增殖性脓性皮炎-脓性口炎一例

【摘要】 患者女,58岁,唇、头皮、皱褶部位反复发生红斑、脓疱、增殖性斑块3个月。患者有溃疡性结肠炎病史2年,皮疹发生前肠炎加重。皮肤科检查：双唇弥漫性增厚,上有密集米粒至绿豆大脓疱,部分脓疱融合,唇缘黄色结痂;左颊黏膜有一1.5 cm × 2 cm的增殖性斑块,边缘脓疱呈环状排列;头皮、颈、左腋窝、脐周、左腹股沟可见多发性大小不等的增殖性斑块、糜烂、黄色结痂,中央和边缘有环状排列的水疱和脓疱,皮疹消退后留色素沉着斑;右腋4个新发脓疱。下唇缘皮损组织病理学检查：表皮轻度增厚伴中性粒细胞微脓肿,真皮密集混合性炎症细胞浸润,可见中性粒细胞和嗜酸性粒细胞微脓肿;下唇皮疹边缘正常皮肤直接免疫荧光检查阴性。血常规检查示嗜酸性粒细胞比例增高。脓疱细菌、真菌培养阴性。诊断：增殖性脓性皮炎-脓性口炎。 【关键词】 增殖性脓性皮炎-脓性口炎     

增殖性脓性皮炎-脓性口炎

患者女,42岁,因口唇脓疱性损害11个月,头面、躯干脓疱、溃疡、增殖性斑块5个月就诊。既往有溃疡性结肠炎病史8年。皮肤科情况：眼睑轻度糜烂,颊黏膜及口唇水肿,脓疱、渗出、黏液形成典型“蜗牛行迹”损害;颈部大片黑褐色增殖性斑块,约20 cm × 10 cm,边缘隆起,分别于前胸、腋下、脐周、左侧腹股沟,可见手掌至核桃大小增殖性斑块,边缘脓性分泌物。组织病理：表皮呈乳头瘤样增生,表皮内可见嗜酸性粒细胞微脓疡,真皮浅层大量中性粒细胞、嗜酸性粒细胞浸润。直接免疫荧光检查IgA、IgG、C3阴性。诊断：增殖性脓性皮炎-脓性口炎。治疗：甲泼尼龙40 mg/d静脉滴注及对症处理,皮疹逐渐消退。     

增殖性脓性口炎——肠炎症性疾病的一种反应性粘膜标志

本文报导2例增殖性脓性口炎患者。例1,23岁女性。1976年开始下腹部间歇性痛性痉挛,交替发作便秘和腹泻,大便带血和粘液。经大便检查,直肠镜及结肠镜检查,钡灌肠及肝活检,确诊为慢性溃疡性结肠炎和胆管周围炎。用柳氮磺胺吡啶(500mg,日3次)和强的松(30mg,日3次)治疗,腹泻和血便消失。当药物减量时,腹泻又发。1978年6月全口粘膜及气管和喉发生痛性溃疡,声音嘶哑。损害活检仅显示粘膜坏死,直接免疫荧光检查阴性。口腔局部应用四环素等几乎无效。1979年8月因柳氮磺胺吡啶引起苔藓样药物反应而停此药。1980年7月在     

增殖性脓皮病一例

<正> 增殖性脓皮病少见,我们于1989年9月收治一例,报告如下: 患者男,24岁,未婚,农民。1984年以来舌常糜烂,唇红、颈后、腋窝、脐部、腹股沟、阴囊、肛周等部位反复起丘疱疹、脓     

播散性瘙痒性血管性皮炎一例

患者男,54岁,因全身紫癜性斑疹伴剧痒1年余就诊.1年前,在无明显诱因下,先于双小腿外踝周围出现红色紫癜样斑疹,压之不褪色,伴有剧烈瘙痒.此后,皮损逐渐增多,并累及四肢和躯干.曾在当地医院就诊,具体诊断不详,予以地塞米松静脉滴注(具体剂量不详),皮损略有好转.此后,每当进食海鲜和辛辣食物时,皮损加重.为明确诊断于2010年11月15日来我院就诊.     

增殖性脓皮病一例

患者女, 75岁。因足趾、会阴部脓疱、增生伴疼痛 1年而入院。 1年前无明确诱因双足趾背起粟粒大小脓疱,周围有红晕,疱破后糜烂,逐渐增生肥厚。继之会阴部、腋窝、双耳后和颈部出现同样皮损,伴疼痛及瘙痒,曾用大剂量抗生素 (安美汀 )治疗无效。 20年前患胃溃疡,已行胃大部切除术。 2年前患慢性胆囊炎、胆结石,已行胆囊摘除术。 体检：痛苦病容,全身浅表淋巴结无肿大,各系统检查无异常。皮肤科情况：双耳后、双侧腋窝、下腹部、会阴部、双大腿内侧、双足趾和足背可见大片灰褐色疣状增生,表面有少量粘液脓性分泌物和散在粟粒大小脓…     

增殖性脓皮病一例报告

<正> 本病又称Hallopeau型增殖性天疱疮,以疣状增殖皮损为主,本病罕见,国内曾有3例报告,我科于1989年收治1例。患者男性,54岁,农民。因皮肤皱折部发生增生性皮疹半年余入院。不明原因的先在双腋下出现指头大增生物,稍痒,后延及枕后、口唇、腋下、会阴部。检查:T38℃,慢性病容,颈及股部表浅淋巴结大,心肺肝脾无异常。口角、颈后、双腋下、会     

增殖性红斑-鳞癌1例

临床资料患者男,42岁.因龟头包皮起红斑3年,加重半年就诊.3年前患者无明显诱因于龟头部出现粟粒大白斑,无自觉症状.后逐渐增大至黄豆大的红斑,疼痛明显,在当地医院诊断为"尖锐湿疣".给予口服药物(具体药物及剂量不详)及激光治疗,效果不明显.2006年2月红斑增至2.8 cm×2.5 cm,并蔓延至包皮内板,表面轻度糜烂,有渗液,疼痛加剧,于2006年8月来我科就诊.患者既往体健,2002年4月曾有2次不洁性交史,家族成员中无类似疾病史.     

Hallopeau型增殖性天疱疮一例

患者男,62岁,就诊前3个月因乘车臀部受磨擦,该部位出现红斑、肿胀、脓疱及糜烂.皮损渐向周围及肛周扩展并融合成片.     

增殖性毛母质瘤一例

患者男,27岁.于1986年2月3日入院.两月前右大腿中段伸侧面出一小疖肿,伴有轻微疼痛和瘙痒,抓后表面皮肤破溃,曾多次换药和理疗不愈.皮下形成肿块,皮肤破溃面不断扩展,肿块增长迅速,渐渐略隆起皮面,呈菜花状外观,触之易出血,周围皮肤红肿.     

Two cases of pyodermatitis-pyostomatitis vegetans

Pyodermatitis-pyostomatitis vegetans (PPV) is a rare chronic pustular and vegetating mucocutaneous dermatosis. The oral lesions present as multiple, friable and yellowish pustules, which form "snail tracts" and rupture easily. The cutaneous lesions begin as crusted erythematous papulopustules that coalesce to form large vegetating plaques, usually in the axillae, genital area and scalp. Cutaneous lesions usually develop at the same time as the oral lesions or thereafter. PPV is usually considered as a specific marker for inflammatory bowel disease since the concurrence of PPV and inflammatory bowel disease has been reported in approximately 70% of cases. We report two patients who showed typical clinical and histopathological features of PPV, but were not accompanied by inflammatory bowel disease.     

增殖型天疱疮1例

增殖型天疱疮是一型较罕见的天疱疮，发病率约占天疱疮的３％左右。我科近期发现１例，临床及病理表现典型，现报告如下。１临床资料患者女，４７岁。因“头面部，口腔，腋下，外阴皮损３个月”收我科住院。患者３个月前无明显诱因颊粘膜破溃，其后局部逐渐增厚，伴表面渗液，疼痛明显。在当地以“扁平苔藓”治疗，效果不佳。１个月前又以“白念珠菌感染”给予氟康唑治疗，病情发展，头面、颈侧、腋下及外阴部陆续出现疣状增生性的皮损，表面糜烂渗出，局部痒痛。自发病以来，精神睡眠可，二便正常，因进食困难，体重下降５kg。患者既往体健…     

增殖型类天疱疮一例

【摘要】 患者女,89岁,因腹股沟、外阴、臀间沟皮疹10个月、水疱3周就诊。皮肤科检查：腹股沟、外阴、臀间沟红白色增生性斑块,斑块部位散在绿豆至豌豆大小的糜烂面及水疱,右腋下及右小腿正常皮肤上散在数个类似水疱,部分破溃结痂。臀间沟皮损组织病理检查：棘层增生肥厚,无棘刺松解,部分区域可见表皮下裂隙和水疱,局灶性真皮浅层水肿,伴嗜酸性粒细胞浸润,真皮浅层血管周围可见淋巴细胞为主的浸润。直接免疫荧光：IgG、C3基底膜带线状沉积,IgM真皮簇状小体阳性,IgA阴性。盐裂皮肤间接免疫荧光：IgG、C3沉积在表皮侧。酶联免疫吸附试验检测血清抗体：BP180抗体26.92 U/ml、BP230抗体68.17 U/ml,桥粒芯蛋白1抗体、桥粒芯蛋白3抗体正常。诊断：增殖型类天疱疮。予口服甲泼尼龙,联合外用卤米松软膏及0.03%他克莫司软膏,皮疹逐渐消退。     

A case of pyoderma vegetans associated with acne conglobata

A 41-year-old man visited our clinic because of vegetating plaques resembling pemphigus vegetans on his sacral and perianal areas. He had also suffered from acne conglobata since adolescence. A biopsy specimen taken from the perianal area showed marked acanthosis, exocytosis, and inflammatory infiltrates in the dermis, but no acantholysis. Direct and indirect immunofluorescent tests were negative for anti-intercellular antibodies. Bacterial cultures from the lesions showed many different types of organisms. We diagnosed the case as pyoderma vegetans and discussed the relationship between pyoderma vegetans and other pyoderma.     

A case of pyoderma vegetans and the follicular occlusion triad.

A case of pyoderma vegetans (PYV) and hidradenitis suppurativa (HS) is described. Our patient had a previous history of perifolliculitis capitis abscedens et suffodiens and acne conglobata. Direct immunofluorescence findings ruled out pemphigus vegetans and suggested a potential pathogenic mechanism.     

A case of acantholytic dermatosis of the vulva with features of pemphigus vegetans

We report an unusual case of vulvar acantholytic dermatosis with features of pemphigus vegetans in a 22-year-old Indian girl who presented with a "warty" lesion in her left labium majus. Following excision of this lesion, she presented with 2 localized recurrent lesions on the left and right labia majora about 21/2 years later which were also excised. All 3 biopsies showed histological features typical of pemphigus which included extensive suprabasal acautholysis with bullae formation, prominent villus-like processes at the base of the bullae, focal hyperkeratosis and papillomatosis, and the occasional mixed neutrophil and eosinophilic intraepidermal abscess. IgG and C₃ immunofluorescence was positive in the intercellular spaces of the epidermis. These lesions, which probably represent a form of pemphigus vegetans, have not been previously reported as a cause of localized vulvar acantholytic dermatosis.