Exploring Lay Definitions of Asthma and Interpersonal Barriers to Care in a Predominantly Puerto Rican, Inner-City Community

Lay definitions of asthma were elicited through a single open-ended question from a population-based sample of mostly Puerto Rican, inner-city residents in Buffalo, New York. One hundred fifty-five household responses to the question, “What do you think asthma is?” were analyzed qualitatively using the editing approach. Five common codes emerged in order of significance: “symptoms,” “disease,” “triggers,” “threat,” and “coping.” Overall, expressions of illness reflected a largely symptomatic perception of asthma regardless of asthma status. Perceptions of “disease” increased with higher level of education. Patients' definitions of illness should be considered to help reduce interpersonal barriers to asthma care.     

Beliefs That Support the Behavior of People with Asthma: A Qualitative Investigation

Differences between patients' knowledge and behavior in relation to asthma may account for continuing morbidity in the face of professional and public asthma education campaigns. We conducted a qualitative study of beliefs that support asthma-related behavior, obtaining data from interviews with 70 adult patients. Analysis identified four clear subgroups, or “streams,” of adults with asthma: an “anonymous” stream, who doubt that they have asthma and manage symptoms outside the organized health system; an “isolated” stream, who feel dependent on bronchodilators and do not understand the potential of preventive therapy; a “suboptimal” stream, who are confident that they are managing their asthma effectively but who are excessively reliant on bronchodilators; and an “optimal stream,” who have high expectations of outcomes and participate actively in a partnership with a doctor. Characteristics of the doctor and the doctor–patient relationship are important elements in altering asthma-related behavior in ways that may facilitate the best health outcomes.     

Factors Associated with Asthma Control among Adults in Five New England States, 2006–2007

Background. Despite the National Asthma Education and Prevention Program (NAEPP) guidelines that specify the goals of asthma control and management strategies, the number of patients with uncontrolled asthma remains high, and factors associated with uncontrolled asthma are unknown. Objective. The aim was to examine the relationship between asthma control and socio-demographic characteristics, health-care access and use, asthma education, and medication use among adults with active asthma residing in New England. Methods. Data from the 2006–2007 Behavior Risk Factor Surveillance System Adult Asthma Call-Back Survey were analyzed using multinomial logistic regression. Asthma control was categorized as “well controlled,” “not well controlled,” or “very poorly controlled” according to the NAEPP guidelines. Results. Of the respondents (n = 3079), 30% met the criteria for well-controlled asthma, 46% for not well-controlled asthma, and 24% for very poorly controlled asthma. Being of Hispanic ethnicity (odds ratio [OR] = 4.0; 95% confidence interval [CI] = 1.2–13.7), unemployed or unable to work (OR = 17.9; 95% CI = 6.0–53.4), high school educated or less (OR = 2.8; 95% CI = 1.6–4.7), current smokers (OR = 2.5; 95% CI = 1.3–5.1), or being unable to see a doctor or specialist for asthma care or unable to buy medication for asthma because of cost (OR = 7.6; 95% CI = 3.4–17.1) were associated with very poorly controlled asthma. In addition, having Coronary Obstructive Pulmonary Disease (COPD) (OR = 2.6; 95% CI = 1.5–4.5), two or more routine checkups for asthma (OR = 4.5; 95% CI = 2.3–8.9), or an emergency department visit, urgent care facility visit, and hospitalization in the past year (OR = 3.9; 95% CI = 2.1–7.3) were also associated with having very poorly controlled asthma. Using controller medication in the past year (OR = 2.6; 95% CI = 1.6–4.2) and taking a course on how to manage asthma (OR = 3.0; 95% CI = 1.2–7.8) were significantly associated with poor asthma control. Conclusion. The high prevalence (70%) of not well-controlled asthma and poorly controlled asthma in this study emphasizes the need to identify factors associated with poor asthma control for development of targeted intervention. A health policy of increasing asthma education, health-care access, and smoking cessation may be effective and result in better asthma control and management.     

Cost-effectiveness of asthma therapy: a comprehensive review

Background: Asthma has an important impact in terms of both direct and indirect costs. In Europe, the disease costs €?19?000 million a year. Moreover, the cost is greater among patients with severe uncontrolled asthma and is even higher when the work productivity is also taken into account. Improved control of the disease results in cost savings. In this context, cost-effectiveness and cost-utility studies offer important information for clinicians in deciding the best treatment options for asthmatic patients and contribute to ensure an efficient use of the available healthcare resources. Methods: An English and Spanish literature search using electronic search engines (PubMed and EMBASE) was conducted in peer-review journals, from 2009 to June 2014. In order to perform the search for the most suitable and representative articles, key words were selected (“asthma”, “cost-effectiveness”, “cost-utility”, “QALY”, “cost-benefit”, “economic impact of asthma” “healthcare cost”, “asthma treatment” and “work productivity with asthma”). Results: Two-hundred forty-three titles and abstracts were identified by the primary literature search. The full text of the potentially 76 eligible papers was reviewed, and 22 articles were qualified to be finally included. Conclusions: This article provides a comprehensive review on the evidence of cost-effectiveness of asthma treatments derived from the published literature and offers an overall summary of the socioeconomic burden of asthma and its relationship with the degree of disease control. Management alternatives, such as the use of combination therapy with ICS/LABA or omalizumab, when administered according to their current therapeutic indications, have been shown to be cost-effective.     

Living with Asthma: An Analysis of Patients' Perspectives

Objectives. To investigate asthmatic patients’ perceptions of their disease. Methods. The study was done with the participation of 23 patients among the asthmatics whose progress is monitored regularly in a university hospital. Phenomenological methodology was used, and the first step was to determine the socio-demographic characteristics of the participants. Then, in order to determine their feelings and opinions on the subject of their asthma, each participant was asked to write a letter to answer the following question: “If asthma were a friend of yours, what would you like to say to it in a letter?” Data were analyzed using the continuous comparative method of Colaizzi (1978; “Psychological research as a phenomenologist views it”, in Valle, R. And King, M. (Eds), Existential Phenomenological Alternatives for Psychology, Oxford University Press, New York, NY.). For this purpose, each researcher read the letters separately and identified the important thoughts, and similar statements were classified under the same theme groups. Results. The mean age of the patients was 41.43 ± 6.23 years, and 69.6% of them were female, 73.9% were married, 34.8% were primary school graduates, and 34.7% were civil servants (with no social security problems). The statements of the asthmatics in the study were grouped according to the following themes: “The Most Important Factor in Accepting Asthma Is Time,” “It’s So Hard to Be Asthmatic,” “Being Asthmatic Means Understanding the Value of Life,” “I Don’t Like Asthma, so I Can’t Make Friends with It,” “Learning to Live with Asthma,” “One Day I May Recover from Asthma,” “Feeling Anger,” and “Suffering from Continuous Worry and Fear.” Conclusion. Asthmatic patients need psychosocial support since they believe that there is no certain treatment for asthma, and attacks are inevitable.     

Glucocorticoid-resistant asthma: more than meets the eye

Abstract

Introduction: For decades glucocorticoids have been considered as the gold standard for the treatment of asthma. We present a case report of typical glucocorticoid-resistant asthma and current consensus in definitions of “severe refractory”, “difficult” and “glucocorticoid-resistant” asthma. Methods: Full-text papers and abstracts were identified on the basis of a comprehensive literature search primarily in MEDLINE (1966 to June 2012) but also in the Cochrane Central Register of Controlled Trials database. Results: Glucocorticoid-resistant asthmatics are a small subset of patients who pose noteworthy diagnostic challenges while contributing disproportionately to health care costs. Recognition of various asthma phenotypes has aided in characterizing groups with severe asthma and given a better understanding of its pathophysiological process. The molecular mechanism of glucocorticoid action is complicated and several pathways have been identified to explain drug resistance, which in turn is crucial for drug development. Tobacco smoking appears to be the single most important contributor of glucocorticoid resistance. We present the emerging and promising concepts in the management of glucocorticoid-resistant asthma, which mainly include drugs targeting specific molecules, receptors, inflammatory cells or immune processes. Conclusion: The challenges in making a diagnosis of glucocorticoid-resistant asthma may contribute to underestimating its prevalence and impact on patient care. Considerable progress has been made in identifying distinct phenotypes and mechanisms of glucocorticoid resistance; therefore the future of new drug development in management of asthma is promising.     

GENERALIZED CYTOMEGALOVIRUS INFECTION IN A PATIENT WITH LUPOID HEPATITIS

A woman aged 18 years had an acute “multisystem disease” of which the major impact was on the liver; the LE cell test was positive. The subsequent course of the illness was that of “autoimmune” lupoid hepatitis: serological tests for antinuclear and smooth muscle antibody were positive, and continued treatment with prednisolone was necessary. Splenectomy was required for thrombocytopenia with bruising. Liver biopsy during the illness showed quiescent hepatitis and no virus inclusions in liver cells. After seven years of illness and two years of treatment with azathioprine, a fatal febrile illness occurred with sharp deterioration of liver function. Autopsy revealed inclusions of cytomegalovirus in liver cells and many other tissues. The discussion is concerned with cytomegalovirus as a cause of liver disease in adults, “latent” cytomegalovirus infection, and the degree to which immunosuppressive therapy in this case predisposed to the fatal illness due to cytomegalovirus.     

A Randomized Controlled Trial Using the School for Anti-inflammatory Therapy in Asthma

This study investigated the impact of providing low-dose inhaled corticosteroids (ICS) at school or at home to asthmatic inner city children over a 14-week period, compared with the existing community standard. Eight elementary schools in the Dallas Independent School District with a high incidence of asthma located in predominantly urban African-American communities were randomly assigned to one of four groups. The treatment arms were school-based delivery of inhaled steroids, home-based delivery of inhaled steroids, and home-based delivery of inhaled steroids with school-based asthma education, and the control group was no change in current therapy. Fifty students were objectively diagnosed with mild, persistent asthma and participated in the study. Students in the treatment arms received beclomethasone (42 mcg/puff) 4 puffs, twice a day, either at school or at home. Students in the control, “community standard of care” group received no additional medical intervention. Higher peak flows for the treatment groups were seen in the first week and maintained throughout the study (P = .047). By week 5 significant differences were found in frequency of bronchodilator use (P = .025), episodes of nocturnal awakening with asthma symptoms (P = .022), and visits to the primary health care provider (P = .022). Treatment groups rated their asthma as “better than the week before” more frequently than the control group (P = .001). Delivering ICS in school is associated with improved asthma control than when anti-inflammatory medication was delivered to children with asthma in a home-based setting, and both are superior when compared with a control, “community standard of care” group in which no additional medical intervention occurred.     

Rinitis,poliposis nasal y su relación con el asma

The aim of this review is to assist pulmonologists in the management of diseases involving both the upper and lower respiratory tract that are linked by a common, interrelated epidemiology, clinical signs and symptoms, and inflammatory mechanism ? asthma, in particular.The document discusses the definitions of the various sinonasal phenotypes associated with asthma: allergic and non-allergic rhinitis and chronic rhinosinusitis with or without nasal polyps. Diagnostic criteria and severity levels are also listed.Particular attention has been given to the 2 main syndromes associated with asthma: (i) allergic rhinitis, the most common, and (ii) chronic rhinosinusitis with nasal polyps, the disease most closely associated with severe asthma.To summarize, the upper respiratory tract should always be evaluated in order to achieve a single diagnosis and comprehensive treatment of the “united airway”.     

Irritable bowel syndrome patients' perspectives on their relationships with healthcare providers

Abstract

Objective. The objective of this qualitative study was to examine patients' perspectives on their relationships with healthcare providers (HCPs) as communicated in their expressive writings about irritable bowel syndrome (IBS). Methods. As part of a large national online study, IBS patients were asked to: (a) write expressively about their IBS illness experience for 30 min/day for four consecutive days and (b) answer the question, “What is the most important thing your HCP can do to maximize his/her relationship with you?” A key word search was used to identify comments that mentioned the words “doctor,” “doc,” “physician,” “MD,” “gastroenterologist,” “nurse,” “nurse practitioner,” or “physician assistant” in the 228 expressive writings completed by the first 57 participants (four writings for each subject). Analyses of the comments about the patient–HCP relationship and responses to the above question were performed by the authors who identified themes and their frequencies over several sessions using a quantitative content analysis method. Results. We report the results of the first 57 subjects who participated in the study. Subjects' mean age was 41.1 (± 12.7) years, gender was 82% female, 98% had seen an MD for IBS, 58% had IBS <10 years, with mild/moderate disease severity (IBS severity scale (IBSSS) 190.6 + 45.55), and IBS-quality of life (QOL; 62.7.3 + 21.58). Of the 57 subjects who wrote expressively about their experiences related to IBS, 40 (70%) wrote about their relationships with their HCPs in at least one of their four writings. Of the 197 relationship comments about HCPs made in a total of 84 writings, 106 (54%) were categorized as “negative,” 22 (11%) as “positive,” and 69 (35%) comments were categorized as “neutral mentions.” The top five themes identified were: “I need more empathy and listening from my HCP about how much IBS affects my life” (27%), “Nothing my HCP does helps my IBS” (25%), “My HCP has been helpful and reassuring” (17%), “My HCP thinks I'm crazy” (8%), and “I don't trust my HCP” (5%). Forty-nine (86%) subjects answered the question regarding maximizing the relationship with their HCP, with 53% reporting that listening, empathy, and providing education were the most important factors for maximizing the relationship. Conclusion. Our results demonstrate that the patient–HCP relationship is central to patients' illness experience. The majority of our study subjects viewed their relationships with HCPs negatively, with major concerns relating to being heard and receiving empathy. The study findings highlight the need for improved patient–HCP communication. Further research utilizing novel modalities, such as expressive writing, in eliciting patient information and perspectives, may provide valuable educational tools.     

Asthma and Human Excellence

Superior intelligence, creative genius, extraordinary personality, and/or social prominence have been associated with asthma often enough to raise the question of a nonrandom concurrence. With no intent to prove any developmental correlation, this section of the journal of Asthma presents such “case reports” (more biographical than biological) for two main reasons: to document the experience of asthma in the life of outstanding persons and to make everyone better acquainted—using asthma as an “excuse”—with the work and the times of some unique human beings.

Arnold Schoenberg and Alban Berg The Serial Music and Serious Asthma of Two Leading 20th-century Composers     

Inaccuracy of asthma-related self-reported health-care utilization data compared to Medicaid claims

Background. Benefits outweigh risks of cardioselective beta-blocker therapy in patients with nonsevere asthma and a history of heart failure or myocardial infarction (MI). This review summarizes the risks versus benefits of using cardioselective beta-blockers in the treatment of hypertension in patients with asthma. Methods. We searched the English literature from 1976 to 2011 via PubMed, EMBASE, and SCOPUS using the following search terms: “beta-blocker treatment of hypertension” AND “asthma”; “cardioselective beta-blockers” AND “asthma.” When pertinent articles were found, we assessed relevant articles cited in those papers. All studies related to cardioselective beta-blocker use in patients with asthma and hypertension were included. Results. Seven studies with patient populations ranging from 10 to 17 patients evaluated cardioselective beta-blockers in patients with asthma and hypertension. Atenolol and/or immediate-release metoprolol were evaluated in these studies. The duration of beta-blocker therapy in four studies was 1–8 weeks; two studies were single dose and one investigation lasted 8 months. Metoprolol and atenolol were generally well tolerated except at higher doses such as metoprolol >100 mg daily. Conclusion. In the absence of concomitant cardiovascular disease, routine use of beta-blockers for the treatment of hypertension in patients with asthma should be avoided     

瓣膜性房颤定义及抗凝治疗研究进展

现阶段对于"瓣膜病变型"房颤(AF)与"非瓣膜病变型"AF的定义尚未达成共识,不仅如此,各指南在表述这些概念时也存在差异。临床试验对于"瓣膜病变型"AF与"非瓣膜病变型"AF定义的阐述不甚理想。两类AF血栓栓塞风险差异较大,抗凝治疗策略也有所不同。本文将对瓣膜性AF定义及抗凝治疗的研究进展予以综述。     

Association Between Asthma Symptoms and Obesity in Preschool (4-5 year old) Children

Objective. There have been many publications looking at the association between asthma and obesity in school aged children and adolescents. There have been few studies looking at the association in preschool children. Methods. Questionnaire data on 1509 4- to 5-year-old children were collected in 2006 from the state of South Australia, Australia. The prevalence of asthma symptoms, allergic rhinitis and eczema was ascertained using the International Study of Asthma and Allergy in Childhood (ISAAC) questionnaire. Body mass index was calculated from height and weight data and prevalence of obesity was defined using the International Obesity Task Force (IOTF) definitions. Results. The prevalence of wheeze in the last 12 months in the preschool population was 23.7%. In the cohort, 199 (13.7%) children were classified as overweight and 83 (5.7%) children were classified as obese. A significant relationship was identified between “wheeze in the last 12 months” (p <.01), “wheeze ever” (p <.001) and “asthma ever” (p <.001) with the trend towards obesity. The relationship was significant for both male and female sex with the exception of “wheeze in the last 12 months” in obese females. (p = 0.09). Conclusion. There is an association between asthma symptoms and obesity in preschool children. The relationship is evident for both male and female sex.     

Visual Analog Scale as a Predictor of GINA-Defined Asthma Control. The SACRA Study in Japan

Objective. The assessment of asthma control is pivotal to treatment decisions. A questionnaire that assesses the Global Initiative for Asthma (GINA)-defined control requires four questions. A visual analog scale (VAS) to evaluate asthma control can be simply marked, but its correlation with GINA-defined control has been insufficiently evaluated. The purpose of this study is to evaluate whether VAS levels can predict GINA-defined asthma control with particular emphasis on the distinctions between “partly controlled” and “uncontrolled” and between “partly controlled” and “controlled” asthma, Methods. A cross-sectional multicenter study was carried out throughout Japan (SACRA) from March to August 2009 among patients with a diagnosis and treatment of asthma. Asthma control was studied using the GINA questionnaire and a VAS measurement of asthma severity. Pulmonary function testing was not carried out, Results. 1910 physicians enrolled 29,518 patients with asthma. 15,051 (51.0%) questionnaires were administered by physicians; patients filled out 14,076 (47.7%) questionnaires themselves. 28,225 (95.6%) of the patients were evaluable. VAS measurement of asthma symptoms was useful in predicting levels of GINA-defined control categories (the area under the receiver operating characteristic curve ranging from 0.704 to 0.837). Patients with “controlled,” “partly controlled,” and “uncontrolled” asthma were discriminated by VAS levels (1.50, 4.79, and 7.19). Similar results have been obtained with self- and physician-administered questionnaires showing the validity of results. Conclusion. Measurement of VAS levels is able to discriminate between patients with “controlled,” “partly controlled,” and “uncontrolled” asthma. The VAS score could be a simple guide in clinical situations requiring daily or regular evaluation of asthma control.     

The influence of lower respiratory illness on childhood asthma: defining risk and susceptibility.

This article reviews the role of lower respiratory illness as a risk factor for the development of asthma in childhood. Lower respiratory illness may influence the natural course of lung-function growth and decline directly or indirectly promoting the development of asthma symptoms in susceptible individuals. The authors discuss the current definitions of lower respiratory illness and asthma and the characteristics of the individuals most prone to their effects. Last, they review how socioeconomic status and race affect the lower respiratory illness-asthma relationship.     

Distribution of asthma by occupation: Washington State Behavioral Risk Factor Surveillance System Data, 2006–2009

Objective: To estimate the prevalence of asthma in workers by occupation in Washington State. Methods: Data from the 2006–2009 Behavioral Risk Factor Surveillance System (BRFSS) and the BRFSS Asthma Call-Back Survey (ACBS) in Washington State (WA) were analyzed. Using state-added and coded Industry and Occupation questions, we calculated prevalence ratios (PRs) for 19 occupational groups. Results: Of the 41?935 respondents who were currently employed during 2006–2009, the prevalence of current asthma was 8.1% [95% confidence interval (CI) 7.8–8.5%] When compared with the reference group of executive, administration and managerial occupations, three occupational groups had significantly (p?Conclusions: Some occupations have a higher prevalence of current asthma than other occupations. The systematic collection of industry and occupation data can help identify worker populations with a high burden of asthma and can be used to target disease prevention efforts as well as to aid clinician recognition and treatment. Workers indicated that work-related asthma exposures are not discussed with their health care provider and this communication gap has implications for asthma management.     

Diagnosis of asthma – new theories

Introduction: Recent studies have shown a remarkably high frequency of poorly controlled asthma. Several reasons for this treatment failure have been discussed, however, the basic question of whether the diagnosis is always correct has not been considered. Follow-up studies have shown that in many patients asthma cannot be verified despite ongoing symptoms. Mechanisms other than bronchial obstruction may therefore be responsible. The current definition of asthma may also include symptoms that are related to mechanisms other than bronchial obstruction, the clinical hallmark of asthma. Aim: Based on a review of the four cornerstones of asthma – inflammation, hyperresponsiveness, bronchial obstruction and symptoms – the aim was to present some new aspects and suggestions related to the diagnosis of adult non-allergic asthma. Conclusion: Recent studies have indicated that “classic” asthma may sometimes be confused with asthma-like disorders such as airway sensory hyperreactivity, small airways disease, dysfunctional breathing, non-obstructive dyspnea, hyperventilation and vocal cord dysfunction. This confusion may be one explanation for the high proportion of misdiagnosis and treatment failure. The current diagnosis, focusing on bronchial obstruction, may be too “narrow”. As there may be common mechanisms a broadening to include also non-obstructive disorders, forming an asthma syndrome, is suggested. Such broadening requires additional diagnostic steps, such as qualitative studies with analysis of reported symptoms, non-effort demanding methods for determining lung function, capsaicin test for revealing airway sensory hyperreactivity, careful evaluation of the therapeutic as well as diagnostic effect of corticosteroids and testing of suggested theories.     

Acute Effect of Inhaled Budesonide on Bronchial Inflammation in Asthmatic Rats

The aim of this study was to determine the level of asthma control and the concordance between physicians' and patients' opinions and the real patients' situation. A total of 777 subjects (55% female) with asthma were recruited. The study comprised a 4-week follow-up period, during which subjects completed a diary recording peak expiratory flow (PEF), symptoms, and use of rescue medication. At the end, both physicians and patients rated asthma control status. The level of control was evaluated using a composite measure. Agreement among subjective assessments of asthma control by patients and physicians and objective evaluation with the composite measure was assessed through kappa scores. A total of 518 (67%) patients had “not well-controlled asthma,” being the remaining “totally controlled” (8%) or “well-controlled” (25%). “Not well-controlled asthma” was more frequent in smokers (82%) than in ex-smokers (70%) or in non-smokers (62%; p = 0.0002). Kappa scores between patients' and physicians' opinions and the real patients' status were 0.02 (95% CI, 0.01–0.05) and 0.07 (95% CI, 0.03–0.09), respectively. In conclusion, current level of asthma control is suboptimal for a majority (67%) of patients in Spain. Besides, asthma control is worse in smokers. Neither patients' nor physicians' opinions agree with patients' real situation. Both patients and physicians accept as normal a suboptimal status of their disease.