复方聚乙二醇电解质散与硫酸镁在结肠镜检查病人肠道准备中的应用效果

[目的]探讨硫酸镁与复方聚乙二醇电解质散(PEG)两种泻药在结肠镜检查肠道准备中应用的效果。[方法]选择2015年1月—2015年6月住院行结肠镜检查的407例病人,将2015年1月—2015年3月住院行结肠镜检查的196例病人作为对照组,将2015年4月—2015年6月住院行结肠镜检查的211例病人作为观察组,对照组肠道准备采用硫酸镁口服,观察组肠道准备采用复方聚乙二醇电解质散口服,比较两组病人的肠道准备清洁度、不良反应发生率、服药依从性及病人满意度。[结果]观察组肠道准备清洁合格率、病人依从性及满意度高于对照组,肠道准备不良反应发生率低于对照组,经比较差异均有统计学意义(P0.05)。[结论]复方聚乙二醇电解质散用于结肠镜检查病人行肠道准备,肠道清洁度好,不良反应发生率低,病人依从性及满意度高,效果明显优于口服硫酸镁。     

复方聚乙二醇电解质散与硫酸镁在结肠镜检查前肠道准备中的效果比较

目的:比较口服复方聚乙二醇电解质散与口服25%硫酸镁在结肠镜检查前肠道准备中的清肠效果及安全性.方法:把524例结肠镜检查患者分成两组.研究组264例,检查前口服复方聚乙二醇电解质散;对照组260例,检查前口服25%硫酸镁进行肠道准备.观察两组肠道清洁度及不良反应情况.结果:研究组的肠道清洁有效率为97.7%,对照组为84.6%,研究组高于对照组(P=0.043).研究组不良反应发生率为25.8%,对照组为43.8%,研究组低于对照组(P=0.016).结论:与口服25%硫酸镁相比,口服复方聚乙二醇电解质散清洁肠道有较好的效果和较高的安全性.     

复方聚乙二醇电解质散用于肠道准备的临床观察

[目的]观察复方聚乙二醇电解质散用于肠镜检查前肠道准备的效果及伴随症状和心理反应。[方法]对我院干部病房和消化科102例准备行肠镜检查的住院病人按入院顺序分为两组，分别用复方聚乙二醇电解质散（Ⅰ组）和20％硫酸镁溶液加清洁灌肠（Ⅱ组）进行肠道准备，观察两组服药后伴随症状和心理反应、排便情况及镜检效果。[结果]Ⅰ组肠道准备效果明显好于Ⅱ组，差异有统计学意义（P〈0．01）；两组肠道准备中伴随症状、排便情况和紧张恐惧心理差异也有统计学意义（P〈0．01）。[结论]复方聚乙二醇电解质散用于肠镜检查前肠道准备，不仅完全达到肠镜检查要求的清洁标准，而且副反应轻，病人易于接受。     

复方聚乙二醇电解质散用于结肠镜检查前肠道准备效果观察

目的:探讨复方聚乙二醇电解质散用于结肠镜检查前肠道准备的效果和安全性.方法:将拟行结肠镜检查的128例患者随机分为研究组与对照组各64例,研究组采用口服复方聚乙二醇电解质散溶液进行肠道准备,对照组采用番泻叶加甘露醇溶液进行肠道准备.比较两组肠道清洁效果,服药后排便时间和恶心呕吐、腹胀腹痛、乏力、饥饿感等不良反应的发生情况.结果:两组不良反应发生情况比较有极显著性差异﹙P﹤0.01﹚.结论:复方聚乙二醇电解质散是一种有效、快速、安全、副反应小、易被患者接受的肠道准备药.     

复方聚乙二醇电解质散用于肠道准备的临床观察

[目的]观察复方聚乙二醇电解质散用于肠镜检查前肠道准备的效果及伴随症状和心理反应.[方法]对我院干部病房和消化科102例准备行肠镜检查的住院病人按入院顺序分为两组,分别用复方聚乙二醇电解质散(Ⅰ组)和20%硫酸镁溶液加清洁灌肠(Ⅱ组)进行肠道准备,观察两组服药后伴随症状和心理反应、排便情况及镜栓效果.[结果]Ⅰ组肠道准备效果明显好于Ⅱ组,差异有统计学意义(P＜0.01);两组肠道准备中伴随症状、排便情况和紧张恐惧心理差异也有统计学意义(P＜0.01).[结论]复方聚乙二醇电解质散用于肠镜检查前肠道准备,不仅完全达到肠镜检查要求的清洁标准,而且副反应轻,病人易于接受.     

不同时间口服复方聚乙二醇电解质散进行肠道准备的效果观察

[目的]观察不同时间口服复方聚乙二醇电解质散进行肠道准备的效果。[方法]将180例结肠镜检查病人随机分为A组、B组、C组,每组60例,A组检查前1d20:00服用2盒复方聚乙二醇电解质散进行肠道准备,B组检查当天06:00服用2盒复方聚乙二醇电解质散进行肠道准备,C组检查前1d20:00及检查当天06:00各服用1盒复方聚乙二醇电解质散进行肠道准备。比较3组病人肠道清洁度和主观耐受度。[结果]3组病人肠道准备均符合要求,3组病人肠道清洁程度比较,差异无统计学意义(P>0.05);3组病人主观耐受度比较,差异有统计学意义(P<0.05),C组优良率高于A组、B组(P<0.05)。[结论]检查前1d20:00及检查当天06:00各服用1盒复方聚乙二醇电解质散进行肠道准备的效果满意,不良反应小、病人易于接受,是比较理想的结肠镜前肠道准备方法。     

复方聚乙二醇电解质散联合石蜡油在便秘患者肠道准备中的应用

目的观察便秘患者应用复方聚乙二醇电解质散(PEGP)联合石蜡油的肠道准备效果。方法将拟行结肠镜检查的便秘患者120例随机分为A和B两组。A组结肠镜检查前6 h口服PEGP278.24 g,B组口服PEGP 139.12 g,且检查前1 d口服石蜡油50 ml,1天2次,清洁肠道。两组均于检查前1 d进少渣饮食,检查当天禁食至检查结束。内镜医师记录患者耐受性、不良反应,肠镜检查时间,行Boston肠道准备量表(BBPS)和肠腔内气泡评分。结果肠道准备有效性方面,B组肠镜检查时间(7.25±0.60)min,少于A组(10.50±0.55)min(P0.05),B组BBPS总分(7.90±1.00)分,高于A组(6.35±1.25)分(P0.05),B组肠腔内气泡评分(0.35±0.55)分,低于A组(0.75±0.50)分(P0.05)。安全和耐受性方面,B组肠道准备接受率96.67%,高于A组65.00%(P0.05),B组再次肠道准备接受率90.00%,高于A组50.00%,B组总体不良反应评分(1.30±0.04)分,低于A组(1.85±0.25)分(P0.05)。结论便秘患者应用复方PEGP联合石蜡油肠道准备,能增强依从性及肠道准备效果,保障结肠镜检查。     

硫酸镁用于肠镜前肠道准备的临床效果研究

目的 探讨进行结肠镜检查的患者全肠道准备的最佳方法,以提高肠道检查及治疗的成功率,减少不适反应的发生.方法 选取准备进行结肠镜检查的患者120例,随机分为A、B、C 3组各40例,A组患者于检查当日晨口服硫酸镁100ml,服药后分次饮水6000ml;B组患者于检查前晚口服硫酸镁50ml并饮水2000ml,当日晨起口服硫酸镁50ml并分次饮水4000ml;C组患者于检查当日晨口服50%硫酸镁100ml,同时急饮4000～5000ml水.同时指导A、B2组患者进行适量活动及健康宣教,比较3组患者肠道准备的效果.结果 B组肠道清洁度优于其他2组(P<0.05),B组患者的不适反应较少,与C组相比差异有统计学意义(P<0.01).结论 早晚口服硫酸镁进行肠道准备可使肠道清洁度高,有利于观察病变部位,不适反应少,检查结果满意,患者容易接受.     

硫酸镁钠钾口服用浓溶液与复方聚乙二醇电解质散（Ⅳ）用于结肠镜检查前肠道准备的效果分析

目的 分析硫酸镁钠钾口服用浓溶液与复方聚乙二醇电解质散（Ⅳ）用于结肠镜检查前肠道准备的效果,为临床治疗提供参考。方法 选取2022年7月至2023年6月北京市健宫医院收治的240例行结肠镜检查的患者为研究对象,根据随机数字表法分为对照组与观察组,各120例。对照组患者采用复方聚乙二醇电解质散（Ⅳ）作为肠道清洁剂,观察组患者采用硫酸镁钠钾口服用浓溶液作为肠道清洁剂。比较两组患者肠道清洁情况、肠道准备效果、不良反应发生情况、电解质紊乱情况。结果 观察组患者肠道清洁效果优于对照组,治疗总有效率高于对照组（均P<0.05）;观察组患者右半结肠、横结肠、左半结肠波士顿肠道准备量表（BBPS）及总BBPS评分均高于对照组（均P<0.05）;观察组患者不良反应总发生率低于对照组（P<0.05）;两组患者电解质紊乱发生情况比较,差异无统计学意义（P>0.05）。结论 硫酸镁钠钾口服用浓溶液在结肠镜检查前的肠道准备效果优于复方聚乙二醇电解质散（Ⅳ）,且安全性较高,值得临床应用。     

分次与单次口服PEG-EP进行肠道准备的效果观察

目的探讨分次与单次口服聚乙二醇电解质散(PEG-EP)进行结肠镜检查前肠道准备的清洁效果和耐受性。方法将432例进行结肠镜检查的无症状个体,随机分为A组(分次口服)和B组(单次口服)。A组于检查前夜8时和检查当日5时分别口服半包PEG-EP,B组于检查当日5时一次性口服1包PEG-EP(65.56g/袋),比较两组肠道准备的清洁效果和不良反应的发生情况。结果 A组肠道准备的清洁效果优于B组(P0.05),A组患者的耐受性优于B组(P0.05)。结论与单次口服相比,分次口服PEG-EP,既可以保证更好的肠道清洁效果,又减少不良反应,患者耐受性好,容易接受,值得临床推广应用。     

Ascorbic acid and low-volume polyethylene glycol for bowel preparation prior to colonoscopy: A meta-analysis

AIM: To evaluate the benefits of low-volume polyethylene glycol (PEG) with ascorbic acid compared to full-dose PEG for colonoscopy preparation. METHODS: MEDLINE, Cochrane Central Register of Controlled Trials and Database of Systematic Reviews, CINAHL, PubMed, and recent abstracts from major conferences were searched (January 2012). Only randomized-controlled trials on adult subjects comparing low-volume PEG (2 L) with ascorbic acid vs full-dose PEG (3 or 4 L) were included. Meta-analysis for the efficacy of low-volume PEG with ascorbic acid and full-dose PEG were analyzed by calculating pooled estimates of number of satisfactory bowel preparations as well as adverse patient events (abdominal pain, nausea, vomiting). Separate analyses were performed for each main outcome by using OR with fixed and random effects models. Heterogeneity was assessed by calculating the I² measure of inconsistency. RevMan 5.1 was utilized for statistical analysis. RESULTS: The initial search identified 242 articles and trials. Nine studies (n = 2911) met the inclusion criteria and were analyzed for this meta-analysis with mean age range from 53.0 to 59.6 years. All studies were randomized controlled trials on adult patients comparing large-volume PEG solutions (3 or 4 L) with low-volume PEG solutions and ascorbic acid. No statistically significant difference was noted between low-volume PEG with ascorbic acid and full-dose PEG for number of satisfactory bowel preparations (OR 1.07, 95%CI: 0.86-1.33, P = 0.56). No statistically significant difference was noted between low-volume PEG with ascorbic acid and full-dose PEG for abdominal pain (OR 1.09, 95%CI: 0.81-1.48, P = 0.56), nausea (OR 0.70, 95%CI: 0.49-1.00, P = 0.05), or vomiting (OR 0.99, 95%CI: 0.78-1.26, P = 0.95). No publication bias was noted. CONCLUSION: Low-volume PEG with the addition of ascorbic acid demonstrates no statistically significant difference to full-dose PEG for satisfactory bowel preparation and side-effects.     

Same-day single-dose vs large-volume split-dose regimens of polyethylene glycol for bowel preparation: A systematic review and meta-analysis

BACKGROUNDSplit-dose regimens (SpDs) of 4 L of polyethylene glycol (PEG) have been established as the “gold standard” for bowel preparation; however, its use is limited by the large volumes of fluids required and sleep disturbance associated with night doses. Meanwhile, the same-day single-dose regimens (SSDs) of PEG has been recommended as an alternative; however, its superiority compared to other regimens is a matter of debate.AIMTo compare the efficacy and tolerability between SSDs and large-volume SpDs PEG for bowel preparation.METHODSWe searched MEDLINE/PubMed, the Cochrane Library, RCA, EMBASE and Science Citation Index Expanded for randomized trials comparing (2 L/4 L) SSDs to large-volume (4 L/3 L) SpDs PEG-based regimens, regardless of adjuvant laxative use. The pooled analysis of relative risk ratio and mean difference was calculated for bowel cleanliness, sleep disturbance, willingness to repeat the procedure using the same preparation and adverse effects. A random effects model or fixed-effects model was chosen based on heterogeneity analysis among studies.RESULTSA total of 18 studies were included. There was no statistically significant difference of adequate bowel preparation (relative risk = 0.97; 95%CI: 0.92-1.02) (14 trials), right colon Boston Bowel Preparation Scale (mean difference = 0.00; 95%CI: -0.04, 0.03) (9 trials) and right colon Ottawa Bowel Preparation Scale (mean difference = 0.04; 95%CI: -0.27, 0.34) (5 trials) between (2 L/4 L) SSDs and large-volume (4 L/3 L) SpDs, regardless of adjuvant laxative use. The pooled analysis favored the use of SSDs with less sleep disturbance (relative risk = 0.52; 95%CI: 0.40, 0.68) and lower incidence of abdominal pain (relative risk = 0.75; 95%CI: 0.62, 0.90). During subgroup analysis, patients that received low-volume (2 L) SSDs showed more willingness to repeat the procedure using the same preparation than SpDs (P < 0.05). No significant difference in adverse effects, including nausea, vomiting and bloating, was found between the two arms (P > 0.05).CONCLUSIONRegardless of adjuvant laxative use, the (2 L/4 L) SSD PEG-based arm was considered equal or better than the large-volume (≥ 3 L) SpDs PEG regimen in terms of bowel cleanliness and tolerability. Patients that received low-volume (2 L) SSDs showed more willingness to repeat the procedure using the same preparation due to the low-volume fluid requirement and less sleep disturbance.     

Efficacy of 1.2L polyethylene glycol plus ascorbic acid for bowel preparations

BACKGROUND A low-volume polyethylene glycol(PEG) solution that combines ascorbic acid with PEG-based electrolyte solution(PEG-ASC) is gaining mainstream acceptance for bowel preparation due to reduced volume and improved taste.Although several reports showed that bowel preparation with PEG-ASC volume lower than 2.0 L with laxative agents could be an alternative to traditional preparation regimen, the cleansing protocols have not been fully investigated.AIM To evaluate the cleansing efficacy of 1.2 L PEG-ASC solution comparing with 2.0 L PEG electrolyte(PEG-ELS) for bowel preparations.METHODS A randomized, single-blinded, open-label, single-center, non-inferiority study was conducted. In total, 312 Japanese adult patients(aged > 18 years) who underwent colonoscopy were enrolled. Patients were randomly allocated to bowel lavage with either 1.2 L of PEG-ASC solution with at least 0.6 L of an additional clear fluid(1.2 L PEG-ASC group) or 2.0 L of PEG-ELS(PEG-ELS group). Then, 48 mg of sennoside was administered at bedtime on the day before colonoscopy, and the designated drug solution was administered at the hospital on the day of colonoscopy. Bowel cleansing was evaluated using the Boston Bowel Preparation Scale(BBPS). The volume of fluid intake and required time for bowel preparation were evaluated. Furthermore, compliance, patient tolerance,and overall acceptability were evaluated using a patient questionnaire, which was assessed using a visual analog scale.RESULTS In total, 291 patients(1.2 L PEG-ASC group, 148; PEG-ELS group, 143) completed the study. There was no significant difference in successful cleansing, defined as a BBPS score ≥ 2 in each segment, between the two groups(1.2 L PEG-ASC group, 91.9%; PEG-ELS group, 90.2%; 95%CI:-0.03-0.09). The required time for bowel preparation was significantly shorter(164.95 min ± 68.95 min vs 202.16 min± 68.69 min, P < 0.001) and the total fluid intake volume was significantly lower(2.23 L ± 0.55 L vs 2.47 L ± 0.56 L, P < 0.001) in the 1.2 L PEG-ASC group than in the PEG-ELS group. Palatability, acceptability of the volume of solution, and overall acceptability evaluated using a patient questionnaire, which was assessed by the visual analog scale, were significantly better in the 1.2 L PEG-ASC group than in the PEG-ELS group(7.70 cm ± 2.57 cm vs 5.80 cm ± 3.24 cm, P < 0.001). No severe adverse event was observed in each group.CONCLUSION The 1.2 L PEG-ASC solution was non-inferior to the 2.0 L PEG-ELS solution in terms of cleansing efficacy and had better acceptability among Japanese patients.     

聚乙二醇电解质溶液在结肠镜检查前肠道准备中的应用与护理

目的研究口服聚乙二醇电解质溶液2 000 ml在肠镜检查前肠道准备中的效果和安全性。方法将100例行结肠镜检查的病人随机分为实验组和对照组,实验组口服聚乙二醇电解质溶液清肠,对照组口服电解质溶液加蓖麻油清肠。观察服药后的排便次数和性状,肠道清洁程度,病人服药后的反应,肠腔内气泡情况。服药前、结肠镜检查结束时分别测心率、血压,进行血、尿常规检查和电解质测定。结果实验组肠道准备时间较对照组明显缩短,两组差异有显著意义;两组清洁肠道有效率均达100%,无明显差异;不良反应实验组明显少于对照组;在耐受性方面,实验组优于对照组。结论口服聚乙二醇电解质溶液清洁肠道效果佳,安全性好,可替代我科传统的电解质溶液加蓖麻油清肠方法。     

肠道准备对钡剂灌肠造影效果影的观察

目的:探讨肠道准备对钡剂灌肠造影的效果影响。方法:将100例接受钡剂灌肠造影的病人随机分成实验组和对照组,实验组给予50％硫酸镁口服,对照组给予常规的清洁灌肠。结果:实验组的造影效果明显优于对照组(P<0.05)。结论:50％硫酸镁口服肠道准备具有简单方便、减少病人痛苦、清洁肠道效果好的优点。     

硫酸镁不同服用方法对静脉肾盂造影检查前肠道准备的效果评价

目的 探讨口服50%硫酸镁 60 ml后最佳的饮水量、饮水方式、饮水时限对静脉肾盂造影(intravenous pyelography,IVP)检查前肠道准备的效果分析.方法 将2009年6月至2010年2月准备行IVP检查的200例患者在知情同意的前提下喝完50%硫酸镁60 ml,并被分成4组.A组:1 h内分次大量口服1200 ml温开水;B组:1 h内小量任意服1200 ml温开水;C组:1 h内分次大量口服2000 ml温开水;D组:2 h内分次中量口服1200 ml温开水.然后将4组肠道准备的效果进行分析.结果 通过对各组的对比,A组在满意度、阅片有效度及胀气有效度等指标上要比其他组好.结论 服药后在1 h内分次大量口服1200 ml温开水能提高导泻的满意度、阅片的有效度、胀气的有效度,值得临床推广应用.

Abstract：

Objective To analyze optimal amount of drinking water,ways of drinking water,timelimit of drinking water on the effect of bowel preparation for intravenous pyelography (IVP) examination after oral administration of 50% magnesium sulfate 60 ml. Methods 200 patients who gave their consentfrom June 2009 to February 2010 drank 50% magnesium sulfate 60 ml for IVP check were divided into four groups. Group A: a large amount of graded oral administration of warm water 1200 ml within 1h; Group B: a small amount of oral administration of warm water 1200 ml within 1h;Group C: a large amount of graded oral administration of warm water 2000 ml within 1h; Group D: a medium amount of graded oral administration of warm water 1200 ml within 2 h. And then the bowel preparation effect of the four gro ups were analyzed. Results Through the comparison, group A was much better than the other groups on the aspects of cathartic satisfaction, the effective degree of reading films and flatulence. Conclusions To take a large amount of graded oral administration of warm water 1200 ml within 1h can improve cathartic satisfaction,the effective degree of reading films and flatulence.     

聚乙二醇电解质散在结肠镜检查前肠道准备中的应用

目的 :探讨聚乙二醇电解质散在结肠镜检查前肠道准备中的效果和安全性。方法 :4 4例接受结肠镜检查的病人随机分为A组和B组 ,A组口服聚乙二醇电解质散 ,B组口服Niflec。观察服药过程中排便情况 ,肠腔清洗效果和气泡存在情况。服药前和结肠镜检查结束后分别进行血尿常规、肝肾功能检查和电解质测定。结果 :两组病人在服药后约 1～ 1.5h开始排便 ,排便 3～ 5次后即可接受肠镜检查 ,清洁肠道的有效率均为10 0 % ,无 1例出现恶心、呕吐、腹痛和头痛等不良反应。两组在排便时间 ,肠腔清洗效果和实验室指标变化间比较均无显著差异。结论 :聚乙二醇电解质散应用于结肠镜检查前的肠道准备安全有效 ,准备时间短 ,不需要饮食限制 ,值得临床推广应用     

结肠镜术前肠道准备三种方案清洁效果的对比研究

目的 比较临床上常用的3种肠道准备方案的肠道清洁效果,寻求最快速有效的肠道准备方案。方法 对2017年5月至6月在江苏省人民医院消化科病房拟行肠镜检查的患者77例行不同方案的肠道准备,并按不同方案分为3组。第1组22例口服聚乙二醇电解质散2 L+乳果糖口服液6包单次服用;第2组31例口服聚乙二醇电解质散2 L+乳果糖口服液6包分次服用;第3组24例口服聚乙二醇电解质散3 L。观察患者服药后肠道准备的效果和不良反应情况。结果 肉眼观察肠道清洁有效的例数,第2组明显多于其他两组（P＜0.05）;肠镜下渥太华量表评分显示,第1组和第2组对比差异无统计学意义（P＞0.05）,第2组和第3组对比,差异有统计学意义（P＜0.05）,说明渥太华评分标准判断下,第2组优于第3组;服药不良反应率比较,第2组明显优于其他两组（P＜0.05）。结论 采用聚乙二醇电解质散2 L+乳果糖口服液6包分次服用方案进行肠道准备,具有较好的肠道清洁效果,不良反应少,患者更易接受。     

不同剂量的聚乙二醇电解质溶液在全结肠镜检查肠道准备中的效果

目的 探究不同剂量的聚乙二醇电解质溶液在全结肠镜检查肠道准备中的效果。方法 选取2016年1月-2017年1月消化内科收治的进行结肠镜检查的患者共9 000例,随机分为A组、B组和C组各3 000例。A组患者服用2L聚乙二醇电解质溶液,B组服用3L聚乙二醇电解质溶液,C组服用4L聚乙二醇电解质溶液,比较3组患者肠道清洁质量、全结肠镜检查时间、息肉检出率、不良反应的发生率以及患者的耐受性和依从性。结果 3组患者肠道清洁质量评分及息肉检出率比较,差异均无统计学意义,A组患者不良反应的发生率低于B组和C组;A组患者的依从性和耐受性高于B组和C组。结论 低剂量聚乙二醇电解质溶液不良反应的发生率较低,患者的依从性和耐受性好。