素治疗,治疗组加用适量的盐酸左氧氟沙星,两组分别治疗一段时间,对比两组患者的治疗效果。结果治疗组的总有效率93.3%,治愈率83.3%,显效率10.0%,进步率3.3%,无效率3.3%。对照组的总有效率为70.0%,对照组治愈率10.0%,显效率60.0%,进步率23.3%,无效率6.7%,两组有效率比较差异有统计学意义(P<0.05)。结论盐酸左氧氟沙星配合青霉素进行盆腔炎的治疗临床效果更好,盐酸左氧氟沙星的疗效相对更好。     

分析左氧氟沙星联合甲硝唑辅助妇科治疗仪治疗慢性盆腔炎患者的临床疗效

目的：对左氧氟沙星联合甲硝唑辅助妇科治疗仪治疗慢性盆腔炎患者的临床疗效进行分析。方法选自2012年6月~2014年2月在我院治疗的慢性盆腔炎患者160例,将其分为两组,各80例,对照组患者行左氧氟沙星联合甲硝唑治疗,研究组患者行左氧氟沙星联合甲硝唑辅助妇科治疗仪治疗,观察两组治疗后的效果和不良反应情况。结果治疗后,研究组患者的总有效率为87.5%,对照组患者的总有效率为78.75%,两组比较差异有统计学意义;研究组不良反应发生率为3.75%;对照组不良反应发生率为2.5%,两组比较差异无统计学意义。结论采用左氧氟沙星联合甲硝唑辅助妇科治疗仪治疗慢性盆腔炎,疗效显著,患者耐受性好,不良反应少,值得在临床上推广应用。     

左氧氟沙星治疗宫颈炎的疗效分析

目的：探讨左氧氟沙星治疗宫颈炎的疗效。方法选取我院2011年3月~2013年9月96例非淋菌性宫颈炎患者,按照数字抽取方法分为研究组与对照组,研究组患者应用左氧氟沙星联合阿奇霉素治疗,对照组患者则单纯予以阿奇霉素治疗,分析对比两组患者临床治疗效果。结果经治疗后,研究组患者总有效率95.8%明显高于对照组62.5%,差异有统计学意义(﹤0.05);研究组患者复发率为6.3%比对照组患者41.7%明显降低,差异有统计学意义(﹤0.05)。结论左氧氟沙星治疗宫颈炎具有较为明显效果,临床应用价值较高。     

左氧氟沙星注射剂致不良反应分析

目的 探讨左氧氟沙星注射剂致不良反应的临床疗效.方法 选取我院2011年6月～2012年7月所接收治疗的80例使用左氧氟沙星注射剂致不良反应的患者,对比分析所有患者左氧氟沙星注射剂致不良反应的临床资料.结果 女性患者的比例为52.5％,男性患者的比例为47.5％.40～60岁年龄阶段的患者较多,＜20岁年龄阶段的患者比较少.皮肤和皮肤附件不良反应比例为35％,人数最多.其次为循环系统和消化系统,循环系统不良反应比例为17.5％,消化系统不良反应比例为27.5％,左氧氟沙星注射剂致不良反应患者的用药方法都是静脉滴注.单独使用左氧氟沙星为25例,所占比例为31.25％.联合应用抗生素为55例,所占比例为68.75％.所有患者的用药时间为1～15d,平均(6.62±3.43)d.左氧氟沙星注射剂致不良反应后期的转归,患者停药和积极的对症治疗中,治愈65例,比例为81.25％,好转15例,比例为18.75％.结论 左氧氟沙星注射剂致不良反应拥有显著的特点,临床治疗一定要积极的去面对.     

口服左氧氟沙星治疗化脓性扁桃体炎疗效分析

目的：讨论研究应用左氧氟沙星治疗化脓性扁桃体炎的临床疗效与意义。方法选取我院呼吸科50例化脓性扁桃体炎患者。随机分为A、B两组,各25例。 A组患者应用青霉素钠进行治疗;B组患者口服左氧氟沙星治疗。比较两组患者使用不同药物治疗后治疗总有效率及不良反应发生人数等指标。结果口服左氧氟沙星组患者其治疗总有效率100%显著优于使用青霉素治疗组患者88.0%。口服左氧氟沙星治疗效果较好(P<0.05)。口服左氧氟沙星组患者各类不良反应发生人数均少于使用青霉素钠组患者(P<0.05)。结论临床应用左氧氟沙星治疗化脓性扁桃体炎疗效显著。药物杀菌力强且药效持续时间长;口服吸收速度快,生物利用度高,能够在短时间内缓解患者不适症状且不良反应率低,细菌清除率高。对加快疾病治疗速度,提高治疗效率及改善预后具有重要意义。     

左氧氟沙星锌乳膏治疗糖尿病足临床疗效观察

目的 探讨左氧氟沙星锌乳膏对糖尿病足的临床疗效.方法 将入选的糖尿病足患者80例随机分为治疗组40例,对照组40例.两组均予以常规综合治疗,治疗组在综合治疗基础上采用左氧氟沙星锌乳膏外涂,对照组在综合治疗基础上采用庆大霉素湿敷.观察比较两组疗效.结果 治疗组临床痊愈23例,好转16例,无效1例,总有效率97.5%:对照组临床痊愈16例,好转19例,无效5例,总有效率87.5%;治疗组疗效优于对照组(P<0.05).结论 综合治疗结合左氧氟沙星锌乳膏外涂治疗糖尿病足有良好疗效,值得临床推广应用.     

左氧氟沙星口服治疗152例成人急性细菌性痢疾疗效评价

目的：观察左氧氟沙星口服治疗治疗成人急性细菌性痢疾的疗效。方法：301例患者分为两组。治疗组152例，饭后口服盐酸左氧氟沙星片0．2g·次-1，2次·d^-1。对照组149例，丁胺卡那霉素0。6g加入5％葡萄耱液中静脉点滴，1次·d^-1。两组均以7d为1疗程。结果：左氧氟沙星组治疗后有效率为92．11％，治疗后细菌清除率为88．16．％，在退热时间、止泻时间、有效率等各方面左氨氟沙星组均明显优于对照组丁胺卡那纽。结论：左氧氟沙星是治疗细菌性痢疾的良好抗菌药物。     

加替沙星与左氧氟沙星治疗泌尿系统感染的临床疗效及经济学分析

目的 比较加替沙星与左氧氟沙星治疗泌尿系统感染的临床疗效及成本-效果分析.方法 采用随机5组静脉治疗及药物经济学原理对两种治疗方案进行成本-效果分析.结果 加替沙星组与左氧沙星组治疗泌尿系统感染的有效率分别为92.86%、88.46%(P＞0.05);不良反应发生率分别为7.1%、9.0%(P＞0.05);成本-效果比(C/E)分别为7.99、6.53.与左氧氟沙星组相比,加替沙星组每增加一个单位效果需多花费37.43元.结论 左氧氟沙星治疗泌尿系统感染的成本-效果比优于加替沙星.     

Preventive and curative effects of probiotics in atopic patients

Normally, the transport of allergens through the intestinal epithelia to the blood is limited. It is hypothesised that if these compounds arrive in the blood circulation, they must percolate through the epithelial cell layer. Thus, food allergy (and thus atopic eczema) implies an increased intercellular leakage of the gut wall. Such increased intercellular leakage is thought to be caused by a slightly changed cellular morphology due to a slight cytopathologic effect because of both a limited decay of the cytoskeleton and a slightly reduced turgor. These events may be due to a reduced production of intracellular metabolic energy in the epithelial cells due to an increased concentration of familiar, frequently occurring, potentially toxic bacterial metabolites, i.e., d-lactic acid and/or ethanol. In this hypothesis we suggest that adequate probiotics can (i) prevent the increased characteristic intestinal permeability of children with atopic eczema and food allergy, (ii) can thus prevent the uptake of allergens, and (iii) finally can prevent the expression of the atopic constitution. The use of adequate probiotic lactobacilli, i.e., homolactic and/or facultatively heterolactic l-lactic acid-producing lactobacilli, reduces the intestinal amounts of the bacterial, toxic metabolites, d-lactic acid and ethanol by fermentative production of merely the non-toxic l-lactic acid from glucose. Thus, it is thought that beneficial probiotic micro-organisms promote gut barrier function and both undo and prevent unfavourable intestinal micro-ecological alterations in allergic individuals.     

Further characterization of the curative antibodies in Trypanosoma musculi infection.

The ability of immune plasma (IP) taken from different donor strains of mice to cure Trypanosoma musculi infection in various recipient mouse strains, when given during the plateau phase of infection, was examined. C57BL/6, B10.A/SgSn, B10.D2/oSn, B10.D2/nSn, DBA/2, and BALB/c strains could be cured of parasitemia (giving 0.4 to 0.8 ml of IP per mouse), whereas A/J and C3H/HeN strains could not (giving up to 1.2 ml of IP per mouse). Noncure appeared to be associated with the high-plateau parasitemias (approximately 10(8] that developed in the latter strains since IP administered early in infection, when the parasite burden was similar to the plateau parasitemias (approximately 10(6] of strains that could be cured, was at least partially effective in A/J and C3H/HeN mice. The IP of any strain tested (C57BL/6, B10.D2/oSn, B10.D2/nSn, DBA/2, A/J, or C3H/HeN) could bring about elimination of trypanosomes in strains able to be cured. The potency of IP from different strains varied, being greater in the strains that developed higher-plateau parasitemias. Potency of IP appears to correlate positively with the titers of trypanosome-specific antibody of the immunoglobulin G2a isotype (the curative antibody). The role of the late-acting complement components was examined. In C5-deficient mice the course of infection was normal, although the elimination phase was delayed by a few days. Cure of parasitemia by IP administered during the plateau phase was equally effective in the presence or absence of C5 in either the donor or the recipient. When tested in vitro, however, IP only exhibited antitrypanosomal activity when added to infected blood taken from C5-sufficient strains of mice. We conclude that in vitro, under the conditions used in the assay, antibody-mediated destruction of the trypanosomes is brought about by complement-mediated lysis. This process, although it probably occurs to some extent, is unlikely to be the major mechanism of trypanosome elimination in vivo.     

Anatomic basis of sharp pelvic dissection for curative resection of rectal cancer

The optimal goals in the surgical treatment of rectal cancer are curative resection, anal sphincter preservation, and preservation of sexual and voiding functions. The quality of complete resection of rectal cancer and the surrounding mesorectum can determine the prognosis of patients and their quality of life. With the emergence of total mesorectal excision in the field of rectal cancer surgery, anatomical sharp pelvic dissection has been emphasized to achieve these therapeutic goals. In the past, the rates of local recurrence and sexual/voiding dysfunction have been high. However, with sharp pelvic dissection based on the pelvic anatomy, local recurrence has decreased to less than 10%, and the preservation rate of sexual and voiding function is high. Improved surgical techniques have created much interest in the surgical anatomy related to curative rectal cancer surgery, with particular focus on the fascial planes and nerve plexuses and their relationship to the surgical planes of dissection. A complete understanding of rectum anatomy and the adjacent pelvic organs are essential for colorectal surgeons who want optimal oncologic outcomes and safety in the surgical treatment of rectal cancer.     

HIV感染者血清IL-16水平变化及HAART对其水平的影响

目的:探索HIV感染者血清白介素16(IL-16)水平变化及HAART对其水平的影响.方法:77例HIV感染者为研究组,按美国疾病控制中心与世界卫生组织标准分期,对照组15例.检测血清CD4+T细胞、CD8+T细胞和IL-16,观察HIV感染组及各期与对照组、HAART治疗组与未治疗组之间的差异.结果:HIV感染者及各期的CD4+T细胞均低于对照组(P＜0.01)、CD8+T细胞均高于对照组(P＜0.05或P＜0.01).HAART治疗组55例血清IL-16为(266.6±174.1)ng/ml,未治疗组22例血清IL-16为(182.9±63.5)ng/ml,治疗组血清IL-16水平明显高于未治疗组(t=3.087,P＜0.01).HIV感染者及A、B期的血清IL-16均低于对照组(P＜0.05).细分期显示,HAART治疗后HIV感染者血清IL-16逐渐回升,C期治疗组明显高于未治疗组(P＜0.05).结论:HAART可提高血清IL-16水平,HIV感染者动态观察血清CD4+T细胞、IL-16,对病情监测有价值.     

20例黄疸患者术前减黄对行胰十二指肠切除术疗效分析

目前，对于壶腹周围癌合并梗阻性黄疸尤其是重度黄疸黄疸（血清总胆红素〉170μmoL／L）的壶腹周围癌患者胰十二指肠切除术（PD）术前是否需减黄国内外学者仍存在争论。我院自1999年12月至2006年12月间，共收治可切除的胰腺、壶腹、十二指肠恶性肿瘤患者60例，我们对其中资料完整的46例进行了回顾性分析，探讨术前减黄对PD手术的影响。现报告如下。     

应用NCPAP治疗继发性新生儿呼吸暂停疗效观察

目的探讨NCPAP治疗继发性新生儿呼吸暂停的疗效。方法总结我院2007.01～2008.08新生儿科及ICU收治的继发性呼吸暂停病例81例（不包括继发于呼吸窘迫综合征病例15例）,分NCPAP治疗组25例、机械通气治疗组16例、氨茶碱一般治疗组40例三组治疗,回顾性分析疗效情况。结果NCPAP组好转时间短于一般治疗组,t=4.13,P〈0.01,差异有显著性,疗效优于一般治疗组;NCPAP组与气管插管组比较,t=0.9,P〉0.05,差异无显著性,疗效相似。结论应用NCPAP可有效治疗新生儿呼吸暂停,减少气管插管机会。     

肾内科医院感染的分析

目的:分析肾内科住院病人医院感染的临床特征,为预防肾内科住院病人医院感染提供预防措施。方法:回顾性分析本院肾内科2011年3月~2015年3月982例住院患者的临床资料,揭示医院感染与住院情况,诊疗操作和临床指标的关系。结果:982例肾内科住院患者发生医院感染97例,医院感染率为9.9%。医院感染部位以呼吸道感染为主,其中上呼吸道感染占47.4%,肺部感染占22.7%。肾内科住院病人医院感染与年龄、住院天数、激素使用、插管时间、血肌酐和血白蛋白有关(P0.05)。结论:肾内科住院病人的医院感染率较高,病人年龄、住院时间、激素的使用、插管时间、血肌酐和血白蛋白为医院感染的危险因素。     

老年慢性阻塞性肺疾病急性期合并肺结核感染的治疗方法及其疗效探讨

目的：探讨老年慢性阻塞性肺疾病(chronic obstructive lung disease,COPD)急性期合并肺结核感染的治疗方法及其疗效。方法：选取2014年2月至2016年2月我院收治的老年慢性阻塞性肺疾病急性期合并肺结核感染的患者92例,根据治疗方式随机分为治疗组和对照组,对照组给予COPD对症支持治疗和抗肺结核治疗,治疗组在对照组基础上加用痰热清,比较两组患者治疗有效率、痰培养阴转率以及肝肾损害情况的差异。结果：治疗组患者治疗后痰培养阴转率(36例,85.71%)与对照组(41例,82.0%)的差异无统计学意义(P>0.05)。两组患者治疗后的症状积分均低于治疗前,且差异具有统计学差异(P<0.05),治疗组治疗后的症状积分(85.62±11.37)低于对照组(91.25±12.38),且差异具有统计学差异(P<0.05)。治疗组治疗后痊愈2例(4.76%),显效26例(61.90%),有效10例(23.81%),无效4例(9.52%);对照组治疗后痊愈1例(2.0%),显效17例(34.0%),有效22例(44.0%),无效10例(20.0%);治疗组治疗疗效明显优于对照组,且差异具有统计学意义(P<0.05)。治疗组治疗后发生肝肾损害14例,对照组11例,两组患者治疗后肝肾损害发生率的差异无统计学意义(P>0.05)。结论：在不影响痰培养阴转率和不加重肝肾负担的情况下,老年COPD急性期合并肺结核感染患者接受一般性治疗的同时进行中医治疗,其疗效更为显著。     

断流术并吻合器横断食管治疗食管曲张静脉出血疗效观察

目的探讨采用断流术并吻合器横断食管治疗门静脉高压症所致食管曲张静脉破裂出血的手术方法和临床效果。方法对48例包括急性出血期急诊手术22例,有出血病史作择期手术的19例和无出血病史作预防性手术的7例,经腹采用吻合器横断食管下段同时进行食管下段及贲门周围血管的选择性离断,观察其近期和远期止血效果。结果术后近期和远期止血效果都比较满意。结论该手术为食管下段横断和对食管下段与贲门周围血管选择性离断的联合应用,术中使用一次性吻合器进行食管下段的横断与吻合,使手术方法简便快捷,可减少手术创伤。     

Evaluation of the risk of pelvic infection following transvaginal oocyte recovery.

The risk of introducing infection into the peritoneal cavity at the time of transvaginal ultrasound-guided recovery of oocytes in assisted reproduction techniques was assessed by culturing peritoneal fluid samples from 25 women with unexplained infertility. The samples were collected laparoscopically at the time of zygote intra-Fallopian transfer (ZIFT), 24-48 h after oocyte collection. High vaginal and endocervical specimens from 25 women treated by in-vitro fertilization (IVF) and transcervical embryo transfer were cultured for comparison. The peritoneal cultures were negative in all but one patient. High vaginal swabs grew Candida albicans in three cases and endocervical specimens were all negative. Seven and three pregnancies occurred in the ZIFT and IVF groups respectively. No pelvic damage was noted at laparoscopy in those women who had had previous treatment cycles with transvaginal oocyte recovery. This method of oocyte recovery, using prophylactic metronidazole and chlorhexidine for preoperative vaginal preparation, appears to be safe for treatment of women with no previous pelvic damage.