眼睑皮肤钙沉着症2例

例1.女,20岁.因双上睑扁平丘疹10年,于2008年8月15日就诊.10年前发现左睑出现黄白色丘疹,无自觉症状,逐渐增大,随后右睑出现相似皮损.自诉外用药物后丘疹可变平.家族中无类似疾病患者.     

结节性黄瘤并发高脂蛋白血症1例

患者男,37岁。面部、四肢皮肤出现黄色丘疹及斑块20年．于2006年4月19日来我院就诊。患者于20年前无明显诱因双肘部皮肤出现黄色扁平丘疹,逐渐增大形成斑块,无任何不适,8年前臀部亦出现大片淡黄色斑块,质软。     

乳房原发性皮肤弥漫性大B细胞淋巴瘤（腿型）1例

患者女,71岁,因左侧乳房红斑、斑块3个月就诊。3个月前患者左侧乳房无明显诱因下出现红斑,其上逐渐出现米粒大小红色丘疹,无痒痛等自觉症状,后皮疹逐渐增多、增大。自行外用“皮炎平”,原有丘疹可变平,但仍有新发丘疹,并且逐渐融合成斑块。既往高血压病史20余年。无家族遗传病及肿瘤病史,无外伤史……     

疣状表皮发育不良并发鲍恩样丘疹病1例

1 病历摘要 患者女,38岁.因面颈部出现红斑、丘疹20余年,外阴及肛周丘疹、斑块伴瘙痒2年,于2008年3月25日来我科门诊就诊.患者20余年前出现面部淡红色至浅褐色斑疹及斑丘疹,伴颈部褐色扁平丘疹,无明显自觉症状.曾于外院诊断为"扁平疣",予以相关治疗(具体药物不详)无效.后皮损逐渐增多,累及躯干及左前臂.     

单侧线状汗孔角化症一例

<正>1临床资料患者男,2岁。因右前胸、右上肢带状分布的丘疹、斑块1年余,于2011年10月就诊。患者于1年前无明显诱因在右前胸及右上肢出现呈带状分布的红色丘疹和斑块,无明显自觉症状,后皮疹逐渐增多增厚。家族史无特殊。体格检查:系     

泛发型环状肉芽肿1例

1 临床资料 患者女,66岁.全身弥漫性丘疹1年半.1年半前患者无明显诱因双小腿出现粟粒大小红色扁平丘疹,无自觉症状.皮疹逐渐增多并蔓延至整个双下肢.1年前,前胸、后背、腹部出现相似皮疹.     

Ascher综合征伴睑黄瘤一例

患者男,29岁,主诉双上睑下垂、黄斑伴口唇肿胀10年,于2010年5月13日至我科就诊.患者出生后双眼睑及口唇正常.10年前无明显诱因出现双上睑反复水肿,开始时每次发作约2～3d后消退,曾多次就诊于当地医院,考虑为过敏,给予抗组胺药口服治疗,眼睑水肿仍反复发作.约半年后水肿不能自行消退,双上睑皮肤逐渐变薄,上睑下垂,睑内侧出现界限清楚的黄色斑块,同时口唇轻度肿胀,无明显自觉症状,视力无异常变化,不伴有其他全身症状.随年龄增长,双上睑皮肤明显变薄,可见皮下毛细血管,其上黄色斑块逐渐增大且高出皮面;口唇明显肿胀,以上唇明显,微笑时口唇明显外翻.患者系足月顺产,一般情况良好,智力正常,近年在外地打工,无特殊不良嗜好.父母非近亲结婚,家族中无类似疾病患者,无特殊遗传疾病病史.     

球形孢子丝菌致面部孢子丝菌病

正患者女,56岁,农民。主诉:右面部红色丘疹、斑块1年。现病史:患者于1年前无明显诱因右颊部出现一个针尖大小红色丘疹,后其周围出现类似几个丘疹,并逐渐增大融合成斑块,部分上覆少量黄色和暗红色痂,无明显瘙痒及疼痛。患者曾于外院就诊,具体诊断不详,未予治疗。后类似皮疹逐渐增多,向下蔓延至颏部     

结节性黄瘤1例

患者 女,16岁。因双肘关节伸侧皮肤增厚3年、股部黄色斑块2年就诊。3年前患者无明显诱因双肘关节伸侧各出现一拇指头大淡黄红色结节,周围散在或呈片状淡黄色丘疹或斑片,双上肢属侧有条状、片状黄色斑片或斑块,无自觉症状,未进行治疗、2年前双股后侧出现小儿拳头大及不规则黄红色或黄色结节、斑块。既往患风湿性心脏病7年,有高胆固醇血症,平素喜高脂饮食,家族中其祖母有高胆固醇血症。[第一段]     

单侧痣样黑棘皮病1例

<正>患者女,18岁。因右背部斑疹4年于2009年11月就诊。患者4年前无明显原因发现右背出现黑褐色斑丘疹,逐渐增多,无自觉症状,呈带状分布。曾于本市一家医院就诊,诊断为表皮痣,未予治疗。患者既往身体健康,其他部位无类似病史。患者家族中无类似病史。体格检查:系统检查无明显异常。皮肤科检查:右背部可见带状分布的多个褐色扁平斑块及扁平丘疹,大小不一(图1)。皮损组织病理检查:表皮角化过度,棘层肥厚,乳头瘤样增生,表皮突延长,基底层黑     

New fillers for the new man

ABSTRACT:  Two new collagen-based lidocaine-containing dermal fillers, ArteSense™/ArteFill™ (Artes Medical, San Diego, CA) and Evolence® (Colbar LifeScience Ltd., Herzliya, Israel), have proved to be of particular interest to men, many of whom seek a long-lasting or permanent correction. ArteFill™ has been available in the United States since 2006, and it is expected that Evolence® will reach the American market in 2008. The properties of the two products will be described, and experience based on the administration of many hundreds of syringes of both products by a Canadian dermatologist will be detailed here, with tips and precautions to optimize patient outcomes.     

Outcomes and adverse effects of ablative vs nonablative lasers for skin resurfacing: A systematic review of 1093 patients

It is generally believed that ablative laser therapies result in prolonged healing and greater adverse events when compared with nonablative lasers for skin resurfacing. To evaluate the efficacy of ablative laser use for skin resurfacing and adverse events as a consequence of treatment in comparison to other modalities, a PRISMA‐compliant systematic review (Systematic Review Registration Number: 204016) of twelve electronic databases was conducted for the terms “ablative laser” and “skin resurfacing” from March 2002 until July 2020. Studies included meta‐analyses, randomized control trials, cohort studies, and case reports to facilitate evaluation of the data. All articles were evaluated for bias. The search strategy produced 34 studies. Of 1093 patients included in the studies of interest, adverse events were reported in a total of 106 patients (9.7%). Higher rates of adverse events were described in nonablative therapies (12.2% ± 2.19%, 31 events) when compared with ablative therapy (8.28% ± 2.46%, 81 events). 147 patients (13.4%) reported no side effects, 68 (6.22%) reported expected, transient self‐resolving events, and five (0.046%) presented with hypertrophic scarring. Excluding transient events, ablative lasers had fewer complications overall when compared with nonablative lasers (2.56% ± 2.19% vs 7.48% ± 3.29%). This systematic review suggests ablative laser use for skin resurfacing is a safe and effective modality to treat a range of pathologies from photodamage and acne scars to hidradenitis suppurativa and posttraumatic scarring from basal cell carcinoma excision. Further studies are needed, but these results suggest that ablative lasers are a superior, safe, and effective modality to treat damaged skin.     

Genetic alterations in RAS‐regulated pathway in acral lentiginous melanoma

Studies integrating clinicopathological and genetic features have revealed distinct patterns of genomic aberrations in Melanoma. Distributions of BRAF or NRAS mutations and gains of several oncogenes differ among melanoma subgroups, while 9p21 deletions are found in all melanoma subtypes. In the study, status of genes involved in cell cycle progression and apoptosis was evaluated in a panel of 17 frozen primary acral melanomas. NRAS mutations were found in 17% of the tumors. In contrast, BRAF mutations were not found. Gains of AURKA gene (20q13.3) were detected in 37.5% of samples, gains of CCND1 gene (11q13) or TERT gene (5p15.33) in 31.2% and gains of NRAS gene (1p13.2) in 25%. Alterations in 9p21 were identified in 69% of tumors. Gains of 11q13 and 20q13 were mutually exclusive, and 1p13.2 gain was associated with 5p15.33. Our findings showed that alterations in RAS‐related pathways are present in 87.5% of acral lentiginous melanomas.     

Self‐resolving superficial primary cutaneous mucormycosis in a 7‐week‐old infant

A 7‐week‐old girl, born at 30 weeks' gestational age, presented to clinic for evaluation of a crop of vesicular lesions that were noted after removal of a bandage that had been in place for 4 days. A punch biopsy of the lesion revealed fungal elements that were later identified as Rhizopus spp. The lesion began to self‐resolve, and no further treatment was needed, with full resolution of the lesion by 1 month after presentation. Clinicians should be aware of the variable presentations of mucormycosis and consider fungal infection in the differential diagnosis when evaluating vulnerable patients with skin eruptions.     

Multiple New-Onset Subcutaneous Nodules of the Upper Extremity Digits: Giant Cell Tumor of Tendon Sheath and Lipoma

A black woman with the concurrent onset of two subcutaneous nodules located on the digits of her upper extremities is described. Initially, a single systemic disorder was considered; yet, the lesions differed in morphology and consistency. Microscopic examination of the nodules showed a giant cell tumor of tendon sheath and a lipoma. Although Occam's “razor” suggests that multiple lesions in the same person are more likely to represent variable manifestations of a single disorder than several different diseases in that individual, the simultaneously appearing lesions in this patient represented two different conditions.