不同空气质量指数期间体外受精-胚胎移植助孕结局

目的观察不同空气质量指数期间体外受精-胚胎移植(IVF-ET)的助孕结局。方法将2013年1月至2014年12月在本中心进行IVF-ET治疗的不孕患者,按月均空气质量指数(AQI)分A组(60≤AQI<80)、B组(80≤AQI<100)和C组(AQI≥100)三组,比较各组的获卵数、正常受精率、卵裂率、可利用胚胎率、种植率、临床妊娠率及流产率。结果 A组MII卵率(86.88%)显著高于B组(84.43%)与C组(83.57%)(P<0.05),A组正常受精率显著高于C组(76.11%vs.72.75%,P<0.05),A组可利用胚胎率(53.09%)显著高于B组(49.40%)与C组(48.92%)(P<0.05);三组间卵裂率、胚胎种植率、临床妊娠率及流产率比较均无统计学差异(P>0.05)。结论随着空气质量下降,IVF-ET过程中的卵母细胞成熟率、正常受精率及优质胚胎率有不同程度的下降。     

体重指数对体外受精-胚胎移植结局的影响

目的探讨体重指数（BMI）对体外受精-胚胎移植（IVF—ET）和卵胞浆内单精子注射（ICSI）结局的影响。方法选择2006年6月至2010年6月间在我院接受IVF-ET／ICSI治疗、年龄〈35岁的不育患者为对象,共449个周期。按BMI分为三组：低体重组（A组）,BMI（18．5kg／m^2,共45个周期;正常体重组（B组）;18．5kg／m^2≤BMI〈25kg／m^2,共356个周期）、超重组（C组）,BMI≥25kg／m^2,共48个周期。比较三组的促性腺激素（Gn）使用天数及用量、人绒毛膜促性腺激素（hCG）注射日内膜厚度及血清雌二醇（E2）水平、获卵数、受精率、卵裂率、优胚率、胚胎着床率、临床妊娠率及早期流产率。结果C组Gn用量显著高于A和B组（P〈0．05）,hCG日血清E2水平显著低于A、B组（P〈0．05）,早期流产率显著高于B组（P〈0．05）;三组获卵数、受精率、卵裂率、优胚率、胚胎着床率及临床妊娠率均无显著性差异（P〉0．05）。结论BMI过高会导致IVF／ICSI治疗过程中Gn用量增加和hCG日血清E2水平降低,早期流产率增加,对IVF的结局有一定的负面影响。     

体外受精-胚胎移植助孕后双胎自然减胎的妊娠结局

目的探讨体外受精-胚胎移植(IVF-ET)助孕妊娠后双胎自然减为单胎的影响因素以及妊娠结局。方法回顾性分析2010年3月至2012年7月在本院生殖中心行试管婴儿助孕的8 567个周期,双胎妊娠自然减为单胎者为研究组(A组,166例),对照为双胎未发生减胎组(B组,264例)和单胎组(C组,200例)。比较3组间临床相关因素及妊娠结局。结果 A组的妊娠年龄、新鲜周期HCG日内膜厚度/复苏周期排卵日内膜厚度高于B组,差异有统计学意义(P0.05);A组移植胚胎质量低于B组,差异具有统计学意义(P0.05);A组早期妊娠流产率低于B组(3.61%vs.12.50%),差异有统计学意义(P0.05);但A组晚期妊娠流产率高于B组(10.24%vs.4.00%),差异有统计学意义(P0.05)。A组妊娠期高血压的发生率高于C组(11.45%vs.5.50%),差异有统计学意义(P0.05)。A组妊娠期糖尿病的发生率高于C组(4.82%vs.2.50%),但差异无统计学意义(P0.05)。A组与C组比较,低体重儿、早产儿出生率及新生儿体重、出生孕周差异均无统计学意义(P0.05)。结论妊娠年龄大于35岁、内膜厚度小于10mm,移植优质胚胎数目比率越低,双胎妊娠发生自然减胎的可能性越大。双胎自然减为单胎的孕妇较正常单胎妊娠者发生妊娠并发症的风险增加。     

体外受精-胚胎移植妊娠数目与母儿结局分析

目的探讨体外受精-胚胎移植(IVF-ET)妊娠数目与母儿结局的关系。方法回顾性分析我中心2005年1月至2007年9月IVF-ET术后受孕322例,比较单胎妊娠及多胎妊娠母儿结局。结果临床妊娠322例,分娩243例,多胎妊娠率为27.6%(89/322)。多胎妊娠各种并发症中妊高征发生率最高(25.42%),多胎妊娠组其卵巢过度刺激综合征(OHSS)以及胎膜早破、妊高征等妊娠并发症的发病率均明显高于单胎妊娠组(P0.05),单胎妊娠者其孕龄及新生儿出生体重均大于双胎妊娠者(P0.01)。结论IVF-ET术后多胎妊娠率较高,多胎妊娠者其OHSS、胎膜早破、妊高征等并发症及早产、低出生体重儿发病率均较单胎妊娠者高,应限制胚胎移植数目以改善IVF-ET妊娠后母儿结局。     

异位妊娠后行体外受精-胚胎移植的临床结局分析

目的探讨异位妊娠(EP)后行体外受精-胚胎移植(IVF-ET)的临床结果以及EP次数及输卵管治疗方法对妊娠结局的影响。方法回顾性分析2012年1~12月在我中心行IVF-ET的患者,选择经腹腔镜或输卵管碘油造影诊断为盆腔、输卵管因素性不孕症患者的401个周期,根据既往有无EP史,分为EP组270周期和非EP组131周期;EP组又根据既往EP的发生次数分为EP1次组和EP≥2次组。分别比较EP组和非EP组、EP1次组和EP≥2次组的种植率、妊娠率以及重复异位妊娠(REP)的发生率。同时根据输卵管治疗方法的不同,分别比较患侧输卵管结扎或根治性手术组(A组)和患侧输卵管保守手术组(B组)以及对侧输卵管结扎或根治性手术组(A1组)和对侧输卵管保留组(A2组)的临床结局。结果 (1)EP组与非EP组促性腺素激素(Gn)用量、Gn天数、子宫内膜厚度、获卵数比较,差异无统计学意义(P0.05),两组的妊娠率、种植率及EP发生率比较,亦无统计学差异(P0.05)。(2)EP1次组和EP≥2次组的妊娠率、EP发生率比较,无统计学差异(P0.05);EP≥2次组的种植率(72.04%)明显高于EP1次组(50.12%),差异有统计学意义(P0.01)。(3)A、B两组的妊娠率、种植率及EP发生率比较无显著性差异(P0.05);A1组的妊娠率(87.14%)和种植率(59.03%)明显高于A2组的妊娠率(65.22%)和种植率(43.31%),差异有统计学意义(P0.01)。结论本研究结果提示EP后行IVF-ET并不影响临床妊娠结局,亦不增加REP的风险,且与既往EP次数无关。患侧输卵管保守手术或根治性手术治疗均不影响妊娠率,不增加REP的风险;对侧输卵管是否保留,则应进行综合评估后判定。对既往发生2次以上EP的患者,双侧输卵管切除更有利于改善妊娠结局。     

口服避孕药对卵巢功能正常不育患者体外受精-胚胎移植妊娠结局影响的Meta分析

目的系统评价口服避孕药(OC)在卵巢储备功能正常不育患者IVF-ET治疗周期妊娠结局中的作用。方法计算机检索Cochrane Library、PubMed、Embase、Biomed Central、CNKI、维普(VIP)和万方数据库的原始论著,收集在IVFET治疗周期前,使用OC和不使用OC对患者妊娠结局影响的临床随机对照研究,同时筛选纳入文献的参考文献。根据Cochrane系统评价方法,由3名独立研究者对文献的质量进行严格的评价和信息提取,并通过RevMan5.2软件对符合质量标准的随机对照试验(RCT)进行Meta分析。结果本研究共纳入6个RCT文献,共计1 620例患者,其中1例退出;Meta分析结果显示:对卵巢功能正常不育患者在IVF-ET前使用OC预处理会使临床妊娠率降低[RR=0.70,95%CI(0.55,0.88),P=0.002],继续妊娠率亦降低[RR=0.70,95%CI(0.54,0.92),P=0.01],但是两组间获卵数[WMD=0.53,95%CI(-1.20,2.26),P=0.55]、可移植胚胎数[WMD=-0.14,95%CI(-0.40,0.11),P=0.27]、优胚数[WMD=0.37,95%CI(-0.36,1.11),P=0.32]、种植率[RR=0.98,95%CI(0.79,1.21),P=0.83]比较均无统计学意义。结论本研究结果表明,对于卵巢功能正常的不育患者,使用OC预处理并不显著改善其IVF-ET的妊娠结局,甚至可能会降低临床妊娠率和继续妊娠率。     

体外受精-胚胎移植受孕与自然受孕双胎妊娠临床结局比较

目的探讨体外受精-胚胎移植(IVF-ET)对双胎妊娠母胎结局的影响。方法回顾性分析2014年1~12月于我院产科分娩的双胎妊娠产妇的临床资料。按照受孕方式分为两组:IVF-ET组(89例)和自然妊娠组(56例)。比较两组的孕产妇并发症、分娩情况及新生儿结局。结果IVF-ET组孕产妇平均年龄(30.45±4.40)岁显著高于自然妊娠组的(28.63±5.12)岁,IVF-ET组孕妇妊娠期高血压疾病发生率(25.8%)、新生儿极早产(28~31+6周)发生率(10.1%)、极低出生体重(1 500g)发生率(10.1%)及转新生儿科比例(55.1%)均显著高于自然妊娠组(分别为12.5%、3.6%、3.6%和34.8%)(P均0.05)。结论 IVF-ET助孕的双胎妊娠发生不良妊娠结局的风险相对较高,建议临床上应加强IVF-ET术后双胎妊娠并发症的防治及产前、产时监护。     

有剖宫产史的不孕患者体外受精-胚胎移植的妊娠结局

目的 探讨有剖宫产手术史的不孕患者体外受精-胚胎移植(in vitro fertilization and embryo transfer,IVF-ET)的妊娠结局.方法 回顾性分析2016年1～12月有剖宫产史的IVF-ET(n=215)资料,按照年龄1:1匹配,选取有阴道分娩史但无剖宫产史IVF-ET(阴道分娩史组...     

高龄不育妇女在体外受精-胚胎移植中的降调节

近年来,女性职业化、社会化和高离婚率使妇女的生育年龄呈上升的趋势,而生育能力随着年龄的增长逐年下降,表现为卵巢储备减少、卵巢体积缩小、窦卵泡数下降、卵巢间质血管分布改变等[1]。据美国辅助生殖技术协会的一项统计显示,自1990年以来,40岁以上美国妇女作体外受精-胚胎移     

输卵管积水处理方式对体外受精-胚胎移植临床结局的影响

目的探讨输卵管积水的不同腹腔镜手术处理方式对体外受精-胚胎移植(IVF-ET)临床结局的影响。方法回顾性分析2006年1月至2007年7月因输卵管因素在本中心行常规IVF-ET治疗的294例不育患者的资料,按IVF-ET前腹腔镜下输卵管积水处理方式分组:A组:双侧输卵管近端结扎术28例;B组:双侧输卵管造口术42例;C组:双侧输卵管切除术64例;D组:输卵管阻塞不伴积水80例;E组:单或双侧输卵管积水80例。比较5组患者在IVF-ET周期中卵巢对超排卵的反应性及临床结局的影响。结果C组的窦卵泡数少于B组,发育的卵泡数及获卵数少于其他4组,均有显著性差异(P<0.05);与其他4组相比,C组使用促性腺激素(Gn)的支数最多,但无显著性差异(P>0.05);E组的胚胎植入率为15.9%,临床妊娠率为27.5%,为各组间最低,其中胚胎植入率与A、C和D组比较有显著性差异,临床妊娠率与A和D组比较有显著性差异(P<0.05);各组流产率E组最高(22.7%),其次为B组(14.4%),E与C组(4%)比较有显著性差异(P<0.05);异位妊娠率E组最高,其次为B组,但各组间无显著性差异(P>0.05)。结论输卵管积水对IVF-ET结局有负面影响,对输卵管积水进行适当预处理有助于改善其临床结局。输卵管近端结扎术不降低卵巢反应性,异位妊娠率及流产率低,是IVF-ET前输卵管积水预处理较理想手术方式。     

子宫内膜异位症不孕患者不同体重指数对IVF-ET妊娠结局的影响

目的分析子宫内膜异位症(EMS)不孕患者不同体重指数(BMI)对IVF/ICSI-ET妊娠结局的影响。方法回顾性分析2013年7月至2018年5月于武汉大学人民医院生殖中心行IVF/ICSI-ET助孕的427例EMS患者的临床资料,按照不同BMI(亚洲标准)分为4组:偏瘦组(60例,BMI<18.5kg/m²)、正常体重组(289例,18.5kg/m2≤BMI<24kg/m²)、超重组(66例,24kg/m2≤BMI<28kg/m²)及肥胖组(12例,BMI≥28kg/m²),比较各组患者的妊娠结局。并按照EMS分期分为Ⅰ～Ⅱ期亚组和Ⅲ～Ⅳ期亚组,比较不同BMI组中各亚组的妊娠结局。结果各组患者一般资料比较显示,偏瘦组的Ⅲ～Ⅳ期EMS比例最高,差异有统计学意义(P<0.01)。超重组的基础FSH、LH水平显著低于偏瘦组、正常体重组(P<0.05)。肥胖组的Gn用量显著高于其他3组(P<0.05)。正常体重组的获卵数显著高于偏瘦组和肥胖组(P均<0.05);肥...     

肥胖对绝经后妇女骨量的双向影响

目的　深入探讨肥胖对绝经后妇女骨量的影响及机理。方法　绝经年限 (YSM) 1～ 10年的妇女 85例 ,测量身高、体重 ,计算体重指数 (BMI) ;测量空腹及糖负荷后 2h胰岛素 ;空腹血甘油三酯(TG)、总胆固醇、瘦素 ;测定腰椎及股骨颈的骨密度。结果　多元逐步回归分析显示 ,腰椎骨密度 =1 0 85 0 0 2 2YSM ,股骨颈骨密度 = 0. 371 0. 6 33身高 0 . 0 11BMI 0 . 0 0 7YSM 0 . 0 5 3lnTG ;BMI与TG成正相关 (r=0 . 2 4 4 ,P =0. 0 2 7) ;如果把人群分为BMI<2 3kg/m2 和BMI≥ 2 3kg/m2 两组 ,则两组之间腰椎骨密度的差异无显著性 ,而股骨颈骨密度的差异有显著性 ,BMI≥ 2 3kg/m2 组大于BMI <2 3kg/m2组 (t=3 4. 96 ,P =0 . 0 0 1)。结论　肥胖对腰椎骨量无保护作用 ,对股骨颈骨量总的影响是保护作用 ,但深入分析发现其影响呈双向性 ,其保护作用与体重负荷有关 ,而损害作用与血TG水平有关。     

The impact of obesity on prostate cancer

Increasing prevalence of obesity in many parts of the world emphasizes the importance of learning more about the relationship between obesity and prostate cancer (PC). The present paper reviews the impact of obesity on PC using knowledge obtained from the available literature. Search of published literature in PUBMED database. Adipose tissue constitutes an active endocrine and metabolic organ which may be relevant in the development and progression of PC by different potential mechanisms. Furthermore, obesity could have an impact on the outcome of different treatment modalities for PC, both functionally as anatomically. Obesity is a growing problem, however, the exact role in the development and progression of PC has not been elucidated. Regarding the optimal treatment of PC in obese patients, comparative prospective studies are needed.     

肥胖者骨密度与体重及其他体成分关系的研究

目的肥胖易伴发多种慢性疾病。本文探讨肥胖者体重与体成份(脂肪、肌肉)之间的关系及其对临床减重的意义。方法经临床确诊系单纯性肥胖者45例,男17例,女28例。使用美国LunarDPX-L型双能X线吸收测量仪(DXA),测量全身骨、第2~4腰椎、股骨颈骨矿密度(BMD)及体脂肪和肌肉量,并计算体重指数(BMI=W/H2)、体重(kg)/身高(m)即W/H数值进行比较分析。结果男性体重平均94.54±17.41kg,BMI33±4.87。女性体重平均124.37±14.0kg,BMI35.41±6.39。男女两性全身BMD与体重相关,分别为r=0.415,P<0.05,r=0.529,P<0.0025。女性体重与脂肪、肌肉之间呈正相关分别为r=0.522,P<0.0025、r=0.612,P<0.005。男性体重与BMI、W/H及全身肌肉量相关,与脂肪组织无明显相关。男女性W/H较BMI相关系数高。男性全身BMD与全身肌肉量正相关r=0.421,P<0.05。女性全身及股骨颈BMD与脂肪量相关r=0.360,P<0.05、r=0.323,P<0.05。女性全身肌肉量与股骨颈BMD呈正相关r=0.373,P<0.05。结论①肥胖者体重增加,男性以肌肉增加为主,女性脂肪和肌肉都增加;②男性全身骨密度增高与肌肉量增加有关,而女性则主要为脂肪量增加;③女性肌肉、脂肪量与股骨颈BMD密切相关;④体重(kg)/身高(m)比计算体重指数能更准确地反映总体肥胖的程度。     

Prostate cancer detection: The impact of obesity on Asian men

ObjectiveTo evaluate the impact of body mass index (BMI) on prostate cancer detection in biopsy-naive men presenting to a single tertiary hospital in Singapore.Materials and methodsWe retrospectively examined 458 men who underwent initial prostate biopsies between January 2012 and April 2014. Indications for biopsy were serum prostate-specific antigen level≥4.0 ng/ml, or digital rectal examination findings suspicious for malignancy, or both. Only men with serum prostate-specific antigen level <20 ng/ml were included. BMI categories were based on the World Health Organization recommendations (normal:<25.0, overweight: 25.0–29.9, and obese: ≥30).ResultsOf the 458 men included in our cohort, 125 (27.3%) men were positive for prostate cancer on biopsy, with 69 (15.1%) being clinically significant (Gleason≥7). Men with BMI≥25 kg/m² (41.7%) were younger (67.2 vs. 68.8 y, P = 0.030), had larger prostates (45.5 vs. 40.1 g, P = 0.014), and were more likely to have a positive biopsy finding (34.6% vs. 22.1%, P = 0.003). On multivariate analysis, being overweight or obese was associated with increased risk of having prostate cancer on biopsy (odds ratio [OR] = 2.61, 95% CI: 1.58–4.30, P<0.001 and OR = 3.26, 95% CI: 1.37–7.73 P = 0.007, respectively). The same trend was observed for clinically significant cancers but not for clinically insignificant cancers (OR = 3.57, 95% CI: 1.87–6.82, P<0.001 and OR = 3.86, 95% CI: 1.33–11.21, P = 0.013 for being overweight and obese, respectively).ConclusionAsian men with BMI≥25 kg/m² are at greater risk of having a positive initial biopsy result. The BMI threshold (BMI≥25 kg/m²) for Asian men to be at increased risk of prostate cancer detection on initial biopsy is lower than that of Western populations (BMI≥30 kg/m²).     

超长方案促性腺激素释放激素激动剂降调节对子宫内膜异位症体外受精-胚胎移植结局的影响

本中心对129例经腹腔镜证实为美国生殖医学会(ASRM)II-IV期子宫内膜异位症(内异症)合并其他不育因素而行体外受精-胚胎移植(IVF-ET)治疗的病例,进行了回顾性统计和分析。一、资料和方法1.临床资料:从2005年4月至2007年3月,在本中心接受IVF-ET治疗经腹腔镜证实为ASRMII-IV期内异症合并其他不育因素的129个周期病例;对照组为输卵管性不育的1,543个周期。内异症组根据有无促性腺激素释放激素激动剂(GnRH-a)药物降调节分为A、B两组进行分析,A组:中重度内异症在手术后接受长效GnRH-a(3.75 mg/支,每28 d一支,共2~6支)抑制治疗的39个…     

Influence of morbid obesity on parathyroidectomy outcomes in primary hyperparathyroidism

Background

We sought to evaluate the influence of morbid obesity in patients undergoing parathyroidectomy for primary hyperparathyroidism (pHPT).

Methods

All patients with pHPT who underwent parathyroidectomy at a single institution between July 2002 and October 2008 were included. Body mass index (BMI), laboratorie vlaues, operative findings, and outcomes were examined.

Results

Two hundred thirteen of the 776 patients identified (28%) were morbidly obese (BMI ≥35 kg/m²). When compared with nonmorbidly obese patients, the morbidly obese patients were younger, had higher preoperative intact parathyroid hormone (iPTH) levels, heavier parathyroids, and required overnight stay more often (P <.05 for all). However, the rates of complications, eucalcemia, and recurrence were similar for all patients.

Conclusion

In this study, more than a quarter of the patients who underwent parathyroidectomy for pHPT were morbidly obese and had significantly higher preoperative iPTH levels, heavier parathyroids, and longer hospital stay but similar rates of complications and operative success.     

肥胖对小主动脉瓣人工瓣膜置入术后长期生存的影响

目的 评估肥胖对于小主动脉瓣人工瓣膜(直径≤21 mm)置换术后长期生存率的影响.方法 1998年1月至2008年12月对307例首次接受小号主动脉瓣置换术生存时间超过1个月者进行长期随访.并根据身体质量指数(BMI)划分为3组:BMI＜ 24.0 kg/m2为正常组(185例),BMI 24.0 ～27.9 kg/m2为超重组(94例),BMI≥28 kg/m2为肥胖组(28例).分别在术后第3、6个月,第1、3、5、8年收集NHYA分级,有效瓣口面积指数(EOAI),左心室质量指数(LVMI),左心室射血分数(LVEF)等指标,了解各组中这些指标的变化及组间比较,分析肥胖是否与生存率有关;计算总体死亡率及3组各自死亡率并比较.结果 经过单变量和多变量分析,并通过倾向得分调节,肥胖均为影响生存率的独立危险因子(HR:1.62;P =0.01).长期随访中,肥胖组和超重组生存率较正常组低,而且术后NYHAⅢ/Ⅳ级患者所占比例偏高.3组中肥胖组和超重组EOAI偏小,LVMI偏高,均有统计学意义.但LVEF无明显变化.结论 肥胖和术后长期生存率密切相关,肥胖和超重均可能降低术后的长期生存率.EOAI可能在其中发挥重要作用,提高EOAI会提高术后长期生存率,改善术后长期生存质量.     

Influence of obesity and surgical weight loss on thyroid hormone levels

BACKGROUND: The pathophysiologic relationship between morbid obesity and thyroid hormones is not well understood. The goal of this study was to evaluate the influence of obesity and weight reduction after bariatric surgery on thyroid hormone levels. METHODS: Patients who underwent gastric bypass or adjustable gastric banding at our institution, had no previous diagnosis of thyroid disorder, were not taking medication that could affect the thyroid function evaluation, and who were nonsmokers were included in this retrospective evaluation. The association between the thyroid-stimulating hormone (TSH) and free thyroxine (T(4)) levels and body mass index (BMI), and the influence of weight loss after bariatric surgery on these hormones were investigated at different points (preoperatively and 6 and 12 months after bariatric surgery). RESULTS: A total of 86 patients met the study criteria. The TSH levels correlated positively with BMI (P <.001, r = .91) within the BMI range of 30-67 kg/m(2). The mean BMI change from 49 to 32 kg/m(2) after bariatric surgery was associated with a mean reduction in the TSH level from 4.5 to 1.9 microU/mL. Free T(4) showed no association with BMI and was not significantly influenced by weight loss. Before bariatric surgery, 10.5% of the subjects had laboratory values consistent with subclinical hypothyroidism. After bariatric surgery, 100% of these patients experienced significant weight reduction with simultaneous resolution of their subclinical hypothyroidism. CONCLUSION: The results of our study have demonstrated a statistically significant positive association between serum TSH within the normal range and BMI. No association was found between BMI and free T(4) serum levels. The prevalence of subclinical hypothyroidism in study group was 10.5%. Weight loss after bariatric surgery improved or normalized thyroid hormone levels.     

Impact of body mass index on outcome in patients undergoing coronary artery bypass grafting and/or valve replacement surgery

Objective

This study aimed to analyze the impact of body mass index on outcomes of 101 patients undergoing coronary artery bypass grafting, valve replacement, or combined valve/ coronary artery bypass grafting surgery in a private hospital in Belo Horizonte, Brazil.

Methods

This was a prospective cross-sectional study of patients undergoing cardiac surgery from May 2009 to December 2012. All patients were followed up from the first day of admission until discharge or death. Patients were divided into three groups according to BMI: normal weight, overweight, and obese. The main outcome measure was the association between BMI and postoperative morbidities and mortality.

Results

Multivariate analysis identified obesity as an independent predictor of increased risk of surgical reintervention (odds ratio [OR] 13.6; 95%CI 1.1 - 162.9; P=0.046) and reduced risk of bleeding (OR 0.05; 95% CI 0.09 - 0.69; P=0.025). Univariate analysis showed that obesity was associated with increased frequency of wound dehiscence (P=0.021). There was no association between BMI and other complications or mortality in univariate analysis. There was also no association between body mass index and duration of cardiopulmonary bypass, aortic clamping, mechanical ventilation, and intensive care unit or hospital stay.

Conclusion

Obese individuals undergoing coronary artery bypass grafting, valve replacement, or combined surgery have a higher postoperative risk of surgical reintervention and lower chances of bleeding.