动脉瘤栓塞术联合脑脊液置换治疗动脉瘤性蛛网膜下腔出血的效果分析

目的探讨动脉瘤栓塞术联合脑脊液置换治疗动脉瘤性蛛网膜下腔出血的临床效果。方法选取2013年3月至2016年9月平顶山市第一人民医院收治的动脉瘤性蛛网膜下腔出血患者160例,随机分为研究组和对照组,研究组接受动脉瘤栓塞术联合脑脊液置换治疗,对照组仅接受动脉瘤栓塞术治疗,比较两组患者脑脊液恢复正常时间、治疗效果及不良反应发生情况。结果研究组脑脊液恢复正常时间短于对照组,差异有统计学意义(P<0.05);研究组治疗总有效率(96.3%)高于对照组(85.0%),差异有统计学意义(P<0.05);研究组不良反应发生率(2.5%)低于对照组(11.3%),差异有统计学意义(P<0.05)。结论动脉瘤栓塞术联合脑脊液置换治疗动脉瘤性蛛网膜下腔出血,能缩短患者脑脊液恢复正常时间,提高治疗效果,减少不良反应的发生,值得临床推广应用。     

腰大池脑脊液持续外引流治疗外伤性蛛网膜下腔出血临床评价

目的探讨腰大池脑脊液持续外引流对外伤性蛛网膜下腔出血患者的治疗效果。方法将天津市天和医院2005年1月～2009年7月收治的48例外伤性蛛网膜下腔出血患者,按照治疗方法分为2组。治疗组24例采用腰大池脑脊液持续外引流,对照组24例每天行腰穿术放脑脊液。对2组的疗效进行比较分析。结果治疗组在缩短头痛、脑膜刺激征和血性脑脊液转清时间、减少并发症及增加GOS评分良好率上优于对照组。结论腰大池脑脊液持续外引流是治疗外伤性蛛网膜下腔出血的有效方法。     

持续腰大池引流术治疗蛛网膜下腔出血

目的 探讨腰大池引流血性脑脊液在治疗蛛网膜下腔出血(SAH)中的价值.方法 对采用腰穿置管引流方法的24例患者进行回顾性研究,观察其临床疗效及并发症情况.结果 腰大池引流血性脑脊液治疗蛛网膜下腔出血疗效确切,治疗效果良好,并发症少.结论 通过腰大池引流血性脑脊液治疗SAH,具有操作简便、安全可靠、创伤小、效果确切、并发症少等优点,可推广应用.     

介入栓塞治疗动脉瘤性蛛网膜下腔出血的临床疗效

目的探讨介入栓塞治疗动脉瘤性蛛网膜下腔出血的临床疗效。方法选取2015年5月至2018年12月就诊于本院的动脉瘤性蛛网膜下腔出血患者共30例作为研究对象,将其随机分为实验组和对照组,各15例。给予对照组患者常规手术夹闭法治疗,给予实验组介入栓塞治疗,比较两组患者近期预后质量及术后并发症发生率。结果两组患者近期预后质量比较,实验组明显优于对照组(P0.05);两组术后并发症发生率比较,实验组明显低于对照组(P0.05)。结论应用介入栓塞技术治疗动脉瘤性蛛网膜下腔出血效果显著,能明显提升患者预后质量,降低术后并发症发生率,治疗安全性高,具有推广应用价值。     

107例动脉瘤性蛛网膜下腔出血后脑血管痉挛的预防及治疗体会

目的探讨颅内动脉瘤性蛛网膜下腔出血后脑血管痉挛的预防及治疗方法。方法对107例颅内动脉瘤性蛛网膜下腔出血患者的临床资料进行回顾性分析。107例均在出血后早期（72 h内）行介入动脉瘤栓塞术或开颅动脉瘤夹闭术。术后均给予尼莫地平持续泵入扩血管、脑脊液引流、3-H疗法等治疗。结果共发生症状性血管痉挛53例,37例恢复良好,13例中重度残疾,3例死亡。104例患者随访3个月未发现再出血。结论尽早行开颅动脉瘤夹闭术或介入动脉瘤栓塞术,术后给予尼莫地平持续泵入、脑脊液引流、3-H疗法等是治疗和预防动脉瘤破裂引起的蛛网膜下腔出血后脑血管痉挛的有效方法。     

早期腰大池持续引流治疗外伤性蛛网膜下腔出血

目的探讨早期腰大池脑脊液持续外引流对外伤性蛛网膜下腔出血的治疗作用。方法将外伤性蛛网膜下腔出血患者135例随机分为两组，治疗组69例早期行腰大池脑脊液持续外引流，对照组66例采用每天腰穿术放脑脊液。结果治疗组患者的头痛、脑膜刺激征、血性脑脊液转清、CT恢复正常的时间均缩短。结论早期腰大池置管脑脊液持续外引流，对外伤性蛛网膜下腔出血的治疗，具有疗效满意，操作简单，易于推广的特点。     

自发性蛛网膜下腔出血合并脑积水行脑室引流加早期介入治疗的临床研究

目的蛛网膜下腔出血后常并发脑积水及脑血管痉挛,早期形成急性脑积水给以脑室外引流,早期介入栓塞动脉瘤,防止再出血,可以降低致残率和致死率.方法对35例自发性蛛网膜下腔出血的患者,入院后头颅CT显示自发性蛛网膜下腔出血合并脑积水,急诊行脑室外引流术引流血性脑脊液,降低颅内压缓解脑血管痉挛,病情缓解后尽早行全脑血管造影,诊断为动脉瘤患者行介入栓塞,防止动脉瘤再次破裂.结论自发性蛛网膜下腔出血合并脑积水,可引起急性颅内压增高,急诊行脑室外引流可迅速降低颅内压缓解脑血管痉挛,但减压后待患者病情平稳,应早期行介入栓塞动脉瘤,防止动脉瘤再次破裂,可降低致死率和致残率.     

脑动脉瘤性蛛网膜下腔出血患者血管栓塞介入治疗的疗效

目的 探讨血管栓塞介入治疗脑动脉瘤性蛛网膜下腔出血的临床疗效.方法 选取2018年5月至2020年5月本院收治的62例脑动脉瘤性蛛网膜下腔出血患者作为研究对象,随机分为对照组(传统开颅手术)和研究组(血管栓塞介入),每组31例.比较两组临床疗效、手术指标及并发症发生情况.结果 研究组治疗总有效率高于对照组(P<0.05);研究组手术时间、术后恢复时间均短于对照组,研究组术中出血量少于对照组(P<0.05);研究组并发症发生率低于对照组(P<0.05).结论 血管栓塞介入治疗脑动脉瘤性蛛网膜下腔出血患者疗效显著,能显著改善手术指标,降低患并发症发生风险,值得临床推广.     

蛛网膜下腔出血动脉瘤介入治疗的临床分析

目的 分析蛛网膜下腔出血动脉瘤介入治疗的临床效果.方法 回顾性分析我院收治的72例蛛网膜下腔出血动脉瘤患者的临床资料,根据治疗方法不同将患者分为治疗组和对照组各36例,其中对照组患者在神经外科显微镜下进行外科手术治疗,治疗组患者采用微弹簧圈血管内介入栓塞治疗,比较两组患者术后的临床效果和不良反应发生情况.结果 术后治疗组患者的临床收益率63.89%,对照组患者的临床收益率36.11%,两组比较差异有统计学意义（P〈0.05）;治疗组患者的总不良反应发生率8.33%,显著低于对照组患者19.44%（P〈0.05）.结论 介入治疗蛛网膜下腔出血动脉瘤相对于神经外科手术治疗临床效果显著,且微创安全.     

血管介入治疗动脉瘤性蛛网膜下腔出血36例

目的:探讨血管内介入栓塞治疗动脉瘤性蛛网膜下腔出血的临床疗效。方法:回顾性分析血管内介入栓塞治疗的36例动脉瘤性蛛网膜下腔出血患者的临床资料,观察其疗效及并发症。结果:36例患者,45个动脉瘤,均给与100%致密栓塞,术中出血死亡1例,术后脑梗死2例,脑血管痉挛1例,随访1年无动脉瘤复发。结论:血管内介入治疗颅内动脉瘤性蛛网膜下腔出血创伤小,成功率高,术后并发症少,效果满意。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.     

Scientific principles and rigorous processes should be followed in developing clinical guidelines for therapeutic interventions of integrative medicine

A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care（~＇4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.