消化系统肿瘤与ABO血型相关性分析

目的分析食管癌、贲门癌、胃癌三种消化系统肿瘤发生率与ABO血型的相关性。方法对2012年6月至2016年8月由冀中能源峰峰集团有限公司总医院确诊的食管癌、贲门癌、胃癌共700例患者的ABO血型分布进行统计分析,并选择同时期邯郸市中心血站的健康献血者700例作为对比参照,分析ABO血型与消化系统肿瘤的相关性。结果邯郸市健康献血者血型分布:B型 O型 A型 AB型,食管癌、胃癌患者血型分布:A型 O型 B型 AB型,贲门癌患者血型分布:B型O型 A型 AB型;食管癌、胃癌患者ABO血型分布与健康人群存在明显差异(P 0. 05),贲门癌患者与健康人群的ABO血型分布无显著差异(P 0. 05);食管癌、胃癌的发生均与A型血呈正相关性(P 0. 05),与B型、O型、AB型血呈负相关性(P 0. 05),但贲门癌的发病率与B型血呈正相关性(P 0. 05),与A型、O型、AB型血呈负相关性(P 0. 05)。结论 A型血相比其他血型人群罹患食管癌和胃癌的风险较高,而B型血人群发生贲门癌的风险相对较高。     

包虫病与血型关系的初步调查

516例包虫病患者,男251例(A型血型68例,B型96例,O型57例,AB型30例);女265例(A型血型60例,B型109例,O型76例,AB型20例)。两性间血型分布均匀,无显著性差异(P>0.05)。 包虫病组516例中,A型128例,B型205例,O型133例,AB型50例;与对照组2301例中,A型651例,B型723例,O型684例,AB型243例间,ABO血型分布有显著性差异(X~2=35.7956,P>0.005)。     

十二指肠球部溃疡与ABO血型相关性探讨

目的从幽门螺杆菌（H.pylori）感染角度，探讨ABO血型鉴定与十二指肠球部溃疡（DU）相关性。方法收集2000—2005年本院120例Du患者资料，与本院门诊300例健康对照组比较血型分布的差别。利用快速尿素酶及C^13呼吸试验确定Du组不同血型者Hp感染并进行比较。结果Du组O型血占58．3％，明显高于O型血在正常人群中分布（30．0％），差异有统计学意义（P〈0．05）。结论O型血者是Du患者的高危人群，临床上应重视O型血患者Hp感染情况，及时诊疗。     

肝硬化与ABO血型的相关性分析

探讨肝硬化与ABO血型的相关性。检测640例肝硬化患者ABO血型，并与对照组进行比较。显示：①朝鲜族肝硬化患者较朝鲜族对照组A型血型显著为多，而汉族肝硬化患者ABO血型分布与汉族对照组比较无显著性差异；②肝硬化合并原发性肝癌(PHC)者较未合并PHC者B血型显著为多，O血型显著为少；③男女肝硬化患者ABO血型分布无显著性差异。提示：肝硬化患者ABO血型分布与民族、是否合并PHC等因素有密切关系，而与性别无明显关系。     

闽南地区汉族人群消化性溃疡与ABO血型和幽门螺杆菌感染的相关性研究

目的探讨闽南地区汉族人群消化性溃疡(peptic ulcer,PU)与ABO血型和幽门螺杆菌(Helicobacter pylori,H.pylori)感染的关系。方法回顾分析2003年11月-2014年12月收治的闽南地区370例汉族PU患者作为溃疡组,选取同期且同地区3 155名健康汉族志愿者作为对照组,比较分析两组ABO血型与H.pylori感染的相关性。结果溃疡组370例患者中,O型血者184例(49.73%),对照组O型血者1 251例(39.65%),溃疡组明显高于对照组(P0.05);溃疡组患者O型血H.pylori感染患者比例(144/370,38.92%)高于对照组(838/3 155,26.56%),溃疡组患者A型血H.pylori感染患者比例(51/370,13.78%)低于对照组(602/3 155,19.08%),差异均有统计学意义(P0.05)。结论闽南地区汉族人群PU与ABO血型和H.pylori感染具有一定的关系,其中O型血人群存在PU和H.pylori感染的风险较高,A型血溃疡患者H.pylori感染的风险较低。     

ABO血型与急性非ST段抬高型心肌梗死的相关性分析

目的:探讨中国人群中ABO血型与急性非ST段抬高型心肌梗死(NSTEMI)的相关性。方法:回顾性分析北京安贞医院2013-01至2014-12收治入院的1 039例NSTEMI患者(病例组)和经冠状动脉(冠脉)造影证实冠脉正常的1 039例患者(对照组)的ABO血型的临床资料。观察记录研究对象的临床资料,包括年龄既往病史及ABO血型等。采用Logistic回归模型进行单因素及多因素分析。结果 :在病例组和对照组中:A血型287例(27.6%)和259例(24.9%),B血型345例(33.3%)和356例(34.3%)AB血型102例(9.8%)和114例(11.0%),O血型305例(29.4%)和310例(29.8%),两组ABO血型分布差异无统计学意义。按A血型与非A血型、B血型与非B血型、AB血型与非AB血型和O血型与非O血型分析,在两组间分布差异均无统计学意义(P0.05)。经多因素Logistic回归分析,在调整年龄、性别、高血压病、糖尿病、高脂血症脑血管疾病和吸烟等心肌梗死危险因素后,模型显示A、B及AB血型者罹患NSTEMI的风险与O血型者相似;A、B AB及O血型与NSTEMI的发生均没有相关性。结论:ABO血型与NSTEMI的发生无关。     

消化性溃疡与ABO血型、Lewis表型分布及幽门螺杆菌感染的相关性研究

目的探讨消化性溃疡（PU）与ABO血型、Lewis表型的分布及幽门螺杆菌（H．pylori）感染的关系。方法70例消化性溃疡患者为研究组,96例健康志愿者为对照组,比较ABO血型、Lewis表型分布和H．pylori感染的差异。结果PU组O型血者占52．9％,明显高于O型血在正常人群中的分布（31．3％,P〈0．05）;在非O型血患者中Lewis表型为Le（a＋b＋）者占51．5％,明显高于Le（a＋b＋）表型在对照组非O型血中的频率（9．1％,P〈0．001）。PU组不同ABO血型者H．pylori感染率比较无统计学差异（P〉0．05）;PU组Le（a-b＋）表型者H．pylori感染率为67．6％,明显高于其他Lewis表型（P〈0．05）。结论ABO血型中O型血者易患消化性溃疡,且非O型血Lewis表型为Le（a＋b＋）者也是消化性溃疡的高危人群。ABO血型间H．pylofi感染比较无显著性差异,Le（a-b＋）表型可能是H．pylori感染的一个危险因素。     

胃癌患者的ABO血型分布及临床特点分析

目的探讨胃癌患者的ABO血型分布及临床特点。方法选择400例胃癌患者的住院病历资料,分析其ABO血型;比较前后5年患者的ABO血型分布,分析后5年患者的一般情况、首发症状、病理特点。结果与前5年比较,后5年A型血检出率明显减少(41.5%vs 23.5%,P<0.01),O型血检出率明显增多(27.5%vs 42.5%,P<0.01),B型、AB型血无统计学差异。后5年中,各血型患者的首发症状均以上腹痛、腹胀、纳差、体质量下降为主;B型血低分化腺癌患者明显高于A型血患者(68.1%vs 36.1%,P<0.05),70.7%浸润深度达全层,且66.4%有淋巴结转移;累及周围组织的AB型血患者明显高于B型血患者(61.5%vs 25.5%,P<0.05)。结论前后5年胃癌患者的ABO血型分布发生了变化;提示非遗传因素对胃癌发病的影响逐渐增强,血型可能与肿瘤的生物学行为有关。     

影响十二指肠球部溃疡发病的ABO血型因素分析

目的　从胃酸及幽门螺杆菌 (H·pylori)感染角度探讨ABO血型影响十二指肠球部溃疡 (DU)发病的因素。方法　取 1995～ 2 0 0 3年 80例DU患者入选为DU组并比较其与北京地区 10 6 1位健康对照者血型分布的差别。比较DU组不同血型发病年龄。利用快速尿素酶实验、病理学及13 C呼吸实验确定DU组不同血型者H·pylori感染率并进行比较 ;利用 2 4h胃pH监测比较DU组不同血型者一天中不同时项胃pH分布。结果　DU组O型血者占 5 6 3% ,明显高于O型血在正常人群中的分布 2 8 7% (χ2 =2 6 6 9,P <0 0 0 5 )。不同血型者DU平均发病年龄差异无显著性 (P >0 0 5 )。DU组不同血型者H·pylori感染率无统计学差别 (P >0 0 5 ) ;且一天中直立位 (主要指白天空腹时 )、卧位 (主要指夜间 )、进餐期及餐后期各时段胃内平均pH值及胃内pH值在 0～ 1,0～ 2 ,0～ 3,0～ 4……的累计时间百分比无统计学差别 (P >0 0 5 )。结论　O型血者易患DU不是通过影响H·pylori感染率或胃酸分泌来起作用的。O型血可能是DU发病的另一独立危险因素。O血型DU发病年龄不早于其他血型。其致病机制仍有待进一步研究。     

中国人群ABO血型与HBV感染及乙型病毒性肝炎发生的Meta分析

目的从循证医学角度评价中国人群ABO血型与乙型肝炎病毒(HBV)感染及乙型病毒性肝炎之间的相互关系。方法通过检索可得的中英文数据库,收集我国不同区域发表的关于ABO血型与HBV或乙型病毒性肝炎关系的病例对照研究。采用R软件对其进行Meta分析。结果中国人群中ABO血型与HBV的感染无关。ABO血型与乙型病毒性肝炎具有相关性,B型血个体较非B型血个体发生乙型病毒性肝炎的风险差异有统计学意义,OR=0.9047,95%CI (0.8328;0.9828),P值为0.0177,0.05。结论 HBV感染与ABO血型之间无相关性,但ABO血型与乙型病毒性肝炎相关,B型血的人群感染HBV后更不容易发展成为乙型病毒性肝炎。     

Seroprevalence of Helicobacter pylori in school-aged Chinese in Taipei City and relationship between ABO blood groups

AIM: To explore the seropositive rate of antibodies against H. pylori (anti-HP) in Taipei City and to compare the relationship of ABO blood groups and H. pylori infection. METHODS: In 1993, high school students in Shih-Lin District were randomly selected for blood samplings by their registration number at school. In addition, similar procedures were performed on the well-children clinics of Taipei Veterans General Hospital. Besides, randomly selected sera from the adults who took the physical examination were recruited for evaluation. Informed consents were obtained from all the subjects before blood samplings and parents were simultaneously informed for those who were younger than 18-year-old. Blood tests for anti-HP and ABO blood groupings were performed by enzyme-linked immunosorbent assay. Chi square tests were used for the comparisons between seroprevalence of H. pylori and ABO blood groups. RESULTS: Totally, 685 subjects were recruited (260 children aged 1-14 years, 425 high school students aged 15-18 years) were evaluated, and another 88 adult healthy volunteers were studied as well for comparison. The age-specific seropositive rate of anti-HP was 1.3 % at age 1-5 years, 7.7 % at age 6-10 years, and 11.5 % at age 11-14 years. The seroprevalence of H. pylori infection was abruptly increased in young adolescence: 18.6 % at age 15 years, 28.1 % at age 16 years, 32.4 % at age 17 years and 41.0 % at age 18 years, respectively. In the 425 high school students, ABO blood groupings were performed, which disclosed 48.5 % (206/425) of blood group O, 24 % (102/425) of blood group A, 21.8 % (93/425) of blood group B and 5.6 % (24/425) of blood group AB. In comparison of the subjects with blood group O and the other blood groups, no statistical significance could be identified in the seroprevalence of H. pylori (P=0.99). CONCLUSION: The seroprevalence of H. pylori infection in Taipei City in adults is similar to the developed countries, and the abrupt increase of H. pylori during high school may be resulted from marked increase of interpersonal social activities. Although blood group O was reported to be related to H. pylori infection in previous literature, we found no association between H. pylori infection and ABO blood groups.     

Peptic ulcer bleeding: interaction between non-steroidal anti-inflammatory drugs, Helicobacter pylori infection, and the ABO blood group system

BACKGROUND: Helicobacter pylori infection is found in almost all patients with an uncomplicated ulcer. Non-steroidal anti-inflammatory drug (NSAID) use is the main risk factor for bleeding peptic ulcer. In the older literature ABO blood groups were mentioned as a risk factor. There is continuing uncertainty about the interaction between these risk factors and the development of peptic ulcer bleeding. We therefore determined the separate and combined effect of NSAIDs, H. pylori infection, and the ABO blood group system in patients with a bleeding peptic ulcer. METHODS: The prevalence of NSAID use, H. pylori infection, and blood group O was determined in 227 patients who were admitted with a bleeding gastric or duodenal ulcer between 1990 and 1997. These results were compared with the expected frequency of these risk factors in the Dutch population. RESULTS: NSAID use was reported in 48.2% of the patients with a bleeding peptic ulcer. The H. pylori prevalence was 62.0%, whereas blood group O was present in 49.3% of the patients. NSAID use was the strongest risk factor for hemorrhage caused by a peptic ulcer (relative risk, 8.4), whereas the relative risk associated with H. pylori infection and blood group O was 1.5 and 1.2, respectively. With univariate analysis NSAID use and H. pylori infection seemed to be separate risk factors and did not really potentiate each other's effect. Moreover, blood group O did not potentiate the strong effect of NSAIDs. CONCLUSION: H. pylori infection may add only a little to the important risk of NSAID use in the development of bleeding peptic ulcers.     

幽门螺杆菌感染与肠易激综合征关系研究

目的研究幽门螺杆菌(H.pylori)感染与肠易激综合征(IBS)之间的关系。方法随机选取肠易激综合征患者40例为实验组,另选取40例正常健康者为对照组,应用13C尿素呼气试验及快速尿素酶法分别测定二者的H.pylori感染率。并根据检测结果将26例H.pylori阳性的IBS患者随机分为观察组(13例)和对照组(13例),观察组加用根除H.pylori药物治疗2周,观察其疗效。结果 IBS患者中的H.pylori感染率(65.00%)明显高于对照组(42.50%),二者相比差异有统计学意义(P<0.05)。H.pylori阳性的IBS患者,观察组治疗有效率(92.31%)明显高于对照组(38.46%),差异有统计学意义(P<0.05)。结论 H.pylori感染与肠易激综合征之间有一定关系,根除H.pylori可能在IBS的治疗中起一定作用。     

克拉霉素、甲硝唑和兰索拉唑联合治疗幽门螺杆菌感染的临床疗效观察

目的：本文报道克拉霉素与甲硝唑及兰索拉唑联合应用治疗ＨＰ阳性的十二指肠溃疡。方法：５９例符合条件的病人随机分成两个治疗组，其中３０例口服充拉霉素２５０ｍｇ，甲硝唑４００ｍｇ，兰索拉唑３０ｍｇ。另一组２９例口服克拉霉素５００ｍｇ，甲硝唑４００ｍｇ．兰索拉唑３０ｍｇ，用法均为每日２次，疗程１周，继而口服兰索拉唑３０ｍｇ，每日１次，共１周。疗程结束后１个月复查胃镜。结果：克拉霉素１０００ｍｇ组ＨＰ根除率及溃疡愈合率分别为９３．１％及８９．７％，稍高于克拉霉素５００ｍｇ组的７６．７％及８０．０％，但差异无显著性（Ｐ＞０．０５）。体外检测。克拉霉素ＨＰ耐药发生率仅４．８％，而甲硝唑ＨＰ耐药发生率则达３３．３％，且甲硝唑耐药对ＨＰ根除率有较大影响。两组病人副反应总发生率为１５．３％，克拉霉素两个剂量组间副反应发生率无明显差别，未发现严重副反应。病人依从性良好。结论：克拉霉素与甲硝唑及兰索拉唑合用１周疗法有较理想的溃疡愈合率与ＨＰ根除率；克拉霉素用量以每日１０００ｍｇ为佳。     

不同疗程三联方案根除幽门螺杆菌后的复发情况

目的观察不同疗程奥美拉唑三联方案根除幽门螺杆菌(Hp)后的复发率。方法Hp阳性的干二指肠溃疡103例患者,随机分为二组:A组50例;B组53例。均给予奥美拉唑20 mg(每日2次)、阿莫西林1.0 g(每日2次)、呋喃唑酮0.1 g(每日3次),A组疗程2周,B组疗程1周。观察2组Hp根除率、溃疡复发率、3年Hp复发率及不良反应。结果A组Hp根除率、溃疡愈合率、Hp根除者3年累积复发率分别为92.0%、96.0%、8.7%;B组分别为88.7%、92.5%、12.8%,两组三项差异均无显著性(P>0.05)。结论1周和2周疗程方案近、远期疗效相同,但1周疗程方案疗程短,病人依从性好,费用减半,效-价比优于2 周疗程方案。     

Association of gastroduodenal disease phenotype with ABO blood group and Helicobacter pylori virulence-specific serotypes

AIMS: To investigate the prevalence of Helicobacter pylori infection in Lebanon and the association between virulence factors (cytotoxin-associated gene A and vacuolating cytotoxin gene A), ABO blood groups, and disease phenotype. METHODS: One hundred and thirty symptomatic patients with H. pylori-associated endoscopic findings and 104 healthy male donors (age range 18-55) were evaluated. Both, patients and donors underwent ABO blood typing and Western blot for cytotoxin-associated gene A and vacuolating cytotoxin gene A. RESULTS: The prevalence of H. pylori infection in healthy donors is 68.3%. Type I (cytotoxin-associated gene A- and vacuolating cytotoxin gene A-positive) was the predominant phenotype in all groups, though significantly less common in the asymptomatic population (46.5%) than in patients with benign disease (71.4%, p<0.01) or malignancy (71.6%, p<0.05). Type II (cytotoxin-associated gene A- and vacuolating cytotoxin gene A-negative) and vacuolating cytotoxin gene A-only strains were more common in the asymptomatic cohort. Overall, 35.2% of asymptomatic individuals and 10.8% of patients with benign disease were cytotoxin-associated gene A-negative (p<0.01). There was no significant association between immunoserotypes, ABO groups or benign gastroduodenal disease. All gastric malignancies (lymphoma and adenocarcinoma) were cytotoxin-associated gene A-positive but this was not significantly different from patients with benign disease. We found a higher prevalence of blood group A in patients with gastric malignancy than in the general population [47.6% versus 25%, p=0.037; RR=2.73 (1.04-7.16; 95% CI)]. CONCLUSIONS: The seroprevalence of H. pylori is moderately high in Lebanon. Phenotypic classification identifies a higher prevalence of Type I in symptomatic patients. A significant relationship between infection with a cytotoxin-associated gene A-positive strain in blood type A patients and the risk of gastric malignancy was noted.     

The Relationship of ABO Blood Group,Age, Gender,Smoking, and <Emphasis Type="Italic">Helicobacter pylori</Emphasis> Infection

It is well known that blood group antigens are related to the development of peptic ulcer and gastric carcinoma. This study sought to determine the relationship between H. pylori and ABO/Rhesus blood groups, age, gender, and smoking. Patients (335 women and 205 men; mean age, 51.68 ± 15.0 years; range, 18–85 years) who attended our outpatient clinic were enrolled in the study. All patients were randomly selected in each age group. Demographic data recorded for each patient included age, gender, and tobacco use. Blood samples were tested for H. pylori antibodies, and ABO/Rhesus blood group antigen typing was performed. Serum antibodies were tested against H. pylori infection. Prevalences of all blood groups were O (29.2%), A (38.2%), B (17.8%), and AB (14.8%). As expected from previous studies, we found that seropositivity for H. pylori increased with age. H. pylori Ig G antibody positivity was detected in 185 of 335 women (60.6%), compared with 88 of 205 men (42.9%), a statistically significant difference (P < 0.05). H. pylori Ig G antibody positivity was detected in 206 of 379 nonsmokers (54.3%) compared with 67 of 161 smokers (41.6%), a statistically significant difference (P < 0.05). Patients in blood groups A and O were more prone to H. pylori infection than were patients in other blood groups (P < 0.05), and patients in the AB blood group were less prone to H. pylori infection compared with patients in other blood groups (P < 0.05). The results of this study demonstrate that H. pylori infection can be related to ABO blood group, age, gender, and smoking.     

幽门螺杆菌阳性的疣状胃炎治疗112例

目的:了解疣状胃炎与H pylori感染的关系方法:胃镜确诊H pylori阳性的疣状胃炎患者112例随机分组,分别以雷贝拉唑钠、阿莫西林、克拉霉素根除H pylori治疗(A组)和雷贝拉唑钠抑酸治疗(B组).治疗后1 mo评价症状、胃镜改善情况和H pylori根除情况.显效者随访至治疗后6 mo再次评价症状和胃镜改善情况、检测H pylori.结果:治疗1 mo后A组症状和胃镜改善情况明显好于B组,两组比较有显著性差异(89.3% vs 75.0%;91.1% vs 76.8%,P<0.05).所有显效者随访至治疗后6 mo,A组复发率11.1%,B组复发率50.0%,A组明显低于B组.两组复发者H pylori均为阳性,未复发者H pylori阳性率为37.7%,二者对比有显著性差异(P<0.05).结论:疣状胃炎与H pylori感染密切相关.     

胃食管反流病与幽门螺杆菌感染的关系探讨

目的探讨胃食管反流病与幽门螺杆菌感染之间的相关性。方法将经过电子胃镜确诊的GERD患者120例及对照组轻度慢性浅表性胃炎患者120例予血清幽门螺杆菌抗体检测和14C呼气试验法进行H.pylori检测,对比两组H.pylori感染情况;将90例反流性食管炎患者分为LA-A、B组及LA-C、D组,对比两组H.pylori感染情况;将120例GERD患者分为轻度症状组、中度症状组、重度症状组及极重度症状组,比较组间H.pylori感染情况。结果 GERD组H.pylori感染的阳性率(39.17%)低于对照组H.pylori感染的阳性率(62.50%),差异有统计学意义(P<0.05)。LA-A、B组H.pylori感染的阳性率(60.87%)高于LA-C、D组H.pylori感染的阳性率(29.55%),差异有统计学意义(P<0.05)。轻度症状组、中度症状组、重度症状组及极重度症状组H.pylori感染的阳性率分别是40.00%、41.67%、40.63%、31.82%。结论幽门螺杆菌感染是反流性食管炎的保护因素,幽门螺杆菌感染与GERD症状的发生无相关性。