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The aim was to give a systematic presentation of physiologic and pathologic calcifications and ossifications in the face and
neck with a special emphasis on clinical relevance. In a sometimes subacute setting one should recognize specific calcifications
which often lead to important diagnoses such as fungal sinusitis or sclerosing labyrinthitis. In a more chronic situation
intraocular calcifications in small children are pathognomonic for retinoblastoma. Juxtatumoral sclerosis of the laryngeal
cartilage in laryngopharyngeal carcinoma is usually caused by tumor infiltration of the cartilage resulting in a higher tumor
stage and, this way, has a major impact on the therapeutical strategy. Calcified lymph nodes are mainly unspecific but can
be the result of tuberculosis or metastases of thyroid cancer. Cross-sectional imaging methods, most of all computed tomography,
are ideally suited to reveal head and neck calcifications and ossifications, especially those which are clinically relevant. 相似文献
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This article discusses the imaging manifestations of infectious and inflammatory conditions of the head and neck. Special attention is paid to the sites, routes of spread, and complications of neck infections. Because the clinical signs and symptoms and the complications of these conditions are often determined by the precise anatomic site involved, anatomic considerations are stressed. Familiarity with the fascial layers, spaces of the neck, and the contents of each space is helpful for this discussion. The fascial layers of the neck are important barriers to infection, and once infection is established, the fascial layers play a part in directing its spread. 相似文献
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Management of benign and malignant diseases of the pancreas, liver, and biliary tract has made remarkable progress in the last two decades. Advances in minimally invasive surgery, interventional radiology, and diagnostic and therapeutic endoscopy have changed the treatment of common diseases such as cholelithiasis and more serious diseases such as pancreatic adenocarcinoma. Advances in biliary tract and pancreatic surgery have paralleled the advances in ultrasonographic imaging, CT, and MR imaging. This article outlines the surgeon's perspective on radiologic imaging and preoperative staging of benign and malignant biliary and pancreatic disease. 相似文献
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目的:分离纯化幽门螺杆菌分泌和重组表达的细胞空泡毒素抗原( VacA)蛋白,并评价其致细胞空泡效应及致细胞凋亡效应。方法分别从幽门螺杆菌ATCC26695菌株培养上清和重组表达VacA蛋白的pQE30-VacA-E.coliM15基因工程菌中分离纯化VacA蛋白,经酸化后,以不同终浓度(5,10 ng/ml)分别与人胃腺癌AGS细胞共孵24 h,观察致空泡效应,并通过流式细胞术检测细胞凋亡。结果成功分离纯化出幽门螺杆菌分泌和重组表达的VacA蛋白;幽门螺杆菌分泌的VacA蛋白能显著引起AGS细胞的空泡样改变及凋亡(P<0.01),而重组表达的VacA蛋白致细胞空泡样改变及凋亡不显著( P>0.05)。结论幽门螺杆菌分泌的VacA蛋白有良好的空泡毒性及致凋亡效应,而重组表达的VacA蛋白无致空泡及凋亡效应,幽门螺杆菌分泌的VacA蛋白可用于VacA作用机制的研究。 相似文献