Prostate cancer with penile metastasis: a case report

A 77-year-old man presented with complaints of dysuria, nocturia and painless nodule on his penis. Laboratory examination revealed elevated serum prostate-specific antigen (PSA) and CA19-9. Pathological examinations on prostate and penile biopsy specimens revealed prostate adenocarcinoma with penile metastasis. The patient was diagnosed as having prostate cancer stage D2 (T4N1M1) with bone, lymph node and penile metastases. There was no response to initial hormonal therapy with the surgical castration and diethylstilbestrol. However, decrease of the tumor size, as well as PSA and CA19-9 values were achieved after the combined chemotherapy with Estramustine, Paclitaxel and Carboplatin.     

Bladder cancer with skin metastasis: a case report

Bladder carcinoma with skin metastasis is extremely rare. We herein report a case of a bladder tumor with skin metastasis. A 68-year-old man was referred to our hospital with macroscopic hematuria. Cystoscopy revealed a trigone papillary tumor. Transurethral resection of bladder tumor (TURBT) was performed and the pathological diagnosis was transitional cell carcinoma (TCC), pT1, G3. Thereafter, he received several courses of TURBT, intravesical chemotherapy (pirarubicin, bacillus Calmette-Guerin and mitomycin C) and intra-arterial chemotherapy because of recurrence. Thirteen years later, he underwent total cystoprostatectomy with neobladder formation. Histological examination revealed muscle-invasive bladder cancer with a staging of T3bNOM0. Two years and three months later, multiple firm nodules with eruptions appeared on the skin in several regions; they were resected and the histological findings revealed TCC. This indicated metastatic spread from the primary bladder TCC. He received only supportive treatment during this period due to renal dysfunction. He died four months after the manifestation of the skin metastasis due to multiple metastases.     

Solitary thyroid metastasis from colorectal cancer: Case report

Introduction and importanceThyroid metastasis of colorectal cancer is rare and the patient with thyroid metastasis has no symptoms early in the disease course. On the other hand, evaluation of thyroid is not generally included in the routine follow-up of colorectal cancer. Therefore, the diagnosis of thyroid metastasis of colorectal cancer may be delayed.Presentation of caseChest computed tomography revealed a nodule on the right lobe of the thyroid in 53-year-old woman diagnosed with sigmoid colon adenocarcinoma. This nodule was identified having as increased metabolic activity by ¹⁸F-fluorodeoxyglucose positron emission tomography-computed tomography and confirmed to be consisted of cystic and solid portions by ultrasonography. Fine needle aspiration cytology of the nodule revealed metastasis of colon cancer. The patient underwent laparoscopic anterior resection and a total thyroidectomy. The size of the thyroid tumor was 1.2 cm with free resection margin.DiscussionThe clinical features of thyroid metastasis from colorectal cancer are not typical. In addition, follow-up examinations of patients with colorectal cancer do not include imaging studies of the neck, so the diagnosis of thyroid metastases is delayed. The management strategies for thyroid metastasis from colorectal cancer include a total thyroidectomy without prophylactic neck lymph node dissection and chemotherapy. However, as the penetration of chemotherapeutic drugs into the thyroid is difficult, the effect on the thyroid is considered insignificant.ConclusionSurgical treatment should be considered for treatment of thyroid metastasis.     

Tardive cecal metastasis from ovarian cancer: a case report

Intestinal insolvement is a frequent sequela of metastatic ovarian cancer may be syncronous or following ovaric resection, after several years of disease free condition. The authors herein describe a clinical report of a case of cecal metastatic neoplasm due to ovarian cancer treated with surgical resection 24 years before.     

Solitary ureteral metastasis from cervical cancer: a case report

A case of solitary ureteral metastasis from cervical cancer in a 36-year-old female is reported. On April 4, 1988, the patient visited the gynecological department of our hospital with abnormal genital bleeding. Colposcopy and cervical biopsy revealed invasive cervical cancer, and computerized tomography (CT) indicated right hydronephrosis. She was referred to the urological department for further examinations. Right retrograde pyelography (RP) however could not be performed. On April 13, 1988, the patient underwent laparotomy due to acute abdomen, which was proved to be caused by subileus. On exploration, a tumor was found in the lower one third section of the right ureter, whereupon a right nephroureterectomy was performed because primary ureteral tumor was suspected. The histology of the ureteral tumor revealed it to be a metastatic squamous cell carcinoma identical to that obtained from punch biopsy of the cervix. At that time, a hysterectomy could not be done because of invasive cervical cancer. Following the operation, radiation therapy was conducted for primary cervical cancer. At present, 7 months after the operation, the patient is alive with good performance status.     

Spermatic cord metastasis from colon cancer: report of a case

We herein report an extremely rare case of a solitary metastasis to the spermatic cord from colon cancer. A 71-year-old man who had undergone a right hemicolectomy for stage II cecal cancer 12 months prior, and who had not received adjuvant chemotherapy, was found to have a mass in the right groin region. Computed tomography (CT) revealed that the right spermatic cord was involved in a heterogeneously enhanced mass that measured 37 mm in diameter. A right high orchiectomy was performed. Histological examination of the resected tumor revealed well-differentiated adenocarcinoma compatible with a metastasis from colon cancer. The patient has been doing well, without recurrence, for 15 months postoperatively. To our knowledge, this is the 9th case of a solitary metastasis to the spermatic cord from colon cancer to be reported in the Japanese literature. The survival data of the collected cases suggest that resection of the solitary metastasis to the spermatic cord from colon cancer improves the patient prognosis.     

Solitary splenic metastasis from gastric cancer: report of a case

We report a rare case of metachronous and solitary metastasis to the spleen from gastric cancer. A 69-year-old man who had undergone a distal gastrectomy for gastric cancer 48 months earlier was found to have a solitary lesion in the spleen, and an increased serum carcinoembryonic antigen (CEA) level. The patient underwent a laparotomy for suspected metastasis to the spleen. At laparotomy, a tumor was found in the upper pole of the spleen without involvement of other organs, and a splenectomy was performed. Histological examination confirmed that the splenic tumor was a well-differentiated adenocarcinoma similar to the primary gastric cancer. The postoperative course was uneventful and his serum CEA decreased to within normal levels. The patient died of multiple metastases to the liver and peritoneal dissemination 40 months after the splenectomy. Received: May 31, 2000 / Accepted: January 9, 2001 Reprint requests to: K. Yamanouchi, 2nd Department of Surgery, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852-8102, Japan     

Pyogenic abscess in hepatic metastasis: unusual first manifestation of colorectal cancer. A case report

Pyogenic liver abscesses and colorectal cancer are rarely reported in association. Necrosis and infection of hepatic metastases from colorectal cancer are rare events which occur in the absence of systemic or local therapy. We report a case of a 72-year-old woman with a four day history of high fever, abdominal pain and a palpable mass in the right upper quadrant. Ultrasonography and CT scan showed a 13-cm solitary abscess in hepatic segment V-VI with multiple satellite metastases. For suspected imminent rupture into the peritoneal cavity a surgical drain was performed. Colorectal cancer was discovered during abdominal exploration and a colon resection was performed two weeks later. The search for the underlying cause of the pyogenic liver abscess should be an integral part of the correct management of liver abscesses. Association with a colorectal cancer is rare but should be taken into consideration.     

卵巢癌术后孤立性脾脏转移一例

正非血液系统的恶性肿瘤很少发生脾脏转移,其中以乳腺癌、肺癌、结直肠癌和黑素瘤较多见,而卵巢癌术后发生孤立性脾脏转移极其罕见。绝大多数的卵巢癌术后孤立性脾转移的患者没有症状,也没有相关特异性影像学表现,虽然肿瘤标志物CA125可用于辅助诊断该病,最终确切诊断需依赖病理组织学和免疫组织化学,需要与脾淋巴管瘤、脾囊肿、脾淋巴瘤、脾脓肿等相鉴别。在治疗方面首选手术切除,术后可辅以化疗。现就吉林大学第一医院收治的一例卵巢癌术后孤立性脾转移的病例报道     

A case report: Renal metastasis of prostate cancer

In this report, a rare case of renal metastasis of prostate cancer in a 55-year-old man is presented.     

Tuberculosis nearly preventing a curative resection for colorectal liver metastasis: A case report

Perihepatic lymph node involvement portends a poor prognosis, and is reported to be the most important prognostic factor following R0 resection of colorectal liver metastases. Tuberculous lymphadenitis is one of the common presentations of tuberculosis and is often diagnosed only after histopathological confirmation. In this patient, a frozen section revealing tuberculosis in the perihepatic nodes allowed us to proceed with the curative liver resection.     

Rectal metastasis of prostatic cancer causing annular stricture: a case report

A 61-year-old man diagnosed with poorly differentiated adenocarcinoma of the prostate (T4 NxM0, stage C) underwent endocrine therapy. The reduction of the tumor was recognized but soon annular rectal stricture appeared. In spite of the subsequent chemotherapy, symptoms aggravated. Then total pelvic exenteration and colostomy were performed. Prostate was easily separated from the rectal wall and the tumor continuity was not proved. Immunohistochemical inspection indicated that the origin of the tumor cells of the rectum was the prostate. Histopathological examination of the rectum using the step section method showed no trace of cancer invasion but many cancer cells in the intramural lymphatic duct. We concluded that adenocarcinoma of the prostate metastasized to the rectum by way of lymphatic flow and caused the annular stricture of the rectum.     

Sternal metastasis of breast cancer; report of a case

A 51-year-old woman presented with a painful sternal lump. Nine years earlier she had undergone right modified mastectomy for breast cancer, followed by chemotherapy. Computed tomography and bone scintigraphy demonstrated a solitary sternal bone metastasis. The patient was treated by partial sternectomy. Thereafter, the sternal defect was reconstructed with Marlex mesh and rectus abdominis myocutaneous flap. The postoperative course was uneventful. The patient subsequently developed brain metastasis and died within 52 months after sternal resection. The stability of the chest wall was well preserved for the duration of follow-up.     

Rectal metastasis from lung cancer; report of a case

A 70-year-old male underwent left pneumonectomy for lung cancer in November 2008. Although he was diagnosed as pT2bN1M0 (stage II B) after the operation, adrenal metastasis was found 8 months later. Positron emission tomography (PET) revealed accumulation in the adrenal gland and rectum. Gastrointestinal tract examination revealed a type 1 tumor in the rectum. Histological examination of biopsy specimens obtained from the lesion suggested papillary adenocarcinoma of rectum. Abdominoperineal resection was performed. The resected rectal tumor was reported immunohistochemically as metastasis from primary lung cancer.     

化学感受器瘤颈椎转移1例报告

正化学感受器瘤(chemodectoma)是指颈动脉化学感受器及其同类组织细胞发生的肿瘤。1950年由Mulhgan首次命名报道,又称为颈动脉体瘤(carotid body tumour)或副神经节瘤(paragangliom)。这是一种罕见的肿瘤,仅占全部嗜铬细胞瘤10%~15%~([1])。化学感受器瘤大多为非功能性,以良性居多,仅有5%~10%为恶性,可经淋巴或血行转移至中纵隔及后纵隔的脊柱旁沟,后者相对较多,脊柱转移较为少见,颈椎转移更为罕见。在近30年文献中,国内     

Osteoplastic bone metastasis in esophageal squamous cell cancer: report of a case

This report presents a case of esophageal squamous cell cancer with osteoplastic bone metastasis. A 58-year-old male patient underwent multimodality treatment for esophageal cancer. Sclerotic changes resembling bone metastasis from prostate cancer were detected in the 4th thoracic and the 5th lumber vertebral body soon after the adjuvant chemoradiotherapy. Systemic examinations revealed no primary cancer as a cause of osteoplastic bone metastasis and no esophageal cancer recurrence. A needle biopsy revealed metastases of esophageal squamous cell cancer with osteoplastic changes. Multiple sclerotic changes were detected in the systemic bones at that time, and new carcinomatous bilateral pleural effusion developed. The drastic systemic progression of the cancer caused the rapid deterioration of the patient's general condition.     

Isolated cervical metastasis of breast cancer: a case report and literature review

Metastasis of distant malignancies to the cervix is a rare event. Patients usually present with abnormal bleeding, pain, and dyspareunia. A smaller number of patients are asymptomatic, and their tumors can be diagnosed early by Pap smears. We present 56-year-old woman with a history of intraductal breast cancer that presented with vaginal bleeding. Colposcopic pathology and fractional curettage revealed a lesion similar to her primary breast cancer. She underwent an extensive workup and hysterectomy that revealed no other lesions. Currently, she is alive and well. Cervical metastasis should be considered in women with a history of breast cancer who present with vaginal bleeding. Aggressive treatment of isolated cervical metastasis from breast cancer is warranted in appropriate patients.     

Vesicorectal fistula caused by pelvic metastasis of penile cancer: a case report

A 65-year-old man was referred to our hospital complaining of glans induration. Tumor biopsy revealed squamous cell carcinoma. Although he was given radiation therapy and subcutaneous injection therapy of bleomycin, viable cancer cells remained. Then he was given combination chemotherapy of bleomycin and cisplatin, and paint therapy of bleomycin ointment. Local recurrence with a cauliflower-like tumor occurred five years after the chemotherapy. Then we performed total penectomy and reconstructive surgery of penis. Five years later, discharge of urine from anal appeared. Computerized tomography of pelvis demonstrated a mass 3 cm in diameter in the anterior portion of anal and cystogram demonstrated a vesicorectal fistula. We tried to perform fistulectomy, but foiled because of large fistula. Then we inserted a urethral catheter, which resulted in obstruction of fistula by its balloon, and we made a cystostomy for securing urinary tract. Pathological examination of tissue around the fistula revealed squamous cell carcinoma. His quality of life was improved, but his general condition became worse gradually and he died of cancer.     

结直肠癌根治术后单纯性肺转移60例临床病例分析

目的:结直肠癌患者根治术后大约有50%会发生远处转移,最常见的转移部位是肝,其次是肺,本文旨在探讨结直肠癌根治术后肺转移的特点、治疗效果和影响预后的因素.方法:随访1967年至2002年间的结直肠癌根治术后发生单纯性肺转移的60例病例,对其临床资料进行回顾性分析和总结.结果:自原发灶切除术后全组病例中位生存时间 37 个月,其中有15例行转移灶的切除手术,中位生存 51个月;其余 45例行非手术治疗,中位生存34 个月;转移瘤大于3个组生中位生存时间 30月,转移瘤小于等于3个组中位生存时间43个月.患者的总生存率可能和是否手术、转移灶的个数有关,而年龄、性别、原发灶病理类型、分期、转移灶大小对生存率无明显影响.结论:结直肠癌根治术后单纯性肺转移的积极治疗是有效的,手术及转移灶个数可能是影响治疗效果的因素.