链霉素耳中毒患者的皮纹学研究

本文报告了257例汉族链霉素耳中毒患者的10项皮纹学参数。选择他们的正常同胞进行对比。男患者L~(?)指纹显著增高,W~S指纹显著减少,左手A~T和右手L~U频率也显著增高;女患者右手A~S频率显著增高;男女患者右手a—b嵴线数均显著高于正常对照;男患者左右手、女患者左手atd角显著大于正常同胞;男患者左右手主线横向指数都显著高于正常对照;男女患者左手主线指数分别明显偏高或偏低;男患者左右手I_3区和I_4区、女患者左手I_4区真实花样出现率都显著高于正常同胞。     

瑶、苗、壮彝族皮纹调查综合报告

本文采用油墨捺印法、按国内统一标准观察瑶、苗、壮、彝等族1300例中学生指端纹型并行总指纹嵴计数(TFRC)及a-b纹嵴计数:使用人类学仪器测量轴三叉距及掌长,计算t百分率(tpD):测量atd角,得出各族各项正常指标,为进一步调查先天性遗传性疾病的异常皮纹特征奠定基础。     

新疆医科大学513名维、汉族学生皮纹分析研究

目的 研究新疆医科大学维吾尔族与汉族学生皮肤纹理的差异与特异性.方法对513名新疆医科大学维、汉族在校生皮纹进行分析.结果 指纹类型以斗和箕最多,两者相加总数达到96.14%,而双箕、弓形纹少.男生平均指纹嵴纹数为142.60,女生平均指纹嵴纹数为133.18,汉族学生平均指纹嵴纹数为140.35,维吾尔族学生平均指纹嵴纹数为133.63.男、女之间及维、汉族学生之间指纹嵴纹数均存在差异(P＜0.05).男生平均atd角为42.29°,女生平均atd角为43.64°,汉族学生平均atd角为42.65°,维吾尔族学生平均atd角为43.06°,男、女生之间及维、汉族学生之间atd角差异均无统计学意义.结论 新疆医科大学男、女之间及维、汉族学生之间皮肤纹理存在差别.     

京族青少年学生手的皮纹学调查分析

对广西防城县父母均是京族、表型正常的青少年学生进行手的皮纹学调查.结果,指端纹型以斗型最多,占50.95%;其次为尺箕型,占45.02%;再次为桡箕型,占2.66%;最少为弓型,仅占1.37%.总指纹嵴计数(TFRC),男性为152.21条,女性为142.75条.a-b纹嵴计数,双手合计,男性为79.25条,女性为79.56条.atd角,双手合计,男性为82.73度,女性为86.31度.t比值,男性为15.34%,女性为17.21%.掌部真实花纹出现率依次为:第4指间区63.07%;小鱼际区13.07%;第3指间区9.34%,大鱼际/第1指间区4.98%;第2指间区1.04%.主线指数均值,左手为5.42,右手为7.37.掌褶纹出现率依次为:常见型61.62%;过渡Ⅰ型25.10%;过渡Ⅱ型9.96%;悉尼型2.49%;通贯型0.83%.     

冠心病患者止凝血与纤溶指标检测的临床意义

目的探讨冠心病患者内皮细胞功能、血小板活化、凝血因子活性、纤溶活性的变化及临床意义.方法134例冠心病患者,其中急性心肌梗死(AMI)组49例、不稳定心绞痛(UA)19例、稳定性心绞痛(SA)组66例,应用ELISA法检测血管性血友病因子(vWF:Ag)、P-选择素(P-selectin)、组织因子(TF)、组织因子途径抑制物(TFPI)及D-二聚体(D-D),应用Clauss法检测纤维蛋白原含量(Fg),并比较各指标在冠心病患者与正常对照者(n=40)的差别.结果所有冠心病患者的各项止凝血和纤溶指标均高于正常对照组.AMI组和UA组各项指标与正常对照组比较有显著性差异(P＜0.05);SA组除D-D与正常对照组比较无显著性差异外,各项指标与正常对照组比较均有显著性差异(P＜0.05).AMI组与UA组比较,Fg、vWF:Ag、TFPI、TF有显著性差异(P＜0.05),而P-selectin二组间无显著性差异(P＞0.05).UA组与SA组比较,P-selectin、D-D二组间有显著性差异P＜0.05),而vWF:Ag、TFPI、TF二组间无显著性差异(P＞0.05).结论冠心病患者存在着内皮细胞损伤、血小板活化、凝血激活和继发性纤溶活性增高,且各项指标异常程度与冠心病严重程度相一致(AMI＞UA＞SA)     

辽宁地区满族正常人皮纹学分析

本文报告了辽宁地区472名满族人的正常皮纹学参数: 指纹型中尺箕占49.06％,斗型纹45.15％,桡箕占2.78％,弓形纹2.01％;民族指数((2W+L)/(10))为14.21;总嵴纹数126.05±35.76(SD);a—b峭纹数是66.36±8.91(SD)双手指间区Ⅰ、Ⅱ、Ⅲ和Ⅳ的真实皮纹型频率分别是0.32％、0.85％、8.37％和51.80％;大、小鱼际区皮纹型频率分别是7.94％和16.63％;atd角平均为38.91±4.84度(SD);正常掌褶纹型占82.94％.通贯手,过渡Ⅰ、Ⅱ型和悉尼型分别占2.97％、11.23％、2.01％和0.85％。所有的皮纹学参数均进行了性别间,左右手间和民族间比较分析。     

云南省少数民族肤纹研究 景颇族496例肤纹正常值测定

本文首次报告景颇族皮肤9项正常参数: (1)各型指纹百分频率:(2)指纹隆线总数;(3)atd角均值:(4)a-b隆线数;(5)主线横向指数;(6)小鱼际区真实花纹出现率;(7)大鱼际/I_1、区真实花纹出现率;(8)指间区真实花纹出现率;(9)通贯手出现率。与汉族资科作了对比,除a-b隆线数、指间区真实花纹及通贯手3项无显著差异外,其他6项皆有显著差异或高度显著差异。     

糖尿病患者肤纹的研究 1.手的纹理

本文调查了31例糖尿病患者12项肤纹参数,对各型指纹百分频率、各手指各种纹型百分频率、左右手相对应手指各种指纹组合格局百分频率、手指纹类型≥8和=10者出现频数及百分频率、手掌各主线走向频数和百分频率分布、轴三角百分距离tPD和atd角和a-b脊纹数(a-bRC)以及掌纹等9项进行了调查和测量,其参数与正常人对比经统计学处理差异不显著。其中:轴三角tPD和atd角的相对频数分布常态曲线二者皆呈正偏态。将二组数据间按回归分析得直线回归方程,回归系数b的t值为5.3113(P<0.001)两组相关系数r值为0.6855(P<0.01),表明二者高度相关。观察值的变异系数tPD大于atd角,表明atd角分布范围较小,比较稳定。指脊纹总数(TRC)、通贯手(猿线)和指(Ⅱ-Ⅴ)单屈纹的频率等参数值偏高,TRC均值为145.23±6.25,有猿线的人占64.52％,指远侧指间关节单屈纹频率为62.50％。糖尿病人此三项的参数值高于正常人群,差异显著,可成为糖尿病患者肤纹的主要特征,并可供临床关于糖尿病辅助诊断参考的标准。     

重点高中学生皮纹与智商相关性研究

目的通过对南开中学高中生指掌嵴纹与智商相关性关系的研究，为临床智力水平的判定提供参考依据。方法用碳沫-透明胶带法和直接观察法，以普通校同龄的学习能力较差的学生作对照组，观察了重点中学（包括数学特长班）学生的指掌嵴纹指标，筛选出差异较大的皮纹参数进行统计学处理。用瑞文推理测试及相应软件包分析，测出以上两组学生的智商，并同中考成绩做相关分析。结果重点高中学生总指嵴数，第Ⅱ指基部嵴线数，a-b嵴线数均高于对照组，差异有非常显著或显著性。ATD角（双手）均小于对照组，差异亦有非常显著性。两组的中考成绩及智商差异均有非常显著性，智商与中考成绩呈正相关。结论重点中学学生智商普遍高于普通校，且具一定表皮嵴纹特征，学生的智商部分与遗传有关，再次证明皮纹与智商有相关性。     

血清C反应蛋白、高半胱氨酸与B型尿钠肽联合检测在冠心病中的临床意义

目的 通过对血清C反应蛋白(CRP)、高半胱氨酸(HCY)与B型尿钠肽(BNP)联合检测分析冠心病患者病情严重程度,探讨其临床意义.方法 回顾性分析我科室收治的188例冠心病患者及98例健康体检者的临床资料,比较两者CRP、HCY、BNP水平差异,并进行统计学分析.结果 ①稳定型心绞痛组CRP与正常对照组比较升高差异有显著性(P＜0.05),不稳定型心绞痛组、急性心肌梗死组CRP与正常对照组比较明显升高,差异有高度显著性(P＜0.01).②稳定型心绞痛、不稳定型心绞痛组、急性心肌梗死组三组HCY均明显升高(P＜0.01),且升高幅度依次明显递增.③稳定型心绞痛组BNP与正常对照组比较升高差异有显著性(P＜0.05),不稳定型心绞痛组、急性心肌梗死组BNP明显升高(P＜0.01),且升高幅度依次递增,尤以急性心肌梗死组升高极为显著.结论 血清CRP、HCY和BNP三者联合检测,可提高冠心病患者的诊断价值及病情程度,可作为冠心病测定的常用检测指标.     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.     

Scientific principles and rigorous processes should be followed in developing clinical guidelines for therapeutic interventions of integrative medicine

A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care（~＇4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.